Role of Ferroptosis in Neurological Diseases

Ferroptosis: past, present and future

(2020) Jie Li et al.   Cell Death & Disease

Ferroptosis was more initial in cell death caused by iron overload and its underlying mechanism in Parkinson's disease

(2020) Pei Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Transferrin Receptor Is a Specific Ferroptosis Marker

(2020) Huizhong Feng et al.   Cell Reports

Metal ion-responsive nanocarrier derived from phosphonated calix[4]arenes for delivering dauricine specifically to sites of brain injury in a mouse model of intracerebral hemorrhage

(2020) Mingxin Li et al.   JOURNAL OF NANOBIOTECHNOLOGY

Correction: Alpha synuclein aggregation drives ferroptosis: an interplay of iron, calcium and lipid peroxidation

(2020) Plamena R. Angelova et al.   CELL DEATH AND DIFFERENTIATION

On the role of synthesized hydroxylated chalcones as dual functional amyloid-β aggregation and ferroptosis inhibitors for potential treatment of Alzheimer's disease

(2019) Lin Cong et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Targeting ferroptosis: A novel therapeutic strategy for the treatment of mitochondrial disease-related epilepsy

(2019) Amanda H. Kahn-Kirby et al.   PLoS One

Global, regional, and national burden of stroke, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016

(2019) Catherine Owens Johnson et al.   LANCET NEUROLOGY

Selenium Drives a Transcriptional Adaptive Program to Block Ferroptosis and Treat Stroke

(2019) Ishraq Alim et al.   CELL

Oxidative Stress in Neurodegenerative Diseases: From a Mitochondrial Point of View

(2019) Giovanna Cenini et al.   Oxidative Medicine and Cellular Longevity

Iron, Myelin, and the Brain: Neuroimaging Meets Neurobiology

(2019) Harald E. Möller et al.   TRENDS IN NEUROSCIENCES

Rutin and Selenium Co-administration Reverse 3-Nitropropionic Acid-Induced Neurochemical and Molecular Impairments in a Mouse Model of Huntington’s Disease

(2019) Mohamed S. Abdelfattah et al.   NEUROTOXICITY RESEARCH

Baicalein Exerts Neuroprotective Effects in FeCl3-Induced Posttraumatic Epileptic Seizures via Suppressing Ferroptosis

(2019) Qin Li et al.   Frontiers in Pharmacology

Ibuprofen induces ferroptosis of glioblastoma cells via downregulation of nuclear factor erythroid 2-related factor 2 signaling pathway

(2019) Xingchun Gao et al.   ANTI-CANCER DRUGS

Dihydroartemisinin-induced unfolded protein response feedback attenuates ferroptosis via PERK/ATF4/HSPA5 pathway in glioma cells

(2019) Yibing Chen et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

miR-212-5p attenuates ferroptotic neuronal death after traumatic brain injury by targeting Ptgs2

(2019) Xiao Xiao et al.   Molecular Brain

Inhibition of neuronal ferroptosis in the acute phase of intracerebral hemorrhage shows long-term cerebroprotective effects

(2019) Bin Chen et al.   BRAIN RESEARCH BULLETIN

Oligodendrocyte Death in Pelizaeus-Merzbacher Disease Is Rescued by Iron Chelation

(2019) Hiroko Nobuta et al.   Cell Stem Cell

The neuroprotective effects of carvacrol on ischemia/reperfusion-induced hippocampal neuronal impairment by ferroptosis mitigation

(2019) Xueying Guan et al.   LIFE SCIENCES

Ferrostatin-1 mitigates cognitive impairment of epileptic rats by inhibiting P38 MAPK activation

(2019) Qing Ye et al.   EPILEPSY & BEHAVIOR

Could Conservative Iron Chelation Lead to Neuroprotection in Amyotrophic Lateral Sclerosis?

(2018) Caroline Moreau et al.   ANTIOXIDANTS & REDOX SIGNALING

Why should neuroscientists worry about iron? The emerging role of ferroptosis in the pathophysiology of neuroprogressive diseases

(2018) Gerwyn Morris et al.   BEHAVIOURAL BRAIN RESEARCH

Inhibiting 12/15-lipoxygenase to treat acute stroke in permanent and tPA induced thrombolysis models

(2018) H. Karatas et al.   BRAIN RESEARCH

Pseudolaric acid B triggers ferroptosis in glioma cells via activation of Nox4 and inhibition of xCT

(2018) Zongqi Wang et al.   CANCER LETTERS

OXIDIZED PHOSPHOLIPID SIGNALING IN TRAUMATIC BRAIN INJURY

(2018) Tamil S. Anthonymuthu et al.   FREE RADICAL BIOLOGY AND MEDICINE

Nano-targeted induction of dual ferroptotic mechanisms eradicates high-risk neuroblastoma

(2018) Behrouz Hassannia et al.   JOURNAL OF CLINICAL INVESTIGATION

Ferroptosis-Induced Endoplasmic Reticulum Stress: Cross-talk between Ferroptosis and Apoptosis

(2018) Young-Sun Lee et al.   MOLECULAR CANCER RESEARCH

Neuronal Cell Death

(2018) Michael Fricker et al.   PHYSIOLOGICAL REVIEWS

α-Lipoic acid improves abnormal behavior by mitigation of oxidative stress, inflammation, ferroptosis, and tauopathy in P301S Tau transgenic mice

(2018) Yan-Hui Zhang et al.   Redox Biology

Glutathione peroxidase 4 participates in secondary brain injury through mediating ferroptosis in a rat model of intracerebral hemorrhage

(2018) Zhuwei Zhang et al.   BRAIN RESEARCH

Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice

(2018) Bao-Shu Xie et al.   CNS Neuroscience & Therapeutics

Increased Iron Levels and Decreased Tissue Integrity in Hippocampus of Alzheimer's Disease Detected in vivo with Magnetic Resonance Imaging

(2018) Erika P. Raven et al.   JOURNAL OF ALZHEIMERS DISEASE

Vitamin E hydroquinone is an endogenous regulator of ferroptosis via redox control of 15-lipoxygenase

(2018) Andrew Hinman et al.   PLoS One

Quantitative Susceptibility MRI to Detect Brain Iron in Amyotrophic Lateral Sclerosis

(2018) Julio Acosta-Cabronero et al.   RADIOLOGY

Fenton-Reaction-Acceleratable Magnetic Nanoparticles for Ferroptosis Therapy of Orthotopic Brain Tumors

(2018) Zheyu Shen et al.   ACS Nano

N-acetylcysteine targets 5 lipoxygenase-derived, toxic lipids and can synergize with prostaglandin E2 to inhibit ferroptosis and improve outcomes following hemorrhagic stroke in mice

(2018) Saravanan S. Karuppagounder et al.   ANNALS OF NEUROLOGY

Ferroptosis Contributes to Neuronal Death and Functional Outcome After Traumatic Brain Injury

(2018) Elizabeth M. Kenny et al.   CRITICAL CARE MEDICINE

NSC-34 motor neuron-like cells are sensitized to ferroptosis upon differentiation

(2018) Alejandra M. Martinez et al.   FEBS Open Bio

Tau-mediated iron export prevents ferroptotic damage after ischemic stroke

(2017) Q-z Tuo et al.   MOLECULAR PSYCHIATRY

The Role of MicroRNA in Traumatic Brain Injury

(2017) Yuan-Bo Pan et al.   NEUROSCIENCE

ATF4 promotes angiogenesis and neuronal cell death and confers ferroptosis in a xCT-dependent manner

(2017) D Chen et al.   ONCOGENE

Gpx 4 is involved in the proliferation, migration and apoptosis of glioma cells

(2017) Hongyu Zhao et al.   PATHOLOGY RESEARCH AND PRACTICE

Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson’s disease

(2017) Lena F. Burbulla et al.   SCIENCE

Neuronal Death After Hemorrhagic Stroke In Vitro and In Vivo Shares Features of Ferroptosis and Necroptosis

(2017) Marietta Zille et al.   STROKE

The oxido-metabolic driver ATF4 enhances temozolamide chemo-resistance in human gliomas

(2017) Daishi Chen et al.   Oncotarget

Neural Vascular Mechanism for the Cerebral Blood Flow Autoregulation after Hemorrhagic Stroke

(2017) Ming Xiao et al.   NEURAL PLASTICITY

Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update

(2017) Sang Joon An et al.   Journal of Stroke

Ablation of ferroptosis regulator glutathione peroxidase 4 in forebrain neurons promotes cognitive impairment and neurodegeneration

(2017) William Sealy Hambright et al.   Redox Biology

On the Mechanism of Cytoprotection by Ferrostatin-1 and Liproxstatin-1 and the Role of Lipid Peroxidation in Ferroptotic Cell Death

(2017) Omkar Zilka et al.   ACS Central Science

Brain iron chelation by deferiprone in a phase 2 randomised double-blinded placebo controlled clinical trial in Parkinson’s disease

(2017) Antonio Martin-Bastida et al.   Scientific Reports

Iron and cancer: recent insights

(2016) David H. Manz et al.   Annals of the New York Academy of Sciences

Autophagy promotes ferroptosis by degradation of ferritin

(2016) Wen Hou et al.   Autophagy

Identification of ACSL4 as a biomarker and contributor of ferroptosis

(2016) Hua Yuan et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Mechanisms of ferroptosis

(2016) Jennifer Yinuo Cao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Mechanism and Therapy of Brain Edema after Intracerebral Hemorrhage

(2016) Haiping Zheng et al.   CEREBROVASCULAR DISEASES

Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis

(2016) Valerian E Kagan et al.   Nature Chemical Biology

Ferroptosis, a newly characterized form of cell death in Parkinson's disease that is regulated by PKC

(2016) Bruce Do Van et al.   NEUROBIOLOGY OF DISEASE

Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice

(2016) Pavle Matak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxidation of polyunsaturated fatty acids by lipoxygenases drives ferroptosis

(2016) Wan Seok Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Docosahexaenoic Acid and Cognition throughout the Lifespan

(2016) Michael Weiser et al.   Nutrients

Temozolomide toxicity operates in a xCT/SLC7a11 dependent manner and is fostered by ferroptosis

(2016) Tina Sehm et al.   Oncotarget

Quantitative Susceptibility Mapping Suggests Altered Brain Iron in Premanifest Huntington Disease

(2015) J. M. G. van Bergen et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Ceruloplasmin activity and iron chelation treatment of patients with Parkinson’s disease

(2015) Guillaume Grolez et al.   BMC Neurology

Ablation of the Ferroptosis Inhibitor Glutathione Peroxidase 4 in Neurons Results in Rapid Motor Neuron Degeneration and Paralysis

(2015) Liuji Chen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mitochondrial dysfunction and seizures: the neuronal energy crisis

(2015) Gábor Zsurka et al.   LANCET NEUROLOGY

Glutaminolysis and Transferrin Regulate Ferroptosis

(2015) Minghui Gao et al.   MOLECULAR CELL

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Molecular mechanisms of epilepsy

(2015) Kevin Staley   NATURE NEUROSCIENCE

The Neuroprotective Role of Ferrostatin-1 Under Rotenone-Induced Oxidative Stress in Dopaminergic Neuroblastoma Cells

(2015) Parijat Kabiraj et al.   PROTEIN JOURNAL

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Ferrostatins Inhibit Oxidative Lipid Damage and Cell Death in Diverse Disease Models

(2014) Rachid Skouta et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

The role of iron in brain ageing and neurodegenerative disorders

(2014) Roberta J Ward et al.   LANCET NEUROLOGY

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice

(2014) Jose Pedro Friedmann Angeli et al.   NATURE CELL BIOLOGY

The global burden of neurologic diseases

(2014) J. H. Chin et al.   NEUROLOGY

Synchronized renal tubular cell death involves ferroptosis

(2014) Andreas Linkermann et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pharmacological inhibition of cystine–glutamate exchange induces endoplasmic reticulum stress and ferroptosis

(2014) Scott J Dixon et al.   eLife

(-)-Epicatechin protects hemorrhagic brain via synergistic Nrf2 pathways

(2014) Che-Feng Chang et al.   Annals of Clinical and Translational Neurology

Alteration of mitochondrial function and ultrastructure in the hippocampus of pilocarpine-treated rat

(2013) Jing Gao et al.   EPILEPSY RESEARCH

Mitochondrial involvement and oxidative stress in temporal lobe epilepsy

(2013) Shane Rowley et al.   FREE RADICAL BIOLOGY AND MEDICINE

Iron-dependent cell death of hepatocellular carcinoma cells exposed to sorafenib

(2013) Christophe Louandre et al.   INTERNATIONAL JOURNAL OF CANCER

Iron Accumulates in Huntington’s Disease Neurons: Protection by Deferoxamine

(2013) Jianfang Chen et al.   PLoS One

Ferroptosis: An Iron-Dependent Form of Nonapoptotic Cell Death

(2012) Scott J. Dixon et al.   CELL

Regulation of Autophagy by Glucose in Mammalian Cells

(2012) Félix Moruno et al.   Cells

An electrostatic potassium channel opener targeting the final voltage sensor transition

(2011) Sara I. Börjesson et al.   JOURNAL OF GENERAL PHYSIOLOGY

Nitric oxide mechanism in the protective effect of antidepressants against 3-nitropropionic acid-induced cognitive deficit, glutathione and mitochondrial alterations in animal model of Huntingtonʼs disease

(2010) Puneet Kumar et al.   BEHAVIOURAL PHARMACOLOGY

Lysosomal degradation of the carboxydextran shell of coated superparamagnetic iron oxide nanoparticles and the fate of professional phagocytes

(2010) Oleg Lunov et al.   BIOMATERIALS

Fish, docosahexaenoic acid and Alzheimer’s disease

(2009) S.C. Cunnane et al.   PROGRESS IN LIPID RESEARCH

Effects of Deferoxamine on Intracerebral Hemorrhage-Induced Brain Injury in Aged Rats

(2009) Masanobu Okauchi et al.   STROKE

Deferoxamine Reduces Intracerebral Hematoma-Induced Iron Accumulation and Neuronal Death in Piglets

(2009) Yuxiang Gu et al.   STROKE

Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death

(2008) Alexander Seiler et al.   Cell Metabolism

Synthetic Lethal Screening Identifies Compounds Activating Iron-Dependent, Nonapoptotic Cell Death in Oncogenic-RAS-Harboring Cancer Cells

(2008) Wan Seok Yang et al.   CHEMISTRY & BIOLOGY