Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation

Structural and functional insights into CWC27/CWC22 heterodimer linking the exon junction complex to spliceosomes

(2020) Virginia Busetto et al.   NUCLEIC ACIDS RESEARCH

Molecular Mechanisms of pre-mRNA Splicing through Structural Biology of the Spliceosome

(2019) Chuangye Yan et al.   Cold Spring Harbor Perspectives in Biology

RNAs in the spliceosome: Insight from cryoEM structures

(2019) Lingdi Zhang et al.   Wiley Interdisciplinary Reviews-RNA

Structural Insights into Nuclear pre-mRNA Splicing in Higher Eukaryotes

(2019) Berthold Kastner et al.   Cold Spring Harbor Perspectives in Biology

Structural Basis of Nuclear pre-mRNA Splicing: Lessons from Yeast

(2019) Clemens Plaschka et al.   Cold Spring Harbor Perspectives in Biology

A high-speed search engine pLink 2 with systematic evaluation for proteome-scale identification of cross-linked peptides

(2019) Zhen-Lin Chen et al.   Nature Communications

Smu1 and RED are required for activation of spliceosomal B complexes assembled on short introns

(2019) Sandra Keiper et al.   Nature Communications

Structure and Conformational Dynamics of the Human Spliceosomal B act Complex

(2018) David Haselbach et al.   CELL

Structure of the human activated spliceosome in three conformational states

(2018) Xiaofeng Zhang et al.   CELL RESEARCH

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

Characterisation of molecular motions in cryo-EM single-particle data by multi-body refinement in RELION

(2018) Takanori Nakane et al.   eLife

Real-space refinement in PHENIX for cryo-EM and crystallography

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

New tools for the analysis and validation of cryo-EM maps and atomic models

(2018) Pavel V. Afonine et al.   Acta Crystallographica Section D-Structural Biology

Structures of the human pre-catalytic spliceosome and its precursor spliceosome

(2018) Xiechao Zhan et al.   CELL RESEARCH

New tools for automated high-resolution cryo-EM structure determination in RELION-3

(2018) Jasenko Zivanov et al.   eLife

Dual-Specificity Phosphatase CDC25B Was Inhibited by Natural Product HB-21 Through Covalently Binding to the Active Site

(2018) Shoude Zhang et al.   Frontiers in Chemistry

Cryo-EM structure of a human spliceosome activated for step 2 of splicing

(2017) Karl Bertram et al.   NATURE

MotionCor2: anisotropic correction of beam-induced motion for improved cryo-electron microscopy

(2017) Shawn Q Zheng et al.   NATURE METHODS

cryoSPARC: algorithms for rapid unsupervised cryo-EM structure determination

(2017) Ali Punjani et al.   NATURE METHODS

Identification of a small molecule inhibitor that stalls splicing at an early step of spliceosome activation

(2017) Anzhalika Sidarovich et al.   eLife

Functions and regulation of the Brr2 RNA helicase during splicing

(2016) Eva Absmeier et al.   CELL CYCLE

Gctf: Real-time CTF determination and correction

(2016) Kai Zhang   JOURNAL OF STRUCTURAL BIOLOGY

Structural Basis for the Functional Coupling of the Alternative Splicing Factors Smu1 and RED

(2016) Alexander K.C. Ulrich et al.   STRUCTURE

CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex

(2015) Febe van Maldegem et al.   NUCLEIC ACIDS RESEARCH

Multiple protein–protein interactions converging on the Prp38 protein during activation of the human spliceosome

(2015) Tonio Schütze et al.   RNA

PQBP1, a factor linked to intellectual disability, affects alternative splicing associated with neurite outgrowth

(2013) Q. Wang et al.   GENES & DEVELOPMENT

RNA catalyses nuclear pre-mRNA splicing

(2013) Sebastian M. Fica et al.   NATURE

A Quantitative High-Throughput In Vitro Splicing Assay Identifies Inhibitors of Spliceosome Catalysis

(2012) M. G. Berg et al.   MOLECULAR AND CELLULAR BIOLOGY

Identification of cross-linked peptides from complex samples

(2012) Bing Yang et al.   NATURE METHODS

Structural bioinformatics of the human spliceosomal proteome

(2012) Iga Korneta et al.   NUCLEIC ACIDS RESEARCH

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

TCERG1 Regulates Alternative Splicing of the Bcl-x Gene by Modulating the Rate of RNA Polymerase II Transcription

(2011) M. Montes et al.   MOLECULAR AND CELLULAR BIOLOGY

Semiquantitative Proteomic Analysis of the Human Spliceosome via a Novel Two-Dimensional Gel Electrophoresis Method

(2011) D. E. Agafonov et al.   MOLECULAR AND CELLULAR BIOLOGY

Molecular Architecture of the Human Prp19/CDC5L Complex

(2010) M. Grote et al.   MOLECULAR AND CELLULAR BIOLOGY

Characterization of purified human Bact spliceosomal complexes reveals compositional and morphological changes during spliceosome activation and first step catalysis

(2010) S. Bessonov et al.   RNA

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The Spliceosome: Design Principles of a Dynamic RNP Machine

(2009) Markus C. Wahl et al.   CELL