Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review
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Title
Dual roles and therapeutic potential of Keap1-Nrf2 pathway in pancreatic cancer: a systematic review
Authors
Keywords
Keap1, Nrf2, Pancreatic cancer, Tumor-suppressive and promoting roles, Small molecule activators and inhibitors, Prevention and therapy
Journal
Cell Communication and Signaling
Volume 17, Issue 1, Pages -
Publisher
Springer Science and Business Media LLC
Online
2019-09-11
DOI
10.1186/s12964-019-0435-2
References
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Note: Only part of the references are listed.- Angiogenesis in Pancreatic Cancer: Pre-Clinical and Clinical Studies
- (2019) Tiziana Annese et al. Cancers
- Molecular subtypes of pancreatic cancer
- (2019) Eric A. Collisson et al. Nature Reviews Gastroenterology & Hepatology
- Nrf2-miR-129-3p-mTOR Axis Controls an miRNA Regulatory Network Involved in HDACi-Induced Autophagy
- (2019) Weijian Sun et al. MOLECULAR THERAPY
- NRF2 Activation in Cancer: From DNA to Protein
- (2019) Erica W. Cloer et al. CANCER RESEARCH
- Digoxin sensitizes gemcitabine-resistant pancreatic cancer cells to gemcitabine via inhibiting Nrf2 signaling pathway
- (2019) Yunjiang Zhou et al. Redox Biology
- aPKCι promotes gallbladder cancer tumorigenesis and gemcitabine resistance by competing with Nrf2 for binding to Keap1
- (2019) Li Tian et al. Redox Biology
- Simultaneous K-ras activation and Keap1 deletion cause atrophy of pancreatic parenchyma
- (2018) Shin Hamada et al. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
- NRF2 and the Hallmarks of Cancer
- (2018) Montserrat Rojo de la Vega et al. CANCER CELL
- dCK negatively regulates the NRF2/ARE axis and ROS production in pancreatic cancer
- (2018) Qiangsheng Hu et al. CELL PROLIFERATION
- Design and Synthesis of Novel Reactive Oxygen Species Inducers for the Treatment of Pancreatic Ductal Adenocarcinoma
- (2018) Yuting Kuang et al. JOURNAL OF MEDICINAL CHEMISTRY
- GRP78-mediated antioxidant response and ABC transporter activity confers chemoresistance to pancreatic cancer cells
- (2018) Patricia Dauer et al. Molecular Oncology
- Brusatol Enhances the Chemotherapy Efficacy of Gemcitabine in Pancreatic Cancer via the Nrf2 Signalling Pathway
- (2018) Yukai Xiang et al. Oxidative Medicine and Cellular Longevity
- NRAL mediates cisplatin resistance in hepatocellular carcinoma via miR-340-5p/Nrf2 axis
- (2018) Li-li Wu et al. Journal of Cell Communication and Signaling
- Discovery and Characterization of Dual Inhibitors of MDM2 and NFAT1 for Pancreatic Cancer Therapy
- (2018) Wei Wang et al. CANCER RESEARCH
- lncRNA KRAL reverses 5-fluorouracil resistance in hepatocellular carcinoma cells by acting as a ceRNA against miR-141
- (2018) Lili Wu et al. Cell Communication and Signaling
- Nrf2 activation drive macrophages polarization and cancer cell epithelial-mesenchymal transition during interaction
- (2018) Rui Feng et al. Cell Communication and Signaling
- Combined inhibition of autophagy and Nrf2 signaling augments bortezomib-induced apoptosis by increasing ROS production and ER stress in pancreatic cancer cells
- (2018) Xu Li et al. International Journal of Biological Sciences
- PIN1 Maintains Redox Balance via the c-Myc/NRF2 Axis to Counteract Kras-Induced Mitochondrial Respiratory Injury in Pancreatic Cancer Cells
- (2018) Chen Liang et al. CANCER RESEARCH
- Therapeutic trends in pancreatic ductal adenocarcinoma (PDAC)
- (2018) Sreenivasa Chandana et al. EXPERT OPINION ON INVESTIGATIONAL DRUGS
- The antioxidant transcription factor Nrf2 modulates the stress response and phenotype of malignant as well as premalignant pancreatic ductal epithelial cells by inducing expression of the ATF3 splicing variant ΔZip2
- (2018) My-Lan Kha et al. ONCOGENE
- Expression Levels of microRNAs miR-93 and miR-200a in Pancreatic Adenocarcinoma with Special Reference to Differentiation and Relapse-Free Survival
- (2018) Peeter Karihtala et al. ONCOLOGY
- Regulation of the mammalian heat shock factor 1
- (2017) Sharadha Dayalan Naidu et al. FEBS Journal
- Neoadjuvant Therapy of Pancreatic Cancer: Definitions and Benefits
- (2017) et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- EMT, CSCs, and drug resistance: the mechanistic link and clinical implications
- (2017) Tsukasa Shibue et al. Nature Reviews Clinical Oncology
- A clinical drug library screen identifies clobetasol propionate as an NRF2 inhibitor with potential therapeutic efficacy in KEAP1 mutant lung cancer
- (2017) E-J Choi et al. ONCOGENE
- Elucidation of Molecular Mechanisms of Streptozotocin-Induced Oxidative Stress, Apoptosis, and Mitochondrial Dysfunction in Rin-5F Pancreatic β-Cells
- (2017) Arwa M. T. Al Nahdi et al. Oxidative Medicine and Cellular Longevity
- EX4 stabilizes and activates Nrf2 via PKCδ, contributing to the prevention of oxidative stress-induced pancreatic beta cell damage
- (2017) Mi-Hwi Kim et al. TOXICOLOGY AND APPLIED PHARMACOLOGY
- The KEAP1–NRF2 System in Cancer
- (2017) Keiko Taguchi et al. Frontiers in Oncology
- The Natural Flavonoid Fisetin Inhibits Cellular Proliferation of Hepatic, Colorectal, and Pancreatic Cancer Cells through Modulation of Multiple Signaling Pathways
- (2017) Mаhmoud Youns et al. PLoS One
- Small Molecule Inhibitor of NRF2 Selectively Intervenes Therapeutic Resistance in KEAP1-Deficient NSCLC Tumors
- (2016) Anju Singh et al. ACS Chemical Biology
- Pterostilbene Decreases the Antioxidant Defenses of Aggressive Cancer Cells In Vivo: A Physiological Glucocorticoids- and Nrf2-Dependent Mechanism
- (2016) María Benlloch et al. ANTIOXIDANTS & REDOX SIGNALING
- Transcription factor NFE2L2/NRF2 is a regulator of macroautophagy genes
- (2016) Marta Pajares et al. Autophagy
- The anti-oxidative transcription factor Nuclear factor E2 related factor-2 (Nrf2) counteracts TGF-β1 mediated growth inhibition of pancreatic ductal epithelial cells -Nrf2 as determinant of pro-tumorigenic functions of TGF-β1
- (2016) Geeske Genrich et al. BMC CANCER
- ALDOA functions as an oncogene in the highly metastatic pancreatic cancer
- (2016) Shunrong Ji et al. CANCER LETTERS
- NRF2 Promotes Tumor Maintenance by Modulating mRNA Translation in Pancreatic Cancer
- (2016) Iok In Christine Chio et al. CELL
- ROS in translation: Chink in the armor
- (2016) Iok In Christine Chio et al. CELL CYCLE
- MBD1 is an Epigenetic Regulator of KEAP1 in Pancreatic Cancer
- (2016) B. Zhang et al. CURRENT MOLECULAR MEDICINE
- In Vitro Effects of Lead on Gene Expression in Neural Stem Cells and Associations between Up-regulated Genes and Cognitive Scores in Children
- (2016) Peter J. Wagner et al. ENVIRONMENTAL HEALTH PERSPECTIVES
- Esculetin induces antiproliferative and apoptotic response in pancreatic cancer cells by directly binding to KEAP1
- (2016) Rashi Arora et al. Molecular Cancer
- NRF2: Translating the Redox Code
- (2016) Krishna S. Tummala et al. TRENDS IN MOLECULAR MEDICINE
- Cellular localization of NRF2 determines the self-renewal and osteogenic differentiation potential of human MSCs via the P53–SIRT1 axis
- (2016) D S Yoon et al. Cell Death & Disease
- NQO1 inhibits proteasome-mediated degradation of HIF-1α
- (2016) Eun-Taex Oh et al. Nature Communications
- Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
- (2016) Eri H. Kobayashi et al. Nature Communications
- A Small Molecule Inhibits Deregulated NRF2 Transcriptional Activity in Cancer
- (2015) Michael J. Bollong et al. ACS Chemical Biology
- Molecular Pathogenesis and Targeted Therapy of Pancreatic Cancer
- (2015) Shinji Tanaka ANNALS OF SURGICAL ONCOLOGY
- Keap1 expression has independent prognostic value in pancreatic adenocarcinomas
- (2015) Joel Isohookana et al. Diagnostic Pathology
- Activation of the p62-Keap1-NRF2 pathway protects against ferroptosis in hepatocellular carcinoma cells
- (2015) Xiaofang Sun et al. HEPATOLOGY
- UHRF1 regulation of the Keap1-Nrf2 pathway in pancreatic cancer contributes to oncogenesis
- (2015) Wafa Abu-Alainin et al. JOURNAL OF PATHOLOGY
- NRF2 regulates serine biosynthesis in non–small cell lung cancer
- (2015) Gina M DeNicola et al. NATURE GENETICS
- Transcription factors Hsf1 and Nrf2 engage in crosstalk for cytoprotection
- (2015) Sharadha Dayalan Naidu et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- ERK inhibition sensitizes cancer cells to oleanolic acid-induced apoptosis through ERK/Nrf2/ROS pathway
- (2015) Jia Liu et al. TUMOR BIOLOGY
- Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma
- (2015) L R Palam et al. Cell Death & Disease
- The Crosstalk between Nrf2 and TGF-β1 in the Epithelial-Mesenchymal Transition of Pancreatic Duct Epithelial Cells
- (2015) Sarah Arfmann-Knübel et al. PLoS One
- Identification of a New Class of MDM2 Inhibitor That Inhibits Growth of Orthotopic Pancreatic Tumors in Mice
- (2014) Wei Wang et al. GASTROENTEROLOGY
- Hrd1 suppresses Nrf2-mediated cellular protection during liver cirrhosis
- (2014) T. Wu et al. GENES & DEVELOPMENT
- Comparative analysis of NRF2-responsive gene expression in AcPC-1 pancreatic cancer cell line
- (2014) Yong Weon Yi et al. Genes & Genomics
- Use of herbal medicines and natural products: An alternative approach to overcoming the apoptotic resistance of pancreatic cancer
- (2014) Lin Li et al. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY
- Apurinic/Apyrimidinic Endonuclease/Redox Factor-1 (APE1/Ref-1) Redox Function Negatively Regulates NRF2
- (2014) Melissa L. Fishel et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Mechanisms of Overcoming Intrinsic Resistance to Gemcitabine in Pancreatic Ductal Adenocarcinoma through the Redox Modulation
- (2014) H.-Q. Ju et al. MOLECULAR CANCER THERAPEUTICS
- Clinicopathological characteristics of anaplastic carcinoma of the pancreas with rhabdoid features
- (2014) Makoto Sano et al. VIRCHOWS ARCHIV
- Tumor-expressed IL-17D recruits NK cells to reject tumors
- (2014) Robert Saddawi-Konefka et al. OncoImmunology
- Oxidative Stress Induced by Inactivation of TP53INP1 Cooperates with KrasG12D to Initiate and Promote Pancreatic Carcinogenesis in the Murine Pancreas
- (2013) Talal Al Saati et al. AMERICAN JOURNAL OF PATHOLOGY
- Antioxidant-mediated up-regulation of OGG1 via NRF2 induction is associated with inhibition of oxidative DNA damage in estrogen-induced breast cancer
- (2013) Bhupendra Singh et al. BMC CANCER
- RXR Inhibits the NRF2-ARE Signaling Pathway through a Direct Interaction with the Neh7 Domain of NRF2
- (2013) H. Wang et al. CANCER RESEARCH
- Inhibition of NRF2 by PIK-75 augments sensitivity of pancreatic cancer cells to gemcitabine
- (2013) HONG-QUAN DUONG et al. INTERNATIONAL JOURNAL OF ONCOLOGY
- Double-strand break repair: 53BP1 comes into focus
- (2013) Stephanie Panier et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Nuclear Nrf2 expression is related to a poor survival in pancreatic adenocarcinoma
- (2013) Y. Soini et al. PATHOLOGY RESEARCH AND PRACTICE
- Overview on how oncogenic Kras promotes pancreatic carcinogenesis by inducing low intracellular ROS levels
- (2013) Bo Kong et al. Frontiers in Physiology
- Glucose availability is a decisive factor for Nrf2-mediated gene expression
- (2013) Elke H. Heiss et al. Redox Biology
- Nrf2 Redirects Glucose and Glutamine into Anabolic Pathways in Metabolic Reprogramming
- (2012) Yoichiro Mitsuishi et al. CANCER CELL
- Structural and Functional Characterization of Nrf2 Degradation by the Glycogen Synthase Kinase 3/ -TrCP Axis
- (2012) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- PALB2 Interacts with KEAP1 To Promote NRF2 Nuclear Accumulation and Function
- (2012) J. Ma et al. MOLECULAR AND CELLULAR BIOLOGY
- Transcription factor Nrf2 maintains the basal expression of Mdm2: An implication of the regulation of p53 signaling by Nrf2
- (2011) Aram You et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- SCF/ -TrCP Promotes Glycogen Synthase Kinase 3-Dependent Degradation of the Nrf2 Transcription Factor in a Keap1-Independent Manner
- (2011) P. Rada et al. MOLECULAR AND CELLULAR BIOLOGY
- Nrf2 is overexpressed in pancreatic cancer: implications for cell proliferation and therapy
- (2011) Adam Lister et al. Molecular Cancer
- Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis
- (2011) Gina M. DeNicola et al. NATURE
- Beneficial Role of Nrf2 in Regulating NADPH Generation and Consumption
- (2011) Kai Connie Wu et al. TOXICOLOGICAL SCIENCES
- Nrf2-deficiency creates a responsive microenvironment for metastasis to the lung
- (2010) Hironori Satoh et al. CARCINOGENESIS
- The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
- (2010) Masaaki Komatsu et al. NATURE CELL BIOLOGY
- Global mapping of binding sites for Nrf2 identifies novel targets in cell survival response through ChIP-Seq profiling and network analysis
- (2010) Deepti Malhotra et al. NUCLEIC ACIDS RESEARCH
- Nuclear Factor (Erythroid-Derived 2)-Like 2 Regulates Drug Resistance in Pancreatic Cancer Cells
- (2010) Young Bin Hong et al. PANCREAS
- Keap1 perceives stress via three sensors for the endogenous signaling molecules nitric oxide, zinc, and alkenals
- (2010) M. McMahon et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Keap1 is a forked-stem dimer structure with two large spheres enclosing the intervening, double glycine repeat, and C-terminal domains
- (2010) T. Ogura et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Regulation of Notch1 Signaling by Nrf2: Implications for Tissue Regeneration
- (2010) N. Wakabayashi et al. Science Signaling
- Acetylation of Nrf2 by p300/CBP Augments Promoter-Specific DNA Binding of Nrf2 during the Antioxidant Response
- (2009) Z. Sun et al. MOLECULAR AND CELLULAR BIOLOGY
- Direct Interaction between Nrf2 and p21Cip1/WAF1 Upregulates the Nrf2-Mediated Antioxidant Response
- (2009) Weimin Chen et al. MOLECULAR CELL
- Increased proteasome subunit protein expression and proteasome activity in colon cancer relate to an enhanced activation of nuclear factor E2-related factor 2 (Nrf2)
- (2009) A Arlt et al. ONCOGENE
- NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer
- (2009) John D. Hayes et al. TRENDS IN BIOCHEMICAL SCIENCES
- Pancreatic cancer: from molecular pathogenesis to targeted therapy
- (2008) Alexios Strimpakos et al. CANCER AND METASTASIS REVIEWS
- Multiple Nuclear Localization Signals Function in the Nuclear Import of the Transcription Factor Nrf2
- (2008) Melanie Theodore et al. JOURNAL OF BIOLOGICAL CHEMISTRY
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