The G Protein-Coupled Receptor Kinases (GRKs) in Chemokine Receptor-Mediated Immune Cell Migration: From Molecular Cues to Physiopathology

Structure of the neurotensin receptor 1 in complex with β-arrestin 1

(2020) Weijiao Huang et al.   NATURE

Structure of the M2 muscarinic receptor–β-arrestin complex in a lipid nanodisc

(2020) Dean P. Staus et al.   NATURE

Author Correction: Chemokine receptor trafficking coordinates neutrophil clustering and dispersal at wounds in zebrafish

(2020) Caroline Coombs et al.   Nature Communications

Demographic and genetic factors influence the abundance of infiltrating immune cells in human tissues

(2020) Andrew R. Marderstein et al.   Nature Communications

ACKR4 Recruits GRK3 Prior to β-Arrestins but Can Scavenge Chemokines in the Absence of β-Arrestins

(2020) Christoph Matti et al.   Frontiers in Immunology

Key phosphorylation sites in GPCR s orchestrate the contribution of β‐Arrestin 1 in ERK 1/2 activation

(2020) Mithu Baidya et al.   EMBO REPORTS

ImmGen at 15

(2020)   NATURE IMMUNOLOGY

The CXCL12/CXCR4/ACKR3 Axis in the Tumor Microenvironment: Signaling, Crosstalk, and Therapeutic Targeting

(2020) Martine J. Smit et al.   Annual Review of Pharmacology and Toxicology

Co-option of Neutrophil Fates by Tissue Environments

(2020) Iván Ballesteros et al.   CELL

Keys to the Kingdom: GPCR phosphorylation patterns direct β‐arrestin

(2020) Richard T Premont   EMBO REPORTS

ACKR3 Regulation of Neuronal Migration Requires ACKR3 Phosphorylation, but Not β-Arrestin

(2019) Friederike Saaber et al.   Cell Reports

CXCR4/ACKR3 phosphorylation and recruitment of interacting proteins: key mechanisms regulating their functional status

(2019) Amos Fumagalli et al.   MOLECULAR PHARMACOLOGY

Concepts of GPCR ‐controlled navigation in the immune system

(2019) Tim Lämmermann et al.   IMMUNOLOGICAL REVIEWS

The COMMD3/8 complex determines GRK6 specificity for chemoattractant receptors

(2019) Akiko Nakai et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Atypical chemokine receptor 3 (ACKR3): a comprehensive overview of its expression and potential roles in the immune system.

(2019) Joyce Koenen et al.   MOLECULAR PHARMACOLOGY

WHIM Syndrome: from Pathogenesis Towards Personalized Medicine and Cure

(2019) Lauren E. Heusinkveld et al.   JOURNAL OF CLINICAL IMMUNOLOGY

G protein-coupled receptor kinase 2 (GRK2) as a multifunctional signaling hub

(2019) Petronila Penela et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Multi-functionality of proteins involved in GPCR and G protein signaling: making sense of structure–function continuum with intrinsic disorder-based proteoforms

(2019) Alexander V. Fonin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Cadherin-Mediated Cell Coupling Coordinates Chemokine Sensing across Collectively Migrating Cells

(2019) Tugba Colak-Champollion et al.   CURRENT BIOLOGY

A Neutrophil Timer Coordinates Immune Defense and Vascular Protection

(2019) José M. Adrover et al.   IMMUNITY

Degradation of GRK2 and AKT is an early and detrimental event in myocardial ischemia/reperfusion

(2019) Petronila Penela et al.   EBioMedicine

Multisystem multitasking by CXCL12 and its receptors CXCR4 and ACKR3

(2018) Philip M. Murphy et al.   CYTOKINE

CXCR4, the master regulator of neutrophil trafficking in homoeostasis and disease

(2018) Katia De Filippo et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Developmental Analysis of Bone Marrow Neutrophils Reveals Populations Specialized in Expansion, Trafficking, and Effector Functions

(2018) Maximilien Evrard et al.   IMMUNITY

GRK2 mediates TCR-induced transactivation of CXCR4 and TCR-CXCR4 complex formation which drives PI3Kγ/PREX1 signaling and T cell cytokine secretion

(2018) Brittney A Dinkel et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphorylation of p38 by GRK2 at the Docking Groove Unveils a Novel Mechanism for Inactivating p38MAPK

(2018) Sandra Peregrin et al.   CURRENT BIOLOGY

Kinase activity is impaired in neutrophils of sepsis patients

(2018) Arie J. Hoogendijk et al.   HAEMATOLOGICA

Adaptive Immunodeficiency in WHIM Syndrome

(2018) Shamik Majumdar et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Neutrophils instruct homeostatic and pathological states in naive tissues

(2018) Maria Casanova-Acebes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Adrenergic control of lymphocyte trafficking and adaptive immune responses

(2018) Akiko Nakai et al.   NEUROCHEMISTRY INTERNATIONAL

Migrating Myeloid Cells Sense Temporal Dynamics of Chemoattractant Concentrations

(2017) Caren E. Petrie Aronin et al.   IMMUNITY

Ligand-specific conformational transitions and intracellular transport are required for atypical chemokine receptor 3–mediated chemokine scavenging

(2017) Nicolas Montpas et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mass spectrometry for the discovery of biomarkers of sepsis

(2017) Katelyn R. Ludwig et al.   Molecular BioSystems

G Protein-Coupled Receptor Kinase 3 and Protein Kinase C Phosphorylate the Distal C-Terminal Tail of the Chemokine Receptor CXCR4 and Mediate Recruitment of β -Arrestin

(2017) Jiansong Luo et al.   MOLECULAR PHARMACOLOGY

Mincle activation enhances neutrophil migration and resistance to polymicrobial septic peritonitis

(2017) Wook-Bin Lee et al.   Scientific Reports

Neutrophil heterogeneity: implications for homeostasis and pathogenesis

(2016) C. Silvestre-Roig et al.   BLOOD

Inflammation-Induced CCR7 Oligomers Form Scaffolds to Integrate Distinct Signaling Pathways for Efficient Cell Migration

(2016) Mark A. Hauser et al.   IMMUNITY

Common and biased signaling pathways of the chemokine receptor CCR7 elicited by its ligands CCL19 and CCL21 in leukocytes

(2016) M. A. Hauser et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The front and rear of collective cell migration

(2016) Roberto Mayor et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Aging: A Temporal Dimension for Neutrophils

(2016) José M. Adrover et al.   TRENDS IN IMMUNOLOGY

GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal

(2016) Qiumin Le et al.   Cell Death & Disease

Chromothriptic Cure of WHIM Syndrome

(2015) David H. McDermott et al.   CELL

On the move: endocytic trafficking in cell migration

(2015) Tanja Maritzen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Collective Cell Motility Promotes Chemotactic Prowess and Resistance to Chemorepulsion

(2015) Gema Malet-Engra et al.   CURRENT BIOLOGY

Phospholipase D2 drives mortality in sepsis by inhibiting neutrophil extracellular trap formation and down-regulating CXCR2

(2015) Sung Kyun Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Functional Consequences of Perturbed CXCL12 Signal Processing: Analyses of Immature Hematopoiesis in GRK6-Deficient Mice

(2015) Doreen Chudziak et al.   STEM CELLS AND DEVELOPMENT

Somatic mutations in MYD88 and CXCR4 are determinants of clinical presentation and overall survival in Waldenstrom macroglobulinemia

(2014) S. P. Treon et al.   BLOOD

Filamin A interaction with the CXCR4 third intracellular loop regulates endocytosis and signaling of WT and WHIM-like receptors

(2014) C. Gomez-Mouton et al.   BLOOD

G Protein-Coupled Receptor Kinase GRK5 Phosphorylates Moesin and Regulates Metastasis in Prostate Cancer

(2014) P. K. Chakraborty et al.   CANCER RESEARCH

CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons

(2014) Philipp Abe et al.   DEVELOPMENT

Fibrates ameliorate the course of bacterial sepsis by promoting neutrophil recruitment via CXCR2

(2014) Ivan Tancevski et al.   EMBO Molecular Medicine

G Protein-Coupled Receptor Kinase-6 Interacts with Activator of G Protein Signaling-3 To Regulate CXCR2-Mediated Cellular Functions

(2014) V. Singh et al.   JOURNAL OF IMMUNOLOGY

Rare and low-frequency coding variants in CXCR2 and other genes are associated with hematological traits

(2014) Paul L Auer et al.   NATURE GENETICS

New nomenclature for atypical chemokine receptors

(2014) Françoise Bachelerie et al.   NATURE IMMUNOLOGY

CXCR7 Controls Competition for Recruitment of β-Arrestin 2 in Cells Expressing Both CXCR4 and CXCR7

(2014) Nathaniel L. Coggins et al.   PLoS One

G protein-coupled receptor kinase 2 (GRK2) is a Rho-activated scaffold protein for the ERK MAP kinase cascade

(2013) James D. Robinson et al.   CELLULAR SIGNALLING

CXCL12/CXCR4-Axis Dysfunctions: Markers of the Rare Immunodeficiency Disorder WHIM Syndrome

(2013) Françoise Bachelerie   DISEASE MARKERS

Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

(2013) Sapna Devi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

G-Protein-Coupled Receptor Kinase-5 Mediates Inflammation but Does Not Regulate Cellular Infiltration or Bacterial Load in a Polymicrobial Sepsis Model in Mice

(2013) Nandakumar Packiriswamy et al.   Journal of Innate Immunity

G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses

(2013) Teresa K. Tarrant et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Directional tissue migration through a self-generated chemokine gradient

(2013) Erika Donà et al.   NATURE

Hierarchical Organization of Multi-Site Phosphorylation at the CXCR4 C Terminus

(2013) Wiebke Mueller et al.   PLoS One

Expression of the Chemokine Receptor CXCR7 in CXCR4-Expressing Human 143B Osteosarcoma Cells Enhances Lung Metastasis of Intratibial Xenografts in SCID Mice

(2013) Patrick Brennecke et al.   PLoS One

Proper desensitization of CXCR4 is required for lymphocyte development and peripheral compartmentalization in mice

(2012) K. Balabanian et al.   BLOOD

Toll-like receptor 9 activation in neutrophils impairs chemotaxis and reduces sepsis outcome*

(2012) Silvia C. Trevelin et al.   CRITICAL CARE MEDICINE

Hematopoietic G-protein-coupled receptor kinase 2 deficiency decreases atherosclerotic lesion formation in LDL receptor-knockout mice

(2012) Jeroen J. T. Otten et al.   FASEB JOURNAL

Rapid Uptake and Degradation of CXCL12 Depend on CXCR7 Carboxyl-terminal Serine/Threonine Residues

(2012) Frauke Hoffmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Chemokine Receptors CXCR1 and CXCR2 Couple to Distinct G Protein-Coupled Receptor Kinases To Mediate and Regulate Leukocyte Functions

(2012) S. K. Raghuwanshi et al.   JOURNAL OF IMMUNOLOGY

Scavenging of CXCL12 by CXCR7 promotes tumor growth and metastasis of CXCR4-positive breast cancer cells

(2012) K E Luker et al.   ONCOGENE

Description and outcome of a cohort of 8 patients with WHIM syndrome from the French Severe Chronic Neutropenia Registry

(2012) Sarah Beaussant Cohen et al.   Orphanet Journal of Rare Diseases

G Protein-Coupled Receptor Kinase 5 Phosphorylation of Hip Regulates Internalization of the Chemokine Receptor CXCR4

(2011) Breann L. Barker et al.   BIOCHEMISTRY

The CXCR4 antagonist plerixafor corrects panleukopenia in patients with WHIM syndrome

(2011) D. H. McDermott et al.   BLOOD

CXCR7 mediated Giα independent activation of ERK and Akt promotes cell survival and chemotaxis in T cells

(2011) Romsha Kumar et al.   CELLULAR IMMUNOLOGY

A novel GRK2/HDAC6 interaction modulates cell spreading and motility

(2011) Vanesa Lafarga et al.   EMBO JOURNAL

CXCR7/CXCR4 Heterodimer Constitutively Recruits β-Arrestin to Enhance Cell Migration

(2011) Fabien M. Décaillot et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Growth differentiation factor 15 deficiency protects against atherosclerosis by attenuating CCR2-mediated macrophage chemotaxis

(2011) Saskia C.A. de Jager et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cxcr7 Controls Neuronal Migration by Regulating Chemokine Responsiveness

(2011) Juan Antonio Sánchez-Alcañiz et al.   NEURON

Angiotensin II causes endothelial dysfunction via the GRK2/Akt/eNOS pathway in aortas from a murine type 2 diabetic model

(2011) Kumiko Taguchi et al.   PHARMACOLOGICAL RESEARCH

G protein-coupled receptor kinases: More than just kinases and not only for GPCRs

(2011) Eugenia V. Gurevich et al.   PHARMACOLOGY & THERAPEUTICS

Phosphorylation Barcoding as a Mechanism of Directing GPCR Signaling

(2011) S. B. Liggett   Science Signaling

Distinct Phosphorylation Sites on the  2-Adrenergic Receptor Establish a Barcode That Encodes Differential Functions of  -Arrestin

(2011) K. N. Nobles et al.   Science Signaling

Neutrophils cascading their way to inflammation

(2011) Christian D. Sadik et al.   TRENDS IN IMMUNOLOGY

Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome

(2010) K. B. Walters et al.   BLOOD

The Mechanism of Chemokine Receptor 9 Internalization Triggered by Interleukin 2 and Interleukin 4

(2010) Xiaoling Tong et al.   Cellular & Molecular Immunology

Cellular responses to extracellular guidance cues

(2010) Anastacia Berzat et al.   EMBO JOURNAL

Immobilized Chemokine Fields and Soluble Chemokine Gradients Cooperatively Shape Migration Patterns of Dendritic Cells

(2010) Kathrin Schumann et al.   IMMUNITY

Site-specific Phosphorylation of CXCR4 Is Dynamically Regulated by Multiple Kinases and Results in Differential Modulation of CXCR4 Signaling

(2010) John M. Busillo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myeloid-specific GPCR kinase-2 negatively regulates NF-κB1p105-ERK pathway and limits endotoxemic shock in mice

(2010) Sonika Patial et al.   JOURNAL OF CELLULAR PHYSIOLOGY

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification of Phosphoproteins Associated with Human Neutrophil Granules Following Chemotactic Peptide Stimulation

(2010) Gregory C. Luerman et al.   MOLECULAR & CELLULAR PROTEOMICS

Interleukin-33 attenuates sepsis by enhancing neutrophil influx to the site of infection

(2010) Jose C Alves-Filho et al.   NATURE MEDICINE

Constitutive and chemokine-dependent internalization and recycling of CXCR7 in breast cancer cells to degrade chemokine ligands

(2010) K E Luker et al.   ONCOGENE

Microglial/macrophage GRK2 determines duration of peripheral IL-1β-induced hyperalgesia: Contribution of spinal cord CX3CR1, p38 and IL-1 signaling

(2010) Hanneke L.D.M. Willemen et al.   PAIN

G-protein-coupled-receptor kinases mediate TNFα-induced NF-κB signalling via direct interaction with and phosphorylation of IκBα

(2009) Sonika Patial et al.   BIOCHEMICAL JOURNAL

G protein-coupled receptor kinase 2 activates radixin, regulating membrane protrusion and motility in epithelial cells

(2009) Alem W. Kahsai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Kinome-wide RNAi studies in human multiple myeloma identify vulnerable kinase targets, including a lymphoid-restricted kinase, GRK6

(2009) R. E. Tiedemann et al.   BLOOD

CXCR7 heterodimerizes with CXCR4 and regulates CXCL12-mediated G protein signaling

(2009) A. Levoye et al.   BLOOD

Impaired Recruitment of Grk6 and β-Arrestin2 Causes Delayed Internalization and Desensitization of a WHIM Syndrome-Associated CXCR4 Mutant Receptor

(2009) Peter J. McCormick et al.   PLoS One

 -arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7

(2009) S. Rajagopal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective engagement of G protein coupled receptor kinases (GRKs) encodes distinct functions of biased ligands

(2009) D. A. Zidar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of chemokine receptor by Toll-like receptor 2 is critical to neutrophil migration and resistance to polymicrobial sepsis

(2009) J. C. Alves-Filho et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCR4 dimerization and  -arrestin-mediated signaling account for the enhanced chemotaxis to CXCL12 in WHIM syndrome

(2008) B. Lagane et al.   BLOOD

G-protein-coupled receptor phosphorylation: where, when and by whom

(2008) A B Tobin   BRITISH JOURNAL OF PHARMACOLOGY

G protein-coupled receptor kinase 2 positively regulates epithelial cell migration

(2008) Petronila Penela et al.   EMBO JOURNAL

Imaging chemokine receptor dimerization with firefly luciferase complementation

(2008) Kathryn E. Luker et al.   FASEB JOURNAL

Leukocyte analysis from WHIM syndrome patients reveals a pivotal role for GRK3 in CXCR4 signaling

(2008) Karl Balabanian et al.   JOURNAL OF CLINICAL INVESTIGATION

GRK2-Dependent Desensitization Downstream of G Proteins

(2008) M. JURADO-PUEYO et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION