Therapies from Fucoidan: An Update

Quantitative determination of fucoidan using polyion-sensitive membrane electrodes

(2015) Ji Min Kim et al.   ANALYTICA CHIMICA ACTA

Chitosan/fucoidan multilayer nanocapsules as a vehicle for controlled release of bioactive compounds

(2015) Ana C. Pinheiro et al.   CARBOHYDRATE POLYMERS

Microwave assisted extraction of sulfated polysaccharides (fucoidan) from Ascophyllum nodosum and its antioxidant activity

(2015) Yuan Yuan et al.   CARBOHYDRATE POLYMERS

Addition of bevacizumab to chemotherapy in patients with ovarian cancer: a systematic review and meta-analysis of randomized trials

(2015) J. Li et al.   Clinical & Translational Oncology

Interference with the CXCL12/CXCR4 axis as potential antitumor strategy: superiority of a sulfated galactofucan from the brown algaSaccharina latissimaand Fucoidan over heparins

(2015) Tino Schneider et al.   GLYCOBIOLOGY

Review: Prospects for the Use of Extracts and Polysaccharides from Marine Algae to Prevent and Treat the Diseases Caused byHelicobacter pylori

(2015) Natalya N. Besednova et al.   HELICOBACTER

Fucoidan from Turbinaria conoides: A multifaceted ‘deliverable’ to combat pancreatic cancer progression

(2015) Caroline R. Delma et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan protects mesenchymal stem cells against oxidative stress and enhances vascular regeneration in a murine hindlimb ischemia model

(2015) Yong-seok Han et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Effects of fucoidan on proliferation, AMP-activated protein kinase, and downstream metabolism- and cell cycle-associated molecules in poorly differentiated human hepatoma HLF cells

(2015) TAKUMI KAWAGUCHI et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Determination of the active transport of fucoidan derived from Okinawa Mozuku across the human intestinal Caco-2 cells as assessed by size-exclusion chromatography

(2015) Takeaki Nagamine et al.   JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES

Prophylactic Administration of Fucoidan Represses Cancer Metastasis by Inhibiting Vascular Endothelial Growth Factor (VEGF) and Matrix Metalloproteinases (MMPs) in Lewis Tumor-Bearing Mice

(2015) Tse-Hung Huang et al.   Marine Drugs

Laminarin from Irish Brown Seaweeds Ascophyllum nodosum and Laminaria hyperborea: Ultrasound Assisted Extraction, Characterization and Bioactivity

(2015) Shekhar Kadam et al.   Marine Drugs

Fucoidan from Macrocystis pyrifera Has Powerful Immune-Modulatory Effects Compared to Three Other Fucoidans

(2015) Wei Zhang et al.   Marine Drugs

Fucoidan and Cancer: A Multifunctional Molecule with Anti-Tumor Potential

(2015) Farzaneh Atashrazm et al.   Marine Drugs

Fucoidan from Fucus vesiculosus Protects against Alcohol-Induced Liver Damage by Modulating Inflammatory Mediators in Mice and HepG2 Cells

(2015) Jung Lim et al.   Marine Drugs

Tuning polyelectrolyte multilayer structure by exploiting natural variation in fucoidan chemistry

(2015) Tracey T. M. Ho et al.   Soft Matter

Novel therapeutic targets for steatohepatitis

(2015) Arun J. Sanyal   Clinics and Research in Hepatology and Gastroenterology

Dietary fucoidan of Acaudina molpadioides and its enzymatically degraded fragments could prevent intestinal mucositis induced by chemotherapy in mice

(2015) Tao Zuo et al.   Food & Function

Are multifunctional marine polysaccharides a myth or reality?

(2015) Svetlana Ermakova et al.   Frontiers in Chemistry

Fucoidan Extracts Ameliorate Acute Colitis

(2015) Qi Ying Lean et al.   PLoS One

Endotoxemia, nutrition, and cardiometabolic disorders

(2014) K. A. Elisa Kallio et al.   ACTA DIABETOLOGICA

Mekabu fucoidan: Structural complexity and defensive effects against avian influenza A viruses

(2014) Andriy Synytsya et al.   CARBOHYDRATE POLYMERS

The curative effect of fucoidan on visceral leishmaniasis is mediated by activation of MAP kinases through specific protein kinase C isoforms

(2014) Gunjan Sharma et al.   Cellular & Molecular Immunology

Anticancer Effect of Fucoidan in Combination with Tyrosine Kinase Inhibitor Lapatinib

(2014) Byeongsang Oh et al.   Evidence-based Complementary and Alternative Medicine

Hepatoprotective effect of fucoidan isolated from the seaweed Turbinaria decurrens in ethanol intoxicated rats

(2014) Selvaraju Meenakshi et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan, a Sulfated Polysaccharide, Inhibits Osteoclast Differentiation and Function by Modulating RANKL Signaling

(2014) Young Kim et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The effects of fucodian on senescence are controlled by the p16INK4a-pRb and p14Arf-p53 pathways in hepatocellular carcinoma and hepatic cell lines

(2014) EUN-YOUNG MIN et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Ascophyllan Purified from Ascophyllum nodosum Induces Th1 and Tc1 Immune Responses by Promoting Dendritic Cell Maturation

(2014) Wei Zhang et al.   Marine Drugs

Fucoidan Extracted from Fucus evanescens Prevents Endotoxin-Induced Damage in a Mouse Model of Endotoxemia

(2014) Tatyana Kuznetsova et al.   Marine Drugs

The Protective Effect of Fucoidan in Rats with Streptozotocin-Induced Diabetic Nephropathy

(2014) Jing Wang et al.   Marine Drugs

Purification of a Low Molecular Weight Fucoidan for SPECT Molecular Imaging of Myocardial Infarction

(2014) Pierre Saboural et al.   Marine Drugs

Intestinal Absorption of Fucoidan Extracted from the Brown Seaweed, Cladosiphon okamuranus

(2014) Takeaki Nagamine et al.   Marine Drugs

Fucoidan as a Marine Anticancer Agent in Preclinical Development

(2014) Jong-Young Kwak   Marine Drugs

Chitosan-Alginate Biocomposite Containing Fucoidan for Bone Tissue Engineering

(2014) Jayachandran Venkatesan et al.   Marine Drugs

Sea, Carbohydrates and Clotting: A Triad on the Road of Drug Discovery

(2014) Vitor Pomin   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Fucoidan Reduces Secretion and Expression of Vascular Endothelial Growth Factor in the Retinal Pigment Epithelium and Reduces Angiogenesis In Vitro

(2014) Michaela Dithmer et al.   PLoS One

Fucoidan Can Function as an Adjuvant In Vivo to Enhance Dendritic Cell Maturation and Function and Promote Antigen-Specific T Cell Immune Responses

(2014) Jun-O Jin et al.   PLoS One

Fucoidan Induces Cancer Cell Apoptosis by Modulating the Endoplasmic Reticulum Stress Cascades

(2014) Shaohua Chen et al.   PLoS One

Rapid Mass Spectrometric Analysis of a Novel Fucoidan, Extracted from the Brown AlgaCoccophora langsdorfii

(2014) Stanislav D. Anastyuk et al.   TheScientificWorldJOURNAL

Pharmacologic therapy for acute pancreatitis

(2014) Swetha Kambhampati   WORLD JOURNAL OF GASTROENTEROLOGY

Fucoidan Supplementation Improves Exercise Performance and Exhibits Anti-Fatigue Action in Mice

(2014) Yi-Ming Chen et al.   Nutrients

Synergistic effect of fucoidan with antibiotics against oral pathogenic bacteria

(2013) Kyung-Yeol Lee et al.   ARCHIVES OF ORAL BIOLOGY

Doxorubicin loading fucoidan acetate nanoparticles for immune and chemotherapy in cancer treatment

(2013) Kun Woo Lee et al.   CARBOHYDRATE POLYMERS

Toll-like receptor agonists: current status and future perspective on their utility as adjuvants in improving antic ancer vaccination strategies

(2013) Constantin N Baxevanis et al.   Immunotherapy

Hydroxyapatite-fucoidan nanocomposites for bone tissue engineering

(2013) Hee-Seok Jeong et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Pharmaceutical potential of a fucoidan-like sulphated polysaccharide isolated from Halodule pinifolia

(2013) Rengasamy Ragupathi Raja Kannan et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Fucoidan Is a Novel Platelet Agonist for the C-type Lectin-like Receptor 2 (CLEC-2)

(2013) Bhanu Kanth Manne et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Safety Evaluation of Excessive Ingestion of Mozuku Fucoidan in Human

(2013) Sunao Abe et al.   JOURNAL OF FOOD SCIENCE

Supplementation of Elderly Japanese Men and Women with Fucoidan from Seaweed Increases Immune Responses to Seasonal Influenza Vaccination

(2013) Hirokuni Negishi et al.   JOURNAL OF NUTRITION

Hydrolysis of Fucoidan by Fucoidanase Isolated from the Marine Bacterium, Formosa algae

(2013) Artem Silchenko et al.   Marine Drugs

6-Bromoisatin Found in Muricid Mollusc Extracts Inhibits Colon Cancer Cell Proliferation and Induces Apoptosis, Preventing Early Stage Tumor Formation in a Colorectal Cancer Rodent Model

(2013) Babak Esmaeelian et al.   Marine Drugs

Cytotoxic Effects of Fucoidan Nanoparticles against Osteosarcoma

(2013) Ryuichiro Kimura et al.   Marine Drugs

Fucoidan Extract Enhances the Anti-Cancer Activity of Chemotherapeutic Agents in MDA-MB-231 and MCF-7 Breast Cancer Cells

(2013) Zhongyuan Zhang et al.   Marine Drugs

Anti-influenza A virus characteristics of a fucoidan from sporophyll of Undaria pinnatifida in mice with normal and compromised immunity

(2013) Kyoko Hayashi et al.   MICROBES AND INFECTION

Protective Effects of Fucoidan, a P- and L-Selectin Inhibitor, in Murine Acute Pancreatitis

(2013) Ana C.S. Carvalho et al.   PANCREAS

Fucoidan Prevents High-Fat Diet-Induced Obesity in Animals by Suppression of Fat Accumulation

(2013) Mi-Ja Kim et al.   PHYTOTHERAPY RESEARCH

Structure-activity relationship of the pro- and anticoagulant effects of Fucus vesiculosus fucoidan

(2013) Cong Jiang et al.   THROMBOSIS AND HAEMOSTASIS

Fucoidan Promotes Early Step of Cardiac Differentiation from Human Embryonic Stem Cells and Long-Term Maintenance of Beating Areas

(2013) Sofiane Hamidi et al.   TISSUE ENGINEERING PART A

The In Vitro and In Vivo Effects of a Low-Molecular-Weight Fucoidan on the Osteogenic Capacity of Human Adipose-Derived Stromal Cells

(2013) Jessica Pereira et al.   TISSUE ENGINEERING PART A

Fucoidan enhances intestinal barrier function by upregulating the expression of claudin-1

(2013) Atsushi Iraha   WORLD JOURNAL OF GASTROENTEROLOGY

Fucoidan induces caspase-dependent apoptosis in MC3 human mucoepidermoid carcinoma cells

(2013) HANG-EUN LEE et al.   Experimental and Therapeutic Medicine

Effect of fruit and vegetable consumption on immune function in older people: a randomized controlled trial

(2012) Andrew Gibson et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Solid-Phase Colorimetric Method for the Quantification of Fucoidan

(2012) Jung Min Lee et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Fucanomics and galactanomics: Current status in drug discovery, mechanisms of action and role of the well-defined structures

(2012) Vitor H. Pomin   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Interactions between Sulfated Polysaccharides from Sea Brown Algae and Toll-Like Receptors on HEK293 Eukaryotic Cells In Vitro

(2012) I. D. Makarenkova et al.   BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE

Fabrication of electrospun biocomposites comprising polycaprolactone/fucoidan for tissue regeneration

(2012) Ji Seok Lee et al.   CARBOHYDRATE POLYMERS

A comparative study of the anticoagulant activities of eleven fucoidans

(2012) Weihua Jin et al.   CARBOHYDRATE POLYMERS

Low molecular weight fucoidan ameliorating the chronic cisplatin-induced delayed gastrointestinal motility in rats

(2012) Moon Yong Song et al.   FOOD AND CHEMICAL TOXICOLOGY

Fucoidan interferes with Porphyromonas gingivalis-induced aneurysm enlargement by decreasing neutrophil activation

(2012) Jean-Marc Alsac et al.   JOURNAL OF VASCULAR SURGERY

Fucanomics and Galactanomics: Marine Distribution, Medicinal Impact, Conceptions, and Challenges

(2012) Vitor H. Pomin   Marine Drugs

Effects of Oral Administration of Fucoidan Extracted from Cladosiphon okamuranus on Tumor Growth and Survival Time in a Tumor-Bearing Mouse Model

(2012) Kazuo Azuma et al.   Marine Drugs

Of Microbes and Meals

(2012) Caleb J. Kelly et al.   NUTRITION IN CLINICAL PRACTICE

Topical Application of Fucoidan Improves Atopic Dermatitis Symptoms in NC/Nga Mice

(2012) Jae-Ho Yang   PHYTOTHERAPY RESEARCH

In vitro characterization of the antiviral activity of fucoidan from Cladosiphon okamuranus against Newcastle Disease Virus

(2012) Regina Elizondo-Gonzalez et al.   Virology Journal

Beneficial effects of fucoidan in patients with chronic hepatitis C virus infection

(2012) Naoki Mori   WORLD JOURNAL OF GASTROENTEROLOGY

Mobilization of mesenchymal stem cells by stromal cell-derived factor-1 released from chitosan/tripolyphosphate/fucoidan nanoparticles

(2011) Yi-Cheng Huang et al.   Acta Biomaterialia

Microwave-assisted extraction of sulfated polysaccharides (fucoidan) from brown seaweed

(2011) Rosa M. Rodriguez-Jasso et al.   CARBOHYDRATE POLYMERS

Fucoidan cures infection with both antimony-susceptible and -resistant strains of Leishmania donovani through Th1 response and macrophage-derived oxidants

(2011) S. Kar et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Radiolabeled Fucoidan as a P-Selectin Targeting Agent for In Vivo Imaging of Platelet-Rich Thrombus and Endothelial Activation

(2011) F. Rouzet et al.   JOURNAL OF NUCLEAR MEDICINE

Important Determinants for Fucoidan Bioactivity: A Critical Review of Structure-Function Relations and Extraction Methods for Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds

(2011) Marcel Tutor Ale et al.   Marine Drugs

Therapies from Fucoidan; Multifunctional Marine Polymers

(2011) Janet Helen Fitton   Marine Drugs

An Antithrombotic Fucoidan, Unlike Heparin, Does Not Prolong Bleeding Time in a Murine Arterial Thrombosis Model: A Comparative Study of Undaria pinnatifida sporophylls and Fucus vesiculosus

(2011) Soon-Ki Min et al.   PHYTOTHERAPY RESEARCH

The Sulfated Polysaccharide Fucoidan Stimulates Osteogenic Differentiation of Human Adipose-Derived Stem Cells

(2011) Soo-jeong Park et al.   STEM CELLS AND DEVELOPMENT

Fucoidan reduces the toxicities of chemotherapy for patients with unresectable advanced or recurrent colorectal cancer

(2011) MASAHIDE IKEGUCHI et al.   Oncology Letters

Fucoidan-Degrading Fungal Strains: Screening, Morphometric Evaluation, and Influence of Medium Composition

(2010) Rosa M. Rodríguez-Jasso et al.   APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY

Fucoidan suppresses IgE production in peripheral blood mononuclear cells from patients with atopic dermatitis

(2010) Kazumasa Iwamoto et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Development of a Fucoidan-Specific Antibody and Measurement of Fucoidan in Serum and Urine by Sandwich ELISA

(2010) Yoshiharu TOKITA et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Structure and antitumour activity of fucoidan isolated from sporophyll of Korean brown seaweed Undaria pinnatifida

(2010) Andriy Synytsya et al.   CARBOHYDRATE POLYMERS

NMR characterization and molecular modeling of fucoidan showing the importance of oligosaccharide branching in its anticomplementary activity

(2010) Marie-Jeanne Clément et al.   GLYCOBIOLOGY

Attenuation of N-nitrosodiethylamine-induced liver fibrosis by high-molecular-weight fucoidan derived fromCladosiphon okamuranus

(2009) Kyoumi Nakazato et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Sulfated oligosaccharides (heparin and fucoidan) binding and dimerization of stromal cell-derived factor-1 (SDF-1/CXCL 12) are coupled as evidenced by affinity CE-MS analysis

(2008) S. Fermas et al.   GLYCOBIOLOGY

Effects of molecular weight and hydrolysis conditions on anticancer activity of fucoidans from sporophyll of Undaria pinnatifida

(2008) Chen Yang et al.   INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES

Toxicity and Antioxidant Activity in Vitro and in Vivo of TwoFucus vesiculosusExtracts

(2008) M. C. Zaragozá et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY