Songorine promotes cardiac mitochondrial biogenesis via Nrf2 induction during sepsis

Chemically synthesized Secoisolariciresinol diglucoside (LGM2605) improves mitochondrial function in cardiac myocytes and alleviates septic cardiomyopathy

(2019) Dimitra Kokkinaki et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

CRAC channels regulate astrocyte Ca2+ signaling and gliotransmitter release to modulate hippocampal GABAergic transmission

(2019) Anna B. Toth et al.   Science Signaling

Enhanced Keap1-Nrf2 signaling protects the myocardium from isoproterenol-induced pathological remodeling in mice

(2019) Gobinath Shanmugam et al.   Redox Biology

Regulation of Mitochondrial Biogenesis as a Way for Active Longevity: Interaction Between the Nrf2 and PGC-1α Signaling Pathways

(2019) Artem P. Gureev et al.   Frontiers in Genetics

Changes in STIM Isoforms Expression and Gender-Specific Alterations in Orai Expression in Human Heart Failure

(2019) R. ČENDULA et al.   PHYSIOLOGICAL RESEARCH

Sepsis roadmap: What we know, what we learned, and where we are going

(2019) Vijay Kumar   CLINICAL IMMUNOLOGY

Beclin-1-Dependent Autophagy Protects the Heart During Sepsis

(2018) Yuxiao Sun et al.   CIRCULATION

Therapeutic potential of songorine, a diterpenoid alkaloid of the genus Aconitum

(2018) Haroon Khan et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The Complex Role of Store Operated Calcium Entry Pathways and Related Proteins in the Function of Cardiac, Skeletal and Vascular Smooth Muscle Cells

(2018) Javier Avila-Medina et al.   Frontiers in Physiology

THE SEPTIC HEART Current Understanding of Molecular Mechanisms and Clinical Implications

(2018) Lukas Martin et al.   CHEST

Metformin Targets Mitochondrial Electron Transport to Reduce Air-Pollution-Induced Thrombosis

(2018) Saul Soberanes et al.   Cell Metabolism

Microglial Calcium Release-Activated Calcium Channel Inhibition Improves Outcome from Experimental Traumatic Brain Injury and Microglia-Induced Neuronal Death

(2018) Atsushi Mizuma et al.   JOURNAL OF NEUROTRAUMA

Mitochondria as a therapeutic target for common pathologies

(2018) Michael P. Murphy et al.   NATURE REVIEWS DRUG DISCOVERY

Involvement of Mitochondrial Disorders in Septic Cardiomyopathy

(2017) Arthur Durand et al.   Oxidative Medicine and Cellular Longevity

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload

(2016) Julia C. Liu et al.   Cell Reports

Mitochondrial biogenesis and dynamics in the developing and diseased heart

(2015) Gerald W. Dorn et al.   GENES & DEVELOPMENT

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

A review on phytochemistry and pharmacological activities of the processed lateral root of Aconitum carmichaelii Debeaux

(2015) Guohong Zhou et al.   JOURNAL OF ETHNOPHARMACOLOGY

Store-Operated Calcium Channels

(2015) Murali Prakriya et al.   PHYSIOLOGICAL REVIEWS

Mitochondrial calcium overload is a key determinant in heart failure

(2015) Gaetano Santulli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Anti-Inflammatory Activity of Diterpene Alkaloids from Aconitum baikalense

(2014) Yu. V. Nesterova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Cardiac mitochondrial biogenesis in endotoxemia is not accompanied by mitochondrial function recovery

(2014) Virginia Vanasco et al.   FREE RADICAL BIOLOGY AND MEDICINE

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

(2014) Edward T. Chouchani et al.   NATURE

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

(2013) Ana P. Gomes et al.   CELL

Activation of Mitochondrial Biogenesis by Heme Oxygenase-1–mediated NF-E2–related Factor-2 Induction Rescues Mice from LethalStaphylococcusaureusSepsis

(2012) Nancy Chou MacGarvey et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

p53 Orchestrates the PGC-1α-Mediated Antioxidant Response Upon Mild Redox and Metabolic Imbalance

(2012) Katia Aquilano et al.   ANTIOXIDANTS & REDOX SIGNALING

Mechanisms and functional consequences of liver failure substantially differ between endotoxaemia and faecal peritonitis in rats

(2012) Peter Recknagel et al.   LIVER INTERNATIONAL

Clinical Spectrum, Frequency, and Significance of Myocardial Dysfunction in Severe Sepsis and Septic Shock

(2012) Juan N. Pulido et al.   MAYO CLINIC PROCEEDINGS

CaMKII determines mitochondrial stress responses in heart

(2012) Mei-ling A. Joiner et al.   NATURE

Transcriptional integration of mitochondrial biogenesis

(2012) Richard C. Scarpulla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Toll-Like Receptor 4 Stimulation Initiates an Inflammatory Response That Decreases Cardiomyocyte Contractility

(2010) Orna Avlas et al.   ANTIOXIDANTS & REDOX SIGNALING

Dynamic regulation of PGC-1α localization and turnover implicates mitochondrial adaptation in calorie restriction and the stress response

(2009) Rozalyn M. Anderson et al.   AGING CELL

AMPK regulates energy expenditure by modulating NAD+ metabolism and SIRT1 activity

(2009) Carles Cantó et al.   NATURE

Heme Oxygenase-1 Regulates Cardiac Mitochondrial Biogenesis via Nrf2-Mediated Transcriptional Control of Nuclear Respiratory Factor-1

(2008) Claude A. Piantadosi et al.   CIRCULATION RESEARCH

Prevention of endotoxin-induced sarcoplasmic reticulum calcium leak improves mitochondrial and myocardial dysfunction*

(2008) Sidi Mohammed Hassoun et al.   CRITICAL CARE MEDICINE

Minireview: The PGC-1 Coactivator Networks: Chromatin-Remodeling and Mitochondrial Energy Metabolism

(2008) Jiandie D. Lin   MOLECULAR ENDOCRINOLOGY