Therapeutic Potential of Nitroxyl (HNO) Donors in the Management of Acute Decompensated Heart Failure

Nitroxyl (HNO) reduces endothelial and monocyte activation and promotes M2 macrophage polarization

(2016) K. L. Andrews et al.   CLINICAL SCIENCE

European Society of Cardiology Heart Failure Long-Term Registry (ESC-HF-LT): 1-year follow-up outcomes and differences across regions

(2016) Maria G. Crespo-Leiro et al.   EUROPEAN JOURNAL OF HEART FAILURE

Potential new drug treatments for congestive heart failure

(2016) Hao A. Tran et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Morphine in the treatment of acute pulmonary oedema — Why?

(2016) C. Ellingsrud et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

The HNO donor Angeli’s salt offers potential haemodynamic advantages over NO or dobutamine in ischaemia–reperfusion injury in the rat heart ex vivo

(2016) Kai Yee Chin et al.   PHARMACOLOGICAL RESEARCH

Contemporary Treatment of Acute Heart Failure

(2016) Ruth Hsiao et al.   PROGRESS IN CARDIOVASCULAR DISEASES

Chronic Administration of the Nitroxyl Donor 1-Nitrosocyclo Hexyl Acetate Limits Left Ventricular Diastolic Dysfunction in a Mouse Model of Diabetes Mellitus In Vivo

(2015) N. Cao et al.   Circulation-Heart Failure

Nitroxyl: a vasodilator of human vessels that is not susceptible to tolerance

(2015) Karen L. Andrews et al.   CLINICAL SCIENCE

Agents with vasodilator properties in acute heart failure: how to design successful trials

(2015) Alexandre Mebazaa et al.   EUROPEAN JOURNAL OF HEART FAILURE

HNO/cGMP-dependent antihypertrophic actions of isopropylamine-NONOate in neonatal rat cardiomyocytes: potential therapeutic advantages of HNO over NO˙

(2013) Jennifer C. Irvine et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

HNO Enhances SERCA2a Activity and Cardiomyocyte Function by Promoting Redox-Dependent Phospholamban Oligomerization

(2013) Vidhya Sivakumaran et al.   ANTIOXIDANTS & REDOX SIGNALING

The concomitant coronary vasodilator and positive inotropic actions of the nitroxyl donor Angeli's salt in the intact rat heart: contribution of soluble guanylyl cyclase-dependent and -independent mechanisms

(2013) Kai Yee Chin et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nitroxyl (HNO)

(2013) Hani N. Sabbah et al.   Circulation-Heart Failure

Nitroxyl (HNO) suppresses vascular Nox2 oxidase activity

(2013) Alyson A. Miller et al.   FREE RADICAL BIOLOGY AND MEDICINE

The nitric oxide redox sibling nitroxyl partially circumvents impairment of platelet nitric oxide responsiveness

(2013) R.F. Dautov et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Nitroxyl-Mediated Disulfide Bond Formation Between Cardiac Myofilament Cysteines Enhances Contractile Function

(2012) Wei Dong Gao et al.   CIRCULATION RESEARCH

ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC

(2012) et al.   EUROPEAN HEART JOURNAL

O2-Sulfonylethyl Protected Isopropylamine Diazen-1-ium-1,2-diolates as Nitroxyl (HNO) Donors: Synthesis, β-Elimination Fragmentation, HNO Release, Positive Inotropic Properties, and Blood Pressure Lowering Studies

(2012) Zhangjian Huang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Serelaxin, recombinant human relaxin-2, for treatment of acute heart failure (RELAX-AHF): a randomised, placebo-controlled trial

(2012) John R Teerlink et al.   LANCET

Ultrafiltration in Decompensated Heart Failure with Cardiorenal Syndrome

(2012) Bradley A. Bart et al.   NEW ENGLAND JOURNAL OF MEDICINE

Endothelium-dependent nitroxyl-mediated relaxation is resistant to superoxide anion scavenging and preserved in diabetic rat aorta

(2012) C.H. Leo et al.   PHARMACOLOGICAL RESEARCH

Nitroxyl (HNO) Stimulates Soluble Guanylyl Cyclase to Suppress Cardiomyocyte Hypertrophy and Superoxide Generation

(2012) Eliane Q. Lin et al.   PLoS One

Vasorelaxant and antiaggregatory actions of the nitroxyl donor isopropylamine NONOate are maintained in hypercholesterolemia

(2011) Michelle L. Bullen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

The Specificity of Nitroxyl Chemistry Is Unique Among Nitrogen Oxides in Biological Systems

(2011) Wilmarie Flores-Santana et al.   ANTIOXIDANTS & REDOX SIGNALING

The Chemistry of Nitroxyl-Releasing Compounds

(2011) Jenna F. DuMond et al.   ANTIOXIDANTS & REDOX SIGNALING

HNO Signaling Mechanisms

(2011) Jon M. Fukuto et al.   ANTIOXIDANTS & REDOX SIGNALING

Playing with Cardiac “Redox Switches”: The “HNO Way” to Modulate Cardiac Function

(2011) Carlo G. Tocchetti et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitric oxide and redox mechanisms in the immune response

(2011) David A. Wink et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Acyloxy Nitroso Compounds as Nitroxyl (HNO) Donors: Kinetics, Reactions with Thiols, and Vasodilation Properties

(2011) Mai E. Shoman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Reversal of Isoflurane-Induced Depression of Myocardial Contraction by Nitroxyl via Myofilament Sensitization to Ca2+

(2011) W. Ding et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A PHASE I/IIA FIRST IN MAN SAFETY AND TOLERABILITY STUDY OF A NOVEL HNO DONOR, CXL-1020, IN PATIENTS WITH STABLE CONGESTIVE HEART FAILURE

(2011) Doug Cowart et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Chronic Administration of the HNO Donor Angeli's Salt Does Not Lead to Tolerance, Cross-Tolerance, or Endothelial Dysfunction: Comparison with GTN and DEA/NO

(2010) Jennifer C. Irvine et al.   ANTIOXIDANTS & REDOX SIGNALING

Nitroxyl (HNO) as a Vasoprotective Signaling Molecule

(2010) Michelle L. Bullen et al.   ANTIOXIDANTS & REDOX SIGNALING

The new HNO donor, 1-nitrosocyclohexyl acetate, increases contractile force in normal and β-adrenergically desensitized ventricular myocytes

(2010) Ali El-Armouche et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hydrogen sulfide interacts with nitric oxide in the heart: possible involvement of nitroxyl

(2010) Q.-C. Yong et al.   CARDIOVASCULAR RESEARCH

Dual Mechanisms of HNO Generation by a Nitroxyl Prodrug of the Diazeniumdiolate (NONOate) Class

(2010) Daniela Andrei et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isopropylamine NONOate (IPA/NO) moderates neointimal hyperplasia following vascular injury

(2010) Nick D. Tsihlis et al.   JOURNAL OF VASCULAR SURGERY

Redox variants of NO (NO· and HNO) elicit vasorelaxation of resistance arteries via distinct mechanisms

(2009) Joanne L. Favaloro et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

A role for nitroxyl (HNO) as an endothelium-derived relaxing and hyperpolarizing factor in resistance arteries

(2009) Karen L Andrews et al.   BRITISH JOURNAL OF PHARMACOLOGY

Nitroxyl Activates SERCA in Cardiac Myocytes via Glutathiolation of Cysteine 674

(2009) Steve Lancel et al.   CIRCULATION RESEARCH

The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity

(2009) Thomas W. Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nitroxyl exacerbates ischemic cerebral injury and oxidative neurotoxicity

(2009) Chi-un Choe et al.   JOURNAL OF NEUROCHEMISTRY

Mechanisms Underlying Activation of Soluble Guanylate Cyclase by the Nitroxyl Donor Angeli's Salt

(2009) A. Zeller et al.   MOLECULAR PHARMACOLOGY

Phospholamban Thiols Play a Central Role in Activation of the Cardiac Muscle Sarcoplasmic Reticulum Calcium Pump by Nitroxyl†

(2008) Jeffrey P. Froehlich et al.   BIOCHEMISTRY

Morphine and outcomes in acute decompensated heart failure: an ADHERE analysis

(2008) W F Peacock et al.   EMERGENCY MEDICINE JOURNAL

Nitroxyl (HNO): the Cinderella of the nitric oxide story

(2008) Jennifer C. Irvine et al.   TRENDS IN PHARMACOLOGICAL SCIENCES