The Cxxc1 subunit of the Trithorax complex directs epigenetic licensing of CD4+ T cell differentiation

Subsets of exhausted CD8+ T cells differentially mediate tumor control and respond to checkpoint blockade

(2019) Brian C. Miller et al.   NATURE IMMUNOLOGY

CD8 T Cell Exhaustion During Chronic Viral Infection and Cancer

(2019) Laura M. McLane et al.   Annual Review of Immunology

Dynamic genetic regulation of gene expression during cellular differentiation

(2019) B. J. Strober et al.   SCIENCE

T Cell Dysfunction in Cancer Immunity and Immunotherapy

(2019) Anliang Xia et al.   Frontiers in Immunology

Striking a Balance—Cellular and Molecular Drivers of Memory T Cell Development and Responses to Chronic Stimulation

(2019) Jennifer L. Hope et al.   Frontiers in Immunology

CD103hi Treg cells constrain lung fibrosis induced by CD103lo tissue-resident pathogenic CD4 T cells

(2019) Tomomi Ichikawa et al.   NATURE IMMUNOLOGY

Amphiregulin-Producing Pathogenic Memory T Helper 2 Cells Instruct Eosinophils to Secrete Osteopontin and Facilitate Airway Fibrosis

(2018) Yuki Morimoto et al.   IMMUNITY

A timer for analyzing temporally dynamic changes in transcription during differentiation in vivo

(2018) David Bending et al.   JOURNAL OF CELL BIOLOGY

Termination of T cell priming relies on a phase of unresponsiveness promoting disengagement from APCs and T cell division

(2018) Armelle Bohineust et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Silencing stemness in T cell differentiation

(2018) Amanda N. Henning et al.   SCIENCE

The epigenetic control of stemness in CD8+T cell fate commitment

(2018) Luigia Pace et al.   SCIENCE

The dynamics of gene expression in vertebrate embryogenesis at single-cell resolution

(2018) James A. Briggs et al.   SCIENCE

CFP1 coordinates histone H3 lysine-4 trimethylation and meiotic cell cycle progression in mouse oocytes

(2018) Qian-Qian Sha et al.   Nature Communications

Epigenetic and Transcriptional Regulation in the Induction, Maintenance, Heterogeneity, and Recall-Response of Effector and Memory Th2 Cells

(2018) Atsushi Onodera et al.   Frontiers in Immunology

Epigenetic regulation of T-helper cell differentiation, memory, and plasticity in allergic asthma

(2017) Damon J. Tumes et al.   IMMUNOLOGICAL REVIEWS

Menin Controls the Memory Th2 Cell Function by Maintaining the Epigenetic Integrity of Th2 Cells

(2017) Atsushi Onodera et al.   JOURNAL OF IMMUNOLOGY

Severe and Difficult-to-Treat Asthma in Adults

(2017) Elliot Israel et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tribbles in the 21st Century: The Evolving Roles of Tribbles Pseudokinases in Biology and Disease

(2017) Patrick A. Eyers et al.   TRENDS IN CELL BIOLOGY

Epigenetics for Plant Improvement: Current Knowledge and Modeling Avenues

(2017) Philippe Gallusci et al.   TRENDS IN PLANT SCIENCE

Dynamics of lineage commitment revealed by single-cell transcriptomics of differentiating embryonic stem cells

(2017) Stefan Semrau et al.   Nature Communications

The SET1 Complex Selects Actively Transcribed Target Genes via Multivalent Interaction with CpG Island Chromatin

(2017) David A. Brown et al.   Cell Reports

Developmental Acquisition of Regulomes Underlies Innate Lymphoid Cell Functionality

(2016) Han-Yu Shih et al.   CELL

CD4+T cell effector commitment coupled to self-renewal by asymmetric cell divisions

(2016) Simone A. Nish et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dynamic stem cell states: naive to primed pluripotency in rodents and humans

(2016) Leehee Weinberger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Weighted enrichment method for prediction of transcription regulators from transcriptome and global chromatin immunoprecipitation data

(2016) Eiryo Kawakami et al.   NUCLEIC ACIDS RESEARCH

Epigenetic balance of gene expression by Polycomb and COMPASS families

(2016) Andrea Piunti et al.   SCIENCE

CXXC finger protein 1 is critical for T-cell intrathymic development through regulating H3K4 trimethylation

(2016) Wenqiang Cao et al.   Nature Communications

T Cells and Gene Regulation: The Switching On and Turning Up of Genes after T Cell Receptor Stimulation in CD8 T Cells

(2016) James M. Conley et al.   Frontiers in Immunology

T Cell Antigen Receptor Recognition of Antigen-Presenting Molecules

(2015) Jamie Rossjohn et al.   Annual Review of Immunology

The JAK-STAT Pathway: Impact on Human Disease and Therapeutic Intervention

(2015) John J. O'Shea et al.   Annual Review of Medicine

The Transcription Factor NFAT Promotes Exhaustion of Activated CD8 + T Cells

(2015) Gustavo J. Martinez et al.   IMMUNITY

Spatial Interplay between Polycomb and Trithorax Complexes Controls Transcriptional Activity in T Lymphocytes

(2015) Atsushi Onodera et al.   MOLECULAR AND CELLULAR BIOLOGY

Primed and ready: understanding lineage commitment through single cell analysis

(2015) Rachael A. Nimmo et al.   TRENDS IN CELL BIOLOGY

TCF-1 at the Tfh and Th1 Divergence

(2015) Yaping Chen et al.   TRENDS IN IMMUNOLOGY

Epigenetics of T cells regulated by Polycomb/Trithorax molecules

(2015) Atsushi Onodera et al.   TRENDS IN MOLECULAR MEDICINE

TCR Signaling in T Cell Memory

(2015) Mark A. Daniels et al.   Frontiers in Immunology

Global transcriptome analyses of human and murine terminal erythroid differentiation

(2014) X. An et al.   BLOOD

Epigenetic Regulation of Pluripotency and Differentiation

(2014) Michael J. Boland et al.   CIRCULATION RESEARCH

Molecular and Transcriptional Basis of CD4+ T Cell Dysfunction during Chronic Infection

(2014) Alison Crawford et al.   IMMUNITY

TCF-1 and LEF-1 act upstream of Th-POK to promote the CD4+ T cell fate and interact with Runx3 to silence Cd4 in CD8+ T cells

(2014) Farrah C Steinke et al.   NATURE IMMUNOLOGY

The Epigenetic Regulator CXXC Finger Protein 1 is Essential for Murine Hematopoiesis

(2014) Kristin T. Chun et al.   PLoS One

Trithorax complex component Menin controls differentiation and maintenance of T helper 17 cells

(2014) Y. Watanabe et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The combination of the prodrugs perforin-CEBPD and perforin-granzyme B efficiently enhances the activation of caspase signaling and kills prostate cancer

(2014) C-H Chuang et al.   Cell Death & Disease

The Menin–Bach2 axis is critical for regulating CD4 T-cell senescence and cytokine homeostasis

(2014) Makoto Kuwahara et al.   Nature Communications

T-bet and Eomes Are Differentially Linked to the Exhausted Phenotype of CD8+ T Cells in HIV Infection

(2014) Marcus Buggert et al.   PLoS Pathogens

Signaling by the Phosphoinositide 3-Kinase Family in Immune Cells

(2013) Klaus Okkenhaug   Annual Review of Immunology

The Polycomb Protein Ezh2 Regulates Differentiation and Plasticity of CD4+ T Helper Type 1 and Type 2 Cells

(2013) Damon J. Tumes et al.   IMMUNITY

The n-SET Domain of Set1 Regulates H2B Ubiquitylation-Dependent H3K4 Methylation

(2013) Jaehoon Kim et al.   MOLECULAR CELL

Transposition of native chromatin for fast and sensitive epigenomic profiling of open chromatin, DNA-binding proteins and nucleosome position

(2013) Jason D Buenrostro et al.   NATURE METHODS

The COMPASS Family of Histone H3K4 Methylases: Mechanisms of Regulation in Development and Disease Pathogenesis

(2012) Ali Shilatifard   Annual Review of Biochemistry

Transcriptional and Epigenetic Control of T Helper Cell Specification: Molecular Mechanisms Underlying Commitment and Plasticity

(2012) Yuka Kanno et al.   Annual Review of Immunology

The COMPASS Subunit Spp1 Links Histone Methylation to Initiation of Meiotic Recombination

(2012) L. Acquaviva et al.   SCIENCE

Priming Microenvironments Dictate Cytokine Requirements for T Helper 17 Cell Lineage Commitment

(2011) Wei Hu et al.   IMMUNITY

Trithorax group proteins: switching genes on and keeping them active

(2011) Bernd Schuettengruber et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

BEDTools: a flexible suite of utilities for comparing genomic features

(2010) Aaron R. Quinlan et al.   BIOINFORMATICS

Distinct Epigenomic Landscapes of Pluripotent and Lineage-Committed Human Cells

(2010) R. David Hawkins et al.   Cell Stem Cell

STAT6-mediated displacement of polycomb by trithorax complex establishes long-term maintenance ofGATA3expression in T helper type 2 cells

(2010) Atsushi Onodera et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Polycomb repressor complex 2 regulates HOXA9 and HOXA10, activating ID2 in NK/T-cell lines

(2010) Stefan Nagel et al.   Molecular Cancer

Simple Combinations of Lineage-Determining Transcription Factors Prime cis-Regulatory Elements Required for Macrophage and B Cell Identities

(2010) Sven Heinz et al.   MOLECULAR CELL

CpG islands influence chromatin structure via the CpG-binding protein Cfp1

(2010) John P. Thomson et al.   NATURE

Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33

(2010) Richard S Houlston et al.   NATURE GENETICS

T Cell Activation

(2009) Jennifer E. Smith-Garvin et al.   Annual Review of Immunology

CEAS: cis-regulatory element annotation system

(2009) Hyunjin Shin et al.   BIOINFORMATICS

The Sequence Alignment/Map format and SAMtools

(2009) H. Li et al.   BIOINFORMATICS

KLF2 Transcription-Factor Deficiency in T Cells Results in Unrestrained Cytokine Production and Upregulation of Bystander Chemokine Receptors

(2009) Michael A. Weinreich et al.   IMMUNITY

Initiation and maintenance of Th2 cell identity

(2008) Toshinori Nakayama et al.   CURRENT OPINION IN IMMUNOLOGY

Molecular Regulation of H3K4 Trimethylation by Wdr82, a Component of Human Set1/COMPASS

(2008) M. Wu et al.   MOLECULAR AND CELLULAR BIOLOGY