Article
Plant Sciences
Ying Wei, Sichen Ren, Jian Wang, Yanling Wang, Yanfei Cui, Miao Tian, Ruilin Wang, Honghong Liu, Yanling Zhao
Summary: DHE alleviated dyspepsia, inflammatory infiltration, and tissue damage induced by IDO through the ERK and p38 signaling pathways rather than the JNK pathway.
Article
Biology
Yingyu Zhou, Tomohiro Takano, Xuyang Li, Yimei Wang, Rong Wang, Zhangliang Zhu, Masaru Tanokura, Takuya Miyakawa, Satoshi Hachimura
Summary: Beta-elemene regulates the balance of proinflammatory cytokines in mouse white adipose tissue through MAPK signaling, affecting the imbalance of M1-M2 macrophages and inhibiting the phosphorylation of MAPK pathways. These results suggest that beta-elemene may be a potential therapeutic medicine for macrophage-mediated chronic diseases.
COMMUNICATIONS BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jiayan Zhang, Yafang Zha, Yuheng Jiao, Yanyan Li, Jian Wang, Song Zhang
Summary: Fibrosis is a crucial factor contributing to cardiac dysfunction after myocardial infarction (MI). This study investigated the function of a protein called OTUD7B in cardiac fibrosis and identified its underlying mechanism. The researchers found that OTUD7B expression is downregulated in a MI rat model and in cultured cardiac fibroblasts under hypoxic conditions and TGF-beta 1 treatment. They also discovered that OTUD7B regulates the phosphorylation of FAK and ERK/P38 MAPK, leading to decreased expression of alpha-SMA and collagen I, both markers of fibrosis. This suggests that OTUD7B could be a potential therapeutic target for fibrosis after MI.
ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
(2022)
Article
Immunology
Walaa Yehia Abdelzaher, Seham A. Abdel-Gaber, Michael Atef Fawzy, Abdel Hamid Sayed Abo Bakr Ali, Mina Ezzat Attya, Ayman Geddawy
Summary: Atorvastatin may protect against cyclophosphamide-induced thyroid injury by regulating the JNK/ERK/p38-MAPK signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Cell Biology
Qi Yan, Linxin Pan, Shunli Qi, Fang Liu, Zhen Wang, Cheng Qian, Lijian Chen, Jian Du
Summary: The up-regulation of RNF2 in liver fibrosis enhances HSC activation and exerts fibrogenic effects by inhibiting the ERK/p38 signaling pathway induced by TGF-beta 1. The inhibition of RNF2 may be a promising therapeutic target for liver fibrosis.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Cell Biology
Ling Liu, Yihao Xing, Mengyao Cao, Jinglei Xu, Jingjing Chen
Summary: JS-K induces apoptosis in hepatocellular carcinoma cells by activating JNK and p38 MAPK and inhibiting the Raf/MEK/ERK signaling pathway.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Medicine, Research & Experimental
Walaa Yehia Abdelzaher, Haitham Ahmed Bahaa, Reham Elkhateeb, Medhat Atta, Michael Atef Fawzy, Amira F. Ahmed, Remon Roshdy Rofaeil
Summary: This study aimed to evaluate the effect of the phosphodiesterase 5 inhibitor, sildenafil (Sild), on cyclophosphamide (CYC)-induced placental injury in rats. The results showed that Sild significantly improved the oxidative stress, inflammation, and apoptosis caused by CYC.
Article
Neurosciences
Saisai Huang, Yingting Chen, Yue Jia, Tuo Yang, Wenfeng Su, Zhenyu Zhu, Peng Xue, Feifan Feng, Yayu Zhao, Gang Chen
Summary: The study identified the time window for therapeutic interventions by characterizing neuropathic pain and motor function recovery in a mouse sciatic nerve crush injury model. It was found that delayed delivery of a combination of ERK and p38 inhibitors at three weeks post-PNI could significantly alleviate PNI-induced neuropathic pain without affecting motor function recovery. Additionally, the combined use of these inhibitors could suppress pain more effectively than using either inhibitor alone, potentially reducing side effects and risks.
Article
Immunology
Wen Ye, Yan Yan, Yunliang Tang, Xiaoyang Dong, Gengfa Chen, Junwei Kang, Lianghua Huang, Qi Xiong, Zhen Feng
Summary: Orexin-A can alleviate the inflammatory response of NSCs by regulating NF-kB and P38/Erk-MAPK signaling pathways, reducing pro-inflammatory cytokines induced by LPS. This finding suggests that Orexin-A may have potential applications in neural stem cell therapy.
JOURNAL OF INFLAMMATION RESEARCH
(2021)
Article
Pharmacology & Pharmacy
Panpan Chen, Rong Wang, Fangbin Liu, Shengnan Li, Yanqiu Gu, Lei Wang, Yongfang Yuan
Summary: Schizandrin C from Schisandra chinensis has been found to ameliorate liver fibrosis by regulating lipid metabolism and inflammation through nuclear factor kappa-B and p38/ERK MAPK signaling pathways, making it a potential drug for liver fibrosis.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Caili Bi, Xue Zhang, Yueyue Chen, Yushuo Dong, Yixin Shi, Yunshen Lei, Dan Lv, Xiaowei Cao, Wei Li, Hongcan Shi
Summary: MAGT1 plays a crucial role in cell proliferation and cell cycle regulation, impacting the expression of multiple key genes and being associated with the MAPK signaling pathway. Down-regulation of MAGT1 results in restricted cell proliferation, indicating its potential as a novel target for anticancer research.
Article
Biochemistry & Molecular Biology
Mengying Xing, Ying Yang, Jiaxue Huang, Yaqun Fang, Yucui Jin, Lingyun Li, Xiang Chen, Xiaoxia Zhu, Changyan Ma
Summary: TFPI expression is significantly lower in breast cancer tissues and cells, and patients with low TFPI levels have worse overall survival. TFPI inhibits the proliferation, migration, and invasion of breast cancer cells by inhibiting the ERK/p38 MAPK signaling pathway. Downregulation of TFPI in breast cancer cells is mainly caused by DNA hypermethylation of the TFPI promoter.
Article
Biology
Hany H. Arab, Ahmed M. Ashour, Abdulmalik M. Alqarni, El-Shaimaa A. Arafa, Ahmed M. Kabel
Summary: The immunosuppressant cyclosporine A can cause renal damage, while camel milk, as a natural substance, has the potential to alleviate cyclosporine-induced renal injury. Camel milk can lower levels of nephrotoxicity markers, inhibit renal inflammation, and enhance renal antioxidant capacity.
Article
Biochemistry & Molecular Biology
Dae-Kyum Kim, Jin-Won Huh, Hyeonseung Yu, Yeji Lee, Yongxin Jin, Un-Hwan Ha
Summary: This study investigated the impact of DnaJ on IL-1 beta expression in macrophages and found that DnaJ modulates macrophages to secrete IL-1 beta by activating NF-kappa B and MAPK signaling pathways. ERK was identified as a positive mediator for IL-1 beta expression, while p38 acted as a negative mediator. Furthermore, the reciprocal actions of MAPKs were found to regulate the activation of inflammasome-related molecules. The study also explored the involvement of CD91/CD40 in ERK signaling-mediated IL-1 beta production from DnaJ-treated macrophages.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Immunology
Guangyu Liu, Yan Zhang, Sansheng Han, Wei Zhuang, Jie Lv, Mengyao Han, Ling Xie, Xiangrui Jiang, Chun Wang, Kaidireya Saimaier, Jingshan Shen, Changsheng Du
Summary: Autoimmune hepatitis (AIH) can lead to irreversible liver damage such as fibrosis, cirrhosis, and hepatocellular carcinoma. The study used a mouse model to investigate the effect of the artemisinin derivative TPN10466 on AIH. It was found that TPN10466 inhibited the production of IFN-gamma by T cells and reduced the severity of AIH by regulating lymphocyte function and number in the liver. The treatment also suppressed T-cell responses through the inhibition of JNK, ERK, and p38 pathways. These findings suggest that TPN10466 has potential as a therapeutic agent for AIH.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Rocio Vila-Bedmar, Marta Cruces-Sande, Elisa Lucas, Hanneke L. D. M. Willemen, Cobi J. Heijnen, Annemieke Kavelaars, Federico Mayor, Cristina Murga
Article
Biochemistry & Molecular Biology
Rocio Vila-Bedmar, Marta Cruces-Sande, Elisa Lucas, Hanneke L. D. M. Willemen, Cobi J. Heijnen, Annemieke Kavelaars, Federico Mayor, Cristina Murga
Review
Biochemistry & Molecular Biology
Elisa Lucas, Marta Cruces-Sande, Ana M. Briones, Mercedes Salaices, Federico Mayor, Cristina Murga, Rocio Vila-Bedmar
ARCHIVES OF PHYSIOLOGY AND BIOCHEMISTRY
(2015)
Article
Cardiac & Cardiovascular Systems
Elisa Lucas, Rocio Vila-Bedmar, Alba C. Arcones, Marta Cruces-Sande, Victoria Cachofeiro, Federico Mayor, Cristina Murga
CARDIOVASCULAR DIABETOLOGY
(2016)
Article
Multidisciplinary Sciences
Pooja Singhmar, XiaoJiao Huo, Niels Eijkelkamp, Susana Rojo Berciano, Faiza Baameur, Fang C. Mei, Yingmin Zhu, Xiaodong Cheng, David Hawke, Federico Mayor, Cristina Murga, Cobi J. Heijnen, Annemieke Kavelaars
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2016)
Review
Cell Biology
Federico Mayor, Marta Cruces-Sande, Alba C. Arcones, Rod Vila-Bedmara, Ana M. Briones, Mercedes Salaices, Cristina Murga
CELLULAR SIGNALLING
(2017)
Article
Biochemistry & Molecular Biology
Marta Cruces-Sande, Rock Vila-Bedmar, Alba C. Arcones, Agueda Gonzalez-Rodriguez, Patricia Rada, Virginia Gutierrez-de-Juan, Javier Vargas-Castrillon, Paula Iruzubieta, Cristina Sanchez-Gonzalez, Laura Formentini, Javier Crespo, Carmelo Garcia-Monzon, Maria L. Martinez-Chantar, Angela M. Valverde, Federico Mayor, Cristina Murga
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2018)
Article
Peripheral Vascular Disease
Maria S. Avendano, Elisa Lucas, Maria Jurado-Pueyo, Sonia Martinez-Revelles, Rocio Vila-Bedmar, Federico Mayor, Mercedes Salaices, Ana M. Briones, Cristina Murga
Article
Multidisciplinary Sciences
Patricia Gomez-Gutierrez, Pedro M. Campos, Miguel Vega, Juan J. Perez
Meeting Abstract
Peripheral Vascular Disease
Ana Briones, Rosa Aras-Lopez, Raquel Rodrigues-Diez, Maria Gonzalez-Amor, Luis Beltran, Rocio Vila-Bedmar, Federico Mayor, Cristina Murga, Mercedes Salaices, Ana Briones
JOURNAL OF HYPERTENSION
(2018)
Review
Pharmacology & Pharmacy
Cristina Murga, Alba C. Arcones, Marta Cruces-Sande, Ana M. Briones, Mercedes Salaices, Federico Mayor
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Maria Gonzalez-Amor, Rocio Vila-Bedmar, Raquel Rodrigues-Diez, Rosa Moreno-Carriles, Alba C. Arcones, Marta Cruces-Sande, Mercedes Salaices, Federico Mayor, Ana M. Briones, Cristina Murga
Article
Biology
Alba C. Arcones, Rocio Vila-Bedmar, Mercedes Mirasierra, Marta Cruces-Sande, Mario Vallejo, Ben Jones, Alejandra Tomas, Federico Mayor, Cristina Murga
Summary: This study demonstrates that GRK2 plays an important negative regulatory role in GLP-1R-mediated insulin secretion, with potential therapeutic implications for enhancing beta-cell insulin secretion specifically during the early phase. The results suggest that GRK2 is involved in regulating the size and release efficacy of insulin granules and that it is required for beta-arrestin recruitment downstream of GLP-1R stimulation.
Article
Cell Biology
Alba C. Arcones, Melanie Raquel Martinez-Cignoni, Rocio Vila-Bedmar, Claudia Yanez, Isabel Llado, Ana M. Proenza, Federico Mayor, Cristina Murga
Summary: A clear sexual dimorphism in cardiovascular disease (CVD) risk is observed, with young women having a lower incidence compared to age-matched men, but this protection is lost after menopause. Changes in G protein-coupled receptor kinase 2 (GRK2) protein levels in the heart are linked to age-related sensitivity to CVD development, with ovarian hormones playing a role in regulating GRK2 levels in the cardiac muscle, contributing to the sex-dependent dynamics of CVD risk.
Meeting Abstract
Cell Biology
F. Mayor, C. Murga, P. Penela
INFLAMMATION RESEARCH
(2015)