Endoplasmic reticulum stress‐dependent activation of iNOS/NO‐NF‐κB signaling and NLRP3 inflammasome contributes to endothelial inflammation and apoptosis associated with microgravity

Inflammasome‐associated cell death: Pyroptosis, apoptosis, and physiological implications

(2020) Kohsuke Tsuchiya   MICROBIOLOGY AND IMMUNOLOGY

Omentin-1 protects against high glucose-induced endothelial dysfunction via the AMPK/PPARδ signaling pathway

(2020) Fang Liu et al.   BIOCHEMICAL PHARMACOLOGY

RhoE Fine-Tunes Inflammatory Response in Myocardial Infarction

(2019) Yuan Dai et al.   CIRCULATION

Recovery from 6-month spaceflight at the International Space Station: muscle-related stress into a proinflammatory setting

(2019) Miriam Capri et al.   FASEB JOURNAL

Stress Related Shift Toward Inflammaging in Cosmonauts After Long-Duration Space Flight

(2019) Judith-Irina Buchheim et al.   Frontiers in Physiology

Growing blood vessels in space: Preparation studies of the SPHEROIDS project using related ground-based studies

(2019) Marcus Krüger et al.   ACTA ASTRONAUTICA

Endoplasmic Reticulum Stress: A Critical Molecular Driver of Endothelial Dysfunction and Cardiovascular Disturbances Associated with Diabetes

(2019) Hatem Maamoun et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Autophagy protects HUVECs against ER stress-mediated apoptosis under simulated microgravity

(2019) Cheng-Fei Li et al.   APOPTOSIS

Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation

(2019) Tao Zhuang et al.   CIRCULATION RESEARCH

Modulation of Nitric Oxide Synthases by Oxidized LDLs: Role in Vascular Inflammation and Atherosclerosis Development

(2019) Micaela Gliozzi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dulaglutide inhibits high glucose- induced endothelial dysfunction and NLRP3 inflammasome activation

(2019) Xiaojia Luo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Dual Inhibition of Cannabinoid‐1 Receptor and iNOS Attenuates Obesity‐induced Chronic Kidney Disease

(2019) Shiran Udi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Ginsenoside Rg1 attenuates cardiomyocyte apoptosis and inflammation via the TLR4/NF‐kB/NLRP3 pathway

(2019) Man Luo et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

ER Stress Activates the NLRP3 Inflammasome: A Novel Mechanism of Atherosclerosis

(2019) Xinnong Chen et al.   Oxidative Medicine and Cellular Longevity

Contribution of the Unfolded Protein Response (UPR) to the Pathogenesis of Proteasome-Associated Autoinflammatory Syndromes (PRAAS)

(2019) Frédéric Ebstein et al.   Frontiers in Immunology

Nickel induces inflammatory activation via NF-κB, MAPKs, IRF3 and NLRP3 inflammasome signaling pathways in macrophages

(2019) Hongrui Guo et al.   Aging-US

Inducible Nitric Oxide Synthase (iNOS) Mediates Vascular Endothelial Cell Apoptosis in Grass Carp Reovirus (GCRV)-Induced Hemorrhage

(2019) Bo Liang et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Modulatory Mechanisms of the NLRP3 Inflammasomes in Diabetes

(2019) Sujuan Ding et al.   Biomolecules

Key Proteins Involved in Spheroid Formation and Angiogenesis in Endothelial Cells After Long-Term Exposure to Simulated Microgravity

(2018) Anita Dittrich et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Ticagrelor protects against AngII-induced endothelial dysfunction by alleviating endoplasmic reticulum stress

(2018) Xiaoyu Wang et al.   MICROVASCULAR RESEARCH

Spaceflight-Induced Intracranial Hypertension and Visual Impairment: Pathophysiology and Countermeasures

(2018) Li-Fan Zhang et al.   PHYSIOLOGICAL REVIEWS

Oxidative stress and reactive oxygen species in endothelial dysfunction associated with cardiovascular and metabolic diseases

(2018) Maria Angela Incalza et al.   VASCULAR PHARMACOLOGY

Endoplasmic Reticulum Stress in Metabolic Disorders

(2018) Rose Ghemrawi et al.   Cells

Therapeutic value of stimulating the nitrate-nitrite-nitric oxide pathway to attenuate oxidative stress and restore nitric oxide bioavailability in cardiorenal disease

(2018) M. Carlstrom et al.   JOURNAL OF INTERNAL MEDICINE

Microgravity-Induced Alterations of Inflammation-Related Mechanotransduction in Endothelial Cells on Board SJ-10 Satellite

(2018) Ning Li et al.   Frontiers in Physiology

Oxidative Stress and the Kidney in the Space Environment

(2018) Paraskevi Pavlakou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

AMP-activated protein kinase activation and NADPH oxidase inhibition by inorganic nitrate and nitrite prevent liver steatosis

(2018) Isabel Cordero-Herrera et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Astronaut ophthalmic syndrome

(2017) Sara R. Zwart et al.   FASEB JOURNAL

Heart in space: effect of the extraterrestrial environment on the cardiovascular system

(2017) Richard L. Hughson et al.   Nature Reviews Cardiology

Myricitrin Modulates NADPH Oxidase-Dependent ROS Production to Inhibit Endotoxin-Mediated Inflammation by Blocking the JAK/STAT1 and NOX2/p47phox Pathways

(2017) Shimei Qi et al.   Oxidative Medicine and Cellular Longevity

Human Pathophysiological Adaptations to the Space Environment

(2017) Gian C. Demontis et al.   Frontiers in Physiology

Ginsenoside Rg3 regulates S-nitrosylation of the NLRP3 inflammasome via suppression of iNOS

(2015) Sung-Jin Yoon et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

NADPH Oxidase Accounts for Changes in Cerebrovascular Redox Status in Hindlimb Unweighting Rats

(2015) Liang PENG et al.   BIOMEDICAL AND ENVIRONMENTAL SCIENCES

Simulated microgravity promotes monocyte adhesion to rat aortic endothelium via nuclear factor-κB activation

(2015) Huan Liu et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Spaceflight impairs antigen-specific tolerance induction in vivo and increases inflammatory cytokines

(2015) Tammy T. Chang et al.   FASEB JOURNAL

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

The Impact of Microgravity and Hypergravity on Endothelial Cells

(2015) Jeanette A. M. Maier et al.   Biomed Research International

Simulated microgravity-induced mitochondrial dysfunction in rat cerebral arteries

(2014) Ran Zhang et al.   FASEB JOURNAL

Plasma Cytokine Concentrations Indicate That In Vivo Hormonal Regulation of Immunity Is Altered During Long-Duration Spaceflight

(2014) Brian E. Crucian et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

PERK pathway are involved in NO-induced apoptosis in endothelial cells cocultured with RPE under high glucose conditions

(2014) Xiang Zhang et al.   NITRIC OXIDE-BIOLOGY AND CHEMISTRY

Mitochondrial Regulation of NADPH Oxidase in Hindlimb Unweighting Rat Cerebral Arteries

(2014) Ran Zhang et al.   PLoS One

The challenging environment on board the International Space Station affects endothelial cell function by triggering oxidative stress through thioredoxin interacting protein overexpression: the ESA-SPHINX experiment

(2013) Silvia Versari et al.   FASEB JOURNAL

The role of the cytoskeleton in sensing changes in gravity by nonspecialized cells

(2013) Daan Vorselen et al.   FASEB JOURNAL

Increased basal nitric oxide amplifies the association of inflammation with all-cause and cardiovascular mortality in prevalent hemodialysis patients

(2013) Ilia Beberashvili et al.   INTERNATIONAL UROLOGY AND NEPHROLOGY

Effects of Gravitational Mechanical Unloading in Endothelial Cells: Association between Caveolins, Inflammation and Adhesion Molecules

(2013) S. Marlene Grenon et al.   Scientific Reports

ER stress-induced inflammation: does it aid or impede disease progression?

(2012) Abhishek D. Garg et al.   TRENDS IN MOLECULAR MEDICINE

Impact of simulated microgravity on microvascular endothelial cell apoptosis

(2011) Chun-Yan Kang et al.   EUROPEAN JOURNAL OF APPLIED PHYSIOLOGY

NAD(P)H oxidase inhibiting with apocynin improved vascular reactivity in tail-suspended hindlimb unweighting rat

(2011) Ran Zhang et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

XBP1U inhibits the XBP1S-mediated upregulation of the iNOS gene expression in mammalian ER stress response

(2010) FengJin Guo et al.   CELLULAR SIGNALLING

Endoplasmic Reticulum Stress As a Therapeutic Target in Cardiovascular Disease

(2010) Tetsuo Minamino et al.   CIRCULATION RESEARCH

Simulated microgravity promotes nitric oxide-supported angiogenesis via the iNOS-cGMP-PKG pathway in macrovascular endothelial cells

(2010) Jamila H. Siamwala et al.   FEBS LETTERS

Modification of proteins secreted by endothelial cells during modeled low gravity exposure

(2010) Cristiana Griffoni et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Biphasic, Bidirectional Regulation of NF-κB by Endoplasmic Reticulum Stress

(2009) Masanori Kitamura   ANTIOXIDANTS & REDOX SIGNALING

Clinorotation upregulates inducible nitric oxide synthase by inhibiting AP-1 activation in human umbilical vein endothelial cells

(2009) Yong-Chun Wang et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Blockade of AT1 receptor partially restores vasoreactivity, NOS expression, and superoxide levels in cerebral and carotid arteries of hindlimb unweighting rats

(2008) Ran Zhang et al.   JOURNAL OF APPLIED PHYSIOLOGY

iNOS expression requires NADPH oxidase-dependent redox signaling in microvascular endothelial cells

(2008) Feng Wu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Increased Vascular Cell Adhesion Molecule–1 Was Associated with Impaired Endothelium–Dependent Relaxation of Cerebral and Carotid Arteries in Simulated Microgravity Rats

(2008) Ran Zhang et al.   Journal of Physiological Sciences