CXCR4, the master regulator of neutrophil trafficking in homoeostasis and disease

CXCL12a/CXCR4b acts to retain neutrophils in caudal hematopoietic tissue and to antagonize recruitment to an injury site in the zebrafish larva

(2017) Susana Paredes-Zúñiga et al.   IMMUNOGENETICS

Visualizing the function and fate of neutrophils in sterile injury and repair

(2017) Jing Wang et al.   SCIENCE

Aged neutrophils contribute to the first line of defense in the acute inflammatory response

(2016) B. Uhl et al.   BLOOD

CXCR4 antagonist AMD3100 redistributes leukocytes from primary immune organs to secondary immune organs, lung, and blood in mice

(2015) Qian Liu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Discovery and Characterization of an Endogenous CXCR4 Antagonist

(2015) Onofrio Zirafi et al.   Cell Reports

A phase 1 clinical trial of long-term, low-dose treatment of WHIM syndrome with the CXCR4 antagonist plerixafor

(2014) D. H. McDermott et al.   BLOOD

A new protective role for S100A9 in regulation of neutrophil recruitment during invasive pneumococcal pneumonia

(2014) Katia De Filippo et al.   FASEB JOURNAL

The HMGB1/RAGE axis triggers neutrophil-mediated injury amplification following necrosis

(2014) Peter Huebener et al.   JOURNAL OF CLINICAL INVESTIGATION

High-mobility group box-1 in sterile inflammation

(2014) A. Tsung et al.   JOURNAL OF INTERNAL MEDICINE

Mast cell and macrophage chemokines CXCL1/CXCL2 control the early stage of neutrophil recruitment during tissue inflammation

(2013) K. De Filippo et al.   BLOOD

Rhythmic Modulation of the Hematopoietic Niche through Neutrophil Clearance

(2013) María Casanova-Acebes et al.   CELL

Neutrophil mobilization via plerixafor-mediated CXCR4 inhibition arises from lung demargination and blockade of neutrophil homing to the bone marrow

(2013) Sapna Devi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Regulation of Circulating Neutrophil Numbers under Homeostasis and in Disease

(2013) Natasha Strydom et al.   Journal of Innate Immunity

HMGB1 promotes recruitment of inflammatory cells to damaged tissues by forming a complex with CXCL12 and signaling via CXCR4

(2012) Milena Schiraldi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The CXCR4 antagonist plerixafor is a potential therapy for myelokathexis, WHIM syndrome

(2011) D. C. Dale et al.   BLOOD

G-CSF-mediated thrombopoietin release triggers neutrophil motility and mobilization from bone marrow via induction of Cxcr2 ligands

(2011) A. Kohler et al.   BLOOD

The increase in surface CXCR4 expression on lung extravascular neutrophils and its effects on neutrophils during endotoxin-induced lung injury

(2011) Mitsuhiro Yamada et al.   Cellular & Molecular Immunology

Cxcl12 evolution - subfunctionalization of a ligand through altered interaction with the chemokine receptor

(2011) B. Boldajipour et al.   DEVELOPMENT

Rapid mobilization of hematopoietic progenitors by AMD3100 and catecholamines is mediated by CXCR4-dependent SDF-1 release from bone marrow stromal cells

(2011) A Dar et al.   LEUKEMIA

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow

(2010) Kyle J. Eash et al.   JOURNAL OF CLINICAL INVESTIGATION

The bone marrow: a site of neutrophil clearance

(2010) S. M. Rankin   JOURNAL OF LEUKOCYTE BIOLOGY

The Novel CXCR4 Antagonist KRH-3955 Is an Orally Bioavailable and Extremely Potent Inhibitor of Human Immunodeficiency Virus Type 1 Infection: Comparative Studies with AMD3100

(2009) T. Murakami et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions

(2009) Kyle J. Eash et al.   BLOOD

Structural Basis of the Interaction between Chemokine Stromal Cell-derived Factor-1/CXCL12 and Its G-protein-coupled Receptor CXCR4

(2009) Yutaka Kofuku et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Migration across the sinusoidal endothelium regulates neutrophil mobilization in response to ELR + CXC chemokines

(2008) Peter C. E. Burdon et al.   BRITISH JOURNAL OF HAEMATOLOGY

The role of the bone marrow in neutrophil clearance under homeostatic conditions in the mouse

(2008) Rebecca C. Furze et al.   FASEB JOURNAL