Multifunctional Roles of the Actin-Binding Protein Flightless I in Inflammation, Cancer and Wound Healing
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Title
Multifunctional Roles of the Actin-Binding Protein Flightless I in Inflammation, Cancer and Wound Healing
Authors
Keywords
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Journal
Frontiers in Cell and Developmental Biology
Volume 8, Issue -, Pages -
Publisher
Frontiers Media SA
Online
2020-11-24
DOI
10.3389/fcell.2020.603508
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Note: Only part of the references are listed.- Flightless Anchors IQGAP1 and R-ras to Mediate Cell Extension Formation and Matrix Remodeling
- (2020) P. D. Arora et al. MOLECULAR BIOLOGY OF THE CELL
- FGF6 and FGF9 regulate UCP1 expression independent of brown adipogenesis
- (2020) Farnaz Shamsi et al. Nature Communications
- Nucleoredoxin interaction with flightless‐I/actin complex is differentially altered in alcoholic liver disease
- (2020) Brisa Rodope Alarcón‐Sánchez et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Flightless-1 inhibits ER stress-induced apoptosis in colorectal cancer cells by regulating Ca2+ homeostasis
- (2020) Sun Sil Choi et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Attenuation of Flightless I Increases Human Pericyte Proliferation, Migration and Angiogenic Functions and Improves Healing in Murine Diabetic Wounds
- (2020) Hannah M Thomas et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The signaling adaptor BCAP inhibits NLRP3 and NLRC4 inflammasome activation in macrophages through interactions with Flightless-1
- (2019) Samuel J. Carpentier et al. Science Signaling
- Effect of Flightless I Expression on Epidermal Stem Cell Niche During Wound Repair
- (2019) Gink N. Yang et al. Advances in Wound Care
- Flightless I, a contributing factor to skin blistering in Kindler syndrome patients?
- (2019) Zlatko Kopecki et al. JOURNAL OF CUTANEOUS PATHOLOGY
- Flightless I exacerbation of inflammatory responses contributes to increased colonic damage in a mouse model of dextran sulphate sodium-induced ulcerative colitis
- (2019) Z. Kopecki et al. Scientific Reports
- Flightless-I blocks p62-mediated recognition of LC3 to impede selective autophagy and promote breast cancer progression
- (2018) Jian-ping He et al. CANCER RESEARCH
- Recombinant Leucine-Rich Repeat Flightless-Interacting Protein-1 Improves Healing of Acute Wounds through Its Effects on Proliferation Inflammation and Collagen Deposition
- (2018) Zlatko Kopecki et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- The leucine-rich region of Flightless I interacts with R-ras to regulate cell extension formation
- (2018) P. D. Arora et al. MOLECULAR BIOLOGY OF THE CELL
- Flightless I Alters the Inflammatory Response and Autoantibody Profile in an OVA-Induced Atopic Dermatitis Skin-Like Disease
- (2018) Zlatko Kopecki et al. Frontiers in Immunology
- The flightless I protein interacts with RNA-binding proteins and is involved in the genome-wide mRNA post-transcriptional regulation in lung carcinoma cells
- (2017) Cuihua Wang et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- TRPV4 mediates the Ca2+influx required for the interaction between flightless-1 and non-muscle myosin, and collagen remodeling
- (2017) Pamma D. Arora et al. JOURNAL OF CELL SCIENCE
- Flightless I Expression Enhances Murine Claw Regeneration Following Digit Amputation
- (2017) Xanthe L. Strudwick et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Development of Topical Delivery Systems for Flightless Neutralizing Antibody
- (2017) Hanif Haidari et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Flightless-I homolog regulates glucocorticoid receptor-mediated transcription via direct interaction of the leucine-rich repeat domain
- (2017) Hong Lan Jin et al. MOLECULAR BIOLOGY REPORTS
- Flightless-I governs cell fate by recruiting the SUMO isopeptidase SENP3 to distinct HOX genes
- (2017) Arnab Nayak et al. Epigenetics & Chromatin
- Epithelial Mesenchymal Transition in Embryonic Development, Tissue Repair and Cancer: A Comprehensive Overview
- (2017) Do Kim et al. Journal of Clinical Medicine
- Flightless I is a key regulator of the fibroproliferative process in hypertrophic scarring and a target for a novel antiscarring therapy
- (2016) A.M. Cameron et al. BRITISH JOURNAL OF DERMATOLOGY
- Reducing Flightless I expression decreases severity of psoriasis in an imiquimod-induced murine model of psoriasiform dermatitis
- (2016) H.T. Chong et al. BRITISH JOURNAL OF DERMATOLOGY
- Polymorphisms of FLII implicate gene expressions and growth traits in Chinese cattle
- (2016) Mei Liu et al. MOLECULAR AND CELLULAR PROBES
- Differential Rac1 signalling by guanine nucleotide exchange factors implicates FLII in regulating Rac1-driven cell migration
- (2016) Hadir Marei et al. Nature Communications
- F-actin dampens NLRP3 inflammasome activity via Flightless-I and LRRFIP2
- (2016) Danielle Burger et al. Scientific Reports
- Delivery of Flightless I Neutralizing Antibody from Porous Silicon Nanoparticles Improves Wound Healing in Diabetic Mice
- (2016) Christopher T. Turner et al. Advanced Healthcare Materials
- Silencing of LRRFIP1 reverses the epithelial–mesenchymal transition via inhibition of the Wnt/β-catenin signaling pathway
- (2015) Daisuke Douchi et al. CANCER LETTERS
- Flightless-1, a novel transcriptional modulator of PPARγ through competing with RXRα
- (2015) Jin Sil Choi et al. CELLULAR SIGNALLING
- Flightless I Homolog Represses Prostate Cancer Progression through Targeting Androgen Receptor Signaling
- (2015) T. Wang et al. CLINICAL CANCER RESEARCH
- Rho GTPase signalling in cell migration
- (2015) Anne J Ridley CURRENT OPINION IN CELL BIOLOGY
- Fibroblast-specific upregulation of Flightless I impairs wound healing
- (2015) Christopher T. Turner et al. EXPERIMENTAL DERMATOLOGY
- Flightless-I (FliI) is a potential negative regulator of the Toll pathway in Litopenaeus vannamei
- (2015) Shuang Zhang et al. FISH & SHELLFISH IMMUNOLOGY
- LRRFIP1 Inhibits Hepatitis C Virus Replication by Inducing Type I Interferon in Hepatocytes
- (2015) Yuan Liu et al. Hepatitis Monthly
- In vivo delivery of functional Flightless I siRNA using layer-by-layer polymer surface modification
- (2015) Penny J Martens et al. JOURNAL OF BIOMATERIALS APPLICATIONS
- Flightless I interacts with NMMIIA to promote cell extension formation, which enables collagen remodeling
- (2015) Pamma D. Arora et al. MOLECULAR BIOLOGY OF THE CELL
- Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression
- (2015) Zlatko Kopecki et al. Oncotarget
- Slit2N Inhibits Transmission of HIV-1 from Dendritic Cells to T-cells by Modulating Novel Cytoskeletal Elements
- (2015) Ashutosh Shrivastava et al. Scientific Reports
- Nod-Like Receptor Protein-3 Inflammasome Plays an Important Role during Early Stages of Wound Healing
- (2015) Eileen M. Weinheimer-Haus et al. PLoS One
- Flightless I (Drosophila) homolog facilitates chromatin accessibility of the estrogen receptor α target genes in MCF-7 breast cancer cells
- (2014) Kwang Won Jeong BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Role of Flightless-I (Drosophila) homolog in the transcription activation of type I collagen gene mediated by transforming growth factor beta
- (2014) Mi-Sun Lim et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Biological Activity Differences between TGF-β1 and TGF-β3 Correlate with Differences in the Rigidity and Arrangement of Their Component Monomers
- (2014) Tao Huang et al. BIOCHEMISTRY
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- (2014) C. Has et al. CLINICAL GENETICS
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- (2014) Yang Zhou et al. PLoS One
- The microRNA miR-132 targets Lrrfip1 to block vascular smooth muscle cell proliferation and neointimal hyperplasia
- (2013) Nakwon Choe et al. ATHEROSCLEROSIS
- The Imitation Switch ATPase Snf2l Is Required for Superovulation and Regulates Fgl2 in Differentiating Mouse Granulosa Cells
- (2013) D. Pepin et al. BIOLOGY OF REPRODUCTION
- Gelsolin: The tail of a molecular gymnast
- (2013) Shalini Nag et al. Cytoskeleton
- Attenuation of flightless I improves wound healing and enhances angiogenesis in a murine model of type 1 diabetes
- (2013) Nadira Ruzehaji et al. DIABETOLOGIA
- Flightless I homolog negatively regulates ChREBP activity in cancer cells
- (2013) Lifang Wu et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Flightless I over-expression impairs skin barrier development, function and recovery following skin blistering
- (2013) Zlatko Kopecki et al. JOURNAL OF PATHOLOGY
- Diet-Induced Over-Expression of Flightless-I Protein and Its Relation to Flightlessness in Mediterranean Fruit Fly, Ceratitis capitata
- (2013) Il Kyu Cho et al. PLoS One
- LRRFIP2 negatively regulates NLRP3 inflammasome activation in macrophages by promoting Flightless-I-mediated caspase-1 inhibition
- (2013) Jing Jin et al. Nature Communications
- The Influence of Flightless I on Toll-Like-Receptor-Mediated Inflammation in a Murine Model of Diabetic Wound Healing
- (2013) Nadira Ruzehaji et al. Biomed Research International
- Flightless I is a focal adhesion-associated actin-capping protein that regulates cell migration
- (2012) Ibrahim Mohammad et al. FASEB JOURNAL
- Caspase-11 Promotes the Fusion of Phagosomes Harboring Pathogenic Bacteria with Lysosomes by Modulating Actin Polymerization
- (2012) Anwari Akhter et al. IMMUNITY
- Flightless, secreted through a late endosome/lysosome pathway, binds LPS and dampens cytokine secretion
- (2012) N. Lei et al. JOURNAL OF CELL SCIENCE
- Topically Applied Flightless I Neutralizing Antibodies Improve Healing of Blistered Skin in a Murine Model of Epidermolysis Bullosa Acquisita
- (2012) Zlatko Kopecki et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Gene-Specific Patterns of Coregulator Requirements by Estrogen Receptor-α in Breast Cancer Cells
- (2012) Kwang Won Jeong et al. MOLECULAR ENDOCRINOLOGY
- Epithelial stem cells and implications for wound repair
- (2012) Maksim V. Plikus et al. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
- TGF-β signaling in fibrosis
- (2011) Anna Biernacka et al. GROWTH FACTORS
- Caspase-1-induced pyroptotic cell death
- (2011) Edward A. Miao et al. IMMUNOLOGICAL REVIEWS
- Regulation of Focal Adhesions by Flightless I Involves Inhibition of Paxillin Phosphorylation via a Rac1-Dependent Pathway
- (2011) Zlatko Kopecki et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Overexpression of the Flii gene increases dermal-epidermal blistering in an autoimmune ColVII mouse model of epidermolysis bullosa acquisita
- (2011) Zlatko Kopecki et al. JOURNAL OF PATHOLOGY
- Decreased expression of Flightless I, a gelsolin family member and developmental regulator, in early-gestation fetal wounds improves healing
- (2011) Cheng-Hung Lin et al. MAMMALIAN GENOME
- The Ras-ERK and PI3K-mTOR pathways: cross-talk and compensation
- (2011) Michelle C. Mendoza et al. TRENDS IN BIOCHEMICAL SCIENCES
- Transcription profiling in human platelets reveals LRRFIP1 as a novel protein regulating platelet function
- (2010) A. H. Goodall et al. BLOOD
- GC-binding factor 2 interacts with dishevelled and regulates Wnt signaling pathways in human carcinoma cell lines
- (2010) Hideo Ohtsuka et al. INTERNATIONAL JOURNAL OF CANCER
- Nucleoredoxin Negatively Regulates Toll-like Receptor 4 Signaling via Recruitment of Flightless-I to Myeloid Differentiation Primary Response Gene (88)
- (2010) Tatsuya Hayashi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Flightless-I (Fli-I) Regulates the Actin Assembly Activity of Diaphanous-related Formins (DRFs) Daam1 and mDia1 in Cooperation with Active Rho GTPase
- (2010) Tomohito Higashi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Leucine-Rich Repeat (in Flightless I) Interacting Protein-1 Regulates a Rapid Type I Interferon Response
- (2010) Asen Bagashev et al. JOURNAL OF INTERFERON AND CYTOKINE RESEARCH
- The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a β-catenin-dependent pathway
- (2010) Pengyuan Yang et al. NATURE IMMUNOLOGY
- Bidirectional control of the inner dynamics of focal adhesions promotes cell migration
- (2010) Jacky G. Goetz Cell Adhesion & Migration
- Attenuation of Flightless I, an actin-remodelling protein, improves burn injury repair via modulation of transforming growth factor (TGF)-β1 and TGF-β3
- (2009) D.H. Adams et al. BRITISH JOURNAL OF DERMATOLOGY
- Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses
- (2009) T. H. Mogensen CLINICAL MICROBIOLOGY REVIEWS
- Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases
- (2009) Bryan T. MacDonald et al. DEVELOPMENTAL CELL
- Identification of Flightless-I as a Substrate of the Cytokine-independent Survival Kinase CISK
- (2009) Jun Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Recruitment of the SWI/SNF Chromatin Remodeling Complex to Steroid Hormone-regulated Promoters by Nuclear Receptor Coactivator Flightless-I
- (2009) Kwang Won Jeong et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Adhesion signaling - crosstalk between integrins, Src and Rho
- (2009) S. Huveneers et al. JOURNAL OF CELL SCIENCE
- Modulation of TLR Signaling by Multiple MyD88-Interacting Partners Including Leucine-Rich Repeat Fli-I-Interacting Proteins
- (2009) P. Dai et al. JOURNAL OF IMMUNOLOGY
- Flightless I Regulates Hemidesmosome Formation and Integrin-Mediated Cellular Adhesion and Migration during Wound Repair
- (2009) Zlatko Kopecki et al. JOURNAL OF INVESTIGATIVE DERMATOLOGY
- Tropomyosin Isoform Expression Regulates the Transition of Adhesions To Determine Cell Speed and Direction
- (2009) C. T. T. Bach et al. MOLECULAR AND CELLULAR BIOLOGY
- FLI-1 Flightless-1 and LET-60 Ras control germ line morphogenesis in C. elegans
- (2008) Jiamiao Lu et al. BMC DEVELOPMENTAL BIOLOGY
- Flightless-I, a gelsolin family member and transcriptional regulator, preferentially binds directly to activated cytosolic CaMK-II
- (2008) Matthew E. Seward et al. FEBS LETTERS
- Flightless-I regulates proinflammatory caspases by selectively modulating intracellular localization and caspase activity
- (2008) Juying Li et al. JOURNAL OF CELL BIOLOGY
- Actin and α-actinin orchestrate the assembly and maturation of nascent adhesions in a myosin II motor-independent manner
- (2008) Colin K. Choi et al. NATURE CELL BIOLOGY
- Comparative Dynamics of Retrograde Actin Flow and Focal Adhesions: Formation of Nascent Adhesions Triggers Transition from Fast to Slow Flow
- (2008) Antonina Y. Alexandrova et al. PLoS One
- CaMK-II promotes focal adhesion turnover and cell motility by inducing tyrosine dephosphorylation of FAK and paxillin
- (2008) Charles A. Easley et al. CELL MOTILITY AND THE CYTOSKELETON
- Gender specific effects on the actin-remodelling protein Flightless I and TGF-β1 contribute to impaired wound healing in aged skin
- (2007) Damian H. Adams et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
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