Identification of 4-Amino-Thieno[2,3-d]Pyrimidines as QcrB Inhibitors in Mycobacterium tuberculosis

Imidazopyridine Compounds Inhibit Mycobacterial Growth by Depleting ATP Levels

(2018) Theresa O'Malley et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Activity of 2-(quinolin-4-yloxy)acetamides in Mycobacterium tuberculosis clinical isolates and identification of their molecular target by whole-genome sequencing

(2018) Fernanda Teixeira Subtil et al.   INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS

Identification of Morpholino Thiophenes as Novel Mycobacterium tuberculosis Inhibitors, Targeting QcrB

(2018) Laura A. T. Cleghorn et al.   JOURNAL OF MEDICINAL CHEMISTRY

The anti-mycobacterial activity of the cytochrome bcc inhibitor Q203 can be enhanced by small-molecule inhibition of cytochrome bd

(2018) Ping Lu et al.   Scientific Reports

Arylvinylpiperazine Amides, a New Class of Potent Inhibitors Targeting QcrB of Mycobacterium tuberculosis

(2018) Caroline S. Foo et al.   mBio

Pyrazolo[1,5-a]pyridine Inhibitor of the Respiratory Cytochrome bcc Complex for the Treatment of Drug-Resistant Tuberculosis

(2018) Xiaoyun Lu et al.   ACS Infectious Diseases

Pyrazolo[1,5-a]pyridine-3-carboxamide hybrids: Design, synthesis and evaluation of anti-tubercular activity

(2017) Xiaoyun Lu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Exploiting the synthetic lethality between terminal respiratory oxidases to killMycobacterium tuberculosisand clear host infection

(2017) Nitin P. Kalia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive Essentiality Analysis of the Mycobacterium tuberculosis Genome via Saturating Transposon Mutagenesis

(2017) Michael A. DeJesus et al.   mBio

Improved Phenoxyalkylbenzimidazoles with Activity against Mycobacterium tuberculosis Appear to Target QcrB

(2017) N. Susantha Chandrasekera et al.   ACS Infectious Diseases

SAR and identification of 2-(quinolin-4-yloxy)acetamides as Mycobacterium tuberculosis cytochrome bc1 inhibitors

(2016) Narisa Phummarin et al.   MedChemComm

Turning the respiratory flexibility of Mycobacterium tuberculosis against itself

(2016) Dirk A. Lamprecht et al.   Nature Communications

Arrival of Imidazo[2,1-b]thiazole-5-carboxamides: Potent Anti-tuberculosis Agents That Target QcrB

(2016) Garrett C. Moraski et al.   ACS Infectious Diseases

Putative 3D Structure of QcrB fromMycobacterium tuberculosisCytochromebc1 Complex, a Novel Drug-Target for New Series of Antituberculosis Agent Q203

(2016) Yoonae Ko et al.   BULLETIN OF THE KOREAN CHEMICAL SOCIETY

Isolation and Characterization of a Hybrid Respiratory Supercomplex Consisting ofMycobacterium tuberculosisCytochromebccandMycobacterium smegmatisCytochromeaa3

(2015) Mi-Sun Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of Phenoxyalkylbenzimidazoles with Antitubercular Activity

(2015) N. Susantha Chandrasekera et al.   JOURNAL OF MEDICINAL CHEMISTRY

Pyrrolo[3,4-c]pyridine-1,3(2H)-diones: A Novel Antimycobacterial Class Targeting Mycobacterial Respiration

(2015) Renier van der Westhuyzen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Treatment of Tuberculosis

(2015) C. Robert Horsburgh et al.   NEW ENGLAND JOURNAL OF MEDICINE

Design, Synthesis, and Biological Evaluation of Pyrazolo[1,5-a]pyridine-3-carboxamides as Novel Antitubercular Agents

(2015) Jian Tang et al.   ACS Medicinal Chemistry Letters

Lansoprazole is an antituberculous prodrug targeting cytochrome bc1

(2015) Jan Rybniker et al.   Nature Communications

Putting Tuberculosis (TB) To Rest: Transformation of the Sleep Aid, Ambien, and “Anagrams” Generated Potent Antituberculosis Agents

(2015) Garrett C. Moraski et al.   ACS Infectious Diseases

Respiratory Flexibility in Response to Inhibition of CytochromecOxidase in Mycobacterium tuberculosis

(2014) Kriti Arora et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Lead Optimization of a Novel Series of Imidazo[1,2-a]pyridine Amides Leading to a Clinical Candidate (Q203) as a Multi- and Extensively-Drug-Resistant Anti-tuberculosis Agent

(2014) Sunhee Kang et al.   JOURNAL OF MEDICINAL CHEMISTRY

Fueling Open-Source Drug Discovery: 177 Small-Molecule Leads against Tuberculosis

(2013) Lluís Ballell et al.   ChemMedChem

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

(2013) Kevin Pethe et al.   NATURE MEDICINE

Identification of Novel Imidazo[1,2-a]pyridine Inhibitors Targeting M. tuberculosis QcrB

(2013) Katherine A. Abrahams et al.   PLoS One

Perturbation of Cytochrome c Maturation Reveals Adaptability of the Respiratory Chain in Mycobacterium tuberculosis

(2013) J. L. Small et al.   mBio

Advancement of Imidazo[1,2-a]pyridines with Improved Pharmacokinetics and nM Activity vs. Mycobacterium tuberculosis

(2013) Garrett C. Moraski et al.   ACS Medicinal Chemistry Letters

OPM database and PPM web server: resources for positioning of proteins in membranes

(2011) Mikhail A. Lomize et al.   NUCLEIC ACIDS RESEARCH

High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism

(2011) Jennifer E. Griffin et al.   PLoS Pathogens

CarD Is an Essential Regulator of rRNA Transcription Required for Mycobacterium tuberculosis Persistence

(2009) Christina L. Stallings et al.   CELL

High-throughput screening for inhibitors of Mycobacterium tuberculosis H37Rv

(2009) Subramaniam Ananthan et al.   TUBERCULOSIS