27-Hydroxycholesterol Promotes the Transfer of Astrocyte-Derived Cholesterol to Neurons in Co-cultured SH-SY5Y Cells and C6 Cells

27-Hydroxycholesterol Contributes to Lysosomal Membrane Permeabilization-Mediated Pyroptosis in Co-cultured SH-SY5Y Cells and C6 Cells

(2019) Si Chen et al.   Frontiers in Molecular Neuroscience

Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer’s Disease Neurons

(2019) Rik van der Kant et al.   Cell Stem Cell

Oxysterols as a biomarker in diseases

(2019) Adam Zmysłowski et al.   CLINICA CHIMICA ACTA

CYP46A1 gene therapy deciphers the role of brain cholesterol metabolism in Huntington’s disease

(2019) Radhia Kacher et al.   BRAIN

Cholesterol 24-Hydroxylation by CYP46A1: Benefits of Modulation for Brain Diseases

(2019) Alexey M. Petrov et al.   Neurotherapeutics

Association of midlife lipids with 20-year cognitive change: A cohort study

(2018) Melinda C. Power et al.   Alzheimers & Dementia

Scavenger receptor class B type 1 regulates neuroblastoma cell proliferation, migration and invasion

(2018) Marlyn Panchoo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Increased Levels of 27-Hydroxycholesterol Induced by Dietary Cholesterol in Brain Contribute to Learning and Memory Impairment in Rats

(2018) Xiaona Zhang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

PDMP, a ceramide analogue, acts as an inhibitor of mTORC1 by inducing its translocation from lysosome to endoplasmic reticulum

(2017) Takashi Ode et al.   EXPERIMENTAL CELL RESEARCH

Astrocyte lipid metabolism is critical for synapse development and function in vivo

(2017) Anne-Lieke F. van Deijk et al.   GLIA

Lipid Metabolism and Survival Across the Frontotemporal Dementia-Amyotrophic Lateral Sclerosis Spectrum: Relationships to Eating Behavior and Cognition

(2017) Rebekah M. Ahmed et al.   JOURNAL OF ALZHEIMERS DISEASE

A High-Cholesterol Diet Increases 27-Hydroxycholesterol and Modifies Estrogen Receptor Expression and Neurodegeneration in Rabbit Hippocampus

(2017) Sylwia W. Brooks et al.   JOURNAL OF ALZHEIMERS DISEASE

Cellular cholesterol homeostasis and Alzheimer’s disease

(2017) Ta-Yuan Chang et al.   JOURNAL OF LIPID RESEARCH

Impaired learning and memory in rats induced by a high-fat diet: Involvement with the imbalance of nesfatin-1 abundance and copine 6 expression

(2017) Z. Chen et al.   JOURNAL OF NEUROENDOCRINOLOGY

Blood cholesterol in late-life and cognitive decline: a longitudinal study of the Chinese elderly

(2017) Chaoran Ma et al.   Molecular Neurodegeneration

27-Hydroxycholesterol regulates cholesterol synthesis and transport in C6 glioma cells

(2017) Yu An et al.   NEUROTOXICOLOGY

Isolation of F. novicida-Containing Phagosome from Infected Human Monocyte Derived Macrophages

(2017) Valentina Marecic et al.   Frontiers in Cellular and Infection Microbiology

Detrimental effects of a high fat/high cholesterol diet on memory and hippocampal markers in aged rats

(2016) Aurélie Ledreux et al.   BEHAVIOURAL BRAIN RESEARCH

Cholesterol 24-hydroxylase: Brain cholesterol metabolism and beyond

(2016) Miguel Moutinho et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Specific Binding of Cholesterol to C99 Domain of Amyloid Precursor Protein Depends Critically on Charge State of Protein

(2016) Afra Panahi et al.   Journal of Physical Chemistry Letters

Cholesterol overload induces apoptosis in SH-SY5Y human neuroblastoma cells through the up regulation of flotillin-2 in the lipid raft and the activation of BDNF/Trkb signaling

(2016) Yen-Ning Huang et al.   NEUROSCIENCE

CYP46A1 inhibition, brain cholesterol accumulation and neurodegeneration pave the way for Alzheimer’s disease

(2015) Fathia Djelti et al.   BRAIN

27-Hydroxycholesterol contributes to disruptive effects on learning and memory by modulating cholesterol metabolism in the rat brain

(2015) D.-D. Zhang et al.   NEUROSCIENCE

Cholesterol overload impairing cerebellar function: The promise of natural products

(2015) Hassan I.H. El-Sayyad   NUTRITION

Cholesterol metabolism and homeostasis in the brain

(2015) Juan Zhang et al.   Protein & Cell

Cholesterol and metal ions in Alzheimer's disease

(2014) Hyuck Jin Lee et al.   CHEMICAL SOCIETY REVIEWS

Induction of apoptosis and necroptosis by 24(S)-hydroxycholesterol is dependent on activity of acyl-CoA:cholesterol acyltransferase 1

(2014) K Yamanaka et al.   Cell Death & Disease

Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?

(2013) Silvia Maioli et al.   PLoS One

Localization of cholesterol, amyloid and glia in Alzheimer’s disease transgenic mouse brain tissue using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and immunofluorescence imaging

(2012) Santiago Solé-Domènech et al.   ACTA NEUROPATHOLOGICA

The link between altered cholesterol metabolism and Alzheimer's disease

(2012) Paola Gamba et al.   Annals of the New York Academy of Sciences

Cholesterol efflux is differentially regulated in neurons and astrocytes: Implications for brain cholesterol homeostasis

(2012) Jing Chen et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Dysregulation of cholesterol balance in the brain: contribution to neurodegenerative diseases

(2012) J. E. Vance   Disease Models & Mechanisms

Cholesterol loss during glutamate-mediated excitotoxicity

(2012) Alejandro O Sodero et al.   EMBO JOURNAL

Cholesterol metabolism is associated with soluble amyloid precursor protein production in Alzheimer's disease

(2012) Julius Popp et al.   JOURNAL OF NEUROCHEMISTRY

Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis

(2012) M. Maulik et al.   MOLECULAR NEUROBIOLOGY

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

Sterol Transfer between Cyclodextrin and Membranes: Similar but Not Identical Mechanism to NPC2-Mediated Cholesterol Transfer

(2011) Leslie A. McCauliff et al.   BIOCHEMISTRY

Oxysterols as biomarkers in neurodegenerative diseases

(2011) Valerio Leoni et al.   CHEMISTRY AND PHYSICS OF LIPIDS

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo

(2011) M. Shafaati et al.   JOURNAL OF INTERNAL MEDICINE

Marked accumulation of 27-hydroxycholesterol in the brains of Alzheimer's patients with the Swedish APP 670/671 mutation

(2011) Marjan Shafaati et al.   JOURNAL OF LIPID RESEARCH

Cholesterol metabolism in neurons and astrocytes

(2011) Frank W. Pfrieger et al.   PROGRESS IN LIPID RESEARCH

Brain cholesterol in normal and pathological aging

(2010) Mauricio Martin et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Oxysterols: Sources, cellular storage and metabolism, and new insights into their roles in cholesterol homeostasis

(2009) Andrew J. Brown et al.   MOLECULAR ASPECTS OF MEDICINE