The molecular mechanism and functional diversity of UPR signaling sensor IRE1

Dynamics and clustering of IRE1α during ER stress

(2020) T. Kelly Rainbolt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Palmitate induces cardiomyocyte death via inositol requiring enzyme-1 (IRE1)-mediated signaling independent of X-box binding protein 1 (XBP1)

(2020) Tsunehisa Yamamoto et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The UPR sensor IRE1α and the adenovirus E3-19K glycoprotein sustain persistent and lytic infections

(2020) Vibhu Prasad et al.   Nature Communications

Endoplasmic reticulum stress‐dependent activation of iNOS/NO‐NF‐κB signaling and NLRP3 inflammasome contributes to endothelial inflammation and apoptosis associated with microgravity

(2020) Min Jiang et al.   FASEB JOURNAL

The UPRosome – decoding novel biological outputs of IRE1α function

(2020) Hery Urra et al.   JOURNAL OF CELL SCIENCE

The Metastable XBP1u Transmembrane Domain Defines Determinants for Intramembrane Proteolysis by Signal Peptide Peptidase

(2019) Sara Suna Yücel et al.   Cell Reports

Sirt1 counteracts decrease in membrane phospholipid unsaturation and diastolic dysfunction during saturated fatty acid overload

(2019) Tsunehisa Yamamoto et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Non-canonical function of IRE1α determines mitochondria-associated endoplasmic reticulum composition to control calcium transfer and bioenergetics

(2019) Amado Carreras-Sureda et al.   NATURE CELL BIOLOGY

tRNA ligase structure reveals kinetic competition between non-conventional mRNA splicing and mRNA decay

(2019) Jirka Peschek et al.   eLife

Emerging roles for the ER stress sensor IRE1α in metabolic regulation and disease

(2019) Shijia Huang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

eIF2α-CHOP-BCl-2/JNK and IRE1α-XBP1/JNK signaling promote apoptosis and inflammation and support the proliferation of Newcastle disease virus

(2019) Yanrong Li et al.   Cell Death & Disease

Publisher Correction: PRKCSH contributes to tumorigenesis by selective boosting of IRE1 signaling pathway

(2019) Gu-Choul Shin et al.   Nature Communications

Quantitative microscopy reveals dynamics and fate of clustered IRE1α

(2019) Vladislav Belyy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphorylation of IRE1 at S729 regulates RIDD in B cells and antibody production after immunization

(2018) Chih-Hang Anthony Tang et al.   JOURNAL OF CELL BIOLOGY

Interactome Screening Identifies the ER Luminal Chaperone Hsp47 as a Regulator of the Unfolded Protein Response Transducer IRE1α

(2018) Denisse Sepulveda et al.   MOLECULAR CELL

The Unfolded Protein Response and Cell Fate Control

(2018) Claudio Hetz et al.   MOLECULAR CELL

Decrease in membrane phospholipids unsaturation correlates with myocardial diastolic dysfunction

(2018) Tsunehisa Yamamoto et al.   PLoS One

XBP1-KLF9 Axis Acts as a Molecular Rheostat to Control the Transition from Adaptive to Cytotoxic Unfolded Protein Response

(2018) Emily E. Fink et al.   Cell Reports

Genome-wide analyses reveal the IRE1a-XBP1 pathway promotes T helper cell differentiation by resolving secretory stress and accelerating proliferation

(2018) Jhuma Pramanik et al.   Genome Medicine

Activation of the Unfolded Protein Response by Lipid Bilayer Stress

(2017) Kristina Halbleib et al.   MOLECULAR CELL

Regulated IRE1-dependent mRNA decay sets the threshold for dendritic cell survival

(2017) Simon J. Tavernier et al.   NATURE CELL BIOLOGY

IRE1α promotes viral infection by conferring resistance to apoptosis

(2017) Susan L. Fink et al.   Science Signaling

Fortilin binds IRE1α and prevents ER stress from signaling apoptotic cell death

(2017) Decha Pinkaew et al.   Nature Communications

An unfolded protein-induced conformational switch activates mammalian IRE1

(2017) G Elif Karagöz et al.   eLife

IRE1α promotes viral infection by conferring resistance to apoptosis

(2017) Susan L. Fink et al.   Science Signaling

Identification of XBP1-u as a novel regulator of the MDM2/p53 axis using an shRNA library

(2017) Can Huang et al.   Science Advances

Ubiquitin D Regulates IRE1α/c-Jun N-terminal Kinase (JNK) Protein-dependent Apoptosis in Pancreatic Beta Cells

(2016) Flora Brozzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

An initial phase of JNK activation inhibits cell death early in the endoplasmic reticulum stress response

(2016) Max Brown et al.   JOURNAL OF CELL SCIENCE

Autonomous translational pausing is required forXBP1umRNA recruitment to the ER via the SRP pathway

(2016) Satoshi Kanda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Absence of the ER Cation Channel TMEM38B/TRIC-B Disrupts Intracellular Calcium Homeostasis and Dysregulates Collagen Synthesis in Recessive Osteogenesis Imperfecta

(2016) Wayne A. Cabral et al.   PLoS Genetics

miR-125a-5p inhibits cell proliferation and induces apoptosis in colon cancer via targeting BCL2, BCL2L12 and MCL1

(2015) Zhiguo Tong et al.   BIOMEDICINE & PHARMACOTHERAPY

The unfolded protein response is shaped by the NMD pathway

(2015) R. Karam et al.   EMBO REPORTS

Cell death induced by endoplasmic reticulum stress

(2015) Raffaella Iurlaro et al.   FEBS Journal

Cleavage ofBLOC1S1mRNA by IRE1 Is Sequence Specific, Temporally Separate fromXBP1Splicing, and Dispensable for Cell Viability under Acute Endoplasmic Reticulum Stress

(2015) Michael D. Bright et al.   MOLECULAR AND CELLULAR BIOLOGY

Ire1-mediated decay in mammalian cells relies on mRNA sequence, structure, and translational status

(2015) Kristin Moore et al.   MOLECULAR BIOLOGY OF THE CELL

The unfolded protein response: the dawn of a new field

(2015) Kazutoshi MORI   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

Molecular mechanisms of human IRE1 activation through dimerization and ligand binding

(2015) Amar Joshi et al.   Oncotarget

A functional link between the co-translational protein translocation pathway and the UPR

(2015) Rachel Plumb et al.   eLife

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

The mammalian tRNA ligase complex mediates splicing ofXBP1mRNA and controls antibody secretion in plasma cells

(2014) Jennifer Jurkin et al.   EMBO JOURNAL

Signal peptide peptidase functions in ERAD to cleave the unfolded protein response regulator XBP1u

(2014) C.-y. Chen et al.   EMBO JOURNAL

Ubiquitination of Inositol-requiring Enzyme 1 (IRE1) by the E3 Ligase CHIP Mediates the IRE1/TRAF2/JNK Pathway

(2014) Xu Zhu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is there quality control of localized mRNAs?

(2014) Robert Walters et al.   JOURNAL OF CELL BIOLOGY

A Synthetic Biology Approach Identifies the Mammalian UPR RNA Ligase RtcB

(2014) Yanyan Lu et al.   MOLECULAR CELL

Druggable sensors of the unfolded protein response

(2014) Dustin J Maly et al.   Nature Chemical Biology

Getting RIDD of RNA: IRE1 in cell fate regulation

(2014) M. Maurel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Ire1 Has Distinct Catalytic Mechanisms for XBP1/HAC1 Splicing and RIDD

(2014) Arvin B. Tam et al.   Cell Reports

Physiological roles of regulated Ire1 dependent decay

(2014) Dina S. Coelho et al.   Frontiers in Genetics

Inhibition of x-box binding protein 1 reduces tunicamycin-induced apoptosis in aged murine macrophages

(2013) Yang Song et al.   AGING CELL

Posttranscriptional Regulation of PER1 Underlies the Oncogenic Function of IRE 

(2013) O. Pluquet et al.   CANCER RESEARCH

RETRACTED: The Unfolded Protein Response Element IRE1α Senses Bacterial Proteins Invading the ER to Activate RIG-I and Innate Immune Signaling

(2013) Jin A. Cho et al.   Cell Host & Microbe

Regulated IRE1-dependent decay participates in curtailing immunoglobulin secretion from plasma cells

(2013) Sandrine Benhamron et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

RNF13, a RING Finger Protein, Mediates Endoplasmic Reticulum Stress-induced Apoptosis through the Inositol-requiring Enzyme (IRE1α)/c-Jun NH2-terminal Kinase Pathway

(2013) Muhammad Arshad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The ire-1 ER stress-response pathway is required for normal secretory-protein metabolism in C. elegans

(2013) M. Safra et al.   JOURNAL OF CELL SCIENCE

Regulation of Sumo mRNA during Endoplasmic Reticulum Stress

(2013) Kristin A. Moore et al.   PLoS One

Sigma-1 Receptor Chaperone at the ER-Mitochondrion Interface Mediates the Mitochondrion-ER-Nucleus Signaling for Cellular Survival

(2013) Tomohisa Mori et al.   PLoS One

Negative feedback by IRE1  optimizes mucin production in goblet cells

(2013) A. Tsuru et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane lipid saturation activates endoplasmic reticulum unfolded protein response transducers through their transmembrane domains

(2013) R. Volmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRE1: ER stress sensor and cell fate executor

(2013) Yani Chen et al.   TRENDS IN CELL BIOLOGY

The intimate relationships of mRNA decay and translation

(2013) Bijoyita Roy et al.   TRENDS IN GENETICS

Structural Basis of the Unfolded Protein Response

(2012) Alexei Korennykh et al.   Annual Review of Cell and Developmental Biology

The unfolded protein response at the crossroads of cellular life and death during endoplasmic reticulum stress

(2012) Richard Jäger et al.   BIOLOGY OF THE CELL

Silencing of Lipid Metabolism Genes through IRE1α-Mediated mRNA Decay Lowers Plasma Lipids in Mice

(2012) Jae-Seon So et al.   Cell Metabolism

IRE1α Induces Thioredoxin-Interacting Protein to Activate the NLRP3 Inflammasome and Promote Programmed Cell Death under Irremediable ER Stress

(2012) Alana G. Lerner et al.   Cell Metabolism

Nonmuscle Myosin IIB Links Cytoskeleton to IRE1α Signaling during ER Stress

(2012) Yin He et al.   DEVELOPMENTAL CELL

BH3-only proteins are part of a regulatory network that control the sustained signalling of the unfolded protein response sensor IRE1α

(2012) Diego A Rodriguez et al.   EMBO JOURNAL

Autocrine control of glioma cells adhesion and migration through IRE1 -mediated cleavage of SPARC mRNA

(2012) N. Dejeans et al.   JOURNAL OF CELL SCIENCE

IRE1α activation protects mice against acetaminophen-induced hepatotoxicity

(2012) Kyu Yeon Hur et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A Novel Feedback Loop Regulates the Response to Endoplasmic Reticulum Stress via the Cooperation of Cytoplasmic Splicing and mRNA Translation

(2012) M. Majumder et al.   MOLECULAR AND CELLULAR BIOLOGY

Kar2p availability defines distinct forms of endoplasmic reticulum stress in living cells

(2012) Patrick Lajoie et al.   MOLECULAR BIOLOGY OF THE CELL

Comparison of mRNA localization and regulation during endoplasmic reticulum stress in Drosophila cells

(2012) Deepika Gaddam et al.   MOLECULAR BIOLOGY OF THE CELL

The Membrane Stress Response Buffers Lethal Effects of Lipid Disequilibrium by Reprogramming the Protein Homeostasis Network

(2012) Guillaume Thibault et al.   MOLECULAR CELL

The mRNA-Bound Proteome and Its Global Occupancy Profile on Protein-Coding Transcripts

(2012) Alexander G. Baltz et al.   MOLECULAR CELL

PARP16 is a tail-anchored endoplasmic reticulum protein required for the PERK- and IRE1α-mediated unfolded protein response

(2012) Miri Jwa et al.   NATURE CELL BIOLOGY

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

(2012) Likun Wang et al.   Nature Chemical Biology

RNA surveillance is required for endoplasmic reticulum homeostasis

(2012) K. Sakaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule

(2012) B. C. S. Cross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IRE1  Cleaves Select microRNAs During ER Stress to Derepress Translation of Proapoptotic Caspase-2

(2012) J.-P. Upton et al.   SCIENCE

The unfolded protein response in fission yeast modulates stability of select mRNAs to maintain protein homeostasis

(2012) Philipp Kimmig et al.   eLife

Cofactor-mediated conformational control in the bifunctional kinase/RNase Ire1

(2011) Alexei V Korennykh et al.   BMC BIOLOGY

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response

(2011) Maruf M U Ali et al.   EMBO JOURNAL

Membrane aberrancy and unfolded proteins activate the endoplasmic reticulum stress sensor Ire1 in different ways

(2011) Thanyarat Promlek et al.   MOLECULAR BIOLOGY OF THE CELL

Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress

(2011) Ira Tabas et al.   NATURE CELL BIOLOGY

Reconstitution and characterization of the unconventional splicing of XBP1u mRNA in vitro

(2011) Sayoko Shinya et al.   NUCLEIC ACIDS RESEARCH

The Unfolded Protein Response: Integrating Stress Signals Through the Stress Sensor IRE1α

(2011) Claudio Hetz et al.   PHYSIOLOGICAL REVIEWS

PKA phosphorylation couples hepatic inositol-requiring enzyme 1  to glucagon signaling in glucose metabolism

(2011) T. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Conserved RNA structures in the non-canonical Hac1/Xbp1 intron

(2011) Katarzyna B. Hooks et al.   RNA Biology

Translational Pausing Ensures Membrane Targeting and Cytoplasmic Splicing of XBP1u mRNA

(2011) K. Yanagitani et al.   SCIENCE

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Unfolded Proteins Are Ire1-Activating Ligands That Directly Induce the Unfolded Protein Response

(2011) B. M. Gardner et al.   SCIENCE

Modulating stress responses by the UPRosome: A matter of life and death

(2011) Ute Woehlbier et al.   TRENDS IN BIOCHEMICAL SCIENCES

Decrease in Membrane Phospholipid Unsaturation Induces Unfolded Protein Response

(2010) Hiroyuki Ariyama et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dual Functions of Yeast tRNA Ligase in the Unfolded Protein Response: Unconventional Cytoplasmic Splicing of HAC1 Pre-mRNA Is Not Sufficient to Release Translational Attenuation

(2010) Takao Mori et al.   MOLECULAR BIOLOGY OF THE CELL

Identification of a consensus element recognized and cleaved by IRE1α

(2010) Daisuke Oikawa et al.   NUCLEIC ACIDS RESEARCH

Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control

(2010) S. Han et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mammalian endoplasmic reticulum stress sensor IRE1 signals by dynamic clustering

(2010) H. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Crucial Role for RACK1 in the Regulation of Glucose-Stimulated IRE1  Activation in Pancreatic   Cells

(2010) Y. Qiu et al.   Science Signaling

Spliceosome Structure and Function

(2010) C. L. Will et al.   Cold Spring Harbor Perspectives in Biology

HSP72 Protects Cells from ER Stress-induced Apoptosis via Enhancement of IRE1α-XBP1 Signaling through a Physical Interaction

(2010) Sanjeev Gupta et al.   PLOS BIOLOGY

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

The role of X-box binding protein-1 in tumorigenicity

(2009) A.N. Shajahan et al.   DRUG NEWS & PERSPECTIVES

XBP-1 regulates signal transduction, transcription factors and bone marrow colonization in B cells

(2009) Chih-Chi Andrew Hu et al.   EMBO JOURNAL

Activation of mammalian IRE1α upon ER stress depends on dissociation of BiP rather than on direct interaction with unfolded proteins

(2009) Daisuke Oikawa et al.   EXPERIMENTAL CELL RESEARCH

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

Targeting of mRNAs to Their Sites of Unconventional Splicing in the Unfolded Protein Response

(2009) David Ron   MOLECULAR CELL

Cotranslational Targeting of XBP1 Protein to the Membrane Promotes Cytoplasmic Splicing of Its Own mRNA

(2009) Kota Yanagitani et al.   MOLECULAR CELL

Fine-Tuning of the Unfolded Protein Response: Assembling the IRE1α Interactome

(2009) Claudio Hetz et al.   MOLECULAR CELL

Thioredoxin-interacting protein links oxidative stress to inflammasome activation

(2009) Rongbin Zhou et al.   NATURE IMMUNOLOGY

Divergent Effects of PERK and IRE1 Signaling on Cell Viability

(2009) Jonathan H. Lin et al.   PLoS One

Function of IRE1 alpha in the placenta is essential for placental development and embryonic viability

(2009) T. Iwawaki et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sustained activation of XBP1 splicing leads to endothelial apoptosis and atherosclerosis development in response to disturbed flow

(2009) L. Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

(2008) Kenneth P.K. Lee et al.   CELL

AIP1 Is Critical in Transducing IRE1-mediated Endoplasmic Reticulum Stress Response

(2008) Dianhong Luo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE

Messenger RNA targeting to endoplasmic reticulum stress signalling sites

(2008) Tomás Aragón et al.   NATURE

The daily job of night killers: alternative roles of the BCL-2 family in organelle physiology

(2008) Claudio Hetz et al.   TRENDS IN CELL BIOLOGY

A kinase inhibitor activates the IRE1α RNase to confer cytoprotection against ER stress

(2007) Dan Han et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS