Metastatic Colonization: Escaping Immune Surveillance

Epigenetic therapy inhibits metastases by disrupting premetastatic niches

(2020) Zhihao Lu et al.   NATURE

Regenerative lineages and immune-mediated pruning in lung cancer metastasis

(2020) Ashley M. Laughney et al.   NATURE MEDICINE

A conserved dendritic-cell regulatory program limits antitumour immunity

(2020) Barbara Maier et al.   NATURE

Systemic dysfunction and plasticity of the immune macroenvironment in cancer models

(2020) Breanna M. Allen et al.   NATURE MEDICINE

Metabolic reprogramming and cancer progression

(2020) Brandon Faubert et al.   SCIENCE

Metastasis-initiating cells induce and exploit a fibroblast niche to fuel malignant colonization of the lungs

(2020) Maren Pein et al.   Nature Communications

Myeloid Cell-Derived Arginase in Cancer Immune Response

(2020) Tomasz M. Grzywa et al.   Frontiers in Immunology

Detection of PD-L1 Expression and Its Clinical Significance in Circulating Tumor Cells from Patients with Non-Small-Cell Lung Cancer

(2020) Yuxin Cheng et al.   Cancer Management and Research

Lung metastases share common immune features regardless of primary tumor origin

(2020) Sandra García-Mulero et al.   Journal for ImmunoTherapy of Cancer

PD-L1 Expression in Circulating Tumor Cells Increases during Radio(chemo)therapy and Indicates Poor Prognosis in Non-small Cell Lung Cancer

(2019) Yang Wang et al.   Scientific Reports

Do tumor cells escape from natural killer cell cytotoxicity by mimicking dendritic cells?

(2019) Hannah Wurzer et al.   Oncotarget

Primary tumor-induced immunity eradicates disseminated tumor cells in syngeneic mouse model

(2019) Raziye Piranlioglu et al.   Nature Communications

Regulatory T cells in cancer immunosuppression — implications for anticancer therapy

(2019) Yosuke Togashi et al.   Nature Reviews Clinical Oncology

Natural killer group 2D receptor and its ligands in cancer immune escape

(2019) Shixin Duan et al.   Molecular Cancer

Actin Cytoskeleton Straddling the Immunological Synapse between Cytotoxic Lymphocytes and Cancer Cells

(2019) Hannah Wurzer et al.   Cells

Change in neutrophil to lymphocyte ratio during immunotherapy treatment is a non-linear predictor of patient outcomes in advanced cancers

(2019) Mingjia Li et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Loss of p53 triggers WNT-dependent systemic inflammation to drive breast cancer metastasis

(2019) Max D. Wellenstein et al.   NATURE

Subclonal cooperation drives metastasis by modulating local and systemic immune microenvironments

(2019) Michalina Janiszewska et al.   NATURE CELL BIOLOGY

Connecting blood and intratumoral Treg cell activity in predicting future relapse in breast cancer

(2019) Lei Wang et al.   NATURE IMMUNOLOGY

Circulating Tumor Cell PD-L1 Expression as Biomarker for Therapeutic Efficacy of Immune Checkpoint Inhibition in NSCLC

(2019) Kloten et al.   Cells

Metastasis as a systemic disease: molecular insights and clinical implications

(2019) Maša Alečković et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Are 90% of deaths from cancer caused by metastases?

(2019) Hanna Dillekås et al.   Cancer Medicine

Tumor Associated Neutrophils. Their Role in Tumorigenesis, Metastasis, Prognosis and Therapy

(2019) Maria Teresa Masucci et al.   Frontiers in Oncology

Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation

(2018) Tathiane M. Malta et al.   CELL

Quiescent Tissue Stem Cells Evade Immune Surveillance

(2018) Judith Agudo et al.   IMMUNITY

TGFβ drives immune evasion in genetically reconstituted colon cancer metastasis

(2018) Daniele V. F. Tauriello et al.   NATURE

Understanding the tumor immune microenvironment (TIME) for effective therapy

(2018) Mikhail Binnewies et al.   NATURE MEDICINE

Unresolved endoplasmic reticulum stress engenders immune-resistant, latent pancreatic cancer metastases

(2018) Arnaud Pommier et al.   SCIENCE

Breast and pancreatic cancer interrupt IRF8-dependent dendritic cell development to overcome immune surveillance

(2018) Melissa A. Meyer et al.   Nature Communications

Monocytes Differentiate to Immune Suppressive Precursors of Metastasis-Associated Macrophages in Mouse Models of Metastatic Breast Cancer

(2018) Takanori Kitamura et al.   Frontiers in Immunology

Actin Cytoskeleton Remodeling Drives Breast Cancer Cell Escape from Natural Killer–Mediated Cytotoxicity

(2018) Antoun Al Absi et al.   CANCER RESEARCH

TGFβ attenuates tumour response to PD-L1 blockade by contributing to exclusion of T cells

(2018) Sanjeev Mariathasan et al.   NATURE

Successful Anti-PD-1 Cancer Immunotherapy Requires T Cell-Dendritic Cell Crosstalk Involving the Cytokines IFN-γ and IL-12

(2018) Christopher S. Garris et al.   IMMUNITY

Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models

(2018) Ioanna Keklikoglou et al.   NATURE CELL BIOLOGY

Comparison of clinical utility between neutrophil count and neutrophil–lymphocyte ratio in patients with ovarian cancer: a single institutional experience and a literature review

(2017) Naoko Komura et al.   International Journal of Clinical Oncology

Rise of PD-L1 expression during metastasis of colorectal cancer: Implications for immunotherapy

(2017) Huan Bin Wang et al.   Journal of Digestive Diseases

Stress-inducible geneAtf3in the noncancer host cells contributes to chemotherapy-exacerbated breast cancer metastasis

(2017) Yi Seok Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynamics of Neutrophils-to-Lymphocyte Ratio Predict Outcomes of PD-1/PD-L1 Blockade

(2017) Michele Moschetta et al.   Biomed Research International

Interleukin-12 from CD103 + Batf3-Dependent Dendritic Cells Required for NK-Cell Suppression of Metastasis

(2017) Deepak Mittal et al.   Cancer Immunology Research

Critical Role for CD103 + /CD141 + Dendritic Cells Bearing CCR7 for Tumor Antigen Trafficking and Priming of T Cell Immunity in Melanoma

(2016) Edward W. Roberts et al.   CANCER CELL

Characteristics and Significance of the Pre-metastatic Niche

(2016) Yang Liu et al.   CANCER CELL

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils

(2016) Yanfang Liu et al.   CANCER CELL

Oxygen Sensing by T Cells Establishes an Immunologically Tolerant Metastatic Niche

(2016) David Clever et al.   CELL

Metastatic Latency and Immune Evasion through Autocrine Inhibition of WNT

(2016) Srinivas Malladi et al.   CELL

Molecular mechanisms involved in dendritic cell dysfunction in cancer

(2016) Michael Tang et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Functions of Murine Dendritic Cells

(2016) Vivek Durai et al.   IMMUNITY

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

Visualization of immediate immune responses to pioneer metastatic cells in the lung

(2016) Mark B. Headley et al.   NATURE

Differential expression of major histocompatibility complex class I in subtypes of breast cancer is associated with estrogen receptor and interferon signaling

(2016) Hee Jin Lee et al.   Oncotarget

Baseline neutrophil-to-lymphocyte ratio is associated with outcome of ipilimumab-treated metastatic melanoma patients

(2015) P F Ferrucci et al.   BRITISH JOURNAL OF CANCER

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

Genotoxic Stress Induces Senescence-Associated ADAM10-Dependent Release of NKG2D MIC Ligands in Multiple Myeloma Cells

(2015) Alessandra Zingoni et al.   JOURNAL OF IMMUNOLOGY

Pulmonary Alveolar Macrophages Contribute to the Premetastatic Niche by Suppressing Antitumor T Cell Responses in the Lungs

(2015) Sharad K. Sharma et al.   JOURNAL OF IMMUNOLOGY

Tumour exosome integrins determine organotropic metastasis

(2015) Ayuko Hoshino et al.   NATURE

IL-17-producing γδ T cells and neutrophils conspire to promote breast cancer metastasis

(2015) Seth B. Coffelt et al.   NATURE

Early-life compartmentalization of human T cell differentiation and regulatory function in mucosal and lymphoid tissues

(2015) Joseph J C Thome et al.   NATURE MEDICINE

Patrolling monocytes control tumor metastasis to the lung

(2015) R. N. Hanna et al.   SCIENCE

Macrophage IL-10 Blocks CD8+ T Cell-Dependent Responses to Chemotherapy by Suppressing IL-12 Expression in Intratumoral Dendritic Cells

(2014) Brian Ruffell et al.   CANCER CELL

Metastatic Stem Cells: Sources, Niches, and Vital Pathways

(2014) Thordur Oskarsson et al.   Cell Stem Cell

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

Secretory pathways generating immunosuppressive NKG2D ligands: New targets for therapeutic intervention

(2014) Aroa Baragaño Raneros et al.   OncoImmunology

The Dendritic Cell Lineage: Ontogeny and Function of Dendritic Cells and Their Subsets in the Steady State and the Inflamed Setting

(2013) Miriam Merad et al.   Annual Review of Immunology

Identification of a population of blood circulating tumor cells from breast cancer patients that initiates metastasis in a xenograft assay

(2013) Irène Baccelli et al.   NATURE BIOTECHNOLOGY

Microenvironmental regulation of tumor progression and metastasis

(2013) Daniela F Quail et al.   NATURE MEDICINE

Granzyme B degradation by autophagy decreases tumor cell susceptibility to natural killer-mediated lysis under hypoxia

(2013) J. Baginska et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recruitment of monocytes/macrophages by tissue factor-mediated coagulation is essential for metastatic cell survival and premetastatic niche establishment in mice

(2012) A. M. Gil-Bernabe et al.   BLOOD

Primary Tumor Hypoxia Recruits CD11b+/Ly6Cmed/Ly6G+Immune Suppressor Cells and Compromises NK Cell Cytotoxicity in the Premetastatic Niche

(2012) Jaclyn Sceneay et al.   CANCER RESEARCH

Cross-presenting CD103+ dendritic cells are protected from influenza virus infection

(2012) Julie Helft et al.   JOURNAL OF CLINICAL INVESTIGATION

High FOXP3+ regulatory T-cell density in the sentinel lymph node is associated with downstream non-sentinel lymph-node metastasis in gastric cancer

(2011) H E Lee et al.   BRITISH JOURNAL OF CANCER

Expression of antigen processing and presenting molecules in brain metastasis of breast cancer

(2011) Yan Liu et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Tumor-Evoked Regulatory B Cells Promote Breast Cancer Metastasis by Converting Resting CD4+ T Cells to T-Regulatory Cells

(2011) P. B. Olkhanud et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

MMP9 mediates MICA shedding in human osteosarcomas

(2011) Dahui Sun et al.   CELL BIOLOGY INTERNATIONAL

Exocytosis of azurophil and arginase 1-containing granules by activated polymorphonuclear neutrophils is required to inhibit T lymphocyte proliferation

(2011) R. Rotondo et al.   JOURNAL OF LEUKOCYTE BIOLOGY

CCL2 recruits inflammatory monocytes to facilitate breast-tumour metastasis

(2011) Bin-Zhi Qian et al.   NATURE

Interactions between cancer stem cells and their niche govern metastatic colonization

(2011) Ilaria Malanchi et al.   NATURE

A Perspective on Cancer Cell Metastasis

(2011) C. L. Chaffer et al.   SCIENCE

Gr-1+CD11b+ Myeloid Cells Tip the Balance of Immune Protection to Tumor Promotion in the Premetastatic Lung

(2010) H. H. Yan et al.   CANCER RESEARCH

A Subpopulation of CD26+ Cancer Stem Cells with Metastatic Capacity in Human Colorectal Cancer

(2010) Roberta Pang et al.   Cell Stem Cell

Accumulation of Foxp3+ T Regulatory Cells in Draining Lymph Nodes Correlates with Disease Progression and Immune Suppression in Colorectal Cancer Patients

(2010) L. Deng et al.   CLINICAL CANCER RESEARCH

Tumor cells disseminate early, but immunosurveillance limits metastatic outgrowth, in a mouse model of melanoma

(2010) Jo Eyles et al.   JOURNAL OF CLINICAL INVESTIGATION

Lipid accumulation and dendritic cell dysfunction in cancer

(2010) Donna L Herber et al.   NATURE MEDICINE

Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models

(2010) H. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Granulocyte-colony stimulating factor promotes lung metastasis through mobilization of Ly6G+Ly6C+ granulocytes

(2010) M. Kowanetz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Breast Cancer Lung Metastasis Requires Expression of Chemokine Receptor CCR4 and Regulatory T Cells

(2009) P. B. Olkhanud et al.   CANCER RESEARCH

Accumulation of regulatory T cells in sentinel lymph nodes is a prognostic predictor in patients with node-negative breast cancer

(2009) Rikiya Nakamura et al.   EUROPEAN JOURNAL OF CANCER

Inflammatory signals in dendritic cell activation and the induction of adaptive immunity

(2008) Olivier Joffre et al.   IMMUNOLOGICAL REVIEWS

Molecular Basis of Metastasis

(2008) Anne C. Chiang et al.   NEW ENGLAND JOURNAL OF MEDICINE