The Loss of a Sugar Chain at C(3) Position Enhances Stemucronatoside K-Induced Apoptosis, Cell Cycle Arrest, and Hedgehog Pathway Inhibition in HT-29 Cells

Crosstalk between Wnt/β-catenin and Hedgehog/Gli signaling pathways in colon cancer and implications for therapy

(2015) Li Song et al.   CANCER BIOLOGY & THERAPY

Hedgehog inhibitors: a patent review (2013 – present)

(2015) Minhang Xin   EXPERT OPINION ON THERAPEUTIC PATENTS

Bioactive C21 Steroidal Glycosides from the Roots of Cynanchum otophyllum That Suppress the Seizure-like Locomotor Activity of Zebrafish Caused by Pentylenetetrazole

(2015) Jin-Long Li et al.   JOURNAL OF NATURAL PRODUCTS

Proanthocyanidins from the bark of Metasequoia glyptostroboides ameliorate allergic contact dermatitis through directly inhibiting T cells activation and Th1/Th17 responses

(2015) Fengyang Chen et al.   PHYTOMEDICINE

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

Small molecule inhibitors of the hedgehog signaling pathway for the treatment of cancer

(2012) Jeong In Yun et al.   ARCHIVES OF PHARMACAL RESEARCH

Glucocorticoid Compounds Modify Smoothened Localization and Hedgehog Pathway Activity

(2012) Yu Wang et al.   CHEMISTRY & BIOLOGY

Stephanthraniline A inhibits the proliferation and activation of T cells in vitro and in vivo

(2012) Fengyang Chen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Hedgehog Pathway Signaling Regulates Human Colon Carcinoma HT-29 Epithelial Cell Line Apoptosis and Cytokine Secretion

(2012) Agnes N. Yoshimoto et al.   PLoS One

Antitumor effects by Wilfoside C3N treatment in ECA109 cells

(2010) Kaiyang Liu et al.   ANTI-CANCER DRUGS

Comparison of immunosuppressive activity of Stephanoside E and its aglycone from Stephanotis mucronata in vitro

(2010) Fengyang Chen et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Caudatin-2,6-dideoxy-3-O-methy-β-d-cymaropyranoside 1 induced apoptosis through caspase 3-dependent pathway in human hepatoma cell line SMMC7721

(2010) Yun-ru Peng et al.   PHYTOTHERAPY RESEARCH

Converse Conformational Control of Smoothened Activity by Structurally Related Small Molecules

(2009) Hongbo Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small-molecule inhibitors reveal multiple strategies for Hedgehog pathway blockade

(2009) J. M. Hyman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stemucronatoside K, a novel C21 steroidal glycoside from Stephanotis mucronata, inhibited the cellular and humoral immune response in mice

(2008) Yiping Ye et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Determination of two C21 steroidal glycosides of Baishouwu and their metabolites in mice plasma and tumor homogenate by liquid chromatography–tandem mass spectrometry

(2008) Wen Xu et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES