Synthesis and Conformational Analysis of Fluorinated Uridine Analogues Provide Insight into a Neighbouring-Group Participation Mechanism

Contribution of Organofluorine Compounds to Pharmaceuticals

(2020) Munenori Inoue et al.   ACS Omega

A short de novo synthesis of nucleoside analogs

(2020) Michael Meanwell et al.   SCIENCE

RX-3117 (fluorocyclopentenyl cytosine): a novel specific antimetabolite for selective cancer treatment

(2019) Beatrice Balboni et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Application of Sugar-Base Anhydro Bridge for Modification of Nucleosides in the 2’- and/or 3’-Positions – Revisited

(2019) Maurycy Szlenkier et al.   CURRENT ORGANIC CHEMISTRY

Anti-tumour activity of a first-in-class agent NUC-1031 in patients with advanced cancer: results of a phase I study

(2018) Sarah P. Blagden et al.   BRITISH JOURNAL OF CANCER

The evolution of antiviral nucleoside analogues: A review for chemists and non-chemists. Part II: Complex modifications to the nucleoside scaffold

(2018) Mary K. Yates et al.   ANTIVIRAL RESEARCH

Fluorinated nucleosides as an important class of anticancer and antiviral agents

(2017) Alessandra Cavaliere et al.   Future Medicinal Chemistry

Fluorometabolite biosynthesis: isotopically labelled glycerol incorporations into the antibiotic nucleocidin in Streptomyces calvus

(2017) Axel Bartholomé et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Synthesis of Antitumor Fluorinated Pyrimidine Nucleosides

(2017) Patrizia Ferraboschi et al.   ORGANIC PREPARATIONS AND PROCEDURES INTERNATIONAL

Metabolism, Biochemical Actions, and Chemical Synthesis of Anticancer Nucleosides, Nucleotides, and Base Analogs

(2016) Jadd Shelton et al.   CHEMICAL REVIEWS

Phase 1b study of the oral gemcitabine ‘Pro-drug’ LY2334737 in combination with capecitabine in patients with advanced solid tumors

(2015) Jeffrey R. Infante et al.   INVESTIGATIONAL NEW DRUGS

Applications of Fluorine in Medicinal Chemistry

(2015) Eric P. Gillis et al.   JOURNAL OF MEDICINAL CHEMISTRY

Synthesis and Properties of 2′-Deoxy-2′,4′-difluoroarabinose-Modified Nucleic Acids

(2015) Saúl Martínez-Montero et al.   JOURNAL OF ORGANIC CHEMISTRY

The synthesis of gemcitabine

(2014) Kylie Brown et al.   CARBOHYDRATE RESEARCH

Discontinued in 2013: oncology drugs

(2014) Robert Williams   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Design, Synthesis, and Pharmacological Evaluation of Fluorinated Tetrahydrouridine Derivatives as Inhibitors of Cytidine Deaminase

(2014) Dana Ferraris et al.   JOURNAL OF MEDICINAL CHEMISTRY

Application of ProTide Technology to Gemcitabine: A Successful Approach to Overcome the Key Cancer Resistance Mechanisms Leads to a New Agent (NUC-1031) in Clinical Development

(2014) Magdalena Slusarczyk et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rigid 2′,4′-Difluororibonucleosides: Synthesis, Conformational Analysis, and Incorporation into Nascent RNA by HCV Polymerase

(2014) Saúl Martínez-Montero et al.   JOURNAL OF ORGANIC CHEMISTRY

Advances in the development of nucleoside and nucleotide analogues for cancer and viral diseases

(2013) Lars Petter Jordheim et al.   NATURE REVIEWS DRUG DISCOVERY

Conformational Analysis of Fluorinated Pyrrolidines Using19F-1H Scalar Couplings and Heteronuclear NOEs

(2012) Lorraine E. Combettes et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highlights in Antiviral Drug Research: Antivirals at the Horizon

(2012) Erik De Clercq   MEDICINAL RESEARCH REVIEWS

Synthesis and structural studies of S-type/N-type-locked/frozen nucleoside analogues and their incorporation in RNA-selective, nuclease resistant 2′–5′ linked oligonucleotides

(2012) Namrata Erande et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Biogenesis of the Unique 4′,5′-Dehydronucleoside of the Uridyl Peptide Antibiotic Pacidamycin

(2011) Amany E. Ragab et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Synthesis and in vitro antiviral activities of 3′-fluoro (or chloro) and 2′,3′-difluoro 2′,3′-dideoxynucleoside analogs against hepatitis B and C viruses

(2010) Naveen C. Srivastav et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Recent advances in the synthesis of fluorinated nucleosides

(2009) Xiao-Long Qiu et al.   TETRAHEDRON

Comprehensive Structural Studies of 2′,3′-Difluorinated Nucleosides: Comparison of Theory, Solution, and Solid State

(2008) Joseph J. Barchi et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Understanding organofluorine chemistry. An introduction to the C–F bond

(2007) David O'Hagan   CHEMICAL SOCIETY REVIEWS