Engineering and elucidation of the lipoinitiation process in nonribosomal peptide biosynthesis

Identification of Holrhizins E–Q Reveals the Diversity of Nonribosomal Lipopeptides in Paraburkholderia rhizoxinica

(2020) Hanna Chen et al.   JOURNAL OF NATURAL PRODUCTS

Genome Mining and Biosynthesis of Primary Amine-Acylated Desferrioxamines in a Marine Gliding Bacterium

(2020) Zong-Jie Wang et al.   ORGANIC LETTERS

Efficient rational modification of non-ribosomal peptides by adenylation domain substitution

(2020) Mark J. Calcott et al.   Nature Communications

Reclassification of 'Polyangium brachysporum' DSM 7029 as Schlegelella brevitalea sp. nov.

(2019) Biao Tang et al.   INTERNATIONAL JOURNAL OF SYSTEMATIC AND EVOLUTIONARY MICROBIOLOGY

Modification and de novo design of non-ribosomal peptide synthetases using specific assembly points within condensation domains

(2019) Kenan A. J. Bozhüyük et al.   Nature Chemistry

The structural basis of N-acyl-α-amino-β-lactone formation catalyzed by a nonribosomal peptide synthetase

(2019) Dale F. Kreitler et al.   Nature Communications

Probing and Engineering the Fatty Acyl Substrate Selectivity of Starter Condensation Domains of Nonribosomal Peptide Synthetases in Lipopeptide Biosynthesis

(2019) Qian Liu et al.   Biotechnology Journal

Structures of a dimodular nonribosomal peptide synthetase reveal conformational flexibility

(2019) Janice M. Reimer et al.   SCIENCE

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Discovery of recombinases enables genome mining of cryptic biosynthetic gene clusters in Burkholderiales species

(2018) Xue Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genomics-driven discovery of a linear lipopeptide promoting host colonization by endofungal bacteria

(2018) Sarah P. Niehs et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

De novo design and engineering of non-ribosomal peptide synthetases

(2017) Kenan A. J. Bozhüyük et al.   Nature Chemistry

ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes

(2017) Hailong Wang et al.   NUCLEIC ACIDS RESEARCH

X-Ray Crystallography and Electron Microscopy of Cross- and Multi-Module Nonribosomal Peptide Synthetase Proteins Reveal a Flexible Architecture

(2017) Michael J. Tarry et al.   STRUCTURE

Interdomain and Intermodule Organization in Epimerization Domain Containing Nonribosomal Peptide Synthetases

(2016) Wei-Hung Chen et al.   ACS Chemical Biology

Engineering of New Pneumocandin Side-Chain Analogues from Glarea lozoyensis by Mutasynthesis and Evaluation of Their Antifungal Activity

(2016) Li Chen et al.   ACS Chemical Biology

Structures of a Nonribosomal Peptide Synthetase Module Bound to MbtH-like Proteins Support a Highly Dynamic Domain Architecture

(2016) Bradley R. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structures of two distinct conformations of holo-non-ribosomal peptide synthetases

(2016) Eric J. Drake et al.   NATURE

Synthetic cycle of the initiation module of a formylating nonribosomal peptide synthetase

(2016) Janice M. Reimer et al.   NATURE

RecET direct cloning and Redαβ recombineering of biosynthetic gene clusters, large operons or single genes for heterologous expression

(2016) Hailong Wang et al.   Nature Protocols

Rational and efficient site-directed mutagenesis of adenylation domain alters relative yields of luminmide derivatives in vivo

(2015) Xiaoying Bian et al.   BIOTECHNOLOGY AND BIOENGINEERING

Complete genome sequence of the glidobactin producing strain [Polyangium] brachysporum DSM 7029

(2015) Biao Tang et al.   JOURNAL OF BIOTECHNOLOGY

Lipopeptide surfactants: Production, recovery and pore forming capacity

(2015) Mnif Inès et al.   PEPTIDES

Synthesis and Structure–Activity Relationship Studies of N-Terminal Analogues of the Antimicrobial Peptide Tridecaptin A1

(2014) Stephen A. Cochrane et al.   JOURNAL OF MEDICINAL CHEMISTRY

Lipopeptides from Bacillus and Paenibacillus spp.: A Gold Mine of Antibiotic Candidates

(2014) Stephen A. Cochrane et al.   MEDICINAL RESEARCH REVIEWS

Deciphering key features in protein structures with the new ENDscript server

(2014) Xavier Robert et al.   NUCLEIC ACIDS RESEARCH

Crystal Structures of the First Condensation Domain of CDA Synthetase Suggest Conformational Changes during the Synthetic Cycle of Nonribosomal Peptide Synthetases

(2013) Kristjan Bloudoff et al.   JOURNAL OF MOLECULAR BIOLOGY

Improved seamless mutagenesis by recombineering using ccdB for counterselection

(2013) Hailong Wang et al.   NUCLEIC ACIDS RESEARCH

MOLE 2.0: advanced approach for analysis of biomacromolecular channels

(2013) David Sehnal et al.   Journal of Cheminformatics

Exploring the mechanism of lipid transfer during biosynthesis of the acidic lipopeptide antibiotic CDA

(2012) Femke I. Kraas et al.   FEBS LETTERS

Full-length RecE enhances linear-linear homologous recombination and facilitates direct cloning for bioprospecting

(2012) Jun Fu et al.   NATURE BIOTECHNOLOGY

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Active site modification of the β-ketoacyl-ACP synthase FabF3 of Streptomyces coelicolor affects the fatty acid chain length of the CDA lipopeptides

(2010) Richard A. Lewis et al.   CHEMICAL COMMUNICATIONS

Adding the Lipo to Lipopeptides: Do More with Less

(2010) Yit-Heng Chooi et al.   CHEMISTRY & BIOLOGY

Functional Dissection of Surfactin Synthetase Initiation Module Reveals Insights into the Mechanism of Lipoinitiation

(2010) Femke I. Kraas et al.   CHEMISTRY & BIOLOGY

N-Acylation during Glidobactin Biosynthesis by the Tridomain Nonribosomal Peptide Synthetase Module GlbF

(2010) Heidi J. Imker et al.   CHEMISTRY & BIOLOGY

Diversity of Nonribosomal Peptide Synthetases Involved in the Biosynthesis of Lipopeptide Biosurfactants

(2010) Niran Roongsawang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Absolute metabolite concentrations and implied enzyme active site occupancy in Escherichia coli

(2009) Bryson D Bennett et al.   Nature Chemical Biology

Crystal Structure of the Termination Module of a Nonribosomal Peptide Synthetase

(2008) A. Tanovic et al.   SCIENCE