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Title
Druggable sensors of the unfolded protein response
Authors
Keywords
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Journal
Nature Chemical Biology
Volume 10, Issue 11, Pages 892-901
Publisher
Springer Nature
Online
2014-10-18
DOI
10.1038/nchembio.1664
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- (2013) J. A. Moreno et al. Science Translational Medicine
- Endoplasmic Reticulum Stress, Pancreatic -Cell Degeneration, and Diabetes
- (2013) F. R. Papa Cold Spring Harbor Perspectives in Medicine
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- (2012) Alexei Korennykh et al. Annual Review of Cell and Developmental Biology
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- (2012) Alana G. Lerner et al. Cell Metabolism
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- (2012) Shiyu Wang et al. JOURNAL OF CELL BIOLOGY
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- (2012) Benoit D Roussel et al. LANCET NEUROLOGY
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- (2012) Likun Wang et al. Nature Chemical Biology
- The molecular basis for selective inhibition of unconventional mRNA splicing by an IRE1-binding small molecule
- (2012) B. C. S. Cross et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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- (2012) J.-P. Upton et al. SCIENCE
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- (2012) Mélissa Flamment et al. TRENDS IN ENDOCRINOLOGY AND METABOLISM
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- (2011) Maruf M U Ali et al. EMBO JOURNAL
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- (2011) S. C. W. Ling et al. HAEMATOLOGICA
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- (2011) Ira Tabas et al. NATURE CELL BIOLOGY
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- (2010) Jerry E. Chipuk et al. MOLECULAR CELL
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- (2010) David Pincus et al. PLOS BIOLOGY
- The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus
- (2009) Jeroen J.M. Hoozemans et al. AMERICAN JOURNAL OF PATHOLOGY
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