Bifurcation and sensitivity analysis reveal key drivers of multistability in a model of macrophage polarization

Krebs Cycle Reborn in Macrophage Immunometabolism

(2020) Dylan G. Ryan et al.   Annual Review of Immunology

Macrophage Polarization in the Development and Progression of Ovarian Cancers: An Overview

(2019) Huiyan Cheng et al.   Frontiers in Oncology

Identifying important parameters in the inflammatory process with a mathematical model of immune cell influx and macrophage polarization

(2019) Marcella Torres et al.   PLoS Computational Biology

NF-κB Signaling in Macrophages: Dynamics, Crosstalk, and Signal Integration

(2019) Michael G. Dorrington et al.   Frontiers in Immunology

Agent-based modeling and bifurcation analysis reveal mechanisms of macrophage polarization and phenotype pattern distribution

(2019) Niloofar Nickaeen et al.   Scientific Reports

A mechanistic integrative computational model of macrophage polarization: Implications in human pathophysiology

(2019) Chen Zhao et al.   PLoS Computational Biology

Exploring the Function of Dynamic Phosphorylation-Dephosphorylation Cycles

(2018) Lendert Gelens et al.   DEVELOPMENTAL CELL

Interferon Gamma Induces Reversible Metabolic Reprogramming of M1 Macrophages to Sustain Cell Viability and Pro-Inflammatory Activity

(2018) Feilong Wang et al.   EBioMedicine

Molecular mechanism of a covalent allosteric inhibitor of SUMO E1 activating enzyme

(2018) Zongyang Lv et al.   Nature Communications

Gene Regulatory Network Modeling of Macrophage Differentiation Corroborates the Continuum Hypothesis of Polarization States

(2018) Alessandro Palma et al.   Frontiers in Physiology

Metabolic and Epigenetic Coordination of T Cell and Macrophage Immunity

(2017) Anthony T. Phan et al.   IMMUNITY

Redirecting tumor-associated macrophages to become tumoricidal effectors as a novel strategy for cancer therapy

(2017) Xiang Zheng et al.   Oncotarget

Macrophage Metabolism As Therapeutic Target for Cancer, Atherosclerosis, and Obesity

(2017) Xenia Geeraerts et al.   Frontiers in Immunology

Statistical ensemble of gene regulatory networks of macrophage differentiation

(2016) Filippo Castiglione et al.   BMC BIOINFORMATICS

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Regulation of macrophage polarization and plasticity by complex activation signals

(2016) Tim D. Smith et al.   Integrative Biology

Monocyte and Macrophage Plasticity in Tissue Repair and Regeneration

(2015) Amitava Das et al.   AMERICAN JOURNAL OF PATHOLOGY

Metabolic reprogramming in macrophages and dendritic cells in innate immunity

(2015) Beth Kelly et al.   CELL RESEARCH

AMP-activated Protein Kinase Suppresses Arachidonate 15-Lipoxygenase Expression in Interleukin 4-polarized Human Macrophages

(2015) Dmitry Namgaladze et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Biomaterial based modulation of macrophage polarization: a review and suggested design principles

(2015) Rukmani Sridharan et al.   Materials Today

Understanding Local Macrophage Phenotypes In Disease: Modulating macrophage function to treat cancer

(2015) Vincenzo Bronte et al.   NATURE MEDICINE

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

(2014) Nan Wang et al.   Frontiers in Immunology

Macrophage plasticity and polarization in liver homeostasis and pathology

(2013) Antonio Sica et al.   HEPATOLOGY

Tristability in Cancer-Associated MicroRNA-TF Chimera Toggle Switch

(2013) Mingyang Lu et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Orchestration of Metabolism by Macrophages

(2012) Subhra K. Biswas et al.   Cell Metabolism

CD4+T Cells: Differentiation and Functions

(2012) Rishi Vishal Luckheeram et al.   Clinical & Developmental Immunology

Double-Stranded RNA Induces Biphasic STAT1 Phosphorylation by both Type I Interferon (IFN)-Dependent and Type I IFN-Independent Pathways

(2012) J. Dempoya et al.   JOURNAL OF VIROLOGY

Integrating Macrophages into Organotypic Co-Cultures: A 3D In Vitro Model to Study Tumor-Associated Macrophages

(2012) Nina Linde et al.   PLoS One

SUMO conjugation of STAT1 protects cells from hyperresponsiveness to IFN 

(2011) A. Begitt et al.   BLOOD

Sensitivity analysis approaches applied to systems biology models

(2011) Z. Zi   IET Systems Biology

Transcriptional regulation by STAT6

(2011) Shreevrat Goenka et al.   IMMUNOLOGIC RESEARCH

Cytokine-induced Paracrystals Prolong the Activity of Signal Transducers and Activators of Transcription (STAT) and Provide a Model for the Regulation of Protein Solubility by Small Ubiquitin-like Modifier (SUMO)

(2011) Mathias Droescher et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A General Model for Binary Cell Fate Decision Gene Circuits with Degeneracy: Indeterminacy and Switch Behavior in the Absence of Cooperativity

(2011) Mircea Andrecut et al.   PLoS One

Functional Motifs in Biochemical Reaction Networks

(2010) John J. Tyson et al.   Annual Review of Physical Chemistry

Macrophage plasticity and interaction with lymphocyte subsets: cancer as a paradigm

(2010) Subhra K Biswas et al.   NATURE IMMUNOLOGY

Activated monocytes in peritumoral stroma of hepatocellular carcinoma foster immune privilege and disease progression through PD-L1

(2009) Dong-Ming Kuang et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Tumor-infiltrating myeloid-derived suppressor cells are pleiotropic-inflamed monocytes/macrophages that bear M1- and M2-type characteristics

(2008) Naoki Umemura et al.   JOURNAL OF LEUKOCYTE BIOLOGY

A methodology for performing global uncertainty and sensitivity analysis in systems biology

(2008) Simeone Marino et al.   JOURNAL OF THEORETICAL BIOLOGY

Origin and physiological roles of inflammation

(2008) Ruslan Medzhitov   NATURE

TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon–response genes

(2008) Anna Yarilina et al.   NATURE IMMUNOLOGY