TRPing to the Point of Clarity: Understanding the Function of the Complex TRPV4 Ion Channel
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Title
TRPing to the Point of Clarity: Understanding the Function of the Complex TRPV4 Ion Channel
Authors
Keywords
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Journal
Cells
Volume 10, Issue 1, Pages 165
Publisher
MDPI AG
Online
2021-01-16
DOI
10.3390/cells10010165
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Note: Only part of the references are listed.- Recent advances in TRPV4 agonists and antagonists
- (2020) Brian G. Lawhorn et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- TRPV4 activation by thermal and mechanical stimuli in disease progression
- (2020) Koji Shibasaki LABORATORY INVESTIGATION
- TRPV4: A Physio and Pathophysiologically Significant Ion Channel
- (2020) Tamara Rosenbaum et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Channels that Cooperate with TRPV4 in the Brain
- (2020) Na Liu et al. JOURNAL OF MOLECULAR NEUROSCIENCE
- Emerging roles of the TRPV4 channel in bladder physiology and dysfunction
- (2020) Yanyuan Wu et al. JOURNAL OF PHYSIOLOGY-LONDON
- Temperature‐sensitive transient receptor potential vanilloid channels: structural insights into ligand‐dependent activation
- (2020) Lejla Zubcevic BRITISH JOURNAL OF PHARMACOLOGY
- The role of TRPV4 channels in ocular function and pathologies
- (2020) Brianna D. Guarino et al. EXPERIMENTAL EYE RESEARCH
- TRPV4 integrates matrix mechanosensing with Ca 2+ signaling to regulate extracellular matrix remodeling
- (2020) Chenfan Ji et al. FEBS Journal
- Cytokine and inflammatory mediator effects on TRPV4 function in choroid plexus epithelial cells
- (2019) Stefanie Simpson et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Activation of Transient Receptor Potential Vanilloid (TRPV) 4 as a Therapeutic Strategy in Osteoarthritis
- (2019) Masakazu Atobe CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Volume sensing in the transient receptor potential vanilloid 4 ion channel is cell type–specific and mediated by an N-terminal volume-sensing domain
- (2019) Trine L. Toft-Bertelsen et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Trafficking of Stretch-Regulated TRPV2 and TRPV4 Channels Inferred Through Interactomics
- (2019) Pau Doñate-Macián et al. Biomolecules
- Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A–mediated phosphorylation
- (2018) Sheng Cao et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Skin neurogenic inflammation
- (2018) Jae Eun Choi et al. Seminars in Immunopathology
- Retinal detachment-induced Müller glial cell swelling activates TRPV4 ion channels and triggers photoreceptor death at body temperature
- (2018) Hidetaka Matsumoto et al. JOURNAL OF NEUROSCIENCE
- Cholesterol regulates polymodal sensory transduction in Müller glia
- (2017) Monika Lakk et al. GLIA
- Calcium influx through TRPV4 channels modulates the adherens contacts between retinal microvascular endothelial cells
- (2017) Tam T. T. Phuong et al. JOURNAL OF PHYSIOLOGY-LONDON
- When size matters: transient receptor potential vanilloid 4 channel as a volume-sensor rather than an osmo-sensor
- (2017) Trine L. Toft-Bertelsen et al. JOURNAL OF PHYSIOLOGY-LONDON
- Transient receptor potential vanilloid 4 (TRPV4) channel as a target of crotamiton and its bimodal effects
- (2017) Hiroki Kittaka et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Omega-3 Fatty Acids Modulate TRPV4 Function through Plasma Membrane Remodeling
- (2017) Rebeca Caires et al. Cell Reports
- Structural determinants of 5′,6′-epoxyeicosatrienoic acid binding to and activation of TRPV4 channel
- (2017) Alejandro Berna-Erro et al. Scientific Reports
- TRPV4-AQP4 interactions ‘turbocharge’ astroglial sensitivity to small osmotic gradients
- (2016) Anthony Iuso et al. Channels
- Differential volume regulation and calcium signaling in two ciliary body cell types is subserved by TRPV4 channels
- (2016) Andrew O. Jo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The speed of swelling kinetics modulates cell volume regulation and calcium signaling in astrocytes: A different point of view on the role of aquaporins
- (2015) Maria Grazia Mola et al. GLIA
- TRPV4 and AQP4 Channels Synergistically Regulate Cell Volume and Calcium Homeostasis in Retinal Muller Glia
- (2015) A. O. Jo et al. JOURNAL OF NEUROSCIENCE
- L596–W733 bond between the start of the S4–S5 linker and the TRP box stabilizes the closed state of TRPV4 channel
- (2015) Jinfeng Teng et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hyperglycemia and Diabetes Downregulate the Functional Expression of TRPV4 Channels in Retinal Microvascular Endothelium
- (2015) Kevin Monaghan et al. PLoS One
- TRPV4, TRPC1, and TRPP2 assemble to form a flow-sensitive heteromeric channel
- (2014) Juan Du et al. FASEB JOURNAL
- Swelling and Eicosanoid Metabolites Differentially Gate TRPV4 Channels in Retinal Neurons and Glia
- (2014) D. A. Ryskamp et al. JOURNAL OF NEUROSCIENCE
- TRPV4 as a therapeutic target for joint diseases
- (2014) Amy L. McNulty et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Yeast Luminometric and Xenopus Oocyte Electrophysiological Examinations of the Molecular Mechanosensitivity of TRPV4
- (2014) Jinfeng Teng et al. Jove-Journal of Visualized Experiments
- Single point mutations of aromatic residues in transmembrane helices 5 and -6 differentially affect TRPV4 activation by 4α-PDD and hypotonicity: Implications for the role of the pore region in regulating TRPV4 activity
- (2013) Thomas Kjær Klausen et al. CELL CALCIUM
- Transient Receptor Potential Channels - Emerging Novel Drug Targets for the Treatment of Pain
- (2013) Kinga Salat et al. CURRENT MEDICINAL CHEMISTRY
- The puzzle of TRPV4 channelopathies
- (2013) Bernd Nilius et al. EMBO REPORTS
- Human skeletal dysplasia caused by a constitutive activated transient receptor potential vanilloid 4 (TRPV4) cation channel mutation
- (2013) Sang Sun Kang et al. EXPERIMENTAL AND MOLECULAR MEDICINE
- Phosphatidylinositol-4,5-biphosphate-dependent rearrangement of TRPV4 cytosolic tails enables channel activation by physiological stimuli
- (2013) Anna Garcia-Elias et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2012) M. Kaßmann et al. Acta Physiologica
- TRPV4-pathy manifesting both skeletal dysplasia and peripheral neuropathy: A report of three patients
- (2012) Tae-Joon Cho et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- TRPV4-associated skeletal dysplasias
- (2012) Gen Nishimura et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART C-SEMINARS IN MEDICAL GENETICS
- Mutations in the TRPV4 Gene Are Not Associated With Sporadic Progressive Muscular Atrophy
- (2012) Lotte Vlam et al. ARCHIVES OF NEUROLOGY
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- (2012) Jessica A. Filosa et al. JOURNAL OF CARDIOVASCULAR PHARMACOLOGY
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- (2012) Meriel McEntagart JOURNAL OF CLINICAL NEUROSCIENCE
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- (2012) Katherine A Fawcett et al. JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY
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- (2011) Xiao-Ru Yang et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
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- (2011) Xin Ma et al. CELL CALCIUM
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- (2011) Samer R. Eid CURRENT TOPICS IN MEDICINAL CHEMISTRY
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- (2011) Luciano Galizia et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Mutations in TRPV4 cause an inherited arthropathy of hands and feet
- (2011) Shireen R Lamandé et al. NATURE GENETICS
- TRPV4 related skeletal dysplasias: a phenotypic spectrum highlighted byclinical, radiographic, and molecular studies in 21 new families
- (2011) Elena Andreucci et al. Orphanet Journal of Rare Diseases
- Isopentenyl pyrophosphate is a novel antinociceptive substance that inhibits TRPV3 and TRPA1 ion channels
- (2011) Sangsu Bang et al. PAIN
- The importance of conventional radiography in the mutational analysis of skeletal dysplasias (the TRPV4 mutational family)
- (2011) Stefan F. Nemec et al. PEDIATRIC RADIOLOGY
- Determinants of TRPV4 Activity following Selective Activation by Small Molecule Agonist GSK1016790A
- (2011) Min Jin et al. PLoS One
- Increased Basal Activity Is a Key Determinant in the Severity of Human Skeletal Dysplasia Caused by TRPV4 Mutations
- (2011) Stephen Loukin et al. PLoS One
- An aquaporin-4/transient receptor potential vanilloid 4 (AQP4/TRPV4) complex is essential for cell-volume control in astrocytes
- (2011) V. Benfenati et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Spondylo-epiphyseal dysplasia, Maroteaux type (pseudo-Morquio syndrome type 2), and parastremmatic dysplasia are caused by TRPV4 mutations
- (2010) Gen Nishimura et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- DominantTRPV4mutations in nonlethal and lethal metatropic dysplasia
- (2010) Natalia Camacho et al. AMERICAN JOURNAL OF MEDICAL GENETICS PART A
- Atomic Force Microscopy Reveals the Alternating Subunit Arrangement of the TRPP2-TRPV4 Heterotetramer
- (2010) Andrew P. Stewart et al. BIOPHYSICAL JOURNAL
- Dominant mutations in the cation channel gene transient receptor potential vanilloid 4 cause an unusual spectrum of neuropathies
- (2010) Magdalena Zimoń et al. BRAIN
- TRP channels in neurogastroenterology: opportunities for therapeutic intervention
- (2010) Werend Boesmans et al. BRITISH JOURNAL OF PHARMACOLOGY
- TRP Channels in the Digestive System
- (2010) Peter Holzer CURRENT PHARMACEUTICAL BIOTECHNOLOGY
- Osmotic and thermal control of magnocellular neurosecretory neurons - role of an N-terminal variant of trpv1
- (2010) Jessica R. Sudbury et al. EUROPEAN JOURNAL OF NEUROSCIENCE
- TRPV1 splice variants: structure and function
- (2010) Mark et al. Frontiers in Bioscience-Landmark
- A 3.5-nm Structure of Rat TRPV4 Cation Channel Revealed by Zernike Phase-contrast Cryoelectron Microscopy
- (2010) Hideki Shigematsu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Farnesyl Pyrophosphate Is a Novel Pain-producing Molecule via Specific Activation of TRPV3
- (2010) Sangsu Bang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Wild-type and Brachyolmia-causing Mutant TRPV4 Channels Respond Directly to Stretch Force
- (2010) Stephen Loukin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Forward Genetic Analysis Reveals Multiple Gating Mechanisms of TRPV4
- (2010) Stephen Loukin et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Arresting a Transient Receptor Potential (TRP) Channel
- (2010) Arun K. Shukla et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TRPV4-pathy, a novel channelopathy affecting diverse systems
- (2010) Jin Dai et al. JOURNAL OF HUMAN GENETICS
- Channelopathies converge on TRPV4
- (2010) Bernd Nilius et al. NATURE GENETICS
- CMT2C with vocal cord paresis associated with short stature and mutations in the TRPV4 gene
- (2010) D.- H. Chen et al. NEUROLOGY
- Epoxyeicosatrienoic acids and endothelium-dependent responses
- (2010) William B. Campbell et al. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
- Interdomain Interactions Control Ca2+-Dependent Potentiation in the Cation Channel TRPV4
- (2010) Rainer Strotmann et al. PLoS One
- Importance of Non-Selective Cation Channel TRPV4 Interaction with Cytoskeleton and Their Reciprocal Regulations in Cultured Cells
- (2010) Chandan Goswami et al. PLoS One
- Inhibition of the cation channel TRPV4 improves bladder function in mice and rats with cyclophosphamide-induced cystitis
- (2010) W. Everaerts et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutations in the Gene Encoding the Calcium-Permeable Ion Channel TRPV4 Produce Spondylometaphyseal Dysplasia, Kozlowski Type and Metatropic Dysplasia
- (2009) Deborah Krakow et al. AMERICAN JOURNAL OF HUMAN GENETICS
- An environmental sensor, TRPV4 is a novel regulator of intracellular Ca2+ in human synoviocytes
- (2009) Yuka Itoh et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure
- (2009) Scott Earley et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Molecular Mechanisms of TRPV4-Mediated Neural Signaling
- (2009) Wolfgang Liedtke Annals of the New York Academy of Sciences
- Identification and characterization of novel TRPV4 modulators
- (2009) Fabien Vincent et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- Identification of a Protein Kinase C-dependent phosphorylation site involved in sensitization of TRPV4 channel
- (2009) Hongquan Peng et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- TRP Channels and Pain
- (2009) Daniel Cortright et al. CURRENT PHARMACEUTICAL DESIGN
- Hypotonic shocks activate rat TRPV4 in yeast in the absence of polyunsaturated fatty acids
- (2009) Stephen H. Loukin et al. FEBS LETTERS
- Activation of the TRPV4 Ion Channel Is Enhanced by Phosphorylation
- (2009) Hueng-Chuen Fan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Hypotension induced by activation of the transient receptor potential vanilloid 4 channels: role of Ca2+-activated K+ channels and sensory nerves
- (2009) Feng Gao et al. JOURNAL OF HYPERTENSION
- Modulation of the Transient Receptor Potential Vanilloid Channel TRPV4 by 4α-Phorbol Esters: A Structure−Activity Study
- (2009) Thomas Kjær Klausen et al. JOURNAL OF MEDICINAL CHEMISTRY
- Tumor Necrosis Factor-Alpha (TNF-α) Enhances Functional Thermal and Chemical Responses of TRP Cation Channels in Human Synoviocytes
- (2009) Mikhail Y Kochukov et al. Molecular Pain
- Alterations in the ankyrin domain of TRPV4 cause congenital distal SMA, scapuloperoneal SMA and HMSN2C
- (2009) Michaela Auer-Grumbach et al. NATURE GENETICS
- Scapuloperoneal spinal muscular atrophy and CMT2C are allelic disorders caused by alterations in TRPV4
- (2009) Han-Xiang Deng et al. NATURE GENETICS
- Mutations in TRPV4 cause Charcot-Marie-Tooth disease type 2C
- (2009) Guida Landouré et al. NATURE GENETICS
- The vanilloid transient receptor potential channel TRPV4: From structure to disease
- (2009) Wouter Everaerts et al. PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY
- Structural Analyses of the Ankyrin Repeat Domain of TRPV6 and Related TRPV Ion Channels†,‡
- (2008) Christopher B. Phelps et al. BIOCHEMISTRY
- Dependence of regulatory volume decrease on transient receptor potential vanilloid 4 (TRPV4) expression in human corneal epithelial cells
- (2008) Zan Pan et al. CELL CALCIUM
- TRPV4-Mediated Calcium Influx Regulates Terminal Differentiation of Osteoclasts
- (2008) Ritsuko Masuyama et al. Cell Metabolism
- Functional interaction of the cation channel transient receptor potential vanilloid 4 (TRPV4) and actin in volume regulation
- (2008) Daniel Becker et al. EUROPEAN JOURNAL OF CELL BIOLOGY
- Stimulus-specific Modulation of the Cation Channel TRPV4 by PACSIN 3
- (2008) Dieter D'hoedt et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- N-((1S)-1- -3-hydroxypropanoyl)-1-piperazinyl]carbonyl}-3-methylbutyl)-1-benzothiophene-2-carboxamide (GSK1016790A), a Novel and Potent Transient Receptor Potential Vanilloid 4 Channel Agonist Induces Urinary Bladder Contraction and Hyperactivity: Part I
- (2008) K. S. Thorneloe et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells
- (2008) I. M. Lorenzo et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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