Oxidative stress dependent microRNA-34a activation via PI3Kα reduces the expression of sirtuin-1 and sirtuin-6 in epithelial cells

Various Mechanistic Pathways Representing the Aging Process Are Altered in COPD

(2016) Erica P.A. Rutten et al.   CHEST

Signature of circulating microRNAs in patients with acute heart failure

(2015) Ekaterina S. Ovchinnikova et al.   EUROPEAN JOURNAL OF HEART FAILURE

Unravelling the complexity of COPD by microRNAs: it's a small world after all

(2015) Emmanuel T. Osei et al.   EUROPEAN RESPIRATORY JOURNAL

The Regulation and Function of miR-21-FOXO3a-miR-34b/c Signaling in Breast Cancer

(2015) Xiangyan Liu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Prevalence and Global Initiative for Chronic Obstructive Lung Disease Group Distribution of Chronic Obstructive Pulmonary Disease Detected by Preoperative Pulmonary Function Test

(2015) Sun Mi Choi et al.   PLoS One

miR-34a induces cellular senescence via modulation of telomerase activity in human hepatocellular carcinoma by targeting FoxM1/c-Myc pathway

(2015) Xinsen Xu et al.   Oncotarget

MicroRNA-34c is associated with emphysema severity and modulates SERPINE1 expression

(2014) Santiyagu M Savarimuthu Francis et al.   BMC GENOMICS

miR-199a-5p Silencing Regulates the Unfolded Protein Response in Chronic Obstructive Pulmonary Disease and α1-Antitrypsin Deficiency

(2013) Tidi Hassan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Oxidative Stress in COPD

(2013) Paul A. Kirkham et al.   CHEST

Cellular and Molecular Mechanisms of Chronic Obstructive Pulmonary Disease

(2013) Peter J. Barnes   CLINICS IN CHEST MEDICINE

A miR-34a-SIRT6 axis in the squamous cell differentiation network

(2013) Karine Lefort et al.   EMBO JOURNAL

Autophagy Induction by SIRT6 through Attenuation of Insulin-like Growth Factor Signaling Is Involved in the Regulation of Human Bronchial Epithelial Cell Senescence

(2013) N. Takasaka et al.   JOURNAL OF IMMUNOLOGY

MicroRNA-34a regulates cardiac ageing and function

(2013) Reinier A. Boon et al.   NATURE

Dysfunction of Endothelial Progenitor Cells from Smokers and Chronic Obstructive Pulmonary Disease Patients Due to Increased DNA Damage and Senescence

(2013) Koralia E. Paschalaki et al.   STEM CELLS

Transcriptional activation of microRNA-34a by NF-kappa B in human esophageal cancer cells

(2012) Juan Li et al.   BMC MOLECULAR BIOLOGY

MicroRNA-199a-5p Is Associated With Hypoxia-Inducible Factor-1α Expression in Lungs From Patients With COPD

(2012) Shiro Mizuno et al.   CHEST

MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1

(2012) Laisheng Li et al.   CLINICAL AND EXPERIMENTAL MEDICINE

ANALYSIS OF SERUM MICRO-RNAs AS POTENTIAL BIOMARKER IN CHRONIC OBSTRUCTIVE PULMONARY DISEASE

(2012) Fahri Akbas et al.   EXPERIMENTAL LUNG RESEARCH

SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice

(2012) Hongwei Yao et al.   JOURNAL OF CLINICAL INVESTIGATION

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Intact p53-Dependent Responses in miR-34–Deficient Mice

(2012) Carla P. Concepcion et al.   PLoS Genetics

Oxidative Stress–induced Antibodies to Carbonyl-modified Protein Correlate with Severity of Chronic Obstructive Pulmonary Disease

(2011) Paul A. Kirkham et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Four faces of cellular senescence

(2011) Francis Rodier et al.   JOURNAL OF CELL BIOLOGY

FOXO3 Deficiency Leads to Increased Susceptibility to Cigarette Smoke-Induced Inflammation, Airspace Enlargement, and Chronic Obstructive Pulmonary Disease

(2011) J.-w. Hwang et al.   JOURNAL OF IMMUNOLOGY

Phosphoinositide 3-kinase as a novel functional target for the regulation of the insulin signaling pathway by SIRT1

(2011) Sara Fröjdö et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Oxidative stress in health and disease: The therapeutic potential of Nrf2 activation

(2011) Brooks M. Hybertson et al.   MOLECULAR ASPECTS OF MEDICINE

Downregulation of the serum response factor/miR-1 axis in the quadriceps of patients with COPD

(2011) Amy Lewis et al.   THORAX

Accelerated epithelial cell senescence in IPF and the inhibitory role of SIRT6 in TGF-β-induced senescence of human bronchial epithelial cells

(2010) Shunsuke Minagawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease

(2010) Yasuo To et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MicroRNA Expression in Induced Sputum of Smokers and Patients with Chronic Obstructive Pulmonary Disease

(2010) Geert R. Van Pottelberge et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

MicroRNA-34a regulation of endothelial senescence

(2010) Takashi Ito et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Reduced expression of PNUTS leads to activation of Rb-phosphatase and caspase-mediated apoptosis

(2010) Gabriel De Leon et al.   CANCER BIOLOGY & THERAPY

SIRT1 is a redox-sensitive deacetylase that is post-translationally modified by oxidants and carbonyl stress

(2010) Samuel Caito et al.   FASEB JOURNAL

Oxidative stress, inflammation, and cancer: How are they linked?

(2010) Simone Reuter et al.   FREE RADICAL BIOLOGY AND MEDICINE

MiR-34a attenuates paclitaxel-resistance of hormone-refractory prostate cancer PC3 cells through direct and indirect mechanisms

(2010) Keitaro Kojima et al.   PROSTATE

COPD as a Disease of Accelerated Lung Aging

(2009) Kazuhiro Ito et al.   CHEST

A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9

(2009) Yuji Nakamaru et al.   FASEB JOURNAL

Immunologic Aspects of Chronic Obstructive Pulmonary Disease

(2009) Manuel G. Cosio et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tobacco Smoke: Involvement of Reactive Oxygen Species and Stable Free Radicals in Mechanisms of Oxidative Damage, Carcinogenesis and Synergistic Effects with Other Respirable Particles

(2009) Athanasios Valavanidis et al.   International Journal of Environmental Research and Public Health

SIRT1, an Antiinflammatory and Antiaging Protein, Is Decreased in Lungs of Patients with Chronic Obstructive Pulmonary Disease

(2008) Saravanan Rajendrasozhan et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Targeting the NF-κB pathway in asthma and chronic obstructive pulmonary disease

(2008) Michael R. Edwards et al.   PHARMACOLOGY & THERAPEUTICS

miR-34a repression of SIRT1 regulates apoptosis

(2008) M. Yamakuchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA