Article
Biochemistry & Molecular Biology
Irene C. Turnbull, Apratim Bajpai, Katherine B. Jankowski, Angelo Gaitas, Alessandra Rampazzo
Summary: Induced pluripotent stem cell-derived cardiomyocytes (iPSC-CMs) show great potential in cardiac disease modeling, drug screening, and regenerative medicine. By using Atomic Force Microscopy (AFM), researchers have identified a significant correlation between normal and lateral force at the single cell level in iPSC-CMs. These findings provide a better understanding of iPSC-CM properties and have implications for the development of therapeutic strategies in cardiovascular medicine.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Philipp Hegner, Marzena Drzymalski, Alexander Biedermann, Bernadette Memmel, Melanie Durczok, Michael Wester, Bernhard Floerchinger, Zdenek Provaznik, Christof Schmid, York Zausig, Lars S. Maier, Stefan Wagner
Summary: The novel selective NCX-inhibitor SAR296968 inhibits atrial pro-arrhythmic activity and improves diastolic and contractile function in human atrial myocardium, which may have therapeutic implications, especially for treatment of HFpEF.
Article
Biochemical Research Methods
Tess Homan, Helene Delanoe-Ayari, Albano C. Meli, Olivier Cazorla, Csilla Gergely, Alexandre Mejat, Philippe Chevalier, Adrien Moreau
Summary: Studying cardiomyocytes derived from stem cells is important and requires robust tools for characterization and analysis. The developed MATLAB toolbox can provide accurate cellular morphology parameters and values for contractile cell organization.
Article
Biochemistry & Molecular Biology
Chintan N. Koyani, Susanne Scheruebel, Ge Jin, Ewald Kolesnik, Klaus Zorn-Pauly, Heinrich Maechler, Gerald Hoefler, Dirk von Lewinski, Frank R. Heinzel, Brigitte Pelzmann, Ernst Malle
Summary: Neutrophil-derived myeloperoxidase (MPO) and hypochlorous acid (HOCl) play important roles in cardiac damage and dysfunction. The presence of proatherogenic HOCl-LDL in infarcted human myocardium adversely affects electrophysiology and contractility of cardiomyocytes, leading to altered action potential characteristics and arrhythmic events. HOCl-LDL also affects the expression and function of key proteins in calcium handling, resulting in impaired contractility and calcium homeostasis.
Article
Cardiac & Cardiovascular Systems
Tim Stuedemann, Judith Roessinger, Christoph Manthey, Birgit Geertz, Rajiven Srikantharajah, Constantin von Bibra, Aya Shibamiya, Maria Koehne, Antonius Wiehler, J. Simon Wiegert, Thomas Eschenhagen, Florian Weinberger
Summary: This study reveals the mechanism of how transplanted cardiomyocytes actively contribute to heart function, supporting the hypothesis that the delivery of new force-generating myocardium can serve as a regenerative therapeutic strategy.
Article
Cardiac & Cardiovascular Systems
Ruben Lopez, Radoslav Janicek, Miguel Fernandez-Tenorio, Marianne Courtehoux, Lluis Matas, Pascale Gerbaud, Ana M. Gomez, Marcel Egger, Ernst Niggli
Summary: This study found that beta-adrenergic receptor (β-AR) activation and stimulation of SR Ca2+ pump (SERCA) can lead to higher frequencies of Ca2+ waves in cardiomyocytes with the RyR2R420Q+/- mutation. The phosphorylation of RyR2s and the resulting SR Ca2+ leak may play a role in this phenomenon.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Takahide Kadosaka, Masaya Watanabe, Hiroyuki Natsui, Takuya Koizumi, Motoki Nakao, Taro Koya, Hikaru Hagiwara, Rui Kamada, Taro Temma, Fuyuki Karube, Fumino Fujiyama, Toshihisa Anzai
Summary: Diabetic cardiomyopathy increases the risk of fatal ventricular arrhythmia, and the effects of sodium-glucose cotransporter-2 inhibitor on antiarrhythmic therapy have not been fully examined. This study aimed to investigate the antiarrhythmic effects of empagliflozin (EMPA) treatment on diabetic cardiomyocytes, particularly focusing on Ca2+ handling. The results showed that EMPA attenuated ventricular arrhythmia inducibility by normalizing intracellular Ca2+ handling, potentially by inhibiting O-GlcNAcylation via the suppression of glucose uptake into cardiomyocytes.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
(2023)
Article
Cell Biology
Peng Zhang, Yu Liu, Chunfeng Li, Lindsay D. Stine, Pei-Hui Wang, Matthew W. Turnbull, Haodi Wu, Qing Liu
Summary: Coronavirus disease 2019 (COVID-19) is associated with adverse impacts in the cardiovascular system. This study investigated the toxic effects of SARS-CoV-2 subunits on cardiomyocytes derived from human induced pluripotent stem cells (hiPSCs) and found that the ectopic expression of S and ORF-9B subunits impaired the contractile function and altered the metabolic profiles in human cardiomyocytes.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Daniel Tarnowski, Anna-Lena Feder, Maximilian Trum, Klaus-Georg Kreitmeier, Laura Stengel, Lars S. Maier, Can Martin Sag
Summary: The BTK inhibitor Ibrutinib impairs IGF-1-dependent activation of intracellular Ca handling in adult ventricular mouse myocytes by inhibiting PI3K/Akt signaling. Similar effects were observed with the BTK inhibitor Acalabrutinib. These findings suggest that BTK inhibitors have a inhibitory effect on IGF-1 activation in cardiac myocytes.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Physiology
Oleg Lookin, Anastasia Khokhlova, Tatiana Myachina, Xenia Butova, Olivier Cazorla, Pieter de Tombe
Summary: There are transmural differences in sarcomere length distribution between subepi- and subendocardial cardiomyocytes, and the intracellular variability in sarcomere length is affected by the state of contraction.
FRONTIERS IN PHYSIOLOGY
(2022)
Article
Cardiac & Cardiovascular Systems
Xenia Butova, Tatiana Myachina, Raisa Simonova, Anastasia Kochurova, Elena Mukhlynina, Galina Kopylova, Daniil Shchepkin, Anastasia Khokhlova
Summary: This study assessed the differences in contractility and underlying mechanisms between atrial cardiomyocytes in patients with paroxysmal atrial fibrillation (AF). The findings indicate that AF has a greater impact on left atrial cardiomyocytes, while right atrial cardiomyocytes may be more sensitive to mechanical load. These differences may contribute to the maintenance and progression of AF.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Article
Cell & Tissue Engineering
Tao Dong, Yan Zhao, Hai-Feng Jin, Lei Shen, Yan Lin, Long-Long Si, Li Chen, Ji-Cheng Liu
Summary: The SNTA1-deficient cardiomyocyte model is of great importance for studying the etiology, pathogenesis, and potential therapies for myocardial diseases.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Cell & Tissue Engineering
Kathryn Ufford, Sabrina Friedline, Zhaowen Tong, Vi T. Tang, Amani S. Dobbs, Yao-Chang Tsan, Stephanie L. Bielas, Allen P. Liu, Adam S. Helms
Summary: This study aims to investigate the impact of myofibrillar structure on contractile function in iPSC-CMs. The results show that myofibrillar abundance is widely variable among iPSC-CMs and strongly correlates with contractile function. Controlling for myofibrillar structure can reduce false-positive findings, improve sensitivity for pharmacologic testing and disease modeling.
Article
Cell & Tissue Engineering
Nadeera M. Wickramasinghe, David Sachs, Bhavana Shewale, David M. Gonzalez, Priyanka Dhanan-Krishnan, Denis Torre, Elizabeth LaMarca, Serena Raimo, Rafael Dariolli, Madhavika N. Serasinghe, Joshua Mayourian, Robert Sebra, Kristin Beaumont, Srinivas Iyengar, Deborah L. French, Arne Hansen, Thomas Eschenhagen, Jerry E. Chipuk, Eric A. Sobie, Adam Jacobs, Schahram Akbarian, Harry Ischiropoulos, Avi Ma'ayan, Sander M. Houten, Kevin Costa, Nicole C. Dubois
Summary: By modulating metabolic pathways, we have successfully facilitated the maturation of human pluripotent stem-cell-derived cardiomyocytes. Activation of PPARd signaling enhances fatty acid oxidation and improves mitochondrial cristae formation and myofibril organization, ultimately enhancing the function of cardiomyocytes.
Article
Engineering, Biomedical
Jacqueline Bliley, Joshua Tashman, Maria Stang, Brian Coffin, Daniel Shiwarski, Andrew Lee, Thomas Hinton, Adam Feinberg
Summary: This study demonstrates the 3D bioprinting of a simplified heart model resembling embryonic development. The engineered heart tubes were cellularized and showed synchronous contractions similar to natural heart beats. These findings establish the feasibility of creating 3D bioprinted human heart tubes and open the door for engineering more complex heart muscle structures.
Article
Biochemistry & Molecular Biology
D. M. Schwab, L. Tilemann, R. Bauer, M. Heckmann, A. Jungmann, M. Wagner, J. Burgis, C. Vettel, H. A. Katus, A. El-Armouche, O. J. Mueller
Article
Biochemical Research Methods
Julia Rossmann, Lars David Renner, Reinhard Oertel, Ali El-Armouche
JOURNAL OF CHROMATOGRAPHY A
(2018)
Article
Multidisciplinary Sciences
J. P. Joos, A. R. Saadatmand, C. Schnabel, I. Viktorinova, T. Brand, M. Kramer, S. Nattel, D. Dobrev, P. Tomancak, J. Backs, P. Kleinbongard, G. Heusch, K. Lorenz, E. Koch, S. Weber, A. El-Armouche
SCIENTIFIC REPORTS
(2018)
Article
Multidisciplinary Sciences
Hayriye Cagnan, Nicolas Mallet, Christian K. E. Moll, Alessandro Gulberti, Abbey B. Holt, Manfred Westphal, Christian Gerloff, Andreas K. Engel, Wolfgang Hamel, Peter J. Magill, Peter Brown, Andrew Sharott
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2019)
Article
Biochemistry & Molecular Biology
Michael Wagner, Mirna S. Sadek, Nataliya Dybkova, Fleur E. Mason, Johann Klehr, Rebecca Firneburg, Eleder Cachorro, Kurt Richter, Erik Klapproth, Stephan R. Kuenzel, Kristina Lorenz, Jordi Heijman, Dobromir Dobrev, Ali El-Armouche, Samuel Sossalla, Susanne Kaemmerer
Summary: The study found that overexpression of PDE2 can reduce the likelihood of ventricular arrhythmia, mainly by preventing the increase of cellular triggers mediated by Epac and CaMKII, indicating that activating myocardial PDE2 may be a novel intracellular antiarrhythmic therapeutic strategy in heart failure.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Joerg B. Schulz, Peter Berlit, Hans-Christoph Diener, Christian Gerloff, Andreas Greinacher, Christine Klein, Gabor C. Petzold, Marco Piccininni, Sven Poli, Rainer Roehrig, Helmuth Steinmetz, Thomas Thiele, Tobias Kurth
Summary: The study found a higher incidence of cerebral sinus and venous thrombosis (CVT) after ChAdOx1 vaccination in Germany, especially among females. Among the 45 CVT patients, 26 were highly probable cases of vaccine-induced immune thrombotic thrombocytopenia (VITT).
ANNALS OF NEUROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Thomas Brock, Elisabeth Boudriot, Anke Klawitter, Marianne Grosser, Trang T. P. Nguyen, Sindy Giebe, Erik Klapproth, Achim Temme, Ali El-Armouche, Georg Breier
Summary: VE-cadherin enhances the adhesion of breast cancer cells to endothelial cells but does not affect their transmigration, indicating that cancer cell adhesion and incorporation are distinct processes governed by different molecular mechanisms.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Robert Schulz, Marlene Boenstrup, Stephanie Guder, Jingchun Liu, Benedikt Frey, Fanny Quandt, Lutz A. Krawinkel, Bastian Cheng, Goetz Thomalla, Christian Gerloff
Summary: This study found an association between motor impairment in stroke patients and the microstructure of CST originating from M1 pyramidal neurons as well as beta oscillatory activity. The findings suggest a potential link between brain structure and function that may contribute to motor deficits in stroke patients.
Article
Clinical Neurology
Nils Schweingruber, Marius Mader, Anton Wiehe, Frank Roeder, Jennifer Goettsche, Stefan Kluge, Manfred Westphal, Patrick Czorlich, Christian Gerloff
Summary: The evolution of intracranial pressure in critically ill patients is difficult to predict. Machine learning models can assist in the clinical management of patients undergoing invasive ICP monitoring. A study used recurrent machine learning models to predict critical increases in ICP and validated the models in two independent datasets.
Letter
Clinical Neurology
Carsten Buhmann, Susanne Lezius, Monika Poetter-Nerger, Christian Gerloff, Jens Kuhle, Chi-un Choe
MOVEMENT DISORDERS
(2022)
Article
Clinical Neurology
Lauranne Scheldeman, Anke Wouters, Patrick Dupont, Soren Christensen, Florent Boutitie, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Christian Gerloff, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Vincent Thijs, Gotz Thomalla, Robin Lemmens
Summary: This study evaluated the ability of quantitative DWI and FLAIR to predict DWI-FLAIR mismatch in ischemic stroke. The results showed that the agreement between quantitative parameters and DWI-FLAIR mismatch was insufficient and there was a moderate correlation between the two quantitative parameters. The interquartile range rDWI SI was found to be associated with excellent functional outcome.
Article
Cardiac & Cardiovascular Systems
Hannes Leischner, Caspar Brekenfeld, Lukas Meyer, Gabriel Broocks, Tobias Faizy, Rosalie McDonough, Christian Gerloff, Goetz Thomalla, Milani Deb-Chatterji, Jens Fiehler, Fabian Flottmann
Summary: Randomized controlled clinical trials have demonstrated the efficacy of endovascular treatment in large vessel occlusions, but the outcome of patients in daily practice differs from the results of these trials. By analyzing selected patient populations, it was found that good clinical outcomes were more frequent in those who met the criteria of the clinical trials compared to those who did not.
JOURNAL OF THE AMERICAN HEART ASSOCIATION
(2021)
Article
Engineering, Biomedical
Fatemeh Sadeghihassanabadi, Jonas Misselhorn, Christian Gerloff, Simone Zittel
Summary: This study aims to find the optimal cerebellar tACS montage with minimal side effects. The simulation and experimental data show that the jaw montage is the best choice for maximizing cerebellar stimulation while minimizing unwanted side effects.
JOURNAL OF NEURAL ENGINEERING
(2022)
Article
Clinical Neurology
Jonatan Biskamp, Sara Isla Cainzos, Focko L. Higgen, Christian Gerloff, Tim Magnus
Summary: This study aims to investigate the electrophysiological signatures of the mouse cortex after ischemic stroke, in order to deepen the understanding of the recovery mechanisms. The results show that ischemic strokes affect sensory cortical areas and lead to motor deficits in the contralateral forepaw of mice. Analyses of electrocorticography signals reveal changes in power spectral density near the infarct, indicating alterations in neuronal activity. Exponents derived from motor areas significantly correlate with motor recovery, suggesting functional modifications.
Article
Clinical Neurology
Lauranne Scheldeman, Anke Wouters, Jeroen Bertels, Patrick Dupont, Bastian Cheng, Martin Ebinger, Matthias Endres, Jochen B. Fiebach, Christian Gerloff, Keith W. Muir, Norbert Nighoghossian, Salvador Pedraza, Claus Z. Simonsen, Vincent Thijs, Goetz Thomalla, Robin Lemmens
Summary: The study aims to investigate the reversibility of diffusion-weighted imaging (DWI) lesions and its association with thrombolysis, reperfusion, and functional outcomes. It found that reversibility of DWI lesions is common in patients from the WAKE-UP trial, and it is more pronounced after thrombolysis.
Article
Biochemistry & Molecular Biology
Soojung Hahn, Gyuri Kim, Sang-Man Jin, Jae Hyeon Kim
Summary: This study utilized three-dimensional intestinal organoids to investigate the effects of metformin on inflammatory bowel disease (IBD) and found that metformin can enhance intestinal barrier function and reduce levels of inflammatory cytokines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
V. V. Sudarev, M. S. Gette, S. V. Bazhenov, O. M. Tilinova, E. V. Zinovev, I. V. Manukhov, A. I. Kuklin, Yu. L. Ryzhykau, A. V. Vlasov
Summary: This study investigated the self-assembly processes of ferritin-based protein complexes and obtained structurally characterized oligomeric states. These results provide new potential and opportunities for the application of ferritin in various fields.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Yalda Sabaghi, Farnaz Pourfarzad, Leila Zolghadr, Azita Bahrami, Tahereh Shojazadeh, Alireza Farasat, Nematollah Gheibi
Summary: p-Coumaric acid (p-CA) is a plant compound with anti-cancer activities. This study designed a nano-liposomal carrier containing p-CA to enhance its effectiveness against melanoma cells. The findings showed that the liposomal form of p-CA had a greater impact on the cells. Kinetic modeling indicated that the best fitting model was zero-order.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
M. D. Nazmul Hasan, Md Mahfuzur Rahman, Al Asmaul Husna, Nobuhiro Nozaki, Osamu Yamato, Naoki Miura
Summary: This study investigated the expression of ncRNAs other than miRNAs in different histologic subtypes of canine mammary gland tumors (MGT). Three aberrantly expressed ncRNAs were identified as potential biomarkers for differentiating MGT subtypes. YRNA and tRFs expression levels were found to be decreased in metastatic compared to primary MGT cell lines.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Seine A. Shintani
Summary: In this study, the researchers used signal analysis to study the instantaneous amplitude and phase of sarcomeric oscillations in skeletal muscle. They identified two types of oscillations, sarcomeric oscillations and sarcosynced oscillations, and visualized their behavior during propagating waves. The researchers discovered the presence of sarcomeric defect holes and sarcomeric collision holes, which are important indicators for understanding the oscillation properties of sarcomeres. This finding has important implications for improving our understanding of muscle function and its regulatory mechanisms.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Shuanglin Zhang, Yuzhong Jia, Guolan Ma, Yanyan Yang, Zhenzhen Cao, Antao Luo, Zefu Zhang, Shihan Li, Jie Wen, Hanfeng Liu, Jihua Ma
Summary: Bupleurum is an antiarrhythmic agent that may exert its effects by inhibiting L-type calcium channels.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Tomotaka Ohkubo, Yasuhiko Matsumoto, Hiroaki Sasaki, Kaoru Kinoshita, Yuki Ogasawara, Takashi Sugita
Summary: This study found that Citrobacter koseri inhibits the growth of Staphylococcus epidermidis, disrupting the balance between S. epidermidis and Staphylococcus aureus, and exacerbating inflammation in atopic dermatitis.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Toshifumi Asano, Philipp Sasse, Takao Nakata
Summary: A Cre recombination-based fluorescent reporter system was developed to monitor cell-cell fusion. The system successfully detected the formation of multinuclear myotubes and placental syncytiotrophoblast. This tool could facilitate the study of cell-to-cell fusion.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Ke Shi, Yunlong Shan, Xiao Sun, Kuida Chen, Qiong Luo, Qiang Xu
Summary: This study found that low expression of TP53INP2 is associated with poor survival in colorectal cancer (CRC) patients. As the malignancy of CRC progresses, TP53INP2 expression gradually decreases. Knockdown of TP53INP2 promotes CRC cell proliferation and tumor growth. Mechanistically, TP53INP2 deficiency decreases phosphorylation of beta-catenin, leading to increased accumulation and enhanced nuclear translocation and transcriptional activity. Additionally, TP53INP2 sequesters TIM50, inhibiting its activation of beta-catenin. In conclusion, downregulation of TP53INP2 promotes CRC progression by activating beta-catenin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Martina Rossi, Fabio Tomaselli, Alejandro Hochkoeppler
Summary: Oligomeric enzymes are known for their higher catalytic rates compared to monomeric enzymes, but the extent of additivity in their activity is still not well understood. This study used tetrameric rabbit lactate dehydrogenase as a model to examine the kinetics of its catalytic action. Surprisingly, when the concentration of the limiting reactant exceeded that of a single subunit, there was a significant slowdown in the enzyme's conformational rearrangements.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Amin Sahraei, Mohammad Javad Shamsoddini, Fakhrossadat Mohammadi, Leila Hassani
Summary: This study explored the inhibitory effects of gallium curcumin, indium curcumin, and vanadyl curcumin on the amyloid fibrillation of hen egg white lysozyme, as well as the binding interactions of these metal complexes with the enzyme. The results showed that indium curcumin and vanadyl curcumin exhibited higher binding affinities and stronger inhibitory effects on amyloid fibrillation compared to gallium curcumin.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Takahiro Sasaki, Yoshiki Kuse, Shinsuke Nakamura, Masamitsu Shimazawa
Summary: PGRN deficiency plays a significant role in cardiac remodeling and arrhythmias post-myocardial infarction (MI), potentially by promoting metabolic abnormalities in macrophages.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Hongwei Zhao, Yiqiang Li, Yibo Zhang, Chi Zhang
Summary: Electrical brain stimulation technology is commonly used to treat brain neurological disorders, but it can cause side effects. This study investigated the impact of electric fields on nerve fibers and revealed the possible origin of side effects. The findings provide guidance for selecting electrical parameters in clinical stimulation therapy.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Julia S. Scott, Lake-Ee Quek, Andrew J. Hoy, Johannes V. Swinnen, Zeyad D. Nassar, Lisa M. Butler
Summary: The fatty acid elongation enzyme ELOVL5 plays a critical role in promoting metastasis in prostate cancer. Knocking down ELOVL5 leads to the accumulation of malonyl-CoA, which inhibits fatty acid oxidation in mitochondria. This study highlights the importance of fatty acid elongation in regulating cell viability and provides a potential target for prostate cancer treatment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)
Article
Biochemistry & Molecular Biology
Zan Zhou, Wen-jun Jiang, Li Li, Jun-qiang Si
Summary: This study investigates the effect of noise exposure on cognitive function in mice and explores the underlying molecular mechanisms. The findings suggest that noise exposure leads to increased inflammation, increased phosphorylation of Tau protein, and decreased levels of postsynaptic density protein, resulting in cognitive impairment.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2024)