Spectrofluorimetric quantification of antibiotic drug concentration in bacterial cells for the characterization of translocation across bacterial membranes

Identification and Structure–Activity Relationships of Novel Compounds that Potentiate the Activities of Antibiotics in Escherichia coli

(2017) Keith M. Haynes et al.   JOURNAL OF MEDICINAL CHEMISTRY

Predictive compound accumulation rules yield a broad-spectrum antibiotic

(2017) Michelle F. Richter et al.   NATURE

Microspectrofluorimetry to dissect the permeation of ceftazidime in Gram-negative bacteria

(2017) Anas Allam et al.   Scientific Reports

Comparing efficacies of moxifloxacin, levofloxacin and gatifloxacin in tuberculosis granulomas using a multi-scale systems pharmacology approach

(2017) Elsje Pienaar et al.   PLoS Computational Biology

Mechanisms of envelope permeability and antibiotic influx and efflux in Gram-negative bacteria

(2017) Muriel Masi et al.   Nature Microbiology

Bifurcation kinetics of drug uptake by Gram-negative bacteria

(2017) David A. Westfall et al.   PLoS One

Fluoroquinolone structure and translocation flux across bacterial membrane

(2017) Julia Vergalli et al.   Scientific Reports

New Insight into Daptomycin Bioavailability and Localization in Staphylococcus aureus Biofilms by Dynamic Fluorescence Imaging

(2016) Rym Boudjemaa et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

A Gestalt approach to Gram-negative entry

(2016) Lynn L. Silver   BIOORGANIC & MEDICINAL CHEMISTRY

Antibiotic Adjuvants: Rescuing Antibiotics from Resistance

(2016) Gerard D. Wright   TRENDS IN MICROBIOLOGY

How to Measure Export via Bacterial Multidrug Resistance Efflux Pumps

(2016) Jessica M. A. Blair et al.   mBio

Fluorescent Trimethoprim Conjugate Probes To Assess Drug Accumulation in Wild Type and Mutant Escherichia coli

(2016) Wanida Phetsang et al.   ACS Infectious Diseases

Microbicides Alter the Expression and Function of RND-Type Efflux Pump AdeABC in Biofilm-Associated Cells of Acinetobacter baumannii Clinical Isolates

(2015) Suvarna Krishnamoorthy et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Visualizing Attack of Escherichia coli by the Antimicrobial Peptide Human Defensin 5

(2015) Haritha R. Chileveru et al.   BIOCHEMISTRY

The Challenge of Efflux-Mediated Antibiotic Resistance in Gram-Negative Bacteria

(2015) Xian-Zhi Li et al.   CLINICAL MICROBIOLOGY REVIEWS

New antibiotics and antimicrobial combination therapy for the treatment of gram-negative bacterial infections

(2015) Matteo Bassetti et al.   Current Opinion in Critical Care

Physical methods to quantify small antibiotic molecules uptake into Gram-negative bacteria

(2015) Mathias Winterhalter et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Antibiotic resistance breakers: can repurposed drugs fill the antibiotic discovery void?

(2015) David Brown   NATURE REVIEWS DRUG DISCOVERY

Microspectrometric insights on the uptake of antibiotics at the single bacterial cell level

(2015) Bertrand Cinquin et al.   Scientific Reports

Permeability Barrier of Gram-Negative Cell Envelopes and Approaches To Bypass It

(2015) Helen I. Zgurskaya et al.   ACS Infectious Diseases

In Vivo Evolution of Bacterial Resistance in Two Cases of Enterobacter aerogenes Infections during Treatment with Imipenem

(2015) Nadège Philippe et al.   PLoS One

General Platform for Systematic Quantitative Evaluation of Small-Molecule Permeability in Bacteria

(2014) Tony D. Davis et al.   ACS Chemical Biology

Probing the Penetration of Antimicrobial Polymyxin Lipopeptides into Gram-Negative Bacteria

(2014) Zakuan Z. Deris et al.   BIOCONJUGATE CHEMISTRY

Discovery and development of new antibacterial agents targeting Gram-negative bacteria in the era of pandrug resistance: is the future promising?

(2014) Malcolm GP Page et al.   CURRENT OPINION IN PHARMACOLOGY

French regional surveillance program of carbapenemase-producing Gram-negative bacilli: results from a 2-year period

(2014) A. Pantel et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Trends and Exceptions of Physical Properties on Antibacterial Activity for Gram-Positive and Gram-Negative Pathogens

(2014) Dean G. Brown et al.   JOURNAL OF MEDICINAL CHEMISTRY

Molecular mechanisms of antibiotic resistance

(2014) Jessica M. A. Blair et al.   NATURE REVIEWS MICROBIOLOGY

TRANSLOCATION Project: How to Get Good Drugs into Bad Bugs

(2014) R. A. Stavenger et al.   Science Translational Medicine

A Combined Pharmacodynamic Quantitative and Qualitative Model Reveals the Potent Activity of Daptomycin and Delafloxacin against Staphylococcus aureus Biofilms

(2013) Julia Bauer et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Deep UV autofluorescence microscopy for cell biology and tissue histology

(2013) Frédéric Jamme et al.   BIOLOGY OF THE CELL

10 x '20 Progress--Development of New Drugs Active Against Gram-Negative Bacilli: An Update From the Infectious Diseases Society of America

(2013) H. W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Permeation rates of penicillins indicate that Escherichia coli porins function principally as nonspecific channels

(2013) S. Kojima et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

New Peptide-Based Antimicrobials for Tackling Drug Resistance in Bacteria: Single-Cell Fluorescence Imaging

(2013) Jean-Marie Pagès et al.   ACS Medicinal Chemistry Letters

Single-molecule imaging in live bacteria cells

(2012) K. Ritchie et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Antibiotic Transport in Resistant Bacteria: Synchrotron UV Fluorescence Microscopy to Determine Antibiotic Accumulation with Single Cell Resolution

(2012) Slávka Kaščáková et al.   PLoS One

Strategies for bypassing the membrane barrier in multidrug resistant Gram-negative bacteria

(2011) Jean-Michel Bolla et al.   FEBS LETTERS

Diffusion of Ofloxacin in the Endocarditis Vegetation Assessed with Synchrotron Radiation UV Fluorescence Microspectrocopy

(2011) Eric Batard et al.   PLoS One

Kinetic Parameters of Efflux of Penicillins by the Multidrug Efflux Transporter AcrAB-TolC of Escherichia coli

(2010) S. P. Lim et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Synchrotron UV Fluorescence Microscopy Uncovers New Probes in Cells and Tissues

(2010) Frederic Jamme et al.   MICROSCOPY AND MICROANALYSIS

Kinetic behavior of the major multidrug efflux pump AcrB of Escherichia coli

(2009) K. Nagano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bad Bugs, No Drugs: No ESKAPE! An Update from the Infectious Diseases Society of America

(2008) Helen W. Boucher et al.   CLINICAL INFECTIOUS DISEASES

Membrane Permeability and Regulation of Drug “Influx and Efflux” in Enterobacterial Pathogens

(2008) Anne Davin-Regli et al.   CURRENT DRUG TARGETS

Physicochemical Properties of Antibacterial Compounds: Implications for Drug Discovery

(2008) Rosemarie O’Shea et al.   JOURNAL OF MEDICINAL CHEMISTRY

The porin and the permeating antibiotic: a selective diffusion barrier in Gram-negative bacteria

(2008) Jean-Marie Pagès et al.   NATURE REVIEWS MICROBIOLOGY