Landscape of Pleiotropic Proteins Causing Human Disease: Structural and System Biology Insights

Analysis of protein-coding genetic variation in 60,706 humans

(2016) Monkol Lek et al.   NATURE

Genetic pleiotropy in complex traits and diseases: implications for genomic medicine

(2016) Jacob Gratten et al.   Genome Medicine

The global impact of non-communicable diseases on healthcare spending and national income: a systematic review

(2015) Taulant Muka et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Mouse genome database 2016

(2015) Carol J. Bult et al.   NUCLEIC ACIDS RESEARCH

The BioMart community portal: an innovative alternative to large, centralized data repositories

(2015) Damian Smedley et al.   NUCLEIC ACIDS RESEARCH

Pleiotropy among Common Genetic Loci Identified for Cardiometabolic Disorders and C-Reactive Protein

(2015) Symen Ligthart et al.   PLoS One

Intrinsically Disordered Proteins and Intrinsically Disordered Protein Regions

(2014) Christopher J. Oldfield et al.   Annual Review of Biochemistry

Inverse association between cancer and neurodegenerative disease: review of the epidemiologic and biological evidence

(2014) Jane A. Driver   BIOGERONTOLOGY

DISOPRED3: precise disordered region predictions with annotated protein-binding activity

(2014) David T. Jones et al.   BIOINFORMATICS

Cancer risks in children with congenital malformations in the nervous and circulatory system—A population based cohort study

(2014) Yuelian Sun et al.   Cancer Epidemiology

Next generation sequencing techniques in neurological diseases: redefining clinical and molecular associations

(2014) R. Guerreiro et al.   HUMAN MOLECULAR GENETICS

Pleiotropic Associations of Risk Variants Identified for Other Cancers With Lung Cancer Risk: The PAGE and TRICL Consortia

(2014) S. Lani Park et al.   JNCI-Journal of the National Cancer Institute

Pleiotropic genes for metabolic syndrome and inflammation

(2014) Aldi T. Kraja et al.   MOLECULAR GENETICS AND METABOLISM

Gene Ontology Consortium: going forward

(2014)   NUCLEIC ACIDS RESEARCH

The BioGRID interaction database: 2015 update

(2014) Andrew Chatr-aryamontri et al.   NUCLEIC ACIDS RESEARCH

A Comprehensive Review on Metabolic Syndrome

(2014) Jaspinder Kaur   Cardiology Research and Practice

The homeobox gene Otx2 in development and disease

(2013) Francis Beby et al.   EXPERIMENTAL EYE RESEARCH

Pleiotropic effects of genetic risk variants for other cancers on colorectal cancer risk: PAGE, GECCO and CCFR consortia

(2013) Iona Cheng et al.   GUT

Pleiotropy in complex traits: challenges and strategies

(2013) Nadia Solovieff et al.   NATURE REVIEWS GENETICS

Assessment of protein disorder region predictions in CASP10

(2013) Bohdan Monastyrskyy et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Genetic signatures shared in embryonic liver development and liver cancer define prognostically relevant subgroups in HCC

(2012) Diana Becker et al.   Molecular Cancer

Three-dimensional reconstruction of protein networks provides insight into human genetic disease

(2012) Xiujuan Wang et al.   NATURE BIOTECHNOLOGY

Disease-Associated Mutations Disrupt Functionally Important Regions of Intrinsic Protein Disorder

(2012) Vladimir Vacic et al.   PLoS Computational Biology

Annotating Cancer Variants and Anti-Cancer Therapeutics in Reactome

(2012) Marija Milacic et al.   Cancers

Abundant Pleiotropy in Human Complex Diseases and Traits

(2011) Shanya Sivakumaran et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The emergence of complexity and restricted pleiotropy in adapting networks

(2011) Hervé Le Nagard et al.   BMC EVOLUTIONARY BIOLOGY

The pleiotropic structure of the genotype–phenotype map: the evolvability of complex organisms

(2011) Günter P. Wagner et al.   NATURE REVIEWS GENETICS

OGEE: an online gene essentiality database

(2011) Wei-Hua Chen et al.   NUCLEIC ACIDS RESEARCH

Network properties of human disease genes with pleiotropic effects

(2010) Sreenivas Chavali et al.   BMC Systems Biology

Vinculin, an adapter protein in control of cell adhesion signalling

(2010) Alex Carisey et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

One Hundred Years of Pleiotropy: A Retrospective

(2010) F. W. Stearns   GENETICS

In silico functional profiling of human disease-associated and polymorphic amino acid substitutions

(2010) Matthew Mort et al.   HUMAN MUTATION

Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: A spectrum of TDP-43 proteinopathies

(2010) Felix Geser et al.   NEUROPATHOLOGY

A Helix Replacement Mechanism Directs Metavinculin Functions

(2010) Erumbi S. Rangarajan et al.   PLoS One

Intrinsically Disordered Proteins in Human Diseases: Introducing the D2 Concept

(2008) Vladimir N. Uversky et al.   Annual Review of Biophysics

Cancer Risk in Children with Birth Defects and in Their Families: A Population Based Cohort Study of 5.2 Million Children from Norway and Sweden

(2008) T. Bjorge et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Amyloidogenesis of Natively Unfolded Proteins

(2008) Vladimir Uversky   Current Alzheimer Research

Function and structure of inherently disordered proteins

(2008) A Keith Dunker et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

A Novel Dominant Negative Mutation of OTX2 Associated with Combined Pituitary Hormone Deficiency

(2008) Daniel Diaczok et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Notch: from neural development to neurological disorders

(2008) Justin D. Lathia et al.   JOURNAL OF NEUROCHEMISTRY

Pleiotropic scaling of gene effects and the ‘cost of complexity’

(2008) Günter P. Wagner et al.   NATURE

PBEQ-Solver for online visualization of electrostatic potential of biomolecules

(2008) Sunhwan Jo et al.   NUCLEIC ACIDS RESEARCH

Null mutations in human and mouse orthologs frequently result in different phenotypes

(2008) B.-Y. Liao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Profiling Essential Genes in Human Mammary Cells by Multiplex RNAi Screening

(2008) J. M. Silva et al.   SCIENCE

Systematic Analysis of Pleiotropy in C. elegans Early Embryogenesis

(2008) Lihua Zou et al.   PLoS Computational Biology