Suppression of amyloid-β production by 24S-hydroxycholesterol via inhibition of intracellular amyloid precursor protein trafficking

Role of Cholesterol in APP Metabolism and Its Significance in Alzheimer’s Disease Pathogenesis

(2012) M. Maulik et al.   MOLECULAR NEUROBIOLOGY

The Amyloid Precursor Protein Has a Flexible Transmembrane Domain and Binds Cholesterol

(2012) P. J. Barrett et al.   SCIENCE

Plasma 24S-hydroxycholesterol levels in elderly subjects with late onset Alzheimer's disease or vascular dementia: a case-control study

(2011) Giovanni Zuliani et al.   BMC Neurology

Oxysterol Derivatives of Cholesterol in Neurodegenerative Disorders

(2011) T. M. Jeitner et al.   CURRENT MEDICINAL CHEMISTRY

24(S)-Hydroxycholesterol Induces Neuronal Cell Death through Necroptosis, a Form of Programmed Necrosis

(2011) Kazunori Yamanaka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Linking lipids to Alzheimer's disease: cholesterol and beyond

(2011) Gilbert Di Paolo et al.   NATURE REVIEWS NEUROSCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

(2010) E. Y. Bryleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Acyl-coenzyme A:cholesterol acyltransferases

(2009) Ta-Yuan Chang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain

(2009) David W. Russell et al.   Annual Review of Biochemistry

Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway

(2009) Henri J. Huttunen et al.   FASEB JOURNAL

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

(2009) Antero Salminen et al.   Journal of Neuroinflammation

Differential effects of 24-hydroxycholesterol and 27-hydroxycholesterol on β-amyloid precursor protein levels and processing in human neuroblastoma SH-SY5Y cells

(2009) Jaya RP Prasanthi et al.   Molecular Neurodegeneration

Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

(2009) Eloise Hudry et al.   MOLECULAR THERAPY

Reduction of cholesterol synthesis in the mouse brain does not affect amyloid formation in Alzheimer's disease, but does extend lifespan

(2009) R. W. Halford et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Precursor Protein Trafficking, Processing, and Function

(2008) Gopal Thinakaran et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transport of LDL-derived cholesterol from the NPC1 compartment to the ER involves the trans-Golgi network and the SNARE protein complex

(2008) Y. Urano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA