Understanding the role of the chromosome 15q25.1 in COPD through epigenetics and transcriptomics

Epigenetic Signatures of Cigarette SmokingCLINICAL PERSPECTIVE

(2016) Roby Joehanes et al.   Circulation-Cardiovascular Genetics

Tobacco smoking is associated with DNA methylation of diabetes susceptibility genes

(2016) Symen Ligthart et al.   DIABETOLOGIA

Genetic and environmental impacts on DNA methylation levels in twins

(2016) Idil Yet et al.   Epigenomics

The role of epigenetics in genetic and environmental epidemiology

(2016) Christine Ladd-Acosta et al.   Epigenomics

Epigenetic Signatures of Cigarette SmokingCLINICAL PERSPECTIVE

(2016) Roby Joehanes et al.   Circulation-Cardiovascular Genetics

Smoking-Associated Site-Specific Differential Methylation in Buccal Mucosa in the COPDGene Study

(2015) Emily S. Wan et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A multiancestry study identifies novel genetic associations withCHRNA5methylation in human brain and risk of nicotine dependence

(2015) Dana B. Hancock et al.   HUMAN MOLECULAR GENETICS

Systematic DNA methylation analysis of multiple cell lines reveals common and specific patterns within and across tissues of origin

(2015) Xiaofei Yang et al.   HUMAN MOLECULAR GENETICS

Genome-wide interaction study of gene-by-occupational exposure and effects on FEV 1 levels

(2015) Kim de Jong et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Susceptibility loci for lung cancer are associated with mRNA levels of nearby genes in the lung

(2014) Justin Dang Uy Nguyen et al.   CARCINOGENESIS

Cigarette smoking reduces DNA methylation levels at multiple genomic loci but the effect is partially reversible upon cessation

(2014) Loukia G Tsaprouni et al.   Epigenetics

Regulatory effect of iron regulatory protein-2 on iron metabolism in lung cancer

(2014) Z. Cheng et al.   GENETICS AND MOLECULAR RESEARCH

Four SNPs in the CHRNA3/5 Alpha-Neuronal Nicotinic Acetylcholine Receptor Subunit Locus Are Associated with COPD Risk Based on Meta-Analyses

(2014) Kai Cui et al.   PLoS One

Risk loci for chronic obstructive pulmonary disease: a genome-wide association study and meta-analysis

(2014) Michael H Cho et al.   Lancet Respiratory Medicine

Heritability of Chronic Obstructive Pulmonary Disease and Related Phenotypes in Smokers

(2013) Jin J. Zhou et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

DNA Methylation Is Globally Disrupted and Associated with Expression Changes in Chronic Obstructive Pulmonary Disease Small Airways

(2013) Emily A. Vucic et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

DNA Methylation as a Long-term Biomarker of Exposure to Tobacco Smoke

(2013) Natalie S. Shenker et al.   EPIDEMIOLOGY

Dissecting direct and indirect genetic effects on chronic obstructive pulmonary disease (COPD) susceptibility

(2013) Mateusz Siedlinski et al.   HUMAN GENETICS

Systematic identification of trans eQTLs as putative drivers of known disease associations

(2013) Harm-Jan Westra et al.   NATURE GENETICS

Tobacco Smoking Leads to Extensive Genome-Wide Changes in DNA Methylation

(2013) Sonja Zeilinger et al.   PLoS One

Genome-Wide Association Studies IdentifyCHRNA5/3andHTR4in the Development of Airflow Obstruction

(2012) Jemma B. Wilk et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease

(2012) Jørgen Vestbo et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

CHRNA3/5,IREB2, andADCY2Are Associated with Severe Chronic Obstructive Pulmonary Disease in Poland

(2012) Megan Hardin et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Association of IREB2 and CHRNA3/5 polymorphisms with COPD and COPD-related phenotypes in a Chinese Han population

(2012) Haixia Zhou et al.   JOURNAL OF HUMAN GENETICS

Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010

(2012) Rafael Lozano et al.   LANCET

Nicotinic Acetylcholine Receptor Variants Are Related to Smoking Habits, but Not Directly to COPD

(2012) Simona E. Budulac et al.   PLoS One

Association of IREB2 and CHRNA3 polymorphisms with airflow obstruction in severe alpha-1 antitrypsin deficiency

(2012) Woo Jin Kim et al.   RESPIRATORY RESEARCH

Systematic Localization of Common Disease-Associated Variation in Regulatory DNA

(2012) M. T. Maurano et al.   SCIENCE

Updates on the COPD gene list

(2012) Yohan Bosse   International Journal of Chronic Obstructive Pulmonary Disease

Variable DNA Methylation Is Associated with Chronic Obstructive Pulmonary Disease and Lung Function

(2011) Weiliang Qiu et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

5-Aza-2′-deoxycytidine Activates Iron Uptake and Heme Biosynthesis by Increasing c-Myc Nuclear Localization and Binding to the E-boxes of Transferrin Receptor 1 (TfR1) and Ferrochelatase (Fech) Genes

(2011) Bo Ning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genome-wide association and large-scale follow up identifies 16 new loci influencing lung function

(2011) María Soler Artigas et al.   NATURE GENETICS

Genetics of Sputum Gene Expression in Chronic Obstructive Pulmonary Disease

(2011) Weiliang Qiu et al.   PLoS One

Aberrant DNA Methylation Links Cancer Susceptibility Locus 15q25.1 to Apoptotic Regulation and Lung Cancer

(2010) Anupam Paliwal et al.   CANCER RESEARCH

Genome-wide meta-analyses identify multiple loci associated with smoking behavior

(2010)   NATURE GENETICS

Variants in FAM13A are associated with chronic obstructive pulmonary disease

(2010) Michael H Cho et al.   NATURE GENETICS

Meta-analysis and imputation refines the association of 15q25 with smoking quantity

(2010) Jason Z Liu et al.   NATURE GENETICS

Multiple Independent Loci at Chromosome 15q25.1 Affect Smoking Quantity: a Meta-Analysis and Comparison with Lung Cancer and COPD

(2010) Nancy L. Saccone et al.   PLoS Genetics

Integration of Genomic and Genetic Approaches Implicates IREB2 as a COPD Susceptibility Gene

(2009) Dawn L. DeMeo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5

(2009) Jen C. Wang et al.   HUMAN MOLECULAR GENETICS

Potential etiologic and functional implications of genome-wide association loci for human diseases and traits

(2009) L. A. Hindorff et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Genome-Wide Association Study in Chronic Obstructive Pulmonary Disease (COPD): Identification of Two Major Susceptibility Loci

(2009) Sreekumar G. Pillai et al.   PLoS Genetics

Global DNA methylation is influenced by smoking behaviour

(2008) Thomas Hillemacher et al.   EUROPEAN NEUROPSYCHOPHARMACOLOGY

A susceptibility locus for lung cancer maps to nicotinic acetylcholine receptor subunit genes on 15q25

(2008) Rayjean J. Hung et al.   NATURE