Journal
PLOS NEGLECTED TROPICAL DISEASES
Volume 11, Issue 8, Pages -Publisher
PUBLIC LIBRARY SCIENCE
DOI: 10.1371/journal.pntd.0005883
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Funding
- MRC Newton Award [RG78439, 093167/Z/10/Z]
- Cystic Fibrosis Trust Grant [RG70975]
- Wellcome Trust Investigator Award [200814/Z/16/Z]
- American Leprosy Mission [RG88726]
- Wellcome Trust [200814/Z/16/Z] Funding Source: Wellcome Trust
- MRC [MR/N501864/1, MR/M026302/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [1103577] Funding Source: researchfish
- Medical Research Council [MR/M026302/1, MR/N501864/1] Funding Source: researchfish
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Mycobacteriaceae comprises pathogenic species such as Mycobacterium tuberculosis, M. leprae and M. abscessus, as well as non-pathogenic species, for example, M. smegmatis and M. thermoresistibile. Genome comparison and annotation studies provide insights into genome evolutionary relatedness, identify unique and pathogenicity-related genes in each species, and explore new targets that could be used for developing new diagnostics and therapeutics. Here, we present a comparative analysis of ten-mycobacterial genomes with the objective of identifying similarities and differences between pathogenic and non-pathogenic species. We identified 1080 core orthologous clusters that were enriched in proteins involved in amino acid and purine/pyrimidine biosynthetic pathways, DNA-related processes (replication, transcription, recombination and repair), RNA-methylation and modification, and cell-wall polysaccharide biosynthetic pathways. For their pathogenicity and survival in the host cell, pathogenic species have gained specific sets of genes involved in repair and protection of their genomic DNA. M. leprae is of special interest owing to its smallest genome (1600 genes and similar to 1300 psuedogenes), yet poor genome annotation. More than 75% of the pseudogenes were found to have a functional ortholog in the other mycobacterial genomes and belong to protein families such as transferases, oxidoreductases and hydrolases.
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