RNA Vaccines: A Suitable Platform for Tackling Emerging Pandemics?

Prototype pathogen approach for pandemic preparedness: world on fire

(2020) Barney S. Graham et al.   JOURNAL OF CLINICAL INVESTIGATION

A Thermostable mRNA Vaccine against COVID-19

(2020) Na-Na Zhang et al.   CELL

SARS-CoV-2 mRNA vaccine design enabled by prototype pathogen preparedness

(2020) Kizzmekia S. Corbett et al.   NATURE

SARS-CoV-2-specific T cell immunity in cases of COVID-19 and SARS, and uninfected controls

(2020) Nina Le Bert et al.   NATURE

Clinical and immunological assessment of asymptomatic SARS-CoV-2 infections

(2020) Quan-Xin Long et al.   NATURE MEDICINE

Evaluation of the mRNA-1273 Vaccine against SARS-CoV-2 in Nonhuman Primates

(2020) Kizzmekia S. Corbett et al.   NEW ENGLAND JOURNAL OF MEDICINE

An mRNA Vaccine against SARS-CoV-2 — Preliminary Report

(2020) Lisa A. Jackson et al.   NEW ENGLAND JOURNAL OF MEDICINE

Self-Amplifying RNA Vaccines for Venezuelan Equine Encephalitis Virus Induce Robust Protective Immunogenicity in Mice

(2019) Marcelo M. Samsa et al.   MOLECULAR THERAPY

mRNA as a Transformative Technology for Vaccine Development to Control Infectious Diseases

(2019) Giulietta Maruggi et al.   MOLECULAR THERAPY

mRNA vaccines against H10N8 and H7N9 influenza viruses of pandemic potential are immunogenic and well tolerated in healthy adults in phase 1 randomized clinical trials

(2019) Robert A. Feldman et al.   VACCINE

Visualization of early events in mRNA vaccine delivery in non-human primates via PET–CT and near-infrared imaging

(2019) Kevin E. Lindsay et al.   Nature Biomedical Engineering

Inside out: optimization of lipid nanoparticle formulations for exterior complexation and in vivo delivery of saRNA

(2019) Anna K. Blakney et al.   GENE THERAPY

A trans-amplifying RNA vaccine strategy for induction of potent protective immunity

(2019) Tim Beissert et al.   MOLECULAR THERAPY

Evaluation of a Single-Dose Nucleoside-Modified Messenger RNA Vaccine Encoding Hendra Virus-Soluble Glycoprotein Against Lethal Nipah virus Challenge in Syrian Hamsters

(2019) Michael K Lo et al.   JOURNAL OF INFECTIOUS DISEASES

Novel Vaccine Technologies

(2018) Barney S. Graham et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Self-Amplifying RNA Vaccines Give Equivalent Protection against Influenza to mRNA Vaccines but at Much Lower Doses

(2018) Annette B. Vogel et al.   MOLECULAR THERAPY

mRNA vaccines — a new era in vaccinology

(2018) Norbert Pardi et al.   NATURE REVIEWS DRUG DISCOVERY

Scaffold-mediated delivery for non-viral mRNA vaccines

(2018) Ruying Chen et al.   GENE THERAPY

A Nanostructured Lipid Carrier for Delivery of a Replicating Viral RNA Provides Single, Low-Dose Protection against Zika

(2018) Jesse H. Erasmus et al.   MOLECULAR THERAPY

Emerging Technologies for Low‐Cost, Rapid Vaccine Manufacture

(2018) Zoltán Kis et al.   Biotechnology Journal

Injectable Biodegradable Chitosan-Alginate 3D Porous Gel Scaffold for mRNA Vaccine Delivery

(2018) Jingxuan Yan et al.   MACROMOLECULAR BIOSCIENCE

An mRNA Vaccine Protects Mice against Multiple Tick-Transmitted Flavivirus Infections

(2018) Laura A. VanBlargan et al.   Cell Reports

Nanotechnologies in delivery of mRNA therapeutics using nonviral vector-based delivery systems

(2017) S Guan et al.   GENE THERAPY

Induction of an IFN-Mediated Antiviral Response by a Self-Amplifying RNA Vaccine: Implications for Vaccine Design

(2017) Timothy Pepini et al.   JOURNAL OF IMMUNOLOGY

Modified mRNA-Based Vaccines Elicit Robust Immune Responses and Protect Guinea Pigs From Ebola Virus Disease

(2017) Michelle Meyer et al.   JOURNAL OF INFECTIOUS DISEASES

Safety and immunogenicity of a mRNA rabies vaccine in healthy adults: an open-label, non-randomised, prospective, first-in-human phase 1 clinical trial

(2017) Martin Alberer et al.   LANCET

Preclinical and Clinical Demonstration of Immunogenicity by mRNA Vaccines against H10N8 and H7N9 Influenza Viruses

(2017) Kapil Bahl et al.   MOLECULAR THERAPY

Zika virus protection by a single low-dose nucleoside-modified mRNA vaccination

(2017) Norbert Pardi et al.   NATURE

A thermostable messenger RNA based vaccine against rabies

(2017) Lothar Stitz et al.   PLoS Neglected Tropical Diseases

Influenza immunology evaluation and correlates of protection: a focus on vaccines

(2016) Claudia Maria Trombetta et al.   Expert Review of Vaccines

Achieving long-term stability of lipid nanoparticles: examining the effect of pH, temperature, and lyophilization

(2016) Rebecca Ball et al.   International Journal of Nanomedicine

Dendrimer-RNA nanoparticles generate protective immunity against lethal Ebola, H1N1 influenza, andToxoplasma gondiichallenges with a single dose

(2016) Jasdave S. Chahal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus

(2016) Anurodh Shankar Agrawal et al.   Human Vaccines & Immunotherapeutics

Brief History and Characterization of Enhanced Respiratory Syncytial Virus Disease

(2015) Patricio L. Acosta et al.   Clinical and Vaccine Immunology

N 1 -methylpseudouridine-incorporated mRNA outperforms pseudouridine-incorporated mRNA by providing enhanced protein expression and reduced immunogenicity in mammalian cell lines and mice

(2015) Oliwia Andries et al.   JOURNAL OF CONTROLLED RELEASE

CD4+ T Cell Differentiation in Infection: Amendments to the Th1/Th2 Axiom

(2015) Dragana Jankovic et al.   Frontiers in Immunology

Comparative analysis of enzymatically produced novel linear DNA constructs with plasmids for use as DNA vaccines

(2014) A A Walters et al.   GENE THERAPY

Animal models for influenza virus pathogenesis, transmission, and immunology

(2014) Rajagowthamee R. Thangavel et al.   JOURNAL OF IMMUNOLOGICAL METHODS

Risk in Vaccine Research and Development Quantified

(2013) Esther S. Pronker et al.   PLoS One

Protective efficacy of in vitro synthesized, specific mRNA vaccines against influenza A virus infection

(2012) Benjamin Petsch et al.   NATURE BIOTECHNOLOGY

Immunization with SARS Coronavirus Vaccines Leads to Pulmonary Immunopathology on Challenge with the SARS Virus

(2012) Chien-Te Tseng et al.   PLoS One

Nonviral delivery of self-amplifying RNA vaccines

(2012) A. J. Geall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The socio-ecology of zoonotic infections

(2010) A. Cascio et al.   CLINICAL MICROBIOLOGY AND INFECTION

New Insights into the Role of RNase L in Innate Immunity

(2010) Arindam Chakrabarti et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

Accessing the therapeutic potential of immunostimulatory nucleic acids

(2008) Winfried Barchet et al.   CURRENT OPINION IN IMMUNOLOGY

Incorporation of Pseudouridine Into mRNA Yields Superior Nonimmunogenic Vector With Increased Translational Capacity and Biological Stability

(2008) Katalin Karikó et al.   MOLECULAR THERAPY