N-acetylserotonin Derivative Exerts a Neuroprotective Effect by Inhibiting the NLRP3 Inflammasome and Activating the PI3K/Akt/Nrf2 Pathway in the Model of Hypoxic-Ischemic Brain Damage
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
N-acetylserotonin Derivative Exerts a Neuroprotective Effect by Inhibiting the NLRP3 Inflammasome and Activating the PI3K/Akt/Nrf2 Pathway in the Model of Hypoxic-Ischemic Brain Damage
Authors
Keywords
-
Journal
NEUROCHEMICAL RESEARCH
Volume -, Issue -, Pages -
Publisher
Springer Science and Business Media LLC
Online
2020-11-22
DOI
10.1007/s11064-020-03169-x
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Induction of HO-1 by Mevastatin Mediated via a Nox/ROS-Dependent c-Src/PDGFRα/PI3K/Akt/Nrf2/ARE Cascade Suppresses TNF-α-Induced Lung Inflammation
- (2020) Chih-Chung Lin et al. Journal of Clinical Medicine
- Hypoxic-Ischemic Encephalopathy and Mitochondrial Dysfunction: Facts, Unknowns and Challenges
- (2020) Marianela Rodriguez et al. ANTIOXIDANTS & REDOX SIGNALING
- Human Umbilical Cord Therapy Improves Long-Term Behavioral Outcomes Following Neonatal Hypoxic Ischemic Brain Injury
- (2019) Tayla R. Penny et al. Frontiers in Physiology
- A novel small molecular NLRP3 inflammasome inhibitor alleviates neuroinflammatory response following traumatic brain injury
- (2019) Ram Kuwar et al. Journal of Neuroinflammation
- Intrinsic Effects of Gold Nanoparticles on Oxygen–Glucose Deprivation/Reperfusion Injury in Rat Cortical Neurons
- (2019) Yafei Zheng et al. NEUROCHEMICAL RESEARCH
- Initiating TrkB/Akt Signaling Cascade Preserves Blood–Brain Barrier after Subarachnoid Hemorrhage in Rats
- (2019) Xiangqian Qi et al. CELL TRANSPLANTATION
- MiRNA-210 induces microglial activation and regulates microglia-mediated neuroinflammation in neonatal hypoxic-ischemic encephalopathy
- (2019) Bo Li et al. Cellular & Molecular Immunology
- FGF21 promotes functional recovery after hypoxic-ischemic brain injury in neonatal rats by activating the PI3K/Akt signaling pathway via FGFR1/β-klotho
- (2019) Lixia Ye et al. EXPERIMENTAL NEUROLOGY
- hUC-MSCs Exert a Neuroprotective Effect via Anti-apoptotic Mechanisms in a Neonatal HIE Rat Model
- (2019) Jianwei Xu et al. CELL TRANSPLANTATION
- SIRT1-regulated HMGB1 release is partially involved in TLR4 signal transduction: A possible anti-neuroinflammatory mechanism of resveratrol in neonatal hypoxic-ischemic brain injury
- (2019) Kai Le et al. INTERNATIONAL IMMUNOPHARMACOLOGY
- Resveratrol Attenuates Oxidative Stress-Induced Intestinal Barrier Injury through PI3K/Akt-Mediated Nrf2 Signaling Pathway
- (2019) Yu Zhuang et al. Oxidative Medicine and Cellular Longevity
- Meisoindigo Protects Against Focal Cerebral Ischemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Regulating Microglia/Macrophage Polarization via TLR4/NF-κB Signaling Pathway
- (2019) Yingze Ye et al. Frontiers in Cellular Neuroscience
- Dl-3-n-Butylphthalide Inhibits NLRP3 Inflammasome and Mitigates Alzheimer's-Like Pathology via Nrf2-TXNIP-TrX Axis
- (2018) Chun-Yan Wang et al. ANTIOXIDANTS & REDOX SIGNALING
- Interaction between hypothermia and delayed mesenchymal stem cell therapy in neonatal hypoxic-ischemic brain injury
- (2018) Josephine Herz et al. BRAIN BEHAVIOR AND IMMUNITY
- Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways
- (2018) Hailong Li et al. FREE RADICAL BIOLOGY AND MEDICINE
- Ginkgolide B ameliorates NLRP3 inflammasome activation after hypoxic-ischemic brain injury in the neonatal male rat
- (2018) Aiming Chen et al. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE
- IRE1α inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic–ischemic brain injury in rats
- (2018) Di Chen et al. Journal of Neuroinflammation
- Gualou Guizhi Granule Protects Against Oxidative Injury by Activating Nrf2/ARE Pathway in Rats and PC12 Cells
- (2018) Yuqin Zhang et al. NEUROCHEMICAL RESEARCH
- Protective Effects of Notoginsenoside R1 via Regulation of the PI3K-Akt-mTOR/JNK Pathway in Neonatal Cerebral Hypoxic–Ischemic Brain Injury
- (2018) Liu Tu et al. NEUROCHEMICAL RESEARCH
- Sirtuin 7 Deficiency Ameliorates Cisplatin-induced Acute Kidney Injury Through Regulation of the Inflammatory Response
- (2018) Yoshikazu Miyasato et al. Scientific Reports
- Inhibition of NLRP3 Inflammasome Ameliorates Cerebral Ischemia-Reperfusion Injury in Diabetic Mice
- (2018) Pu Hong et al. NEURAL PLASTICITY
- Mitochondrial dysfunction induces NLRP3 inflammasome activation during cerebral ischemia/reperfusion injury
- (2018) Zhe Gong et al. Journal of Neuroinflammation
- Andrographolide ameliorates intracerebral hemorrhage induced secondary brain injury by inhibiting neuroinflammation induction
- (2018) Xiang Li et al. NEUROPHARMACOLOGY
- The multiple protective roles and molecular mechanisms of melatonin and its precursor N-acetylserotonin in targeting brain injury and liver damage and in maintaining bone health
- (2018) Chengliang Luo et al. FREE RADICAL BIOLOGY AND MEDICINE
- Pretreatment with Korean red ginseng or dimethyl fumarate attenuates reactive gliosis and confers sustained neuroprotection against cerebral hypoxic-ischemic damage by an Nrf2-dependent mechanism
- (2018) Lei Liu et al. FREE RADICAL BIOLOGY AND MEDICINE
- Brain-immune interactions in perinatal hypoxic-ischemic brain injury
- (2017) Bo Li et al. PROGRESS IN NEUROBIOLOGY
- Neonatal Hypoxia Ischaemia: Mechanisms, Models, and Therapeutic Challenges
- (2017) Lancelot J. Millar et al. Frontiers in Cellular Neuroscience
- Neuroprotective action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB/CREB/BDNF pathway and Akt/Nrf2/Antioxidant enzyme in neuronal cells
- (2017) Jae-Myung Yoo et al. Redox Biology
- Butein provides neuroprotective and anti-neuroinflammatory effects through Nrf2/ARE-dependent haem oxygenase 1 expression by activating the PI3K/Akt pathway
- (2016) Dong-Sung Lee et al. BRITISH JOURNAL OF PHARMACOLOGY
- Reactive Oxygen Species-Induced TXNIP Drives Fructose-Mediated Hepatic Inflammation and Lipid Accumulation Through NLRP3 Inflammasome Activation
- (2015) Xian Zhang et al. ANTIOXIDANTS & REDOX SIGNALING
- New horizons for newborn brain protection: enhancing endogenous neuroprotection
- (2015) K Jane Hassell et al. Archives of Disease in Childhood-Fetal and Neonatal Edition
- Molecular mechanisms regulating NLRP3 inflammasome activation
- (2015) Eun-Kyeong Jo et al. Cellular & Molecular Immunology
- Hypoxic Preconditioning Suppresses Glial Activation and Neuroinflammation in Neonatal Brain Insults
- (2015) Chien-Yi Chen et al. MEDIATORS OF INFLAMMATION
- Neuroprotective role of an N-acetyl serotonin derivative via activation of tropomyosin-related kinase receptor B after subarachnoid hemorrhage in a rat model
- (2015) Junjia Tang et al. NEUROBIOLOGY OF DISEASE
- Animal studies of neonatal hypothermic neuroprotection have translated well in to practice
- (2015) Alistair J. Gunn et al. RESUSCITATION
- N-Acetyl-Serotonin Offers Neuroprotection through Inhibiting Mitochondrial Death Pathways and Autophagic Activation in Experimental Models of Ischemic Injury
- (2014) H. Zhou et al. JOURNAL OF NEUROSCIENCE
- N-acetyl serotonin derivatives as potent neuroprotectants for retinas
- (2012) J. Shen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Prolonged Exposure to Isoflurane Ameliorates Infarction Severity in the Rat Pup Model of Neonatal Hypoxia-Ischemia
- (2011) Hank Chen et al. Translational Stroke Research
Create your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create NowAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started