CDC20 assists its catalytic incorporation in the mitotic checkpoint complex

A tripartite mechanism catalyzes Mad2-Cdc20 assembly at unattached kinetochores

(2021) Pablo Lara-Gonzalez et al.   SCIENCE

TRIP13 regulates DNA repair pathway choice through REV7 conformational change

(2020) Connor S. Clairmont et al.   NATURE CELL BIOLOGY

Cyclin B1 scaffolds MAD 1 at the kinetochore corona to activate the mitotic checkpoint

(2020) Lindsey A Allan et al.   EMBO JOURNAL

Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex

(2019) Gang Zhang et al.   EMBO JOURNAL

GalaxyRefine2: simultaneous refinement of inaccurate local regions and overall protein structure

(2019) Gyu Rie Lee et al.   NUCLEIC ACIDS RESEARCH

The G2-to-M Transition Is Ensured by a Dual Mechanism that Protects Cyclin B from Degradation by Cdc20-Activated APC/C

(2019) Pablo Lara-Gonzalez et al.   DEVELOPMENTAL CELL

SWISS-MODEL: homology modelling of protein structures and complexes

(2018) Andrew Waterhouse et al.   NUCLEIC ACIDS RESEARCH

TRIP13 Functions in the Establishment of the Spindle Assembly Checkpoint by Replenishing O-MAD2

(2018) Hoi Tang Ma et al.   Cell Reports

Simplified Protocol for Cross-linking Mass Spectrometry Using the MS-Cleavable Cross-linker DSBU with Efficient Cross-link Identification

(2018) Dongqing Pan et al.   ANALYTICAL CHEMISTRY

TRIP13 and APC15 drive mitotic exit by turnover of interphase- and unattached kinetochore-produced MCC

(2018) Dong Hyun Kim et al.   Nature Communications

Kinetochores accelerate or delay APC/C activation by directing Cdc20 to opposing fates

(2017) Taekyung Kim et al.   GENES & DEVELOPMENT

An Attachment-Independent Biochemical Timer of the Spindle Assembly Checkpoint

(2017) Junbin Qian et al.   MOLECULAR CELL

Basis of catalytic assembly of the mitotic checkpoint complex

(2017) Alex C. Faesen et al.   NATURE

Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling

(2017) Gang Zhang et al.   Nature Communications

A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling

(2017) Zhejian Ji et al.   eLife

Cryo-EM of Mitotic Checkpoint Complex-Bound APC/C Reveals Reciprocal and Conformational Regulation of Ubiquitin Ligation

(2016) Masaya Yamaguchi et al.   MOLECULAR CELL

Molecular basis of APC/C regulation by the spindle assembly checkpoint

(2016) Claudio Alfieri et al.   NATURE

Molecular basis of outer kinetochore assembly on CENP-T

(2016) Pim J Huis in 't Veld et al.   eLife

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

The ABBA Motif Binds APC/C Activators and Is Shared by APC/C Substrates and Regulators

(2015) Barbara Di Fiore et al.   DEVELOPMENTAL CELL

The multifaceted roles of the HORMA domain in cellular signaling

(2015) Scott C. Rosenberg et al.   JOURNAL OF CELL BIOLOGY

Dissecting the roles of human BUB1 in the spindle assembly checkpoint

(2015) M. Vleugel et al.   JOURNAL OF CELL SCIENCE

xVis: a web server for the schematic visualization and interpretation of crosslink-derived spatial restraints

(2015) Maximilian Grimm et al.   NUCLEIC ACIDS RESEARCH

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

(2015) Katharina Overlack et al.   eLife

Role of Intrinsic and Extrinsic Factors in the Regulation of the Mitotic Checkpoint Kinase Bub1

(2015) Claudia Breit et al.   PLoS One

A direct role of Mad1 in the spindle assembly checkpoint beyond Mad2 kinetochore recruitment

(2014) T. Kruse et al.   EMBO REPORTS

Mad1 contribution to spindle assembly checkpoint signalling goes beyond presenting Mad2 at kinetochores

(2014) S. Heinrich et al.   EMBO REPORTS

Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint

(2014) N. London et al.   GENES & DEVELOPMENT

A Bub1–Mad1 interaction targets the Mad1–Mad2 complex to unattached kinetochores to initiate the spindle checkpoint

(2014) Mark W. Moyle et al.   JOURNAL OF CELL BIOLOGY

The mitotic checkpoint complex binds a second CDC20 to inhibit active APC/C

(2014) Daisuke Izawa et al.   NATURE

Catalytic Assembly of the Mitotic Checkpoint Inhibitor BubR1-Cdc20 by a Mad2-Induced Functional Switch in Cdc20

(2013) Joo Seok Han et al.   MOLECULAR CELL

Mad2 and the APC/C compete for the same site on Cdc20 to ensure proper chromosome segregation

(2012) Daisuke Izawa et al.   JOURNAL OF CELL BIOLOGY

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Structure of human Mad1 C-terminal domain reveals its involvement in kinetochore targeting

(2012) S. Kim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation

(2011) Maria Maldonado et al.   NATURE CELL BIOLOGY

Ultra-fast FFT protein docking on graphics processors

(2010) David W. Ritchie et al.   BIOINFORMATICS

Kinetic Analysis of Mad2−Cdc20 Formation: Conformational Changes in Mad2 Are Catalyzed by a C-Mad2−Ligand Complex

(2009) Latesh Lad et al.   BIOCHEMISTRY

Unattached Kinetochores Catalyze Production of an Anaphase Inhibitor that Requires a Mad2 Template to Prime Cdc20 for BubR1 Binding

(2009) Anita Kulukian et al.   DEVELOPMENTAL CELL

Bub1 regulates chromosome segregation in a kinetochore-independent manner

(2009) Christiane Klebig et al.   JOURNAL OF CELL BIOLOGY

CHARMM: The biomolecular simulation program

(2009) B. R. Brooks et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The Influence of Catalysis on Mad2 Activation Dynamics

(2009) Marco Simonetta et al.   PLOS BIOLOGY

Protein Metamorphosis: The Two-State Behavior of Mad2

(2008) Xuelian Luo et al.   STRUCTURE