Advances in identification and selection of personalized neoantigen/T-cell pairs for autologous adoptive T cell therapies

T Cell Epitope Predictions

(2020) Bjoern Peters et al.   Annual Review of Immunology

Engineering bionic T cells: signal 1, signal 2, signal 3, reprogramming and the removal of inhibitory mechanisms

(2020) Iñaki Etxeberria et al.   Cellular & Molecular Immunology

Adoptive cellular therapy with T cells expressing the dendritic cell growth factor Flt3L drives epitope spreading and antitumor immunity

(2020) Junyun Lai et al.   NATURE IMMUNOLOGY

Systemic dysfunction and plasticity of the immune macroenvironment in cancer models

(2020) Breanna M. Allen et al.   NATURE MEDICINE

Overcoming genetically-based resistance mechanisms to PD-1 blockade

(2020) Davis Y. Torrejon et al.   Cancer Discovery

Tracking Neoantigens by Personalized Circulating Tumor DNA Sequencing during Checkpoint Blockade Immunotherapy in Non‐Small Cell Lung Cancer

(2020) Qingzhu Jia et al.   Advanced Science

Orthotopic T-Cell Receptor Replacement—An “Enabler” for TCR-Based Therapies

(2020) Kilian Schober et al.   Cells

Adoptive T Cell Therapy Targeting Different Gene Products Reveals Diverse and Context-Dependent Immune Evasion in Melanoma

(2020) Maike Effern et al.   IMMUNITY

Towards new horizons: characterization, classification and implications of the tumour antigenic repertoire

(2020) Sebastian P. Haen et al.   Nature Reviews Clinical Oncology

Identifying and Targeting Human Tumor Antigens for T Cell-Based Immunotherapy of Solid Tumors

(2020) Vid Leko et al.   CANCER CELL

Key Parameters of Tumor Epitope Immunogenicity Revealed Through a Consortium Approach Improve Neoantigen Prediction

(2020) Daniel K. Wells et al.   CELL

A Phase Ib Trial of Personalized Neoantigen Therapy Plus Anti-PD-1 in Patients with Advanced Melanoma, Non-small Cell Lung Cancer, or Bladder Cancer

(2020) Patrick A. Ott et al.   CELL

Safety and Efficacy of the BNT162b2 mRNA Covid-19 Vaccine

(2020) Fernando P. Polack et al.   NEW ENGLAND JOURNAL OF MEDICINE

Stem-like CD8 T cells mediate response of adoptive cell immunotherapy against human cancer

(2020) Sri Krishna et al.   SCIENCE

Safety and Tolerability of Adoptive Cell Therapy in Cancer

(2019) Benita Wolf et al.   DRUG SAFETY

Persistent mutant oncogene specific T cells in two patients benefitting from anti-PD-1

(2019) Kellie N. Smith et al.   Journal for ImmunoTherapy of Cancer

Identification of neoantigen-specific T cells and their targets: implications for immunotherapy of head and neck squamous cell carcinoma

(2019) Lili Ren et al.   OncoImmunology

Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients

(2019) Gal Cafri et al.   Nature Communications

Mechanisms of resistance to CAR T cell therapy

(2019) Nirali N. Shah et al.   Nature Reviews Clinical Oncology

T cell antigen discovery via trogocytosis

(2019) Guideng Li et al.   NATURE METHODS

T cell antigen discovery via signaling and antigen-presenting bifunctional receptors

(2019) Alok V. Joglekar et al.   NATURE METHODS

Deciphering CD4+ T cell specificity using novel MHC–TCR chimeric receptors

(2019) Jan Kisielow et al.   NATURE IMMUNOLOGY

Induction of neoantigen-reactive T cells from healthy donors

(2019) Muhammad Ali et al.   Nature Protocols

Determinants for Neoantigen Identification

(2019) Andrea Garcia-Garijo et al.   Frontiers in Immunology

Empty peptide-receptive MHC class I molecules for efficient detection of antigen-specific T cells

(2019) Sunil Kumar Saini et al.   Science Immunology

T-Scan: A Genome-wide Method for the Systematic Discovery of T Cell Epitopes

(2019) Tomasz Kula et al.   CELL

Sensitive Detection and Analysis of Neoantigen-Specific T Cell Populations from Tumors and Blood

(2019) Songming Peng et al.   Cell Reports

Endogenous T cells prevent tumor immune escape following adoptive T cell therapy

(2019) Scott R. Walsh et al.   JOURNAL OF CLINICAL INVESTIGATION

Predicting HLA class II antigen presentation through integrated deep learning

(2019) Binbin Chen et al.   NATURE BIOTECHNOLOGY

Spatial heterogeneity of the T cell receptor repertoire reflects the mutational landscape in lung cancer

(2019) Kroopa Joshi et al.   NATURE MEDICINE

Rapid selection and identification of functional CD8+ T cell epitopes from large peptide-coding libraries

(2019) Govinda Sharma et al.   Nature Communications

HLA and proteasome expression body map

(2018) Sebastian Boegel et al.   BMC Medical Genomics

Antigen Identification for Orphan T Cell Receptors Expressed on Tumor-Infiltrating Lymphocytes

(2018) Marvin H. Gee et al.   CELL

Peptide–MHC Class I Tetramers Can Fail To Detect Relevant Functional T Cell Clonotypes and Underestimate Antigen-Reactive T Cell Populations

(2018) Cristina Rius et al.   JOURNAL OF IMMUNOLOGY

An Efficient Single-Cell RNA-Seq Approach to Identify Neoantigen-Specific T Cell Receptors

(2018) Yong-Chen Lu et al.   MOLECULAR THERAPY

Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer

(2018) Nikolaos Zacharakis et al.   NATURE MEDICINE

Bispecific antibodies for cancer therapy: A review

(2018) Anuradha Krishnamurthy et al.   PHARMACOLOGY & THERAPEUTICS

CAR T cell immunotherapy for human cancer

(2018) Carl H. June et al.   SCIENCE

Co-expression of CD39 and CD103 identifies tumor-reactive CD8 T cells in human solid tumors

(2018) Thomas Duhen et al.   Nature Communications

Current Concepts of Antigen Cross-Presentation

(2018) Maria Embgenbroich et al.   Frontiers in Immunology

Single Cell T Cell Receptor Sequencing: Techniques and Future Challenges

(2018) Marco De Simone et al.   Frontiers in Immunology

Generation of Tumor-Reactive T Cells by Co-culture of Peripheral Blood Lymphocytes and Tumor Organoids

(2018) Krijn K. Dijkstra et al.   CELL

Urine-derived lymphocytes as a non-invasive measure of the bladder tumor immune microenvironment

(2018) Yien Ning Sophia Wong et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reprogramming human T cell function and specificity with non-viral genome targeting

(2018) Theodore L. Roth et al.   NATURE

Bystander CD8+ T cells are abundant and phenotypically distinct in human tumour infiltrates

(2018) Yannick Simoni et al.   NATURE

Selection of Tumor-Specific Cytotoxic T Lymphocytes in Acute Myeloid Leukemia Patients Through the Identification of T-Cells Capable to Establish Stable Interactions With the Leukemic Cells: “Doublet Technology”

(2018) Estefanía García-Guerrero et al.   Frontiers in Immunology

Deep learning using tumor HLA peptide mass spectrometry datasets improves neoantigen identification

(2018) Brendan Bulik-Sullivan et al.   NATURE BIOTECHNOLOGY

High-throughput determination of the antigen specificities of T cell receptors in single cells

(2018) Shu-Qi Zhang et al.   NATURE BIOTECHNOLOGY

Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers

(2018) Wouter Scheper et al.   NATURE MEDICINE

Cell death and thymic tolerance

(2017) Stephen R. Daley et al.   IMMUNOLOGICAL REVIEWS

T-lymphocyte homing: an underappreciated yet critical hurdle for successful cancer immunotherapy

(2017) Robert Sackstein et al.   LABORATORY INVESTIGATION

Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer

(2017) Ugur Sahin et al.   NATURE

Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer

(2017) Sanja Stevanović et al.   SCIENCE

The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy

(2017) Terhi Karpanen et al.   Frontiers in Immunology

Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression

(2016) Maria Parkhurst et al.   CLINICAL CANCER RESEARCH

Resistance Mechanisms to Immune-Checkpoint Blockade in Cancer: Tumor-Intrinsic and -Extrinsic Factors

(2016) Jonathan M. Pitt et al.   IMMUNITY

A High-avidity WT1-reactive T-Cell Receptor Mediates Recognition of Peptide and Processed Antigen but not Naturally Occurring WT1-positive Tumor Cells

(2016) Adnan Jaigirdar et al.   JOURNAL OF IMMUNOTHERAPY

Prospective identification of neoantigen-specific lymphocytes in the peripheral blood of melanoma patients

(2016) Alena Gros et al.   NATURE MEDICINE

Clonal neoantigens elicit T cell immunoreactivity and sensitivity to immune checkpoint blockade

(2016) N. McGranahan et al.   SCIENCE

Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry

(2016) Michal Bassani-Sternberg et al.   Nature Communications

Tumor- and Neoantigen-Reactive T-cell Receptors Can Be Identified Based on Their Frequency in Fresh Tumor

(2016) A. Pasetto et al.   Cancer Immunology Research

Prospective Derivation of a Living Organoid Biobank of Colorectal Cancer Patients

(2015) Marc van de Wetering et al.   CELL

Translational Implications of Tumor Heterogeneity

(2015) M. Jamal-Hanjani et al.   CLINICAL CANCER RESEARCH

More tricks with tetramers: a practical guide to staining T cells with peptide-MHC multimers

(2015) Garry Dolton et al.   IMMUNOLOGY

Isolation of neoantigen-specific T cells from tumor and peripheral lymphocytes

(2015) Cyrille J. Cohen et al.   JOURNAL OF CLINICAL INVESTIGATION

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Immunogenicity of somatic mutations in human gastrointestinal cancers

(2015) E. Tran et al.   SCIENCE

Targeting T cell metabolism for therapy

(2015) David O'Sullivan et al.   TRENDS IN IMMUNOLOGY

Cancer vaccines

(2015) L. H. Butterfield   BMJ-British Medical Journal

Cancer vaccines

(2015) L. H. Butterfield   BMJ-British Medical Journal

Characterization of T cell repertoire of blood, tumor, and ascites in ovarian cancer patients using next generation sequencing

(2015) Miran Jang et al.   OncoImmunology

Multiplex Identification of Antigen-Specific T Cell Receptors Using a Combination of Immune Assays and Immune Receptor Sequencing

(2015) Mark Klinger et al.   PLoS One

Comparison of peptide-major histocompatibility complex tetramers and dextramers for the identification of antigen-specific T cells

(2014) G. Dolton et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions

(2014) Y.-C. Lu et al.   CLINICAL CANCER RESEARCH

PD-1 identifies the patient-specific CD8+ tumor-reactive repertoire infiltrating human tumors

(2014) Alena Gros et al.   JOURNAL OF CLINICAL INVESTIGATION

Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing

(2014) Mahesh Yadav et al.   NATURE

High-throughput epitope discovery reveals frequent recognition of neo-antigens by CD4+ T cells in human melanoma

(2014) Carsten Linnemann et al.   NATURE MEDICINE

Cancer Immunotherapy Based on Mutation-Specific CD4+ T Cells in a Patient with Epithelial Cancer

(2014) E. Tran et al.   SCIENCE

γδ T cells for cancer immunotherapy

(2014) Jonathan PH Fisher et al.   OncoImmunology

Cardiovascular toxicity and titin cross-reactivity of affinity-enhanced T cells in myeloma and melanoma

(2013) G. P. Linette et al.   BLOOD

Mutated PPP1R3B Is Recognized by T Cells Used To Treat a Melanoma Patient Who Experienced a Durable Complete Tumor Regression

(2013) Y.-C. Lu et al.   JOURNAL OF IMMUNOLOGY

Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cells

(2013) Paul F Robbins et al.   NATURE MEDICINE

Combining Next-Generation Sequencing and Immune Assays: A Novel Method for Identification of Antigen-Specific T Cells

(2013) Mark Klinger et al.   PLoS One

Cytometry by Time-of-Flight Shows Combinatorial Cytokine Expression and Virus-Specific Cell Niches within a Continuum of CD8+ T Cell Phenotypes

(2012) Evan W. Newell et al.   IMMUNITY

Selection of CD8+PD-1+ Lymphocytes in Fresh Human Melanomas Enriches for Tumor-reactive T Cells

(2010) Takashi Inozume et al.   JOURNAL OF IMMUNOTHERAPY

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

Parallel detection of antigen-specific T-cell responses by multidimensional encoding of MHC multimers

(2009) Sine Reker Hadrup et al.   NATURE METHODS