Applications of Copper-Catalyzed Click Chemistry in Activity-Based Protein Profiling

Proteome-Wide Reactivity Profiling Identifies Diverse Carbamate Chemotypes Tuned for Serine Hydrolase Inhibition

(2013) Jae Won Chang et al.   ACS Chemical Biology

A Competitive Chemical-Proteomic Platform To Identify Zinc-Binding Cysteines

(2013) Nicholas J. Pace et al.   ACS Chemical Biology

Development and Mechanism of γ-Secretase Modulators for Alzheimer’s Disease

(2013) Christina J. Crump et al.   BIOCHEMISTRY

An Isotopically Tagged Azobenzene-Based Cleavable Linker for Quantitative Proteomics

(2013) Yu Qian et al.   CHEMBIOCHEM

Bioorthogonal chemistry: strategies and recent developments

(2013) Carlo P. Ramil et al.   CHEMICAL COMMUNICATIONS

Protein Analysis by Shotgun/Bottom-up Proteomics

(2013) Yaoyang Zhang et al.   CHEMICAL REVIEWS

Modulation of Fatty Acid Synthase Enzyme Activity and Expression during Hepatitis C Virus Replication

(2013) Neda Nasheri et al.   CHEMISTRY & BIOLOGY

γ-Secretase Modulator (GSM) Photoaffinity Probes Reveal Distinct Allosteric Binding Sites on Presenilin

(2013) Nikolay Pozdnyakov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Incorporation of Non-natural Amino Acids Improves Cell Permeability and Potency of Specific Inhibitors of Proteasome Trypsin-like Sites

(2013) Paul P. Geurink et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Activity-Based Probes for Ubiquitin and Ubiquitin-like Protein Signaling Pathways

(2013) Heeseon An et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A chemoproteomic platform to quantitatively map targets of lipid-derived electrophiles

(2013) Chu Wang et al.   NATURE METHODS

A New Class of Rhomboid Protease Inhibitors Discovered by Activity-Based Fluorescence Polarization

(2013) Eliane V. Wolf et al.   PLoS One

Cell-permeable probe for identification and imaging of sialidases

(2013) C.-S. Tsai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-Based Probes Linked with Laser-Cleavable Mass Tags for Signal Amplification in Imaging Mass Spectrometry: Analysis of Serine Hydrolase Enzymes in Mammalian Tissue

(2012) Junhai Yang et al.   ANALYTICAL CHEMISTRY

Europium-Labeled Activity-Based Probe through Click Chemistry: Absolute Serine Protease Quantification Using 153Eu Isotope Dilution ICP/MS

(2012) Xiaowen Yan et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Development of clickable active site-directed photoaffinity probes for γ-secretase

(2012) Christina J. Crump et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The protein arginine deiminases: Structure, function, inhibition, and disease

(2012) Kevin L. Bicker et al.   BIOPOLYMERS

Sulfonyl Fluoride Analogues as Activity-Based Probes for Serine Proteases

(2012) D. Alexander Shannon et al.   CHEMBIOCHEM

Intracellular Protein Degradation: From a Vague Idea through the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting

(2012) Aaron Ciechanover   Neurodegenerative Diseases

Bioorthogonal Chemistry: Applications in Activity-Based Protein Profiling

(2011) Lianne I. Willems et al.   ACCOUNTS OF CHEMICAL RESEARCH

Biomedical Applications of Tetrazine Cycloadditions

(2011) Neal K. Devaraj et al.   ACCOUNTS OF CHEMICAL RESEARCH

Development and Use of Clickable Activity Based Protein Profiling Agents for Protein Arginine Deiminase 4

(2011) Jessica L. Slack et al.   ACS Chemical Biology

Alkyne derivatives of isocoumarins as clickable activity-based probes for serine proteases

(2011) Ute Haedke et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Activity based subcellular resolution imaging of lipases

(2011) Martin Viertler et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Two-step bioorthogonal activity-based proteasome profiling using copper-free click reagents: A comparative study

(2011) Wouter A. van der Linden et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

(2011) Jonathan Z. Long et al.   CHEMICAL REVIEWS

Labeling Live Cells by Copper-Catalyzed Alkyne−Azide Click Chemistry

(2010) Vu Hong et al.   BIOCONJUGATE CHEMISTRY

Activity-based Proteomics of Enzyme Superfamilies: Serine Hydrolases as a Case Study

(2010) Gabriel M. Simon et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activity-Based Probes That Target Functional Subclasses of Phospholipases in Proteomes

(2010) Sarah E. Tully et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Quantitative reactivity profiling predicts functional cysteines in proteomes

(2010) Eranthie Weerapana et al.   NATURE

The secretases: enzymes with therapeutic potential in Alzheimer disease

(2010) Bart De Strooper et al.   Nature Reviews Neurology

Copper-free click chemistry in living animals

(2010) P. V. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exploring the chemical space of γ-secretase modulators

(2010) Heiko Zettl et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Fast and Sensitive Pretargeted Labeling of Cancer Cells through a Tetrazine/trans-Cyclooctene Cycloaddition

(2009) Neal K. Devaraj et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Using peptidyl aldehydes in activity-based proteomics

(2009) Eduard Sabidó et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activity-Based Probes for Monitoring Postproline Protease Activity

(2009) Eduard Sabidó et al.   CHEMBIOCHEM

Small molecule probes that target Ablkinase

(2009) Karunakaran A. Kalesh et al.   CHEMICAL COMMUNICATIONS

A Click Chemistry Mediatedin VivoActivity Probe for Dimethylarginine Dimethylaminohydrolase

(2009) Yun Wang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Suite of Activity-Based Probes for Human Cytochrome P450 Enzymes

(2009) Aaron T. Wright et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

(2008) Benjamin F. Cravatt et al.   Annual Review of Biochemistry

Tetrazine-Based Cycloadditions: Application to Pretargeted Live Cell Imaging

(2008) Neal K. Devaraj et al.   BIOCONJUGATE CHEMISTRY

Chemical probes for profiling fatty acid-associated proteins in living cells

(2008) Anuradha Raghavan et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Activity-based probes as a tool for functional proteomic analysis of proteases

(2008) Marko Fonović et al.   Expert Review of Proteomics

Optimization of Activity-Based Probes for Proteomic Profiling of Histone Deacetylase Complexes

(2008) Cleo M. Salisbury et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

An Activity-Based Protein Profiling Probe for the Nicotinic Acetylcholine Receptor

(2008) Mathew Tantama et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

In-cell Selectivity Profiling of Serine Protease Inhibitors by Activity-based Proteomics

(2008) Ludovic C. J. Gillet et al.   MOLECULAR & CELLULAR PROTEOMICS

Disparate proteome reactivity profiles of carbon electrophiles

(2008) Eranthie Weerapana et al.   Nature Chemical Biology

Minitags for small molecules: detecting targets of reactive small molecules in living plant tissues using ‘click chemistry’

(2008) Farnusch Kaschani et al.   PLANT JOURNAL