Synthesis of Artemisinin-Derived Dimers, Trimers and Dendrimers: Investigation of Their Antimalarial and Antiviral Activities Including Putative Mechanisms of Action

Artemisinin as an anticancer drug: Recent advances in target profiling and mechanisms of action

(2017) Yin Kwan Wong et al.   MEDICINAL RESEARCH REVIEWS

Facile access to potent antiviral quinazoline heterocycles with fluorescence properties via merging metal-free domino reactions

(2017) Felix E. Held et al.   Nature Communications

Mechanistic Investigation of the Specific Anticancer Property of Artemisinin and Its Combination with Aminolevulinic Acid for Enhanced Anticolorectal Cancer Activity

(2017) Jigang Wang et al.   ACS Central Science

Profiling of Multiple Targets of Artemisinin Activated by Hemin in Cancer Cell Proteome

(2016) Yiqing Zhou et al.   ACS Chemical Biology

A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile

(2016) Hanafy M. Ismail et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mechanism-Guided Design and Synthesis of a Mitochondria-Targeting Artemisinin Analogue with Enhanced Anticancer Activity

(2016) Chong-Jing Zhang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Artemisinin-Derived Dimers: Potent Antimalarial and Anticancer Agents

(2016) Tony Fröhlich et al.   JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasitesPlasmodium falciparum3D7

(2016) Hanafy M. Ismail et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Novel CDK7 Inhibitor of the Pyrazolotriazine Class Exerts Broad-Spectrum Antiviral Activity at Nanomolar Concentrations

(2015) Corina Hutterer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

The broad-spectrum antiinfective drug artesunate interferes with the canonical nuclear factor kappa B (NF-κB) pathway by targeting RelA/p65

(2015) Corina Hutterer et al.   ANTIVIRAL RESEARCH

Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection

(2015) Fan Chai et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Highly potent artemisinin-derived dimers and trimers: Synthesis and evaluation of their antimalarial, antileukemia and antiviral activities

(2015) Christoph Reiter et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Untargeted Proteomics and Systems-Based Mechanistic Investigation of Artesunate in Human Bronchial Epithelial Cells

(2015) Kodihalli C. Ravindra et al.   CHEMICAL RESEARCH IN TOXICOLOGY

New efficient artemisinin derived agents against human leukemia cells, human cytomegalovirus and Plasmodium falciparum: 2nd generation 1,2,4-trioxane-ferrocene hybrids

(2015) Christoph Reiter et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

(2015) Jigang Wang et al.   Nature Communications

Phospho-TCTP as a therapeutic target of Dihydroartemisinin for aggressive breast cancer cells

(2015) Maria Lucibello et al.   Oncotarget

Antiviral Effects of Artesunate on JC Polyomavirus Replication in COS-7 Cells

(2014) Biswa Nath Sharma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A review of dihydroartemisinin as another gift from traditional Chinese medicine not only for malaria control but also for schistosomiasis control

(2014) Xu-Guang Zhang et al.   PARASITOLOGY RESEARCH

Proteomic Analyses of Human Cytomegalovirus Strain AD169 Derivatives Reveal Highly Conserved Patterns of Viral and Cellular Proteins in Infected Fibroblasts

(2014) Sabine Reyda et al.   Viruses-Basel

Assessment of drug candidates for broad-spectrum antiviral therapy targeting cellular pyrimidine biosynthesis

(2013) Manfred Marschall et al.   ANTIVIRAL RESEARCH

Synthesis of artemisinin dimers using the Ugi reaction and their in vitro efficacy on breast cancer cells

(2013) Shusheng Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dihydroartemisinin induces apoptosis of cervical cancer cells via upregulation of RKIP and downregulation of bcl-2

(2013) Chun-jie Hu et al.   CANCER BIOLOGY & THERAPY

Stability and antiviral activity against human cytomegalovirus of artemisinin derivatives

(2013) A. Flobinus et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Artemisinins: Pharmacological actions beyond anti-malarial

(2013) Wanxing Eugene Ho et al.   PHARMACOLOGY & THERAPEUTICS

New artesunic acid homodimers: Potent reversal agents of multidrug resistance in leukemia cells

(2012) Christoph Reiter et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The unique antiviral activity of artesunate is broadly effective against human cytomegaloviruses including therapy-resistant mutants

(2011) Sunwen Chou et al.   ANTIVIRAL RESEARCH

Human cytomegalovirus kinetics following institution of artesunate after hematopoietic stem cell transplantation

(2011) Dana G. Wolf et al.   ANTIVIRAL RESEARCH

Artemisinin: Discovery from the Chinese Herbal Garden

(2011) Louis H. Miller et al.   CELL

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

(2011) Youyou Tu   NATURE MEDICINE

New Method for the Synthesis of Ether Derivatives of Artemisinin

(2011) Pranjal P. Bora et al.   SYNTHETIC COMMUNICATIONS

Cytotoxicity of Artesunic Acid Homo- and Heterodimer Molecules toward Sensitive and Multidrug-Resistant CCRF-CEM Leukemia Cells

(2010) Cindy Horwedel et al.   JOURNAL OF MEDICINAL CHEMISTRY

Artemisinin and its derivatives: a novel class of anti-malarial and anti-cancer agents

(2009) Devdutt Chaturvedi et al.   CHEMICAL SOCIETY REVIEWS

Malaria-Infected Mice Are Cured by a Single Oral Dose of New Dimeric Trioxane Sulfones Which Are Also Selectively and Powerfully Cytotoxic to Cancer Cells

(2009) Andrew S. Rosenthal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Onset of Human Cytomegalovirus Replication in Fibroblasts Requires the Presence of an Intact Vimentin Cytoskeleton

(2009) M. S. Miller et al.   JOURNAL OF VIROLOGY

Synthesis and biological evaluation of extraordinarily potent C-10 carba artemisinin dimers against P. falciparum malaria parasites and HL-60 cancer cells

(2008) James Chadwick et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Synthesis and evaluation of dihydroartemisinin and dihydroartemisitene acetal dimers showing anticancer and antiprotozoal activity

(2008) Ahmed M. Galal et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Antiviral Activities of Artemisinin and Artesunate

(2008) Thomas Efferth et al.   CLINICAL INFECTIOUS DISEASES

Malaria-Infected Mice Are Cured by Oral Administration of New Artemisinin Derivatives

(2008) Gary H. Posner et al.   JOURNAL OF MEDICINAL CHEMISTRY