Cyclin B1 scaffolds MAD 1 at the kinetochore corona to activate the mitotic checkpoint

Cyclin B1-Cdk1 facilitates MAD1 release from the nuclear pore to ensure a robust spindle checkpoint

(2020) Mark Jackman et al.   JOURNAL OF CELL BIOLOGY

PlotsOfData—A web app for visualizing data together with their summaries

(2019) Marten Postma et al.   PLOS BIOLOGY

CDK1-CCNB1 creates a spindle checkpoint–permissive state by enabling MPS1 kinetochore localization

(2019) Daniel Hayward et al.   JOURNAL OF CELL BIOLOGY

MAD1-dependent recruitment of CDK1-CCNB1 to kinetochores promotes spindle checkpoint signaling

(2019) Tatiana Alfonso-Pérez et al.   JOURNAL OF CELL BIOLOGY

Efficient mitotic checkpoint signaling depends on integrated activities of Bub1 and the RZZ complex

(2019) Gang Zhang et al.   EMBO JOURNAL

Spindle checkpoint silencing at kinetochores with submaximal microtubule occupancy

(2019) Banafsheh Etemad et al.   JOURNAL OF CELL SCIENCE

PP1 and PP2A Use Opposite Phospho-dependencies to Control Distinct Processes at the Kinetochore

(2019) Richard J. Smith et al.   Cell Reports

Killing a zombie: a full deletion of the BUB 1 gene in HAP 1 cells

(2019) Jonne A Raaijmakers et al.   EMBO JOURNAL

Dynamic kinetochore size regulation promotes microtubule capture and chromosome biorientation in mitosis

(2018) Carlos Sacristan et al.   NATURE CELL BIOLOGY

Distinct Roles of RZZ and Bub1-KNL1 in Mitotic Checkpoint Signaling and Kinetochore Expansion

(2018) Jose-Antonio Rodriguez-Rodriguez et al.   CURRENT BIOLOGY

Self-Assembly of the RZZ Complex into Filaments Drives Kinetochore Expansion in the Absence of Microtubule Attachment

(2018) Cláudia Pereira et al.   CURRENT BIOLOGY

Direct interactions of mitotic arrest deficient 1 (MAD1) domains with each other and MAD2 conformers are required for mitotic checkpoint signaling

(2017) Wenbin Ji et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An Attachment-Independent Biochemical Timer of the Spindle Assembly Checkpoint

(2017) Junbin Qian et al.   MOLECULAR CELL

Basis of catalytic assembly of the mitotic checkpoint complex

(2017) Alex C. Faesen et al.   NATURE

Bub1 positions Mad1 close to KNL1 MELT repeats to promote checkpoint signalling

(2017) Gang Zhang et al.   Nature Communications

A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling

(2017) Zhejian Ji et al.   eLife

The ASA's Statement onp-Values: Context, Process, and Purpose

(2016) Ronald L. Wasserstein et al.   AMERICAN STATISTICIAN

Bub3-Bub1 Binding to Spc7/KNL1 Toggles the Spindle Checkpoint Switch by Licensing the Interaction of Bub1 with Mad1-Mad2

(2016) Maria del Mar Mora-Santos et al.   CURRENT BIOLOGY

Attachment issues: kinetochore transformations and spindle checkpoint silencing

(2016) Banafsheh Etemad et al.   CURRENT OPINION IN CELL BIOLOGY

biGBac enables rapid gene assembly for the expression of large multisubunit protein complexes

(2016) Florian Weissmann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aligning statistical and scientific reasoning

(2016) Steven N. Goodman   SCIENCE

Insights from the reconstitution of the divergent outer kinetochore ofDrosophila melanogaster

(2016) Yahui Liu et al.   Open Biology

Molecular basis of outer kinetochore assembly on CENP-T

(2016) Pim J Huis in 't Veld et al.   eLife

The ABBA Motif Binds APC/C Activators and Is Shared by APC/C Substrates and Regulators

(2015) Barbara Di Fiore et al.   DEVELOPMENTAL CELL

KNL1-Bubs and RZZ Provide Two Separable Pathways for Checkpoint Activation at Human Kinetochores

(2015) Virginia Silió et al.   DEVELOPMENTAL CELL

Kinetochore function is controlled by a phospho-dependent coexpansion of inner and outer components

(2015) David J. Wynne et al.   JOURNAL OF CELL BIOLOGY

Dissecting the roles of human BUB1 in the spindle assembly checkpoint

(2015) M. Vleugel et al.   JOURNAL OF CELL SCIENCE

Sequential Multisite Phospho-Regulation of KNL1-BUB3 Interfaces at Mitotic Kinetochores

(2015) Mathijs Vleugel et al.   MOLECULAR CELL

Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling

(2015) Y. Hiruma et al.   SCIENCE

Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C

(2015) Z. Ji et al.   SCIENCE

Cenp-E inhibitor GSK923295: Novel synthetic route and use as a tool to generate aneuploidy

(2015) Ailsa Bennett et al.   Oncotarget

The RZZ complex requires the N-terminus of KNL1 to mediate optimal Mad1 kinetochore localization in human cells

(2015) Gina V. Caldas et al.   Open Biology

Nuclear Pores Protect Genome Integrity by Assembling a Premitotic and Mad1-Dependent Anaphase Inhibitor

(2014) Veronica Rodriguez-Bravo et al.   CELL

Mad1 kinetochore recruitment by Mps1-mediated phosphorylation of Bub1 signals the spindle checkpoint

(2014) N. London et al.   GENES & DEVELOPMENT

A Bub1–Mad1 interaction targets the Mad1–Mad2 complex to unattached kinetochores to initiate the spindle checkpoint

(2014) Mark W. Moyle et al.   JOURNAL OF CELL BIOLOGY

Negative feedback at kinetochores underlies a responsive spindle checkpoint signal

(2014) Wilco Nijenhuis et al.   NATURE CELL BIOLOGY

Distinct phosphatases antagonize the p53 response in different phases of the cell cycle

(2014) I. A. Shaltiel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arrayed BUB recruitment modules in the kinetochore scaffold KNL1 promote accurate chromosome segregation

(2013) Mathijs Vleugel et al.   JOURNAL OF CELL BIOLOGY

Kinetic framework of spindle assembly checkpoint signalling

(2013) Amalie E. Dick et al.   NATURE CELL BIOLOGY

Phosphodependent Recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 Kinase Maintains the Spindle Checkpoint

(2012) Lindsey A. Shepperd et al.   CURRENT BIOLOGY

Phosphoregulation of Spc105 by Mps1 and PP1 Regulates Bub1 Localization to Kinetochores

(2012) Nitobe London et al.   CURRENT BIOLOGY

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components

(2012) Yuya Yamagishi et al.   NATURE CELL BIOLOGY

Constitutive Mad1 targeting to kinetochores uncouples checkpoint signalling from chromosome biorientation

(2011) Maria Maldonado et al.   NATURE CELL BIOLOGY

Aurora B potentiates Mps1 activation to ensure rapid checkpoint establishment at the onset of mitosis

(2011) Adrian T. Saurin et al.   Nature Communications

Release of Mps1 from kinetochores is crucial for timely anaphase onset

(2010) Nannette Jelluma et al.   JOURNAL OF CELL BIOLOGY

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

(2010) Laura Hewitt et al.   JOURNAL OF CELL BIOLOGY

Antitumor activity of an allosteric inhibitor of centromere-associated protein-E

(2010) K. W. Wood et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Dynein light intermediate chain 1 is required for progress through the spindle assembly checkpoint

(2009) Mylavarapu V S Sivaram et al.   EMBO JOURNAL

Cells satisfy the mitotic checkpoint in Taxol, and do so faster in concentrations that stabilize syntelic attachments

(2009) Zhenye Yang et al.   JOURNAL OF CELL BIOLOGY

Role of a Novel Splice Variant of Mitotic Arrest Deficient 1 (MAD1), MAD1 , in Mitotic Checkpoint Control in Liver Cancer

(2008) K. M.-F. Sze et al.   CANCER RESEARCH

Cyclin B1 is localized to unattached kinetochores and contributes to efficient microtubule attachment and proper chromosome alignment during mitosis

(2008) Qiang Chen et al.   CELL RESEARCH

Mps1 kinase activity restrains anaphase during an unperturbed mitosis and targets Mad2 to kinetochores

(2008) Anthony Tighe et al.   JOURNAL OF CELL BIOLOGY

Dynein Light Intermediate Chain: An Essential Subunit That Contributes to Spindle Checkpoint Inactivation

(2008) Sarah Mische et al.   MOLECULAR BIOLOGY OF THE CELL

Inference by eye: Reading the overlap of independent confidence intervals

(2008) Geoff Cumming   STATISTICS IN MEDICINE