Genome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors

Association studies of up to 1.2 million individuals yield new insights into the genetic etiology of tobacco and alcohol use

(2019) Mengzhen Liu et al.   NATURE GENETICS

GARFIELD classifies disease-relevant genomic features through integration of functional annotations with association signals

(2019) Valentina Iotchkova et al.   NATURE GENETICS

Blood pressure, hypertension and the risk of abdominal aortic aneurysms: a systematic review and meta-analysis of cohort studies

(2019) Elsa Kobeissi et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Chromatin Conformation Links Putative Enhancers in Intracranial Aneurysm–Associated Regions to Potential Candidate Genes

(2019) Melanie D. Laarman et al.   Journal of the American Heart Association

A global overview of pleiotropy and genetic architecture in complex traits

(2019) Kyoko Watanabe et al.   NATURE GENETICS

Risk Factors for Unruptured Intracranial Aneurysms and Subarachnoid Hemorrhage in a Prospective Population-Based Study

(2019) Tomm B. Müller et al.   STROKE

Rare Coding Variants in ANGPTL6 Are Associated with Familial Forms of Intracranial Aneurysm

(2018) Romain Bourcier et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics

(2018) Ivana Nedeljkovic et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Genetic identification of brain cell types underlying schizophrenia

(2018) Nathan G. Skene et al.   NATURE GENETICS

Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes

(2018) Rainer Malik et al.   NATURE GENETICS

Efficiently controlling for case-control imbalance and sample relatedness in large-scale genetic association studies

(2018) Wei Zhou et al.   NATURE GENETICS

Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits

(2018) Evangelos Evangelou et al.   NATURE GENETICS

Leveraging Polygenic Functional Enrichment to Improve GWAS Power

(2018) Gleb Kichaev et al.   AMERICAN JOURNAL OF HUMAN GENETICS

SumHer better estimates the SNP heritability of complex traits from summary statistics

(2018) Doug Speed et al.   NATURE GENETICS

Trans-ethnic association study of blood pressure determinants in over 750,000 individuals

(2018) Ayush Giri et al.   NATURE GENETICS

PCNT point mutations and familial intracranial aneurysms

(2018) Oswaldo Lorenzo-Betancor et al.   NEUROLOGY

Interethnic analyses of blood pressure loci in populations of East Asian and European descent

(2018) Fumihiko Takeuchi et al.   Nature Communications

Arterial smooth muscle cell PKD2 (TRPP1) channels regulate systemic blood pressure

(2018) Simon Bulley et al.   eLife

Stroke

(2017) Graeme J Hankey   LANCET

Epidemiology, Risk Factors, and Clinical Features of Intracerebral Hemorrhage: An Update

(2017) Sang Joon An et al.   Journal of Stroke

RNF213 Is Associated with Intracranial Aneurysms in the French-Canadian Population

(2016) Sirui Zhou et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Colocalization of GWAS and eQTL Signals Detects Target Genes

(2016) Farhad Hormozdiari et al.   AMERICAN JOURNAL OF HUMAN GENETICS

LD Hub: a centralized database and web interface to perform LD score regression that maximizes the potential of summary level GWAS data for SNP heritability and genetic correlation analysis

(2016) Jie Zheng et al.   BIOINFORMATICS

THSD1preserves vascular integrity and protects against intraplaque haemorrhaging in ApoE−/−mice

(2016) Remco A. Haasdijk et al.   CARDIOVASCULAR RESEARCH

Meta-Analysis of Genome-Wide Association Studies for Abdominal Aortic Aneurysm Identifies Four New Disease-Specific Risk LociNovelty and Significance

(2016) Gregory T. Jones et al.   CIRCULATION RESEARCH

Genome-wide association study of sporadic brain arteriovenous malformations

(2016) Shantel Weinsheimer et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Genome-wide association analyses using electronic health records identify new loci influencing blood pressure variation

(2016) Thomas J Hoffmann et al.   NATURE GENETICS

A missense variant in FGD6 confers increased risk of polypoidal choroidal vasculopathy

(2016) Lulin Huang et al.   NATURE GENETICS

Integration of summary data from GWAS and eQTL studies predicts complex trait gene targets

(2016) Zhihong Zhu et al.   NATURE GENETICS

Integrative approaches for large-scale transcriptome-wide association studies

(2016) Alexander Gusev et al.   NATURE GENETICS

Sex, Smoking, and Risk for Subarachnoid Hemorrhage

(2016) Joni Valdemar Lindbohm et al.   STROKE

Patient- and Aneurysm-Specific Risk Factors for Intracranial Aneurysm Growth

(2016) Daan Backes et al.   STROKE

THSD1 (Thrombospondin Type 1 Domain Containing Protein 1) Mutation in the Pathogenesis of Intracranial Aneurysm and Subarachnoid Hemorrhage

(2016) Teresa Santiago-Sim et al.   STROKE

Deficiency of Endothelium-Specific Transcription Factor Sox17 Induces Intracranial Aneurysm

(2015) S. Lee et al.   CIRCULATION

p130Cas/BCAR1 scaffold protein in tissue homeostasis and pathogenesis

(2015) Maria del Pilar Camacho Leal et al.   GENE

Partitioning heritability by functional annotation using genome-wide association summary statistics

(2015) Hilary K Finucane et al.   NATURE GENETICS

LD Score regression distinguishes confounding from polygenicity in genome-wide association studies

(2015) Brendan K Bulik-Sullivan et al.   NATURE GENETICS

Vascular complications in autosomal dominant polycystic kidney disease

(2015) Ronald D. Perrone et al.   Nature Reviews Nephrology

Genetic Study of Intracranial Aneurysms

(2015) Junxia Yan et al.   STROKE

Meta-analysis of Genome-wide Association Studies Identifies 1q22 as a Susceptibility Locus for Intracerebral Hemorrhage

(2014) Daniel Woo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Common variation in PHACTR1 is associated with susceptibility to cervical artery dissection

(2014) Stéphanie Debette et al.   NATURE GENETICS

High Risk Population Isolate Reveals Low Frequency Variants Predisposing to Intracranial Aneurysms

(2014) Mitja I. Kurki et al.   PLoS Genetics

Genome-Wide Association Studies of Intracranial Aneurysms

(2013) Ibrahim Hussain et al.   STROKE

Risk of Rupture of an Intracranial Aneurysm Based on Patient Characteristics

(2013) Monique H.M. Vlak et al.   STROKE

Conditional and joint multiple-SNP analysis of GWAS summary statistics identifies additional variants influencing complex traits

(2012) Jian Yang et al.   NATURE GENETICS

Female risk factors for subarachnoid hemorrhage: A systematic review

(2012) A. M. Algra et al.   NEUROLOGY

Genome-Wide Association Study of Intracranial Aneurysms Confirms Role of Anril and SOX17 in Disease Risk

(2012) Tatiana Foroud et al.   STROKE

Genome-wide meta-analyses of smoking behaviors in African Americans

(2012) S P David et al.   Translational Psychiatry

Prevalence of unruptured intracranial aneurysms, with emphasis on sex, age, comorbidity, country, and time period: a systematic review and meta-analysis

(2011) Monique HM Vlak et al.   LANCET NEUROLOGY

Common variant near the endothelin receptor type A (EDNRA) gene is associated with intracranial aneurysm risk

(2011) K. Yasuno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems Genetics Analysis of Gene-by-Environment Interactions in Human Cells

(2010) Casey E. Romanoski et al.   AMERICAN JOURNAL OF HUMAN GENETICS

METAL: fast and efficient meta-analysis of genomewide association scans

(2010) C. J. Willer et al.   BIOINFORMATICS

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

(2010)   NATURE GENETICS

Genome-wide association study of intracranial aneurysm identifies three new risk loci

(2010) Katsuhito Yasuno et al.   NATURE GENETICS

Genetic Epidemiology of Spontaneous Subarachnoid Hemorrhage

(2010) Miikka Korja et al.   STROKE

Changes in case fatality of aneurysmal subarachnoid haemorrhage over time, according to age, sex, and region: a meta-analysis

(2009) Dennis J Nieuwkamp et al.   LANCET NEUROLOGY