QcrB in Mycobacterium tuberculosis : The new drug target of antitubercular agents

Intracellular and in vivo evaluation of imidazo[2,1-b]thiazole-5-carboxamide anti-tuberculosis compounds

(2020) Garrett C. Moraski et al.   PLoS One

New 2-Ethylthio-4-methylaminoquinazoline derivatives inhibiting two subunits of cytochrome bc1 in Mycobacterium tuberculosis

(2020) Andréanne Lupien et al.   PLoS Pathogens

Respiratory supercomplexes III2IV2 come into focus

(2019) Joana S. Sousa et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An overview of new antitubercular drugs, drug candidates, and their targets

(2019) Aparna Bahuguna et al.   MEDICINAL RESEARCH REVIEWS

Identification of 4-Amino-Thieno[2,3-d]Pyrimidines as QcrB Inhibitors in Mycobacterium tuberculosis

(2019) Gregory A. Harrison et al.   mSphere

Cytochrome bd in Mycobacterium tuberculosis: A respiratory chain protein involved in the defense against antibacterials

(2019) Ludovica Mascolo et al.   PROGRESS IN BIOPHYSICS & MOLECULAR BIOLOGY

Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels

(2018) Theresa O'Malley et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activity of 2-(quinolin-4-yloxy)acetamides in Mycobacterium tuberculosis clinical isolates and identification of their molecular target by whole-genome sequencing

(2018) Fernanda Teixeira Subtil et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

(2018) Laura A. T. Cleghorn et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure of a functional obligate complex III2IV2 respiratory supercomplex from Mycobacterium smegmatis

(2018) Benjamin Wiseman et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An electron transfer path connects subunits of a mycobacterial respiratory supercomplex

(2018) Hongri Gong et al.   SCIENCE

Pyrazolo[1,5-a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis

(2018) Xiaoyun Lu et al.   ACS Infectious Diseases

Synthesis and structure-activity studies of side chain analogues of the anti-tubercular agent, Q203

(2017) Sunhee Kang et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Pyrazolo[1,5-a]pyridine-3-carboxamide hybrids: Design, synthesis and evaluation of anti-tubercular activity

(2017) Xiaoyun Lu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Imidazo[1,2-a]pyridine Ethers and Squaramides as Selective and Potent Inhibitors of Mycobacterial Adenosine Triphosphate (ATP) Synthesis

(2017) Subramanyam J. Tantry et al.   JOURNAL OF MEDICINAL CHEMISTRY

Mycobacterial Membrane Proteins QcrB and AtpE: Roles in Energetics, Antibiotic Targets, and Associated Mechanisms of Resistance

(2017) Luke Bown et al.   JOURNAL OF MEMBRANE BIOLOGY

Exploiting the synthetic lethality between terminal respiratory oxidases to killMycobacterium tuberculosisand clear host infection

(2017) Nitin P. Kalia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting Energy Metabolism in Mycobacterium tuberculosis , a New Paradigm in Antimycobacterial Drug Discovery

(2017) Dirk Bald et al.   mBio

Decoding the similarities and differences among mycobacterial species

(2017) Sony Malhotra et al.   PLoS Neglected Tropical Diseases

Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB

(2017) N. Susantha Chandrasekera et al.   ACS Infectious Diseases

Searching for New Leads for Tuberculosis: Design, Synthesis, and Biological Evaluation of Novel 2-Quinolin-4-yloxyacetamides

(2016) Eleni Pitta et al.   JOURNAL OF MEDICINAL CHEMISTRY

The architecture of the mammalian respirasome

(2016) Jinke Gu et al.   NATURE

Structure of a bd oxidase indicates similar mechanisms for membrane-integrated oxygen reductases

(2016) Schara Safarian et al.   SCIENCE

SAR and identification of 2-(quinolin-4-yloxy)acetamides as Mycobacterium tuberculosis cytochrome bc1 inhibitors

(2016) Narisa Phummarin et al.   MedChemComm

2-(Quinolin-4-yloxy)acetamides Are Active against Drug-Susceptible and Drug-Resistant Mycobacterium tuberculosis Strains

(2016) Kenia Pissinate et al.   ACS Medicinal Chemistry Letters

Arrival of Imidazo[2,1-b]thiazole-5-carboxamides: Potent Anti-tuberculosis Agents That Target QcrB

(2016) Garrett C. Moraski et al.   ACS Infectious Diseases

Perspective: Challenges and opportunities in TB drug discovery from phenotypic screening

(2015) Ujjini H. Manjunatha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Isolation and Characterization of a Hybrid Respiratory Supercomplex Consisting ofMycobacterium tuberculosisCytochromebccandMycobacterium smegmatisCytochromeaa3

(2015) Mi-Sun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Phenoxyalkylbenzimidazoles with Antitubercular Activity

(2015) N. Susantha Chandrasekera et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration

(2015) Renier van der Westhuyzen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents

(2015) Jian Tang et al.   ACS Medicinal Chemistry Letters

Lansoprazole is an antituberculous prodrug targeting cytochrome bc1

(2015) Jan Rybniker et al.   Nature Communications

Putting Tuberculosis (TB) To Rest: Transformation of the Sleep Aid, Ambien, and “Anagrams” Generated Potent Antituberculosis Agents

(2015) Garrett C. Moraski et al.   ACS Infectious Diseases

Energy Metabolism and Drug Efflux in Mycobacterium tuberculosis

(2014) P. A. Black et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Respiratory Flexibility in Response to Inhibition of CytochromecOxidase in Mycobacterium tuberculosis

(2014) Kriti Arora et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

ATP synthase in mycobacteria: Special features and implications for a function as drug target

(2014) Ping Lu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Anticytolytic Screen Identifies Inhibitors of Mycobacterial Virulence Protein Secretion

(2014) Jan Rybniker et al.   Cell Host & Microbe

Tuberculosis drug discovery in the post-post-genomic era

(2014) Benoit Lechartier et al.   EMBO Molecular Medicine

Lead Optimization of a Novel Series of Imidazo[1,2-a]pyridine Amides Leading to a Clinical Candidate (Q203) as a Multi- and Extensively-Drug-Resistant Anti-tuberculosis Agent

(2014) Sunhee Kang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Bactericidal Activity of an Imidazo[1, 2-a]pyridine Using a Mouse M. tuberculosis Infection Model

(2014) Yong Cheng et al.   PLoS One

Bedaquiline for the treatment of resistant tuberculosis: Promises and pitfalls

(2014) Ashish Kumar Kakkar et al.   TUBERCULOSIS

Synthesis and structure activity relationship of imidazo[1,2-a]pyridine-8-carboxamides as a novel antimycobacterial lead series

(2013) Sreekanth Ramachandran et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A medicinal chemists’ guide to the unique difficulties of lead optimization for tuberculosis

(2013) Véronique Dartois et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis

(2013) Lluís Ballell et al.   ChemMedChem

Design, diversity-oriented synthesis and structure activity relationship studies of quinolinyl heterocycles as antimycobacterial agents

(2013) Venkatesham Rachakonda et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

(2013) Kevin Pethe et al.   NATURE MEDICINE

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

(2013) Katherine A. Abrahams et al.   PLoS One

Why are membrane targets discovered by phenotypic screens and genome sequencing in Mycobacterium tuberculosis?

(2013) Robert C. Goldman   TUBERCULOSIS

Advancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and nM Activity vs. Mycobacterium tuberculosis

(2013) Garrett C. Moraski et al.   ACS Medicinal Chemistry Letters

A High-Throughput Screen To Identify Inhibitors of ATP Homeostasis in Non-replicating Mycobacterium tuberculosis

(2012) Puiying A. Mak et al.   ACS Chemical Biology

Generation and exploration of new classes of antitubercular agents: The optimization of oxazolines, oxazoles, thiazolines, thiazoles to imidazo[1,2-a]pyridines and isomeric 5,6-fused scaffolds

(2012) Garrett C. Moraski et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Antituberculosis Drug Research: A Critical Overview

(2012) Beena et al.   MEDICINAL RESEARCH REVIEWS

Identification and Validation of Tetracyclic Benzothiazepines as Plasmodium falciparum Cytochrome bc1 Inhibitors

(2011) Carolyn K. Dong et al.   CHEMISTRY & BIOLOGY

High throughput screening of a library based on kinase inhibitor scaffolds against Mycobacterium tuberculosis H37Rv

(2011) Robert C. Reynolds et al.   TUBERCULOSIS

Advent of Imidazo[1,2-a]pyridine-3-carboxamides with Potent Multi- and Extended Drug Resistant Antituberculosis Activity

(2011) Garrett C. Moraski et al.   ACS Medicinal Chemistry Letters

Respiratory ATP synthesis: the new generation of mycobacterial drug targets?

(2010) Dirk Bald et al.   FEMS MICROBIOLOGY LETTERS

Unique Flexibility in Energy Metabolism Allows Mycobacteria to Combat Starvation and Hypoxia

(2010) Michael Berney et al.   PLoS One

Functionalized 3-amino-imidazo[1,2-a]pyridines: A novel class of drug-like Mycobacterium tuberculosis glutamine synthetase inhibitors

(2009) Luke R. Odell et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv

(2009) Subramaniam Ananthan et al.   TUBERCULOSIS

The protonmotive force is required for maintaining ATP homeostasis and viability of hypoxic, nonreplicating Mycobacterium tuberculosis

(2008) S. P. S. Rao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc1 complexes by center N inhibitors antimycin, ilicicolin H and funiculosin

(2007) Frederik A.J. Rotsaert et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS