Viral Vectors as Gene Therapy Agents for Treatment of Glioblastoma

Astrocytes monitor cerebral perfusion and control systemic circulation to maintain brain blood flow

(2020) Nephtali Marina et al.   Nature Communications

Preclinical Toxicology of rQNestin34.5v.2: An Oncolytic Herpes Virus with Transcriptional Regulation of the ICP34.5 Neurovirulence Gene

(2020) E. Antonio Chiocca et al.   Molecular Therapy-Methods & Clinical Development

Effect of Vocimagene Amiretrorepvec in Combination With Flucytosine vs Standard of Care on Survival Following Tumor Resection in Patients With Recurrent High-Grade Glioma

(2020) Timothy F. Cloughesy et al.   JAMA Oncology

The enhanced tumor specificity of TG6002, an armed-oncolytic vaccinia virus deleted in two genes involved in nucleotide metabolism

(2019) Johann Foloppe et al.   Molecular Therapy-Oncolytics

First-in-human phase I trial of the combination of two adenoviral vectors expressing HSV1-TK and FLT3L for the treatment of newly diagnosed resectable malignant glioma: Initial results from the therapeutic reprogramming of the brain immune system.

(2019) Pedro R. Lowenstein et al.   JOURNAL OF CLINICAL ONCOLOGY

From Clinical Trials to Clinical Practice: Practical Considerations for Gene Replacement Therapy in SMA Type 1

(2019) Samiah A. Al-Zaidy et al.   PEDIATRIC NEUROLOGY

Localized Treatment with Oncolytic Adenovirus Delta-24-RGDOX Induces Systemic Immunity against Disseminated Subcutaneous and Intracranial Melanomas

(2019) Hong Jiang et al.   CLINICAL CANCER RESEARCH

Regulatable interleukin-12 gene therapy in patients with recurrent high-grade glioma: Results of a phase 1 trial

(2019) E. Antonio Chiocca et al.   Science Translational Medicine

DNX-2401: an investigational drug for the treatment of recurrent glioblastoma

(2019) Brandon Philbrick et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

A randomized controlled phase III study of VB-111 combined with bevacizumab vs bevacizumab monotherapy in patients with recurrent glioblastoma (GLOBE)

(2019) Timothy F Cloughesy et al.   NEURO-ONCOLOGY

Regulated intratumoral expression of IL-12 using a RheoSwitch Therapeutic System® (RTS®) gene switch as gene therapy for the treatment of glioma

(2018) John A. Barrett et al.   CANCER GENE THERAPY

Molecular Analyses Support the Safety and Activity of Retroviral Replicating Vector Toca 511 in Patients

(2018) Daniel J Hogan et al.   CLINICAL CANCER RESEARCH

Evolutionary basis of a new gene- and immune-therapeutic approach for the treatment of malignant brain tumors: from mice to clinical trials for glioma patients

(2018) Pedro R. Lowenstein et al.   CLINICAL IMMUNOLOGY

Phase I Study of DNX-2401 (Delta-24-RGD) Oncolytic Adenovirus: Replication and Immunotherapeutic Effects in Recurrent Malignant Glioma

(2018) Frederick F. Lang et al.   JOURNAL OF CLINICAL ONCOLOGY

Herpes Simplex Virus 1 Mutant with Point Mutations in UL39 Is Impaired for Acute Viral Replication in Mice, Establishment of Latency, and Explant-Induced Reactivation

(2018) Heba H. Mostafa et al.   JOURNAL OF VIROLOGY

Durable complete responses in some recurrent high-grade glioma patients treated with Toca 511 + Toca FC

(2018) Timothy F Cloughesy et al.   NEURO-ONCOLOGY

Recurrent Glioblastoma Treated with Recombinant Poliovirus

(2018) Annick Desjardins et al.   NEW ENGLAND JOURNAL OF MEDICINE

The EF-1α promoter maintains high-level transgene expression from episomal vectors in transfected CHO-K1 cells

(2017) Xiaoyin Wang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Oncolytic H-1 Parvovirus Shows Safety and Signs of Immunogenic Activity in a First Phase I/IIa Glioblastoma Trial

(2017) Karsten Geletneky et al.   MOLECULAR THERAPY

Engineered AAVs for efficient noninvasive gene delivery to the central and peripheral nervous systems

(2017) Ken Y Chan et al.   NATURE NEUROSCIENCE

Pre-clinical Assessment of C134, a Chimeric Oncolytic Herpes Simplex Virus, in Mice and Non-human Primates

(2017) Kevin A. Cassady et al.   Molecular Therapy-Oncolytics

The 2016 World Health Organization Classification of Tumors of the Central Nervous System: a summary

(2016) David N. Louis et al.   ACTA NEUROPATHOLOGICA

61. Ascending Dose Trials of a Retroviral Replicating Vector (Toca 511) in Patients with Recurrent High-Grade Glioma: Clinical Update, Molecular Analyses, and Proposed Mechanism of Action

(2016) Douglas J. Jolly et al.   MOLECULAR THERAPY

In vivo genome editing via CRISPR/Cas9 mediated homology-independent targeted integration

(2016) Keiichiro Suzuki et al.   NATURE

Advances in the molecular genetics of gliomas — implications for classification and therapy

(2016) Guido Reifenberger et al.   Nature Reviews Clinical Oncology

Phase II multicenter study of gene-mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma

(2016) Lee A. Wheeler et al.   NEURO-ONCOLOGY

Phase 1 trial of vocimagene amiretrorepvec and 5-fluorocytosine for recurrent high-grade glioma

(2016) Timothy F. Cloughesy et al.   Science Translational Medicine

Survival outcomes and safety of carmustine wafers in the treatment of high-grade gliomas: a meta-analysis

(2015) Sajeel A. Chowdhary et al.   JOURNAL OF NEURO-ONCOLOGY

DDEL-06PRELIMINARY SAFETY OF TOCA 511, A RETROVIRAL REPLICATING VECTOR, IN PATIENTS WITH RECURRENT HIGH GRADE GLIOMA ACROSS THREE SEPARATE PHASE 1 STUDIES

(2015) Steven N. Kalkanis et al.   NEURO-ONCOLOGY

Oncolytic parvoviruses: from basic virology to clinical applications

(2015) Antonio Marchini et al.   Virology Journal

Adenovirus-mediated delivery of herpes simplex virus thymidine kinase administration improves outcome of recurrent high-grade glioma

(2015) Nan Ji et al.   Oncotarget

Designing herpes viruses as oncolytics

(2015) Cole Peters et al.   Molecular Therapy-Oncolytics

Adenovirus Vectors for Gene Therapy, Vaccination and Cancer Gene Therapy

(2014) William Wold et al.   CURRENT GENE THERAPY

A Phase 1 Trial of Oncolytic HSV-1, G207, Given in Combination With Radiation for Recurrent GBM Demonstrates Safety and Radiographic Responses

(2014) James M Markert et al.   MOLECULAR THERAPY

Lactate-mediated glia-neuronal signalling in the mammalian brain

(2014) F. Tang et al.   Nature Communications

Toca 511 gene transfer and 5-fluorocytosine in combination with temozolomide demonstrates synergistic therapeutic efficacy in a temozolomide-sensitive glioblastoma model

(2013) T T Huang et al.   CANCER GENE THERAPY

Phase I/IIa study of intratumoral/intracerebral or intravenous/intracerebral administration of Parvovirus H-1 (ParvOryx) in patients with progressive primary or recurrent glioblastoma multiforme: ParvOryx01 protocol

(2012) Karsten Geletneky et al.   BMC CANCER

Design and Selection of Toca 511 for Clinical Use: Modified Retroviral Replicating Vector With Improved Stability and Gene Expression

(2012) Omar D Perez et al.   MOLECULAR THERAPY

On the origin of glioma

(2012) Yiwen Jiang et al.   UPSALA JOURNAL OF MEDICAL SCIENCES

Adenovirus E1A Directly Targets the E2F/DP-1 Complex

(2011) P. Pelka et al.   JOURNAL OF VIROLOGY

Targeted methylation of CMV and E1A viral promoters

(2010) Chia-Chen Hsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Astrocytes Control Breathing Through pH-Dependent Release of ATP

(2010) A. V. Gourine et al.   SCIENCE

Integrin αvβ5 is a primary receptor for adenovirus in CAR-negative cells

(2010) Cynthia Lyle et al.   Virology Journal

The Oncolytic Activity of Newcastle Disease Virus NDV-HUJ on Chemoresistant Primary Melanoma Cells Is Dependent on the Proapoptotic Activity of the Inhibitor of Apoptosis Protein Livin

(2009) I. Lazar et al.   JOURNAL OF VIROLOGY

Effects of radiotherapy with concomitant and adjuvant temozolomide versus radiotherapy alone on survival in glioblastoma in a randomised phase III study: 5-year analysis of the EORTC-NCIC trial

(2009) Roger Stupp et al.   LANCET ONCOLOGY

A MDR1 (ABCB1) gene single nucleotide polymorphism predicts outcome of temozolomide treatment in glioblastoma patients

(2008) M. Schaich et al.   ANNALS OF ONCOLOGY

Viral vectors based on bidirectional cell-specific mammalian promoters and transcriptional amplification strategy for use in vitro and in vivo

(2008) Beihui Liu et al.   BMC BIOTECHNOLOGY

A Phase I Trial of Ad.hIFN-β Gene Therapy for Glioma

(2008) E Antonio Chiocca et al.   MOLECULAR THERAPY

A Phase I Trial of Intratumoral Administration of Reovirus in Patients With Histologically Confirmed Recurrent Malignant Gliomas

(2008) Peter Forsyth et al.   MOLECULAR THERAPY

Phase Ib Trial of Mutant Herpes Simplex Virus G207 Inoculated Pre-and Post-tumor Resection for Recurrent GBM

(2008) James M Markert et al.   MOLECULAR THERAPY