Review
Biochemistry & Molecular Biology
Young-Su Yi
Summary: Inflammasome, activated in response to infection and damage, triggers inflammatory responses, while methylation, a critical biological process, modulates gene expression. The functional relationship between inflammasome regulation and methylation may play a key role in inflammatory responses and disease development.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Disha Agarwal, Ruchika Kumari, Ashal Ilyas, Shweta Tyagi, Rajnish Kumar, Nitesh Kumar Poddar
Summary: Epigenetics has opened a new dimension in exploring unanswered questions in genetics, particularly in neurodegenerative diseases like Alzheimer's and cancers. The alterations in DNA methylation levels, histone acetylation, and methylation play a significant role in conditions such as Alzheimer's disease. Studying the interplay between the mTOR regulatory pathway and epigenetic machinery may lead to early diagnosis and novel therapeutic strategies for Alzheimer's disease.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Cell Biology
Yoshitaka Kubota, Hidekazu Nagano, Kentaro Kosaka, Hideyuki Ogata, Akitoshi Nakayama, Masataka Yokoyama, Kazutaka Murata, Shinsuke Akita, Motone Kuriyama, Nobutaka Furuyama, Masayuki Kuroda, Tomoaki Tanaka, Nobuyuki Mitsukawa
Summary: Ceiling culture-derived preadipocytes (ccdPAs) and adipose-derived stem cells (ASCs) were isolated from human subcutaneous fat tissue and showed differences in adipogenic potential due to variations in methylation and histone modification levels of adipogenesis-related genes, such as PPARc, fatty acid-binding protein 4, and leptin. Genomewide epigenetic analysis revealed distinct patterns in CpG methylation and H3K4me3 modification between ccdPAs and ASCs, suggesting epigenetic mechanisms underlying adipogenic differentiation capabilities of these cell types.
AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
(2021)
Article
Biochemistry & Molecular Biology
Svetlana Sharifulina, Valentina Dzreyan, Valeria Guzenko, Svetlana Demyanenko
Summary: The study found that the levels and intracellular localization of DNMT1 and G9a proteins changed in penumbra neurons and astrocytes in the rat cerebral cortex after stroke. Inhibition of DNMT1 and G9a protected penumbra cells from apoptosis and reduced the volume of cerebral infarction induced by stroke.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Barbara Kunzler Souza, Natalia Hogetop Freire, Thiago Santos Monteiro, Alice Laschuk Herlinger, Mariane Jaeger, Matheus G. S. Dalmolin, Caroline Brunetto de Farias, Lauro Gregianin, Andre T. Brunetto, Algemir L. Brunetto, Carol J. Thiele, Rafael Roesler
Summary: This study found that higher expression of G9a and GLP is associated with poorer prognosis and shorter overall survival in neuroblastoma and Ewing sarcoma. Pharmacological inhibition of G9a/GLP reduced the viability of tumor cells. The findings suggest that G9a and GLP may serve as potential epigenetic targets for pediatric solid cancers.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Cell Biology
Aidan J. Levinsky, Gregor McEdwards, Nasha Sethna, Mark A. Currie
Summary: H3K9 methyltransferases play crucial roles in genome stability, cell type-specific gene expression, and non-histone methylation. They are involved in histone modification and regulate the methylation of various non-histone targets, contributing to genome regulation and cellular functions.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Review
Urology & Nephrology
Anbarasu Kumaraswamy, Katherine R. Welker Leng, Thomas C. Westbrook, Joel A. Yates, Shuang G. Zhao, Christopher P. Evans, Felix Y. Feng, Todd M. Morgan, Joshi J. Alumkal
Summary: This study systematically reviewed the role of epigenetic factors in prostate cancer from 2015 to 2020, highlighting key preclinical and translational data. Findings from both preclinical and clinical studies were reviewed and summarized, along with a discussion on 12 ongoing clinical studies with epigenetic targeted therapies.
Article
Cell Biology
Saikat Bhattacharya, Divya Reddy, Ning Zhang, Hua Li, Jerry L. L. Workman
Summary: The methyltransferase SETD2 plays a crucial role in regulating transcription, splicing, and other processes through the deposition of the H3K36me3 histone mark. Its stability is controlled by proteasome-mediated degradation to maintain low levels. Excessive SETD2 leads to upregulation of cell cycle-associated pathways, resulting in increased cell proliferation and migration.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Neurosciences
Alireza Paniri, Mohammad Mahdi Hosseini, Haleh Akhavan-Niaki
Summary: Epigenetic mechanisms play a significant role in Alzheimer's disease, regulating gene expression related to neuron plasticity and memory development. This review discusses the impact of dynamic and reversible epigenetic modifications and factors on memory and plasticity throughout life, as well as their potential as therapeutic targets for Alzheimer's disease.
MOLECULAR NEUROBIOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Futaba Inoue, Kenbun Sone, Yusuke Toyohara, Yu Takahashi, Asako Kukita, Aki Hara, Ayumi Taguchi, Michihiro Tanikawa, Tetsushi Tsuruga, Yutaka Osuga
Summary: Epigenetic changes play a crucial role in endometrial cancer, including DNA methylation and histone modification. There are currently inhibitors targeting epigenetic regulators in preclinical studies and clinical trials.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biochemistry & Molecular Biology
Charalabos Antonatos, Katerina Grafanaki, Paschalia Asmenoudi, Panagiotis Xiropotamos, Paraskevi Nani, Georgios K. Georgakilas, Sophia Georgiou, Yiannis Vasilopoulos
Summary: This review provides an overview of the environmental factors, epigenetic modifications, and non-coding RNAs associated with the onset and progression of psoriasis. It also discusses therapeutic applications targeting the epigenome to suppress the inflammatory cutaneous cascade.
Review
Biochemistry & Molecular Biology
Matea Nikolac Perkovic, Alja Videtic Paska, Marcela Konjevod, Katarina Kouter, Dubravka Svob Strac, Gordana Nedic Erjavec, Nela Pivac
Summary: Validated biomarkers for accurately diagnosing Alzheimer's disease (AD) are currently lacking, but epigenetic modifications have been identified as important factors in the pathogenesis of AD. DNA methylation, hydroxymethylation, histone modifications, and non-coding RNA regulation play critical roles in the development of AD, while mitochondrial DNA may serve as a potential biomarker for AD.
Article
Cell Biology
Virginia Lopez, Juan Ramon Tejedor, Antonella Carella, Maria G. Garcia, Pablo Santamarina-Ojeda, Raul F. Perez, Cristina Mangas, Rocio G. Urdinguio, Aitziber Aranburu, Daniel de la Nava, Maria D. Corte-Torres, Aurora Astudillo, Manuela Mollejo, Barbara Melendez, Agustin F. Fernandez, Mario F. Fraga
Summary: Epigenetic mechanisms, particularly involving the histone methyltransferase KMT5B and its mark H4K20me2, play a key role in glioblastoma multiforme (GBM). Downregulation of KMT5B is associated with DNA hypermethylation and loss of DNA hydroxymethylation in GBM samples. Ectopic overexpression of KMT5B induces tumor suppressor-like features and changes in gene expression, suggesting a possible role in GBM through epigenetic modulation of key target cancer genes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Review
Oncology
Jiaxin Liu, Jia-nan Li, Hongyu Wu, Panpan Liu
Summary: Epigenetic regulation plays a crucial role in lymphoma development and is closely associated with various malignancies. Understanding these epigenetic mechanisms can guide the development of clinical treatments.
FRONTIERS IN ONCOLOGY
(2022)
Review
Plant Sciences
Hongmiao Hu, Jiamu Du
Summary: This review focuses on the central role of histone methylation in regulating chromatin state and gene expression in Arabidopsis. It summarizes the current understanding of the dynamic regulation of histone methylation, with a particular emphasis on the histone methyltransferases and demethylases involved.
CURRENT OPINION IN PLANT BIOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Z. Xu, H. Jiang, P. Zhong, Z. Yan, S. Chen, J. Feng
MOLECULAR PSYCHIATRY
(2016)
Article
Neurosciences
Luye Qin, Wenhua Liu, Kaijie Ma, Jing Wei, Ping Zhong, Kei Cho, Zhen Yan
NEUROBIOLOGY OF DISEASE
(2016)
Article
Cell Biology
Ping Zhong, Zhixing Hu, Houbo Jiang, Zhen Yan, Jian Feng
Article
Neurosciences
Wei Wang, Benjamin Rein, Freddy Zhang, Tao Tan, Ping Zhong, Luye Qin, Zhen Yan
JOURNAL OF NEUROSCIENCE
(2018)
Article
Neurosciences
Luye Qin, Kaijie Mal, Zi-Jun Wang, Zihua Hu, Emmanuel Matas, Jing Wei, Zhen Yan
NATURE NEUROSCIENCE
(2018)
Article
Neurosciences
Kaijie Ma, Luye Qin, Emmanuel Matas, Lara J. Duffney, Aiyi Liu, Zhen Yan
NEUROPSYCHOPHARMACOLOGY
(2018)
Article
Neurosciences
Ping Zhong, Zhen Yan
Article
Biochemistry & Molecular Biology
Zi-Jun Wang, Ping Zhong, Kaijie Ma, Ji-Seon Seo, Fengwei Yang, Zihua Hu, Freddy Zhang, Lin Lin, Jie Wang, Tao Liu, Emmanuel Matas, Paul Greengard, Zhen Yan
MOLECULAR PSYCHIATRY
(2020)
Article
Psychiatry
Tao Tan, Wei Wang, Jamal Williams, Kaijie Ma, Qing Cao, Zhen Yan
SCHIZOPHRENIA BULLETIN
(2019)
Article
Clinical Neurology
Yan Zheng, Aiyi Liu, Zi-Jun Wang, Qing Cao, Wei Wang, Lin Lin, Kaijie Ma, Freddy Zhang, Jing Wei, Emmanuel Matas, Jia Cheng, Guo-Jun Chen, Xiaomin Wang, Zhen Yan
Article
Biochemistry & Molecular Biology
Maximiliano Rapanelli, Tao Tan, Wei Wang, Xue Wang, Zi-Jun Wang, Ping Zhong, Luciana Frick, Luye Qin, Kaijie Ma, Jun Qu, Zhen Yan
Summary: The Cul3 gene, encoding a core component of the E3 ubiquitin ligase complex, has been identified as a true high-risk factor for autism. Deletion of Cul3 in the forebrain or specific brain regions results in distinct behavioral deficits associated with changes in NMDA receptor function and neuronal excitability. The study suggests a potential molecular mechanism underlying the manifestation of different autism-like behavioral deficits by Cul3 deletion in cortico-striatal circuits.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Jennifer A. Martin, Craig T. Werner, Swarup Mitra, Ping Zhong, Zi-Jun Wang, Pedro H. Gobira, Andrew. F. Stewart, Jay Zhang, Kyra Erias, Justin N. Siemian, Devin Hagarty, Lauren E. Mueller, Rachael L. Neve, Jun-Xu Li, Ramesh Chandra, Karen C. Dietz, Mary Kay Lobo, Amy M. Gancarz, Zhen Yan, David M. Dietz
NATURE COMMUNICATIONS
(2019)
Article
Biochemistry & Molecular Biology
Benjamin Rein, Tao Tan, Fengwei Yang, Wei Wang, Jamal Williams, Freddy Zhang, Alea Mills, Zhen Yan
Summary: 16p11.2 duplication mice show social and cognitive deficits similar to ASD and ID, but not schizophrenia-related symptoms. The study suggests that prefrontal cortical GABAergic synaptic circuitry and Npas4 play crucial roles in 16p11.2 duplication pathology, representing potential therapeutic targets for ASD intervention.
MOLECULAR PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
Ashley E. Lepack, Craig T. Werner, Andrew F. Stewart, Sasha L. Fulton, Ping Zhong, Lorna A. Farrelly, Alexander C. W. Smith, Aarthi Ramakrishnan, Yang Lyu, Ryan M. Bastle, Jennifer A. Martin, Swarup Mitra, Richard M. O'Connor, Zi-Jun Wang, Henrik Molina, Gustavo Turecki, Li Shen, Zhen Yan, Erin S. Calipari, David M. Dietz, Paul J. Kenny, Ian Maze