Effects of hydrogen sulfide on mitochondrial function and cellular bioenergetics

Opposing effects of polysulfides and thioredoxin on apoptosis through caspase persulfidation

(2020) Ilana Braunstein et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Control of protein function through oxidation and reduction of persulfidated states

(2020) É. Dóka et al.   Science Advances

Pathogenic variants in SQOR encoding sulfide:quinone oxidoreductase are a potentially treatable cause of Leigh disease

(2020) Marisa W. Friederich et al.   JOURNAL OF INHERITED METABOLIC DISEASE

PINK1 and Parkin mitochondrial quality control: a source of regional vulnerability in Parkinson’s disease

(2020) Preston Ge et al.   Molecular Neurodegeneration

Role of 3-Mercaptopyruvate Sulfurtransferase in the Regulation of Proliferation and Cellular Bioenergetics in Human Down Syndrome Fibroblasts

(2020) Theodora Panagaki et al.   Biomolecules

3-mercaptopyruvate sulfurtransferase supports endothelial cell angiogenesis and bioenergetics

(2019) Armita Abdollahi Govar et al.   BRITISH JOURNAL OF PHARMACOLOGY

Impairment of an Endothelial NAD+-H2S Signaling Network Is a Reversible Cause of Vascular Aging

(2019) Abhirup Das et al.   CELL

Impact of Pharmacological Inhibition of Hydrogen Sulphide Production in the SOD1G93A-ALS Mouse Model

(2019) Alida Spalloni et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Supplementing preservation solution with mitochondria‐targeted H 2 S donor AP39 protects cardiac grafts from prolonged cold ischemia reperfusion injury in heart transplantation

(2019) Cuilin Zhu et al.   AMERICAN JOURNAL OF TRANSPLANTATION

S-Sulfhydration of SIRT3 by Hydrogen Sulfide Attenuates Mitochondrial Dysfunction in Cisplatin-Induced Acute Kidney Injury

(2019) Yujia Yuan et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen sulfide perturbs mitochondrial bioenergetics and triggers metabolic reprogramming in colon cells

(2019) Marouane Libiad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Extended hypoxia‐mediated H 2 S production provides for long‐term oxygen sensing

(2019) Kenneth R. Olson et al.   Acta Physiologica

Overproduction of H2S, generated by CBS, inhibits mitochondrial Complex IV and suppresses oxidative phosphorylation in Down syndrome

(2019) Theodora Panagaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective Persulfide Detection Reveals Evolutionarily Conserved Antiaging Effects of S-Sulfhydration

(2019) Jasmina Zivanovic et al.   Cell Metabolism

Cytochrome c Reduction by H2S Potentiates Sulfide Signaling

(2018) Victor Vitvitsky et al.   ACS Chemical Biology

Sulfhydrated Sirtuin-1 Increasing Its Deacetylation Activity Is an Essential Epigenetics Mechanism of Anti-Atherogenesis by Hydrogen Sulfide

(2018) Congkuo Du et al.   ANTIOXIDANTS & REDOX SIGNALING

Gasotransmitter hydrogen sulfide signaling in neuronal health and disease

(2018) Bindu D. Paul et al.   BIOCHEMICAL PHARMACOLOGY

H 2 S and polysulfide metabolism: Conventional and unconventional pathways

(2018) Kenneth R. Olson   BIOCHEMICAL PHARMACOLOGY

Persulfide synthases that are functionally coupled with translation mediate sulfur respiration in mammalian cells

(2018) Shigemoto Fujii et al.   BRITISH JOURNAL OF PHARMACOLOGY

Hydrogen sulfide regulates cardiac mitochondrial biogenesis via the activation of AMPK

(2018) Yuuki Shimizu et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Exogenous H2S switches cardiac energy substrate metabolism by regulating SIRT3 expression in db/db mice

(2018) Yu Sun et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Amelioration of mitochondrial dysfunction in heart failure through S-sulfhydration of Ca2+/calmodulin-dependent protein kinase II

(2018) Dan Wu et al.   Redox Biology

AP39, a Modulator of Mitochondrial Bioenergetics, Reduces Antiangiogenic Response and Oxidative Stress in Hypoxia-Exposed Trophoblasts

(2018) Ambart E. Covarrubias et al.   AMERICAN JOURNAL OF PATHOLOGY

Assessment of H2Sin vivousing the newly developed mitochondria-targeted mass spectrometry probe MitoA

(2017) Sabine Arndt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

International Union of Basic and Clinical Pharmacology. CII: Pharmacological Modulation of H 2 S Levels: H 2 S Donors and H 2 S Biosynthesis Inhibitors

(2017) Csaba Szabo et al.   PHARMACOLOGICAL REVIEWS

NAD + in Aging: Molecular Mechanisms and Translational Implications

(2017) Evandro F. Fang et al.   TRENDS IN MOLECULAR MEDICINE

Cysteinyl-tRNA synthetase governs cysteine polysulfidation and mitochondrial bioenergetics

(2017) Takaaki Akaike et al.   Nature Communications

Hydrogen Sulfide Protects Renal Grafts Against Prolonged Cold Ischemia-Reperfusion Injury via Specific Mitochondrial Actions

(2016) I. Lobb et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Decreased Gluconeogenesis in the Absence of Cystathionine Gamma-Lyase and the Underlying Mechanisms

(2016) Ashley A. Untereiner et al.   ANTIOXIDANTS & REDOX SIGNALING

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Stimulatory effect of CSE-generated H2S on hepatic mitochondrial biogenesis and the underlying mechanisms

(2016) Ashley A. Untereiner et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

AP39, a Mitochondria-Targeted Hydrogen Sulfide Donor, Supports Cellular Bioenergetics and Protects against Alzheimer’s Disease by Preserving Mitochondrial Function in APP/PS1 Mice and Neurons

(2016) Feng-li Zhao et al.   Oxidative Medicine and Cellular Longevity

Regulation of soluble guanylyl cyclase redox state by hydrogen sulfide

(2016) Zongmin Zhou et al.   PHARMACOLOGICAL RESEARCH

The novel mitochondria-targeted hydrogen sulfide (H 2 S) donors AP123 and AP39 protect against hyperglycemic injury in microvascular endothelial cells in vitro

(2016) Domokos Gerő et al.   PHARMACOLOGICAL RESEARCH

S- Sulfhydration of ATP synthase by hydrogen sulfide stimulates mitochondrial bioenergetics

(2016) Katalin Módis et al.   PHARMACOLOGICAL RESEARCH

Both the H 2 S biosynthesis inhibitor aminooxyacetic acid and the mitochondrially targeted H 2 S donor AP39 exert protective effects in a mouse model of burn injury

(2016) Akbar Ahmad et al.   PHARMACOLOGICAL RESEARCH

Improved tag-switch method reveals that thioredoxin acts as depersulfidase and controls the intracellular levels of protein persulfidation

(2016) Rudolf Wedmann et al.   Chemical Science

A novel persulfide detection method reveals protein persulfide- and polysulfide-reducing functions of thioredoxin and glutathione systems

(2016) E. Doka et al.   Science Advances

Evidence of hydrogen sulfide involvement in amyotrophic lateral sclerosis

(2015) Alessandro Davoli et al.   ANNALS OF NEUROLOGY

Hydrogen Sulfide Maintains Mitochondrial DNA Replication via Demethylation of TFAM

(2015) Shuangshuang Li et al.   ANTIOXIDANTS & REDOX SIGNALING

Modes of Physiologic H2S Signaling in the Brain and Peripheral Tissues

(2015) Bindu D. Paul et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen Sulfide as an Oxygen Sensor

(2015) Kenneth R. Olson   ANTIOXIDANTS & REDOX SIGNALING

NAD+ Metabolism and the Control of Energy Homeostasis: A Balancing Act between Mitochondria and the Nucleus

(2015) Carles Cantó et al.   Cell Metabolism

Endothelial Cell Metabolism in Normal and Diseased Vasculature

(2015) Guy Eelen et al.   CIRCULATION RESEARCH

Protein kinase G–regulated production of H2S governs oxygen sensing

(2015) Guoxiang Yuan et al.   Science Signaling

H 2 S: A Novel Gasotransmitter that Signals by Sulfhydration

(2015) Bindu D. Paul et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein kinase G–regulated production of H2S governs oxygen sensing

(2015) Guoxiang Yuan et al.   Science Signaling

Sulfhydration of p66Shc at Cysteine59 Mediates the Antioxidant Effect of Hydrogen Sulfide

(2014) Zhi-Zhong Xie et al.   ANTIOXIDANTS & REDOX SIGNALING

USP8 regulates mitophagy by removing K6-linked ubiquitin conjugates from parkin

(2014) T. M. Durcan et al.   EMBO JOURNAL

Protective and biogenesis effects of sodium hydrosulfide on brain mitochondria after cardiac arrest and resuscitation

(2014) Hao Pan et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

AP39, a novel mitochondria-targeted hydrogen sulfide donor, stimulates cellular bioenergetics, exerts cytoprotective effects and protects against the loss of mitochondrial DNA integrity in oxidatively stressed endothelial cells in vitro

(2014) Bartosz Szczesny et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

NAD+ and sirtuins in aging and disease

(2014) Shin-ichiro Imai et al.   TRENDS IN CELL BIOLOGY

Polysulfides Link H2S to Protein Thiol Oxidation

(2013) Romy Greiner et al.   ANTIOXIDANTS & REDOX SIGNALING

Hydrogen sulfide-mediated stimulation of mitochondrial electron transport involves inhibition of the mitochondrial phosphodiesterase 2A, elevation of cAMP and activation of protein kinase A

(2013) Katalin Módis et al.   BIOCHEMICAL PHARMACOLOGY

Regulation of mitochondrial bioenergetic function by hydrogen sulfide. Part II. Pathophysiological and therapeutic aspects

(2013) Katalin Módis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inverse cancer comorbidity: a serendipitous opportunity to gain insight into CNS disorders

(2013) Rafael Tabarés-Seisdedos et al.   NATURE REVIEWS NEUROSCIENCE

Tumor-derived hydrogen sulfide, produced by cystathionine- -synthase, stimulates bioenergetics, cell proliferation, and angiogenesis in colon cancer

(2013) C. Szabo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sulfhydration mediates neuroprotective actions of parkin

(2013) M. Scott Vandiver et al.   Nature Communications

H2S signalling through protein sulfhydration and beyond

(2012) Bindu D. Paul et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Physiological Implications of Hydrogen Sulfide: A Whiff Exploration That Blossomed

(2012) Rui Wang   PHYSIOLOGICAL REVIEWS

Hydrogen sulfide (H2S) metabolism in mitochondria and its regulatory role in energy production

(2012) M. Fu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hypoxic regulation of the cerebral microcirculation is mediated by a carbon monoxide-sensitive hydrogen sulfide pathway

(2012) T. Morikawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

H2S-Induced Sulfhydration of the Phosphatase PTP1B and Its Role in the Endoplasmic Reticulum Stress Response

(2011) N. Krishnan et al.   Science Signaling

Hydrogen Sulfide Is an Endogenous Inhibitor of Phosphodiesterase Activity

(2010) Mariarosaria Bucci et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Genetic and Pharmacologic Hydrogen Sulfide Therapy Attenuates Ischemia-Induced Heart Failure in Mice

(2010) John W. Calvert et al.   CIRCULATION

Cyclic AMP Produced inside Mitochondria Regulates Oxidative Phosphorylation

(2009) Rebeca Acin-Perez et al.   Cell Metabolism

H2S Signals Through Protein S-Sulfhydration

(2009) A. K. Mustafa et al.   Science Signaling

Three enzymatic activities catalyze the oxidation of sulfide to thiosulfate in mammalian and invertebrate mitochondria

(2008) Tatjana M. Hildebrandt et al.   FEBS Journal