Review
Chemistry, Multidisciplinary
Tatiana Rogova, Eric Ahrweiler, Markus D. Schoetz, Franziska Schoenebeck
Summary: Within the traditional Pd0/PdII cross coupling reactions, organogermanes have been historically underutilized as coupling partners. Recent studies have discovered alternative activation modes that unlock their chemoselective and orthogonal reactivity, making the germanium motif the most reactive site on a given substrate. Herein, we highlight some of the latest advances in organogermane chemistry, particularly in synthetic transformations and preparation.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biochemistry & Molecular Biology
Yun Hu, Jennifer M. Schomaker
Summary: In the past decade, various metal-free bioorthogonal reactions have been developed to achieve simultaneous double-click labeling with minimal competing cross-reactivities, referred to as "mutually orthogonal". Recently, successful triple ligation strategies have also been described. This mini-review discusses the progress in developing orthogonal bioorthogonal reactions and strategies for achieving simultaneous, mutually orthogonal click reactions in one pot.
Review
Chemistry, Multidisciplinary
Florian M. Zielke, Floris P. J. T. Rutjes
Summary: This overview highlights recent advances in the field of bioconjugation, including protein functionalization using the specific reactivity of amino acids and the use of novel bioorthogonal reagents for biomolecular modification.
TOPICS IN CURRENT CHEMISTRY
(2023)
Article
Chemistry, Organic
Chaohuang Chen, Gerald Kehr, Gerhard Erker
Summary: Negatively charged borataalkenes and neutral boraalkenes are isolable organoelement compounds containing BC double bonds. The use of strongly electron withdrawing fluoroaryl substituents at boron greatly facilitates their preparation. The presence of fluoroaryl groups on boranes enhances the acidity of a-CH, promoting the formation of borataalkenes through deprotonation. Synthetic routes involving B-H borenium cations with fluoroaryl groups have been developed to produce reactive boraalkenes. Both borataalkenes and boraalkenes can serve as p-ligands in organometallic and coordination chemistry.
ORGANIC CHEMISTRY FRONTIERS
(2023)
Review
Chemistry, Applied
Farid Ahmed, Hai Xiong
Summary: This review summarizes the latest developments in chemosensors based on click generated triazoles for a range of metal cations, anions, and neutral analytes, highlighting the need for continuous research accumulation in this rapidly growing field to meet demand.
Review
Chemistry, Inorganic & Nuclear
Nathan T. Coles, Anne Sofie Abels, Julia Leitl, Robert Wolf, Hansjoerg Gruetzmacher, Christian Mueller
Summary: This review summarizes the progress made in the coordination chemistry of 1-phosphinines, 1,4-diphosphinines and 1,3,5-triphosphinines and related ligands over the past 10 years. It emphasizes the reactivity and application of phosphinine-containing transition metal complexes, as well as the electronic, structural and coordination properties of the corresponding phosphorus heterocycle.
COORDINATION CHEMISTRY REVIEWS
(2021)
Review
Chemistry, Multidisciplinary
Ying Zhang, Jun-Jie Chen, Huan-Ming Huang
Summary: The Brook rearrangement is an important molecular rearrangement in synthetic chemistry that has applications in the generation of complexes, drug discovery, material science, and natural products synthesis. While the radical Brook rearrangement has received less attention compared to the widely known ionic mechanism, recent advances in photocatalytic reactions and transition-metal-catalyzed cross-coupling reactions have contributed to its exploration.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2022)
Review
Chemistry, Multidisciplinary
Xin Wang, Xianrui Zhang, Zongyu Huang, Xinyuan Fan, Peng R. Chen
Summary: Bioorthogonal chemistry refers to chemical reactions that can be carried out in biological systems without interfering with natural biochemical processes. Chinese chemical biologists have actively participated in this area, particularly in the creation and development of bioorthogonal cleavage reactions. Future developments in remote-control bioorthogonal chemistry may drive these reactions into living animals or even human beings.
ACTA CHIMICA SINICA
(2021)
Review
Food Science & Technology
Jessica Pandohee, Emmanuel Kyereh, Saurabh Kulshrestha, Baojun Xu, Mohamad Fawzi Mahomoodally
Summary: Phytochemicals are important bioactive components found in natural products. The identification of their main bioactive molecules and their mechanisms of action in the human body was previously unknown but is now made possible through the development of metabolomics. This review discusses the importance of key dietary phytochemicals and their potential functions for human health, and highlights the use of untargeted metabolomics as the most common method for studying phytochemicals in foods.
CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION
(2023)
Review
Chemistry, Inorganic & Nuclear
Awal Noor
Summary: Stabilization of transition metals in unusually low coordination numbers has been a challenging area of interest in coordination chemistry. The use of appropriate sterically bulky ligands enables the isolation and exploration of such rare species, allowing for the study of their bonding and chemical reactivity. The fine tuning of ligand design, balancing bulk and electronic effects, plays a crucial role in determining their reactivity. Despite synthetic difficulties, the isolation and characterization of these low coordinate transition metal complexes have received significant attention in recent years. This review discusses the synthetic approaches and the establishment of their geometric and electronic structures using advanced spectroscopic techniques in the past decade.
COORDINATION CHEMISTRY REVIEWS
(2023)
Review
Chemistry, Multidisciplinary
Eszter Kozma, Marton Bojtar, Peter Kele
Summary: Photoresponsive materials with spatiotemporal control have significant potential in targeted cancer therapies. The combination of photoactivatable approaches with bioorthogonal chemistry enhances precision and may have profound implications in treating disperse/diffuse tumors. The intensified research in bioorthogonally assisted phototherapy is justified by the anticipated growth of further developments in the field, making a timely summary of the state of the art necessary.
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
(2023)
Review
Biotechnology & Applied Microbiology
Markus Hobisch, Dirk Holtmann, Patricia Gomez de Santos, Miguel Alcalde, Frank Hollmann, Selin Kara
Summary: Peroxygenases are a new class of enzymes that allow selective oxyfunctionalisation reactions without the need for a cofactor, different from well-known P450 monooxygenases. Recent developments in organic synthesis, molecular biotechnology, and reaction engineering have focused on utilizing these enzymes in industrial applications. There is great potential for peroxygenases in selective oxyfunctionalisations and further studies are required to explore their full capabilities in organic synthesis.
BIOTECHNOLOGY ADVANCES
(2021)
Review
Biochemistry & Molecular Biology
Wenzhe Yi, Ping Xiao, Xiaochen Liu, Zitong Zhao, Xiangshi Sun, Jue Wang, Lei Zhou, Guanru Wang, Haiqiang Cao, Dangge Wang, Yaping Li
Summary: Bioorthogonal chemistry reactions can occur in physiological conditions and have shown great potential in drug delivery with high efficiency and specificity.
SIGNAL TRANSDUCTION AND TARGETED THERAPY
(2022)
Review
Chemistry, Multidisciplinary
Nasim Ghavidel, Pedram Fatehi
Summary: This Review focused on the recent progress in using plant-based polymers and particles for stabilizing Pickering and non-Pickering emulsion systems. It discussed how the source, modification, and formulation of cellulose, starch, protein, and lignin-based polymers and particles affect their emulsion stabilization, as well as the material synthesis and effects on oil/water systems and oil droplet structures. The wide range of applications and future perspectives of plant-based stabilizers in different technologies were also described.
Review
Biochemistry & Molecular Biology
Karine Porte, Maxime Riberaud, Remi Chatre, Davide Audisio, Sebastien Papot, Frederic Taran
Summary: The advent of bioorthogonal chemistry has enabled ambitious applications of unnatural chemical reactions within living organisms, a long-sought goal in chemical biology. This review highlights the progress in understanding fundamental biological processes and the development of novel imaging and therapeutic strategies using bioorthogonal chemistry in animal models.