Defining new chemical space for drug penetration into Gram-negative bacteria
Published 2020 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Defining new chemical space for drug penetration into Gram-negative bacteria
Authors
Keywords
-
Journal
Nature Chemical Biology
Volume 16, Issue 12, Pages 1293-1302
Publisher
Springer Science and Business Media LLC
Online
2020-11-17
DOI
10.1038/s41589-020-00674-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Electrophysiological characterization of transport across outer membrane channels from Gram-negative bacteria in presence of lipopolysaccharides (LPS)
- (2020) Jiajun Wang et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Drug Permeation against Efflux by Two Transporters
- (2020) Paramita Saha et al. ACS Infectious Diseases
- A Gram-Negative Antibiotic Active Through Inhibition of an Essential Riboswitch
- (2020) Stephen E. Motika et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Discovery of multidrug efflux pump inhibitors with a novel chemical scaffold
- (2020) Adam T. Green et al. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
- Development and optimization of a higher throughput bacterial compound accumulation assay
- (2019) Marcella Widya et al. ACS Infectious Diseases
- First-generation structure-activity relationship studies of 2,3,4,9-tetrahydro-1H-carbazol-1-amines as CpxA phosphatase inhibitors
- (2019) Yangxiong Li et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Breaching the Barrier: Quantifying Antibiotic Permeability across Gram-negative Bacterial Membranes
- (2019) Jehangir Cama et al. JOURNAL OF MOLECULAR BIOLOGY
- Electrically induced bacterial membrane-potential dynamics correspond to cellular proliferation capacity
- (2019) James P. Stratford et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Permeability barriers of Gram-negative pathogens
- (2019) Helen I. Zgurskaya et al. Annals of the New York Academy of Sciences
- Pleiotropic effects of rfa-gene mutations on Escherichia coli envelope properties
- (2019) Christophe Pagnout et al. Scientific Reports
- Efflux Pumps of Burkholderia thailandensis Control the Permeability Barrier of the Outer Membrane
- (2019) Ganesh Krishnamoorthy et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Flow Cytometric Analysis of Efflux by Dye Accumulation
- (2019) Emily E. Whittle et al. Frontiers in Microbiology
- Implementation of permeation rules leads to a FabI inhibitor with activity against Gram-negative pathogens
- (2019) Erica N. Parker et al. Nature Microbiology
- Porins and small-molecule translocation across the outer membrane of Gram-negative bacteria
- (2019) Julia Vergalli et al. NATURE REVIEWS MICROBIOLOGY
- Recent achievements and current trajectories of diversity-oriented synthesis
- (2019) Christopher J Gerry et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- The challenge of converting Gram-positive-only compounds into broad-spectrum antibiotics
- (2018) Michelle F. Richter et al. Annals of the New York Academy of Sciences
- Drug permeation and metabolism in Mycobacterium tuberculosis : Prioritising local exposure as essential criterion in new TB drug development
- (2018) Lloyd Tanner et al. IUBMB LIFE
- Spectrofluorimetric quantification of antibiotic drug concentration in bacterial cells for the characterization of translocation across bacterial membranes
- (2018) Julia Vergalli et al. Nature Protocols
- Trans-envelope multidrug efflux pumps of Gram-negative bacteria and their synergism with the outer membrane barrier
- (2018) Helen I. Zgurskaya et al. RESEARCH IN MICROBIOLOGY
- Fluorescent Antibiotics: New Research Tools to Fight Antibiotic Resistance
- (2018) M. Rhia L. Stone et al. TRENDS IN BIOTECHNOLOGY
- High throughput reaction screening using desorption electrospray ionization mass spectrometry
- (2018) Michael Wleklinski et al. Chemical Science
- Molecular Properties That Define the Activities of Antibiotics in Escherichia coli and Pseudomonas aeruginosa
- (2018) Sarah J. Cooper et al. ACS Infectious Diseases
- Getting drugs into Gram-negative bacteria: Rational rules for permeation through general porins
- (2018) Silvia Acosta-Gutierrez et al. ACS Infectious Diseases
- Antibacterial Drug Discovery: Some Assembly Required
- (2018) Rubén Tommasi et al. ACS Infectious Diseases
- Evaluating LC–MS/MS To Measure Accumulation of Compounds within Bacteria
- (2018) Ramkumar Iyer et al. ACS Infectious Diseases
- Subcellular Quantification of Uptake in Gram-Negative Bacteria
- (2018) Hans Prochnow et al. ANALYTICAL CHEMISTRY
- Real-Time Screening of Biocatalysts in Live Bacterial Colonies
- (2017) Cunyu Yan et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Predictive compound accumulation rules yield a broad-spectrum antibiotic
- (2017) Michelle F. Richter et al. NATURE
- Synergy between Active Efflux and Outer Membrane Diffusion Defines Rules of Antibiotic Permeation into Gram-Negative Bacteria
- (2017) Ganesh Krishnamoorthy et al. mBio
- Whole-Cell-Based Assay To Evaluate Structure Permeation Relationships for Carbapenem Passage through the Pseudomonas aeruginosa Porin OprD
- (2017) Ramkumar Iyer et al. ACS Infectious Diseases
- Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria
- (2017) Muriel Masi et al. Nature Microbiology
- Bifurcation kinetics of drug uptake by Gram-negative bacteria
- (2017) David A. Westfall et al. PLoS One
- The Power of Asymmetry: Architecture and Assembly of the Gram-Negative Outer Membrane Lipid Bilayer
- (2016) Jeremy C. Henderson et al. Annual Review of Microbiology
- A Gestalt approach to Gram-negative entry
- (2016) Lynn L. Silver BIOORGANIC & MEDICINAL CHEMISTRY
- Thinking Outside the “Bug”: A Unique Assay To Measure Intracellular Drug Penetration in Gram-Negative Bacteria
- (2015) Ying Zhou et al. ANALYTICAL CHEMISTRY
- Microbicides Alter the Expression and Function of RND-Type Efflux Pump AdeABC in Biofilm-Associated Cells of Acinetobacter baumannii Clinical Isolates
- (2015) Suvarna Krishnamoorthy et al. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY
- Toward the Rational Design of Carbapenem Uptake in Pseudomonas aeruginosa
- (2015) Vincent M. Isabella et al. CHEMISTRY & BIOLOGY
- Mass spectrometry imaging of levofloxacin distribution in TB-infected pulmonary lesions by MALDI-MSI and continuous liquid microjunction surface sampling
- (2015) Brendan Prideaux et al. INTERNATIONAL JOURNAL OF MASS SPECTROMETRY
- ESKAPEing the labyrinth of antibacterial discovery
- (2015) Ruben Tommasi et al. NATURE REVIEWS DRUG DISCOVERY
- Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It
- (2015) Helen I. Zgurskaya et al. ACS Infectious Diseases
- General Platform for Systematic Quantitative Evaluation of Small-Molecule Permeability in Bacteria
- (2014) Tony D. Davis et al. ACS Chemical Biology
- Following Drug Uptake and Reactions inside Escherichia coli Cells by Raman Microspectroscopy
- (2014) Hossein Heidari Torkabadi et al. BIOCHEMISTRY
- Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens
- (2014) Dean G. Brown et al. JOURNAL OF MEDICINAL CHEMISTRY
- A ring-distortion strategy to construct stereochemically complex and structurally diverse compounds from natural products
- (2013) Robert W. Huigens III et al. Nature Chemistry
- Diversity-oriented synthesis: producing chemical tools for dissecting biology
- (2012) Cornelius J. O' Connor et al. CHEMICAL SOCIETY REVIEWS
- Recover the lost art of drug discovery
- (2012) Kim Lewis NATURE
- Antibiotic Transport in Resistant Bacteria: Synchrotron UV Fluorescence Microscopy to Determine Antibiotic Accumulation with Single Cell Resolution
- (2012) Slávka Kaščáková et al. PLoS One
- A Microfluidic Vesicle Screening Platform: Monitoring the Lipid Membrane Permeability of Tetracyclines
- (2011) Phillip Kuhn et al. ANALYTICAL CHEMISTRY
- High-Sensitivity MALDI-MRM-MS Imaging of Moxifloxacin Distribution in Tuberculosis-Infected Rabbit Lungs and Granulomatous Lesions
- (2011) Brendan Prideaux et al. ANALYTICAL CHEMISTRY
- Fluorometric determination of ethidium bromide efflux kinetics in Escherichia coli
- (2009) Laura Paixão et al. Journal of Biological Engineering
- Development of a liquid chromatography/mass spectrometry-based drug accumulation assay in Pseudomonas aeruginosa
- (2008) Hongliang Cai et al. ANALYTICAL BIOCHEMISTRY
- Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE
- (2008) Louis B. Rice JOURNAL OF INFECTIOUS DISEASES
- Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery
- (2008) Rosemarie O’Shea et al. JOURNAL OF MEDICINAL CHEMISTRY
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAsk a Question. Answer a Question.
Quickly pose questions to the entire community. Debate answers and get clarity on the most important issues facing researchers.
Get Started