PGRN−/− TAMs-derived exosomes inhibit breast cancer cell invasion and migration and its mechanism exploration

Macrophages derived exosomes deliver miR-223 to epithelial ovarian cancer cells to elicit a chemoresistant phenotype

(2019) Xiaolan Zhu et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Linkage between endosomal escape of LNP-mRNA and loading into EVs for transport to other cells

(2019) Marco Maugeri et al.   Nature Communications

Triple negative breast cancer: Key role of Tumor-Associated Macrophages in regulating the activity of anti-PD-1/PD-L1 agents

(2018) Matteo Santoni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

New insights into the biological impacts of immune cell-derived exosomes within the tumor environment

(2018) Meng Shen et al.   CANCER LETTERS

Macrophage-derived granulin drives resistance to immune checkpoint inhibition in metastatic pancreatic cancer

(2018) Valeria Quaranta et al.   CANCER RESEARCH

Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis

(2018) Xiaofeng Wang et al.   CANCER RESEARCH

The role of CXCL12 in tumor microenvironment

(2018) Wenfang Meng et al.   GENE

Progranulin promotes lymphangiogenesis through VEGF-C and is an independent risk factor in human esophageal cancers

(2018) Guanhua Li et al.   HUMAN PATHOLOGY

Targeting Gas6/TAM in cancer cells and tumor microenvironment

(2018) Guiling Wu et al.   Molecular Cancer

Breast cancer metastasis to liver and lung is facilitated by Pit-1-CXCL12-CXCR4 axis

(2018) Anxo Martinez-Ordoñez et al.   ONCOGENE

Progranulin modulates cholangiocarcinoma cell proliferation, apoptosis, and motility via the PI3K/pAkt pathway

(2018) Minerva Daya et al.   OncoTargets and Therapy

Tumor-associated macrophages-derived exosomes promote the migration of gastric cancer cells by transfer of functional Apolipoprotein E

(2018) Peiming Zheng et al.   Cell Death & Disease

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

(2018) Tian Fang et al.   Nature Communications

Effect of exosomal miRNA on cancer biology and clinical applications

(2018) Zhenqiang Sun et al.   Molecular Cancer

Exosomes Released from Tumor-Associated Macrophages Transfer miRNAs That Induce a Treg/Th17 Cell Imbalance in Epithelial Ovarian Cancer

(2018) Jieru Zhou et al.   Cancer Immunology Research

Exosomal transfer of tumor-associated macrophage-derived miR-21 confers cisplatin resistance in gastric cancer cells

(2017) Peiming Zheng et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Progranulin and its biological effects in cancer

(2017) Fabian Arechavaleta-Velasco et al.   MEDICAL ONCOLOGY

Implications of the tumor immune microenvironment for staging and therapeutics

(2017) Janis M Taube et al.   MODERN PATHOLOGY

Exosomes derived from hypoxic epithelial ovarian cancer deliver microRNA-940 to induce macrophage M2 polarization

(2017) Xin Chen et al.   ONCOLOGY REPORTS

Emerging roles of the CXCL12/CXCR4 axis in pancreatic cancer progression and therapy

(2017) Richard L. Sleightholm et al.   PHARMACOLOGY & THERAPEUTICS

Exosomes: Therapy delivery tools and biomarkers of diseases

(2017) Lucio Barile et al.   PHARMACOLOGY & THERAPEUTICS

Long Distance Metabolic Regulation through Adipose-Derived Circulating Exosomal miRNAs: A Trail for RNA-Based Therapies?

(2017) Farah Fatima et al.   Frontiers in Physiology

PGRN promotes migration and invasion of epithelial ovarian cancer cells through an epithelial mesenchymal transition program and the activation of cancer associated fibroblasts

(2016) Taotao Dong et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Overexpression of microRNA-5100 decreases the aggressive phenotype of pancreatic cancer cells by targeting PODXL

(2016) YOSHIRO CHIJIIWA et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

Macrophage-secreted granulin supports pancreatic cancer metastasis by inducing liver fibrosis

(2016) Sebastian R. Nielsen et al.   NATURE CELL BIOLOGY

CXCR4 Regulates the Early Extravasation of Metastatic Tumor Cells In Vivo

(2015) Peter Gassmann et al.   NEOPLASIA

Growth factor progranulin contributes to cervical cancer cell proliferation and transformation in vivo and in vitro

(2014) Yi Lu et al.   GYNECOLOGIC ONCOLOGY

Tumor-Associated Macrophages: From Mechanisms to Therapy

(2014) Roy Noy et al.   IMMUNITY

Proteomics, transcriptomics and lipidomics of exosomes and ectosomes

(2013) Dong-Sic Choi et al.   PROTEOMICS

The novel growth factor, progranulin, stimulates mouse cholangiocyte proliferation via sirtuin-1-mediated inactivation of FOXO1

(2012) Gabriel Frampton et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Progranulin Stimulated by LPA Promotes the Migration of Aggressive Breast Cancer Cells

(2011) Muthulekha Swamydas et al.   CELL COMMUNICATION AND ADHESION

Microvesicles secreted by macrophages shuttle invasion-potentiating microRNAs into breast cancer cells

(2011) Mei Yang et al.   Molecular Cancer

CXCL12 (SDF-1)/CXCR4 Pathway in Cancer

(2010) B. A. Teicher et al.   CLINICAL CANCER RESEARCH

Mechanisms of Motility in Metastasizing Cells

(2010) Mahmut Yilmaz et al.   MOLECULAR CANCER RESEARCH

Zerumbone Down-regulates Chemokine Receptor CXCR4 Expression Leading to Inhibition of CXCL12-Induced Invasion of Breast and Pancreatic Tumor Cells

(2008) Bokyung Sung et al.   CANCER RESEARCH

Contact inhibition of locomotion in vivo controls neural crest directional migration

(2008) Carlos Carmona-Fontaine et al.   NATURE