Cell-Type-Specific Gene Regulatory Networks Underlying Murine Neonatal Heart Regeneration at Single-Cell Resolution

Single-Cell Transcriptome Atlas of Murine Endothelial Cells

(2020) Joanna Kalucka et al.   CELL

The Role of the Epicardium During Heart Development and Repair

(2020) Pearl Quijada et al.   CIRCULATION RESEARCH

Single-cell reconstruction of the adult human heart during heart failure and recovery reveals the cellular landscape underlying cardiac function

(2020) Li Wang et al.   NATURE CELL BIOLOGY

Dynamic Interstitial Cell Response during Myocardial Infarction Predicts Resilience to Rupture in Genetically Diverse Mice

(2020) Elvira Forte et al.   Cell Reports

Phosphoproteomic Analysis of Neonatal Regenerative Myocardium Revealed Important Roles of Checkpoint Kinase 1 via Activating Mammalian Target of Rapamycin C1/Ribosomal Protein S6 Kinase b-1 Pathway

(2020) Yi Fan et al.   CIRCULATION

Transcriptional and Cellular Diversity of the Human Heart

(2020) Nathan R. Tucker et al.   CIRCULATION

Dynamic Transcriptional Responses to Injury of Regenerative and Non-regenerative Cardiomyocytes Revealed by Single-Nucleus RNA Sequencing

(2020) Miao Cui et al.   DEVELOPMENTAL CELL

Cells of the adult human heart

(2020) Monika Litviňuková et al.   NATURE

Single-Cell Transcriptome Analysis Maps the Developmental Track of the Human Heart

(2019) Yueli Cui et al.   Cell Reports

WNT3a and WNT5a Transported by Exosomes Activate WNT Signaling Pathways in Human Cardiac Fibroblasts

(2019) Edyta Działo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Unique Collateral Artery Development Program Promotes Neonatal Heart Regeneration

(2019) Soumyashree Das et al.   CELL

Cardiac Reprogramming Factors Synergistically Activate Genome-wide Cardiogenic Stage-Specific Enhancers

(2019) Hisayuki Hashimoto et al.   Cell Stem Cell

Single-Cell Transcriptomics of Human and Mouse Lung Cancers Reveals Conserved Myeloid Populations across Individuals and Species

(2019) Rapolas Zilionis et al.   IMMUNITY

Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury

(2019) Nona Farbehi et al.   eLife

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Proteomic profiling of key transcription factors in the process of neonatal mouse cardiac regeneration capacity loss

(2019) Wang Mangyuan et al.   CELL BIOLOGY INTERNATIONAL

A cellular atlas of Pitx2-dependent cardiac development

(2019) Matthew C. Hill et al.   DEVELOPMENT

Metascape provides a biologist-oriented resource for the analysis of systems-level datasets

(2019) Yingyao Zhou et al.   Nature Communications

Single-Cell RNA-Seq of the Developing Cardiac Outflow Tract Reveals Convergent Development of the Vascular Smooth Muscle Cells

(2019) Xuanyu Liu et al.   Cell Reports

Mechanistic basis of neonatal heart regeneration revealed by transcriptome and histone modification profiling

(2019) Zhaoning Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Spatiotemporal Organ-Wide Gene Expression and Cell Atlas of the Developing Human Heart

(2019) Michaela Asp et al.   CELL

Single-Cell Sequencing of Mouse Heart Immune Infiltrate in Pressure Overload–Driven Heart Failure Reveals Extent of Immune Activation

(2019) Elisa Martini et al.   CIRCULATION

Single-Cell Sequencing of the Healthy and Diseased Heart Reveals Cytoskeleton-Associated Protein 4 as a New Modulator of Fibroblasts Activation

(2018) Monika M. Gladka et al.   CIRCULATION

Regenerative Potential of Neonatal Porcine Hearts

(2018) Wuqiang Zhu et al.   CIRCULATION

Early Regenerative Capacity in the Porcine Heart

(2018) Lei Ye et al.   CIRCULATION

Endocardial Hippo signaling regulates myocardial growth and cardiogenesis

(2018) Stanley Artap et al.   DEVELOPMENTAL BIOLOGY

Hippo Signaling Plays an Essential Role in Cell State Transitions during Cardiac Fibroblast Development

(2018) Yang Xiao et al.   DEVELOPMENTAL CELL

Deletion of delta-like 1 homologue accelerates fibroblast–myofibroblast differentiation and induces myocardial fibrosis

(2018) Patricia Rodriguez et al.   EUROPEAN HEART JOURNAL

Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart

(2018) Xing Fu et al.   JOURNAL OF CLINICAL INVESTIGATION

Integrating single-cell transcriptomic data across different conditions, technologies, and species

(2018) Andrew Butler et al.   NATURE BIOTECHNOLOGY

Single-nucleus analysis of accessible chromatin in developing mouse forebrain reveals cell-type-specific transcriptional regulation

(2018) Sebastian Preissl et al.   NATURE NEUROSCIENCE

The epicardium as a hub for heart regeneration

(2018) Jingli Cao et al.   Nature Reviews Cardiology

Single-Cell Transcriptional Profiling Reveals Cellular Diversity and Intercommunication in the Mouse Heart

(2018) Daniel A. Skelly et al.   Cell Reports

Single-Cell Deconvolution of Fibroblast Heterogeneity in Mouse Pulmonary Fibrosis

(2018) Ting Xie et al.   Cell Reports

High-throughput chromatin accessibility profiling at single-cell resolution

(2018) Anja Mezger et al.   Nature Communications

A conserved HH-Gli1-Mycn network regulates heart regeneration from newt to human

(2018) Bhairab N. Singh et al.   Nature Communications

Single cell RNA-seq and ATAC-seq analysis of cardiac progenitor cell transition states and lineage settlement

(2018) Guangshuai Jia et al.   Nature Communications

Wnt5a is elevated in heart failure and affects cardiac fibroblast function

(2017) Aurelija Abraityte et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypoxia induces heart regeneration in adult mice

(2017) Yuji Nakada et al.   NATURE

The extracellular matrix protein agrin promotes heart regeneration in mice

(2017) Elad Bassat et al.   NATURE

Frequency of mononuclear diploid cardiomyocytes underlies natural variation in heart regeneration

(2017) Michaela Patterson et al.   NATURE GENETICS

chromVAR: inferring transcription-factor-associated accessibility from single-cell epigenomic data

(2017) Alicia N Schep et al.   NATURE METHODS

Chasing the recipe for a pro-regenerative immune system

(2017) James W. Godwin et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Single cardiomyocyte nuclear transcriptomes reveal a lincRNA-regulated de-differentiation and cell cycle stress-response in vivo

(2017) Kelvin See et al.   Nature Communications

Endocardium Minimally Contributes to Coronary Endothelium in the Embryonic Ventricular Free WallsNovelty and Significance

(2016) Hui Zhang et al.   CIRCULATION RESEARCH

Single-Cell Resolution of Temporal Gene Expression during Heart Development

(2016) Daniel M. DeLaughter et al.   DEVELOPMENTAL CELL

Pitx2 promotes heart repair by activating the antioxidant response after cardiac injury

(2016) Ge Tao et al.   NATURE

Extracellular Matrix and Dermal Fibroblast Function in the Healing Wound

(2016) Lauren E. Tracy et al.   Advances in Wound Care

FoxO4 Promotes Early Inflammatory Response Upon Myocardial Infarction via Endothelial Arg1Novelty and Significance

(2015) Min Zhu et al.   CIRCULATION RESEARCH

Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders

(2015) Natalie A. Sims   CYTOKINE & GROWTH FACTOR REVIEWS

Single-cell chromatin accessibility reveals principles of regulatory variation

(2015) Jason D. Buenrostro et al.   NATURE

ERBB2 triggers mammalian heart regeneration by promoting cardiomyocyte dedifferentiation and proliferation

(2015) Gabriele D’Uva et al.   NATURE CELL BIOLOGY

A draft network of ligand–receptor-mediated multicellular signalling in human

(2015) Jordan A. Ramilowski et al.   Nature Communications

Immune Modulation of Stem Cells and Regeneration

(2014) Arin B. Aurora et al.   Cell Stem Cell

Macrophages are required for neonatal heart regeneration

(2014) Arin B. Aurora et al.   JOURNAL OF CLINICAL INVESTIGATION

Hippo pathway effector Yap promotes cardiac regeneration

(2013) Mei Xin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

YAP1, the nuclear target of Hippo signaling, stimulates heart growth through cardiomyocyte proliferation but not hypertrophy

(2012) A. von Gise et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of neonatal and adult mammalian heart regeneration by the miR-15 family

(2012) E. R. Porrello et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rspo1/Wnt signaling promotes angiogenesis via Vegfc/Vegfr3

(2011) A. V. Gore et al.   DEVELOPMENT

Adult mouse epicardium modulates myocardial injury by secreting paracrine factors

(2011) Bin Zhou et al.   JOURNAL OF CLINICAL INVESTIGATION

Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling

(2011) Wim de Lau et al.   NATURE

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

ChIP-Seq identification of weakly conserved heart enhancers

(2010) Matthew J Blow et al.   NATURE GENETICS

WNT5A Is a Regulator of Fibroblast Proliferation and Resistance to Apoptosis

(2009) Louis J. Vuga et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY