Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis
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Title
Overcoming hypoxia-induced resistance of pancreatic and lung tumor cells by disrupting the PERK-NRF2-HIF-axis
Authors
Keywords
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Journal
Cell Death & Disease
Volume 12, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2021-01-13
DOI
10.1038/s41419-020-03319-7
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Note: Only part of the references are listed.- HIF-1α and HIF-2α Differently Regulate the Radiation Sensitivity of NSCLC Cells
- (2019) Eloy Moreno Roig et al. Cells
- Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review
- (2019) Jiang-Jiang Qin et al. Cell Communication and Signaling
- Suppression of the SLC7A11/glutathione axis causes synthetic lethality in KRAS-mutant lung adenocarcinoma
- (2019) Kewen Hu et al. JOURNAL OF CLINICAL INVESTIGATION
- NRF2 facilitates breast cancer cell growth via HIF1ɑ-mediated metabolic reprogramming
- (2018) Hong-Sheng Zhang et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Identification of a functional antioxidant response element at the HIF1A locus
- (2018) Sarah E. Lacher et al. Redox Biology
- Targeting the unfolded protein response in cancer
- (2017) Rani Ojha et al. PHARMACOLOGICAL RESEARCH
- Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
- (2017) Marta Pajares et al. Redox Biology
- Andrographolide inhibits hypoxia-induced HIF-1α-driven endothelin 1 secretion by activating Nrf2/HO-1 and promoting the expression of prolyl hydroxylases 2/3 in human endothelial cells
- (2016) Hung-Chih Lin et al. ENVIRONMENTAL TOXICOLOGY
- Hypoxia increases Nrf2-induced HO-1 expression via the PI3K Akt pathway
- (2016) Guoxiang He Frontiers in Bioscience-Landmark
- PERK Integrates Oncogenic Signaling and Cell Survival During Cancer Development
- (2016) Yiwen Bu et al. JOURNAL OF CELLULAR PHYSIOLOGY
- Interplay between VEGF and Nrf2 regulates angiogenesis due to intracranial venous hypertension
- (2016) Liwen Li et al. Scientific Reports
- p62/SQSTM1 functions as a signaling hub and an autophagy adaptor
- (2015) Yoshinori Katsuragi et al. FEBS Journal
- Dual roles of NRF2 in tumor prevention and progression: Possible implications in cancer treatment
- (2015) Eui Jung Moon et al. FREE RADICAL BIOLOGY AND MEDICINE
- The complexity of the Nrf2 pathway: beyond the antioxidant response
- (2015) Ying Huang et al. JOURNAL OF NUTRITIONAL BIOCHEMISTRY
- Nrf2 facilitates repair of radiation induced DNA damage through homologous recombination repair pathway in a ROS independent manner in cancer cells
- (2015) Sundarraj Jayakumar et al. MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS
- Expression Atlas update—an integrated database of gene and protein expression in humans, animals and plants
- (2015) Robert Petryszak et al. NUCLEIC ACIDS RESEARCH
- Depletion of the thiol oxidoreductase ERp57 in tumor cells inhibits proliferation and increases sensitivity to ionizing radiation and chemotherapeutics
- (2015) Melanie Hussmann et al. Oncotarget
- The structural basis for cancer treatment decisions
- (2015) Ruth Nussinov et al. Oncotarget
- Oncogenic KRAS signalling in pancreatic cancer
- (2014) S Eser et al. BRITISH JOURNAL OF CANCER
- Targeting tumour hypoxia to prevent cancer metastasis. From biology, biosensing and technology to drug development: the METOXIA consortium
- (2014) Erik O. Pettersen et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Characterization of a Novel PERK Kinase Inhibitor with Antitumor and Antiangiogenic Activity
- (2013) C. Atkins et al. CANCER RESEARCH
- The emerging role of the Nrf2-Keap1 signaling pathway in cancer
- (2013) M. C. Jaramillo et al. GENES & DEVELOPMENT
- Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke
- (2013) Yi-Lin Cheng et al. NEUROBIOLOGY OF DISEASE
- Integrative Analysis of Complex Cancer Genomics and Clinical Profiles Using the cBioPortal
- (2013) J. Gao et al. Science Signaling
- Discovery of GSK2656157: An Optimized PERK Inhibitor Selected for Preclinical Development
- (2013) Jeffrey M. Axten et al. ACS Medicinal Chemistry Letters
- Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis
- (2012) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- Nrf2 and p21 regulate the fine balance between life and death by controlling ROS levels
- (2010) Nicole F. Villeneuve et al. CELL CYCLE
- HIF-1α signaling is augmented during intermittent hypoxia by induction of the Nrf2 pathway in NOX1-expressing adenocarcinoma A549 cells
- (2010) Viktor Malec et al. FREE RADICAL BIOLOGY AND MEDICINE
- HIF-1 Induction Attenuates Nrf2-Dependent IL-8 Expression in Human Endothelial Cells
- (2009) Agnieszka Loboda et al. ANTIOXIDANTS & REDOX SIGNALING
- An efficient one-step site-directed deletion, insertion, single and multiple-site plasmid mutagenesis protocol
- (2009) Huanting Liu et al. BMC BIOTECHNOLOGY
- Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response
- (2009) Weimin Chen et al. MOLECULAR CELL
- Targeting NRF2 signaling for cancer chemoprevention
- (2009) Mi-Kyoung Kwak et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- Phosphorylation of Nrf2 in the transcription activation domain by casein kinase 2 (CK2) is critical for the nuclear translocation and transcription activation function of Nrf2 in IMR-32 neuroblastoma cells
- (2008) Patrick L. Apopa et al. JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
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