HIV-1 Vpr degrades the HLTF DNA translocase in T cells and macrophages

Cell Surface Proteomic Map of HIV Infection Reveals Antagonism of Amino Acid Metabolism by Vpu and Nef

(2015) Nicholas J. Matheson et al.   Cell Host & Microbe

HIV-1 Vpr Protein Enhances Proteasomal Degradation of MCM10 DNA Replication Factor through the Cul4-DDB1[VprBP] E3 Ubiquitin Ligase to Induce G2/M Cell Cycle Arrest

(2015) Bizhan Romani et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of a Novel DNA-binding Domain of Helicase-like Transcription Factor (HLTF) and Its Functional Implication in DNA Damage Tolerance

(2015) Asami Hishiki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Vpr Enhances Tumor Necrosis Factor Production by HIV-1-Infected T Cells

(2015) Ferdinand Roesch et al.   JOURNAL OF VIROLOGY

HLTF’s Ancient HIRAN Domain Binds 3′ DNA Ends to Drive Replication Fork Reversal

(2015) Andrew C. Kile et al.   MOLECULAR CELL

Determinants for degradation of SAMHD1, Mus81 and induction of G 2 arrest in HIV-1 Vpr and SIVagm Vpr

(2015) Ana Beatriz DePaula-Silva et al.   VIROLOGY

Vpr Promotes Macrophage-Dependent HIV-1 Infection of CD4+ T Lymphocytes

(2015) David R. Collins et al.   PLoS Pathogens

Premature Activation of the SLX4 Complex by Vpr Promotes G2/M Arrest and Escape from Innate Immune Sensing

(2014) Nadine Laguette et al.   CELL

Vpr Overcomes Macrophage-Specific Restriction of HIV-1 Env Expression and Virion Production

(2014) Michael Mashiba et al.   Cell Host & Microbe

Tolerating DNA damage during eukaryotic chromosome replication

(2014) Irene Saugar et al.   EXPERIMENTAL CELL RESEARCH

How SLX4 cuts through the mystery of HIV-1 Vpr-mediated cell cycle arrest

(2014) Marie-Lise Blondot et al.   Retrovirology

DNA damage and innate immunity: links and trade-offs

(2014) Georgia Chatzinikolaou et al.   TRENDS IN IMMUNOLOGY

DNA damage repair machinery and HIV escape from innate immune sensing

(2014) Christelle Brégnard et al.   Frontiers in Microbiology

ATR phosphorylates SMARCAL1 to prevent replication fork collapse

(2013) F. B. Couch et al.   GENES & DEVELOPMENT

HIV-1 Vpr Protein Inhibits Telomerase Activity via the EDD-DDB1-VPRBP E3 Ligase Complex

(2013) Xin Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Human immunodeficiency virus type 1 Vpr polymorphisms associated with progressor and nonprogressor individuals alter Vpr-associated functions

(2013) K. Hadi et al.   JOURNAL OF GENERAL VIROLOGY

Causes and consequences of replication stress

(2013) Michelle K. Zeman et al.   NATURE CELL BIOLOGY

Strand invasion by HLTF as a mechanism for template switch in fork rescue

(2013) Peter Burkovics et al.   NUCLEIC ACIDS RESEARCH

Helicase-Like Transcription Factor (Hltf) Regulates G2/M Transition, Wt1/Gata4/Hif-1a Cardiac Transcription Networks, and Collagen Biogenesis

(2013) Rebecca A. Helmer et al.   PLoS One

p21-mediated RNR2 repression restricts HIV-1 replication in macrophages by inhibiting dNTP biosynthesis pathway

(2013) A. Allouch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The HIV-1 protein Vpr targets the endoribonuclease Dicer for proteasomal degradation to boost macrophage infection

(2013) Laurieann Casey Klockow et al.   VIROLOGY

HIV-1 Vpr Accelerates Viral Replication during Acute Infection by Exploitation of Proliferating CD4+ T Cells In Vivo

(2013) Kei Sato et al.   PLoS Pathogens

SMARCAL1 deficiency predisposes to non-Hodgkin lymphoma and hypersensitivity to genotoxic agents in vivo

(2012) Alireza Baradaran-Heravi et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

SMARCAL1 catalyzes fork regression and Holliday junction migration to maintain genome stability during DNA replication

(2012) R. Betous et al.   GENES & DEVELOPMENT

Loss of HLTF function promotes intestinal carcinogenesis

(2012) Sumit Sandhu et al.   Molecular Cancer

SAMHD1 restricts the replication of human immunodeficiency virus type 1 by depleting the intracellular pool of deoxynucleoside triphosphates

(2012) Hichem Lahouassa et al.   NATURE IMMUNOLOGY

Differential Effects of Vpr on Single-cycle and Spreading HIV-1 Infections in CD4+ T-cells and Dendritic Cells

(2012) Suresh de Silva et al.   PLoS One

Molecular Insight into How HIV-1 Vpr Protein Impairs Cell Growth through Two Genetically Distinct Pathways

(2011) Claire Maudet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Aicardi-Goutières Syndrome Gene and HIV-1 Restriction Factor SAMHD1 Is a dGTP-regulated Deoxynucleotide Triphosphohydrolase

(2011) Rebecca D. Powell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SHPRH and HLTF Act in a Damage-Specific Manner to Coordinate Different Forms of Postreplication Repair and Prevent Mutagenesis

(2011) Jia-Ren Lin et al.   MOLECULAR CELL

HIV-1 restriction factor SAMHD1 is a deoxynucleoside triphosphate triphosphohydrolase

(2011) David C. Goldstone et al.   NATURE

SAMHD1 is the dendritic- and myeloid-cell-specific HIV-1 restriction factor counteracted by Vpx

(2011) Nadine Laguette et al.   NATURE

Vpx relieves inhibition of HIV-1 infection of macrophages mediated by the SAMHD1 protein

(2011) Kasia Hrecka et al.   NATURE

Coordinated protein and DNA remodeling by human HLTF on stalled replication fork

(2011) Y. J. Achar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Limelight on two HIV/SIV accessory proteins in macrophage infection: Is Vpx overshadowing Vpr?

(2010) Diana Ayinde et al.   Retrovirology

Viral Genetic Determinants of Nonprogressive HIV Type 1 Subtype C Infection in Antiretroviral Drug-Naive Children

(2009) D.B. Tzitzivacos et al.   AIDS RESEARCH AND HUMAN RETROVIRUSES

Mammalian BTBD12/SLX4 Assembles A Holliday Junction Resolvase and Is Required for DNA Repair

(2009) Jennifer M. Svendsen et al.   CELL

Human SLX4 Is a Holliday Junction Resolvase Subunit that Binds Multiple DNA Repair/Recombination Endonucleases

(2009) Samira Fekairi et al.   CELL

HIV-1 Mediated Immune Pathogenesis: Spotlight on the Role of Viral Protein R (VPR)

(2009) Biswanath Majumder et al.   CURRENT HIV RESEARCH

Human Immunodeficiency Virus Type 1 Mediates Global Disruption of Innate Antiviral Signaling and Immune Defenses within Infected Cells

(2009) B. P. Doehle et al.   JOURNAL OF VIROLOGY

The CDK Inhibitor p21Cip1/WAF1 Is Induced by Fc R Activation and Restricts the Replication of Human Immunodeficiency Virus Type 1 and Related Primate Lentiviruses in Human Macrophages

(2009) A. Bergamaschi et al.   JOURNAL OF VIROLOGY

Role of Double-Stranded DNA Translocase Activity of Human HLTF in Replication of Damaged DNA

(2009) A. Blastyak et al.   MOLECULAR AND CELLULAR BIOLOGY

Coordination of Structure-Specific Nucleases by Human SLX4/BTBD12 Is Required for DNA Repair

(2009) Ivan M. Muñoz et al.   MOLECULAR CELL

Characterization of the Molecular Determinants of Primary HIV-1 Vpr Proteins: Impact of the Q65R and R77Q Substitutions on Vpr Functions

(2009) Guillaume Jacquot et al.   PLoS One

HIV-1 Vpr Triggers Natural Killer Cell–Mediated Lysis of Infected Cells through Activation of the ATR-Mediated DNA Damage Response

(2009) Jeffrey Ward et al.   PLoS Pathogens

Human HLTF functions as a ubiquitin ligase for proliferating cell nuclear antigen polyubiquitination

(2008) I. Unk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired nuclear import and viral incorporation of Vpr derived from a HIV long-term non-progressor

(2008) Leon Caly et al.   Retrovirology

HIV-1 accessory proteins VPR and Vif modulate antiviral response by targeting IRF-3 for degradation

(2007) Atsushi Okumura et al.   VIROLOGY