Article
Biology
Yo Han Lee, Hyun-Jun Jang, Sounkou Kim, Sun Sil Choi, Keon Woo Khim, Hye-jin Eom, Jimin Hyun, Kyeong Jin Shin, Young Chan Chae, Hongtae Kim, Jiyoung Park, Neung Hwa Park, Chang-Yun Woo, Chung Hwan Hong, Eun Hee Koh, Dougu Nam, Jang Hyun Choi
Summary: The study identifies that MIR20B targets PPARA and plays a significant role in NAFLD, with overexpression of MIR20B leading to increased hepatic lipid accumulation and triglyceride levels, and inhibiting FA oxidation and mitochondrial biogenesis. Inhibition of MIR20B can enhance FA oxidation and uptake, improving insulin sensitivity and reducing NAFLD progression.
Article
Endocrinology & Metabolism
Fangli Zhou, Yan Wang, Yujue Li, Mengjia Tang, Shan Wan, Haoming Tian, Xiang Chen
Summary: The study found that circulating sclerostin levels were significantly lower in NAFLD patients compared to controls, and were negatively correlated with multiple metabolic parameters in NAFLD patients. Mice fed on a high-fat diet had reduced bone mass and lower sclerostin expression levels. Therefore, liver-lipid-bone interactions may play a key role in abnormal bone metabolism in NAFLD.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Review
Nutrition & Dietetics
Camila Farias, Camila Cisternas, Juan Cristobal Gana, Gigliola Alberti, Francisca Echeverria, Luis A. Videla, Lorena Mercado, Yasna Munoz, Rodrigo Valenzuela
Summary: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in pediatrics, and children and adolescents with obesity are at increased risk of the disease. Currently, there is no effective drug therapy in pediatrics, making lifestyle interventions the primary treatment option.
Review
Clinical Neurology
Yunpeng Gu, Wei Zhang, Yanli Hu, Yutong Chen, Junping Shi
Summary: Nonalcoholic fatty liver disease (NAFLD) is significantly associated with depression, and individuals with NAFLD have an increased risk of depression. Additionally, depressed patients have a higher risk of developing NAFLD compared to non-depressed patients.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Review
Environmental Sciences
Shuilin Zheng, Yue Yang, Cong Wen, Wenya Liu, Linghui Cao, Xiangling Feng, Jihua Chen, Hui Wang, Yan Tang, Li Tian, Xiaoyan Wang, Fei Yang
Summary: The global prevalence of nonalcoholic fatty liver disease (NAFLD) is rapidly increasing, with environmental chemical contaminants being considered as tangible environmental risk factors for NAFLD.
ENVIRONMENT INTERNATIONAL
(2021)
Review
Gastroenterology & Hepatology
Jane Ha, Sun Young Yim, Raffi Karagozian
Summary: This study found that patients with lean nonalcoholic fatty liver disease (NAFLD) have a higher risk of liver-related mortality compared to non-lean NAFLD patients. This finding emphasizes the importance of further understanding the pathophysiology, risk factors of adverse outcomes, and genetic and ethnic variabilities of the lean NAFLD phenotype for individualized treatment strategies.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Review
Pharmacology & Pharmacy
Jie Liu, Bingyi Yao, Liangcai Gao, Yuanjin Zhang, Shengbo Huang, Xin Wang
Summary: This review provides an overview of the role and potential value of carboxylesterases (CESs) in the progression and treatment of nonalcoholic fatty liver disease (NAFLD). The relationship between CESs and hepatic lipid metabolism and inflammation is analyzed, and the regulation of CESs by nuclear receptors is reviewed. Additionally, the advantages and disadvantages of existing NAFLD animal models are evaluated, and the application of CES-related animal models in NAFLD research is summarized.
BIOCHEMICAL PHARMACOLOGY
(2022)
Article
Endocrinology & Metabolism
Katarzyna Marcinkiewicz, Anita Horodnicka-Jozwa, Tomasz Jackowski, Kamila Straczek, Agnieszka Biczysko-Mokosa, Mieczyslaw Walczak, Elzbieta Petriczko
Summary: NAFLD is a common disease in overweight and obese children, with glucose intolerance increasing the risk. ALT and ultrasound can be used to assess the occurrence of NAFLD, and ultrasound is effective in identifying fatty liver features.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Endocrinology & Metabolism
Ni Cui, Hui Li, Yaoshan Dun, Jeffrey W. Ripley-Gonzalez, Baiyang You, Dezhao Li, Yuan Liu, Ling Qiu, Cui Li, Suixin Liu
Summary: This study found that hepatocyte-expressed macrophage migration inhibitory factor (MIF) can limit the occurrence of fatty liver during obesity. Exercise can reduce lipotoxicity and inhibit JNK activation by modulating endogenous hepatic MIF in nonalcoholic fatty liver disease (NAFLD). These findings have important clinical implications for the prevention and intervention of NAFLD induced by immoderate diet.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jian Ding, Ming Xu, Wei Du, Zhi-Qiang Fang, Hao Xu, Jing-Jing Liu, Ping Song, Chen Xu, Zhi-Wen Li, Zhen-Sheng Yue, Yu-Wei Ling, Juan-Li Duan, Tao . Kai-Shan, Fei He, Lin Wang
Summary: The Notch signaling pathway in macrophages plays a critical role in the development and progression of NAFLD. Inhibiting Notch signaling in macrophages can attenuate experimental steatohepatitis. Exosomes loaded with RBP-J decoy ODNs have the potential to effectively inhibit Notch signaling in liver macrophages in vivo and ameliorate steatohepatitis or steatosis in NAFLD mice.
INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Maria Notarnicola, Alberto Ruben Osella, Maria Gabriella Caruso, Pasqua Letizia Pesole, Antonio Lippolis, Valeria Tutino, Caterina Bonfiglio, Valentina De Nunzio, Maria Principia Scavo, Antonella Mirizzi, Isabella Franco, Tamara Lippolis, Rosalba D'Alessandro, Maria Grazia Refolo, Caterina Messa
Summary: NAFLD is considered as a hepatic manifestation of metabolic syndrome, characterized by excessive lipid accumulation and oxidative stress leading to liver injury. The identification of genetic and epigenetic modifications contributing to NAFLD pathogenesis is crucial, while lifestyle modifications remain the main prevention and treatment approach.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Food Science & Technology
Hui Han, Yi Jiang, Mengyu Wang, Mebratu Melaku, Lei Liu, Yong Zhao, Nadia Everaert, Bao Yi, Hongfu Zhang
Summary: Nonalcoholic fatty liver disease (NAFLD) is a common chronic liver disorder that is closely related to gut dysfunction. The bidirectional communication between the gut and liver, mediated by metabolites, plays a role in the pathogenesis of NAFLD.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Article
Cell Biology
Shun Fujinuma, Hirokazu Nakatsumi, Hideyuki Shimizu, Shigeaki Sugiyama, Akihito Harada, Takeshi Goya, Masatake Tanaka, Motoyuki Kohjima, Masatomo Takahashi, Yoshihiro Izumi, Mikako Yagi, Dongchon Kang, Mari Kaneko, Mayo Shigeta, Takeshi Bamba, Yasuyuki Ohkawa, Keiichi I. Nakayama
Summary: Nonalcoholic fatty liver disease (NAFLD) is a metabolic disorder that can lead to nonalcoholic steatohepatitis (NASH) and hepatocellular carcinoma (HCC). The transcription factor FOXK1 plays a key role in hepatic lipid metabolism by suppressing lipid catabolism. Inhibition of FOXK1 has shown promising results in improving hepatic steatosis, inflammation, fibrosis, and tumorigenesis, making it a potential therapeutic strategy for NAFLD-NASH and HCC.
Review
Endocrinology & Metabolism
Laura E. Dichtel, Jose Cordoba-Chacon, Rhonda D. Kineman
Summary: This article summarizes the high prevalence of nonalcoholic fatty liver disease (NAFLD) in patients with obesity and its progression to nonalcoholic steatohepatitis (NASH). Understanding the etiology of NAFLD is clinically relevant as it is an independent risk factor for diabetes and cardiovascular disease. The potential role of growth hormone and insulin-like growth factor 1 in regulating hepatic steatosis, inflammation, and fibrosis is discussed.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Gastroenterology & Hepatology
Lina Gruneau, Mattias Ekstedt, Stergios Kechagias, Martin Henriksson
Summary: This systematic literature review investigates the modeling of the natural history of nonalcoholic fatty liver disease (NAFLD). Differences were seen in model structure and data input among the included studies. Clear definitions of nonalcoholic steatohepatitis and NAFLD were often lacking. Differences in disease progression modeling may have a large impact when assessing the value of emerging pharmacologic treatments.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
(2023)
Article
Immunology
Jun Cui, Cheng Chen, Xiao Zhou, Wenju Shan, Yuhong Jian, Panpan Li, Yang Sun, Wei Yi
Summary: Bone marrow mesenchymal stem cells (BMSCs) are a promising therapy for sepsis, but metabolic syndromes threaten their effectiveness. This study investigated the potential of small extracellular vesicles from high-fat diet BMSCs in sepsis-induced liver-heart axis injury.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Binbin Zhu, Angyang Cao, Chunqu Chen, Weijian Zhou, Wenjun Luo, Yu Gui, Qinwen Wang, Zhipeng Xu, Jianhua Wang
Summary: GM6001 alleviates postoperative cognitive deficits and neuroinflammation, preserves blood-brain barrier integrity, and rescues aquaporin-4 mislocalization. MMP-9 inhibition plays a dual role in cognitive protection through direct anti-neuroinflammatory effects and regulation of aquaporin-4 membrane distribution.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Anika Sood, Valencia Fernandes, Kumari Preeti, Shruti Rajan, Dharmendra Kumar Khatri, Shashi Bala Singh
Summary: S1PR2 inhibitor improves cognitive function and skews microglia toward anti-inflammatory phenotype in type 2 diabetic mice, promising to be a potential therapy for neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Haochun Guo, Ran Yu, Haijun Zhang, Wanpeng Wang
Summary: Radiation therapy is an effective treatment for thoracic malignancies, but it can cause radiation-induced lung injury (RILI), including radiation pneumonitis (RP) and radiation pulmonary fibrosis (RPF). The damage to normal lung cells during radiation treatment leads to a pulmonary inflammatory response, resulting in RP and RPF.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Guanghui Wang, Haotian Zheng, Yunzhi Xiang, Yadong Wang, Kai Wang, Xiaoyang Ren, Jiajun Du
Summary: This study identified a T-cell synthetic driver-associated prognostic model that accurately predicted prognosis and effectiveness of immunotherapy in LUAD patients. It also highlighted the role of LDHA in promoting tumor cell proliferation, invasion, and resistance to treatment, as well as its involvement in immune escape within the tumor microenvironment. These findings provide a promising new therapeutic strategy for LUAD.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Bowen Wei, Aihua Wang, Wei Liu, Qingyun Yue, Yihua Fan, Bin Xue, Siwei Wang
Summary: This study systematically analyzed the association between pSS and cuproptosis, established a predictive model based on 5 genes, explored the pathogenic mechanisms and novel therapeutic strategies for pSS, and identified EED, CBL, and NFU1 as potential targets for treatment.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Nusrit Iqbal Andrabi, Aminur R. Sarkar, Syed Assim Haq, Diljeet Kumar, Dilpreet Kour, Diksha Saroch, Sanket Kumar Shukla, Ajay Kumar, Asha Bhagat, Asif Ali, Gurleen Kour, Zabeer Ahmed
Summary: Koenimbine and its novel semi-synthetic derivative 1G demonstrate significant anti-inflammatory effects by downregulating the nuclear factor kappa-B (NF-kappa B) signaling pathway.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Jing-Mei Lu, Xiang Xu, Fumie Aosai, Ming-Yue Zhang, Lian-Xun Piao
Summary: This study found that arctiin can improve allergic acute liver injury caused by T.g.HSP70 by inhibiting TLR4 signaling and reducing the production of inflammatory mediators.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Minxuan Xu, Fang Shi, Yongshen Gao, Shumei Han, Chensuo Huang, Qinsheng Hou, Xiaoweng Wen, Bengshi Wang, Zhenyu Zhu, Lei Zou, Mingxin Xiong, Wei Dong, Jun Tan
Summary: There is a growing body of research highlighting the involvement of metabolic imbalance and the inflammatory response in the advancement of colitis. This study recognizes arabinose as a significant protector of the intestinal mucosal barrier, reducing damage to the intestines. In addition, lower levels of arabinose in the bloodstream are associated with a higher severity of inflammatory bowel disease and colorectal cancer.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yueqing Han, Haoxin Song, Yanshan Li, Rongxin Li, Ling Chen, Bo Gao, Yijun Chen, Shuzhen Wang
Summary: The combination of tetracycline antibiotics, demeclocycline (D), chlortetracycline (C), and minocycline (M), showed therapeutic potential against liver fibrosis by inhibiting the activation of hepatic stellate cells and the MAPK signaling. This study suggests that tetracyclines may be repurposed for the treatment of liver fibrosis.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yu Li, Hailing Liu, Danwen Zhao, Danjie Zhang
Summary: Chronic stress can lead to lung injury, with the spleen playing a crucial role. This study found that the spleen contributes to chronic restraint stress-induced lung injury, and splenic CD11b+ cells may be an important factor in this process.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Yingqian Mi, Mengyan Tang, Qiong Wu, Yinan Wang, Qihui Liu, Pei Zhu, Xiaoyang Xue, Yuntong Liu, Xinyu Chai, Yuyang Hou, Dongmei Yan
Summary: BCG therapy can induce macrophage polarization to the M1 type, and NMAAP1 plays a crucial role in this process by regulating glycolysis and HIF-1α expression. This promotes the antitumor effect of macrophages.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Xiaosheng Liu, Tingxia Lv, Xiuxia Li, Jing Xue, Ling Lin, Lianfeng Lu, Xiaodi Li, Yang Yang, Yuanni Wu, Qiang Wei, Wei Cao, Taisheng Li
Summary: LLDT-8 exhibits notable efficacy in alleviating immune activation in both an in vivo animal model and in vitro human cell experiments, suggesting its potential as a drug for managing systemic immune activation associated with SIV/HIV infection.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Honghong Yu, Qi Li, Huimin Zhu, Chang Liu, Weiwei Chen, Lingyun Sun
Summary: The activation of the inflammasome plays a critical role in the pathogenesis of systemic lupus erythematosus (SLE), and mesenchymal stem cells (MSC) have been shown to alleviate SLE by suppressing inflammasome activation. This study found that the NLRP3 inflammasome was activated in macrophages from SLE patients and mice, and its activation correlated with disease activity. After MSC transplantation, the severity of SLE was reduced, and NLRP3 inflammasome activation was inhibited. These findings suggest that MSC suppress inflammasome activation and provide a potential therapeutic target for SLE.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)
Article
Immunology
Wei Zhou, Dan Zeng, Shunan Liu, Yunxia Huang, Fenglin Lv, Weikang Zhou
Summary: This study found that inhibiting HDAC3 can protect the skin from atopic dermatitis by activating the Nrf2 transcription to upregulate Nrf2/HO-1 signaling pathway activity.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2024)