IMU-838, a Developmental DHODH Inhibitor in Phase II for Autoimmune Disease, Shows Anti-SARS-CoV-2 and Broad-Spectrum Antiviral Efficacy In Vitro

Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro

(2020) Manli Wang et al.   CELL RESEARCH

Detection of 2019 novel coronavirus (2019-nCoV) by real-time RT-PCR

(2020) Victor M Corman et al.   Eurosurveillance

Safety, Tolerability and Pharmacokinetics of Vidofludimus calcium (IMU-838) After Single and Multiple Ascending Oral Doses in Healthy Male Subjects

(2020) Andreas Muehler et al.   EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS

Patterns of Autologous and Nonautologous Interactions between Core Nuclear Egress Complex (NEC) Proteins of α-, β- and γ-Herpesviruses

(2020) Sigrun Häge et al.   Viruses-Basel

Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro

(2020) Jia Liu et al.   Cell Discovery

The trimeric artesunate derivative TF27 exerts strong anti-cytomegaloviral efficacy: Focus on prophylactic efficacy and oral treatment of immunocompetent mice

(2020) Markus Wild et al.   ANTIVIRAL RESEARCH

Target verification of artesunate-related antiviral drugs: Assessing the role of mitochondrial and regulatory proteins by click chemistry and fluorescence labeling

(2020) Friedrich Hahn et al.   ANTIVIRAL RESEARCH

Novel Dihydroorotate Dehydrogenase Inhibitors with Potent Interferon-Independent Antiviral Activity against Mammarenaviruses In Vitro

(2020) Yu-Jin Kim et al.   Viruses-Basel

In vitro screening of a FDA approved chemical library reveals potential inhibitors of SARS-CoV-2 replication

(2020) Franck Touret et al.   Scientific Reports

Remdesivir Inhibits SARS-CoV-2 in Human Lung Cells and Chimeric SARS-CoV Expressing the SARS-CoV-2 RNA Polymerase in Mice

(2020) Andrea J. Pruijssers et al.   Cell Reports

Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2

(2020) Rui Xiong et al.   Protein & Cell

Vidofludimus calcium, a next generation DHODH inhibitor for the Treatment of relapsing-remitting multiple sclerosis

(2020) Andreas Muehler et al.   Multiple Sclerosis and Related Disorders

Neutrophil extracellular traps in COVID-19

(2020) Yu Zuo et al.   JCI Insight

An enzyme-based immunodetection assay to quantify SARS-CoV-2 infection

(2020) Carina Conzelmann et al.   ANTIVIRAL RESEARCH

Antimalarial drugs inhibit the replication of SARS-CoV-2: An in vitro evaluation

(2020) Mathieu Gendrot et al.   Travel Medicine and Infectious Disease

Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects

(2019) Luisa Klotz et al.   Science Translational Medicine

Chemically sulfated polysaccharides from natural sources: Assessment of extraction-sulfation efficiencies, structural features and antiviral activities

(2019) Shuvam Mukherjee et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Artesunate derivative TF27 inhibits replication and pathogenesis of an oncogenic avian alphaherpesvirus

(2019) Luca D. Bertzbach et al.   ANTIVIRAL RESEARCH

The Selective Oral Immunomodulator Vidofludimus in Patients with Active Rheumatoid Arthritis: Safety Results from the COMPONENT Study

(2019) Andreas Muehler et al.   Drugs in research & development

A highly potent trimeric derivative of artesunate shows promising treatment profiles in experimental models for congenital HCMV infection in vitro and ex vivo

(2019) Chloé Jacquet et al.   ANTIVIRAL RESEARCH

Wedelolactone inhibits human cytomegalovirus replication by targeting distinct steps of the viral replication cycle

(2019) Adriana Svrlanska et al.   ANTIVIRAL RESEARCH

Artesunate-derived monomeric, dimeric and trimeric experimental drugs – Their unique mechanistic basis and pronounced antiherpesviral activity

(2018) Friedrich Hahn et al.   ANTIVIRAL RESEARCH

Synthesis of Artemisinin-Derived Dimers, Trimers and Dendrimers: Investigation of Their Antimalarial and Antiviral Activities Including Putative Mechanisms of Action

(2018) Tony Fröhlich et al.   CHEMISTRY-A EUROPEAN JOURNAL

Intraocular DHODH-inhibitor PP-001 suppresses relapsing experimental uveitis and cytokine production of human lymphocytes, but not of RPE cells

(2018) Maria Diedrichs-Möhring et al.   Journal of Neuroinflammation

Pyrimidine synthesis inhibition enhances cutaneous defenses against antibiotic resistant bacteria through activation of NOD2 signaling

(2018) Samreen Jatana et al.   Scientific Reports

Inhibiting pyrimidine biosynthesis impairs Ebola virus replication through depletion of nucleoside pools and activation of innate immune responses

(2018) Priya Luthra et al.   ANTIVIRAL RESEARCH

Novel cytomegalovirus-inhibitory compounds of the class pyrrolopyridines show a complex pattern of target binding that suggests an unusual mechanism of antiviral activity

(2018) Friedrich Hahn et al.   ANTIVIRAL RESEARCH

A genome-wide siRNA screen identifies a druggable host pathway essential for the Ebola virus life cycle

(2018) Scott Martin et al.   Genome Medicine

Human cytomegalovirus utilises cellular dual-specificity tyrosine phosphorylation-regulated kinases during placental replication

(2018) Stuart T. Hamilton et al.   PLACENTA

Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response

(2017) Nam Nam Cheung et al.   JOURNAL OF GENERAL VIROLOGY

Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions

(2017) Felix E. Held et al.   Nature Communications

Cross Talk between Nucleotide Synthesis Pathways with Cellular Immunity in Constraining Hepatitis E Virus Replication

(2016) Yijin Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Discovery of a new structural class of competitive h DHODH inhibitors with in vitro and in vivo anti-inflammatory, immunosuppressive effects

(2016) Wenbin Shen et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Cytomegalovirus pUL50 is the multi-interacting determinant of the core nuclear egress complex (NEC) that recruits cellular accessory NEC components

(2016) Eric Sonntag et al.   JOURNAL OF GENERAL VIROLOGY

A Novel CDK7 Inhibitor of the Pyrazolotriazine Class Exerts Broad-Spectrum Antiviral Activity at Nanomolar Concentrations

(2015) Corina Hutterer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The broad-spectrum antiinfective drug artesunate interferes with the canonical nuclear factor kappa B (NF-κB) pathway by targeting RelA/p65

(2015) Corina Hutterer et al.   ANTIVIRAL RESEARCH

Assessment of drug candidates for broad-spectrum antiviral therapy targeting cellular pyrimidine biosynthesis

(2013) Manfred Marschall et al.   ANTIVIRAL RESEARCH

Inhibition of Pyrimidine Biosynthesis Pathway Suppresses Viral Growth through Innate Immunity

(2013) Marianne Lucas-Hourani et al.   PLoS Pathogens

The unique antiviral activity of artesunate is broadly effective against human cytomegaloviruses including therapy-resistant mutants

(2011) Sunwen Chou et al.   ANTIVIRAL RESEARCH

A reporter system for Epstein-Barr virus (EBV) lytic replication: Anti-EBV activity of the broad anti-herpesviral drug artesunate

(2011) Sabrina Auerochs et al.   JOURNAL OF VIROLOGICAL METHODS

Inhibition of Dengue Virus through Suppression of Host Pyrimidine Biosynthesis

(2011) Q.-Y. Wang et al.   JOURNAL OF VIROLOGY

Identification of broad-spectrum antiviral compounds and assessment of the druggability of their target for efficacy against respiratory syncytial virus (RSV)

(2011) A. Bonavia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Broad-spectrum antiviral that interferes with de novo pyrimidine biosynthesis

(2011) H.-H. Hoffmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

4SC-101, A Novel Small Molecule Dihydroorotate Dehydrogenase Inhibitor, Suppresses Systemic Lupus Erythematosus in MRL-(Fas)lpr Mice

(2010) Onkar P. Kulkarni et al.   AMERICAN JOURNAL OF PATHOLOGY

4SC-101, a novel immunosuppressive drug, inhibits IL-17 and attenuates colitis in two murine models of inflammatory bowel disease†

(2010) Leo R. Fitzpatrick et al.   INFLAMMATORY BOWEL DISEASES

Antibody Elution Method for Multiple Immunohistochemistry on Primary Antibodies Raised in the Same Species and of the Same Subtype

(2009) Daniel Pirici et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Neutral red uptake assay for the estimation of cell viability/cytotoxicity

(2008) Guillermo Repetto et al.   Nature Protocols