Let-7a regulates EV secretion and mitochondrial oxidative phosphorylation by targeting SNAP23 in colorectal cancer

miR-26a regulates extracellular vesicle secretion from prostate cancer cells via targeting SHC4, PFDN4, and CHORDC1

(2020) Fumihiko Urabe et al.   Science Advances

Long non-coding RNA HOTAIR promotes exosome secretion by regulating RAB35 and SNAP23 in hepatocellular carcinoma

(2019) Liang Yang et al.   Molecular Cancer

CAFs secreted exosomes promote metastasis and chemotherapy resistance by enhancing cell stemness and epithelial-mesenchymal transition in colorectal cancer

(2019) J. L. Hu et al.   Molecular Cancer

Dual mechanisms of posttranscriptional regulation of Tet2 by Let-7 microRNA in macrophages

(2019) Shuai Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous Let-7a-5p Induces A549 Lung Cancer Cell Death Through BCL2L1-Mediated PI3Kγ Signaling Pathway

(2019) Shuyin Duan et al.   Frontiers in Oncology

Serum extracellular vesicles contain SPARC and LRG1 as biomarkers of colon cancer and differ by tumour primary location

(2019) Min-Er Zhong et al.   EBioMedicine

Hypoxic tumor-derived exosomal miR-301a mediates M2 macrophage polarization via PTEN/PI3Kγ to promote pancreatic cancer metastasis

(2018) Xiaofeng Wang et al.   CANCER RESEARCH

IGF1/IGF1R and microRNA let-7e down-regulate each other and modulate proliferation and migration of colorectal cancer cells

(2018) Zhenjun Li et al.   CELL CYCLE

Let-7 Suppresses B Cell Activation through Restricting the Availability of Necessary Nutrients

(2018) Shuai Jiang et al.   Cell Metabolism

Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells

(2018) Wei Yan et al.   NATURE CELL BIOLOGY

Tumor-derived exosomal miR-1247-3p induces cancer-associated fibroblast activation to foster lung metastasis of liver cancer

(2018) Tian Fang et al.   Nature Communications

The Secretion of miR-200s by a PKCζ/ADAR2 Signaling Axis Promotes Liver Metastasis in Colorectal Cancer

(2018) Phillip M. Shelton et al.   Cell Reports

Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

(2018) Freddie Bray et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Recent findings regarding let-7 in immunity

(2018) Shuai Jiang   CANCER LETTERS

Long-chain acyl-CoA synthetase 1 interacts with key proteins that activate and direct fatty acids into niche hepatic pathways

(2018) Pamela A. Young et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Toll‐like receptor 2 regulates metabolic reprogramming in gastric cancer via superoxide dismutase 2

(2018) You Dong Liu et al.   INTERNATIONAL JOURNAL OF CANCER

Cancer-derived exosomal miR-25-3p promotes pre-metastatic niche formation by inducing vascular permeability and angiogenesis

(2018) Zhicheng Zeng et al.   Nature Communications

Pyruvate kinase type M2 promotes tumour cell exosome release via phosphorylating synaptosome-associated protein 23

(2017) Yao Wei et al.   Nature Communications

The LIN28/let-7 Pathway in Cancer

(2017) Julien Balzeau et al.   Frontiers in Genetics

Let-7a inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer

(2016) Bin Li et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Versatile roles of extracellular vesicles in cancer

(2016) Nobuyoshi Kosaka et al.   JOURNAL OF CLINICAL INVESTIGATION

Mitochondria and Cancer

(2016) Wei-Xing Zong et al.   MOLECULAR CELL

Linc00152 Functions as a Competing Endogenous RNA to Confer Oxaliplatin Resistance and Holds Prognostic Values in Colon Cancer

(2016) Ben Yue et al.   MOLECULAR THERAPY

Colorectal Cancer Heterogeneity and Targeted Therapy: A Case for Molecular Disease Subtypes

(2015) J. F. Linnekamp et al.   CANCER RESEARCH

DICER1 regulated let-7 expression levels in p53-induced cancer repression requires cyclin D1

(2015) Xin Sun et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Exosome mediated communication within the tumor microenvironment

(2015) Lara Milane et al.   JOURNAL OF CONTROLLED RELEASE

PKM2 promotes glucose metabolism and cell growth in gliomas through a mechanism involving a let-7a/c-Myc/hnRNPA1 feedback loop

(2015) Wenkang Luan et al.   Oncotarget

The tumour-induced systemic environment as a critical regulator of cancer progression and metastasis

(2014) Sandra S. McAllister et al.   NATURE CELL BIOLOGY

Effects of let-7 microRNA on Cell Growth and Differentiation of Papillary Thyroid Cancer

(2014) Jølio Cezar Marques et al.   Translational Oncology

Lin28/let-7 axis regulates aerobic glycolysis and cancer progression via PDK1

(2014) Xiaoyu Ma et al.   Nature Communications

Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism

(2013) Ng Shyh-Chang et al.   CELL

Exosome removal as a therapeutic adjuvant in cancer

(2012) Annette M Marleau et al.   Journal of Translational Medicine

Potential role of HER2-overexpressing exosomes in countering trastuzumab-based therapy

(2011) Valentina Ciravolo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Lipid droplets interact with mitochondria using SNAP23

(2009) Sara Jägerström et al.   CELL BIOLOGY INTERNATIONAL

Rab27a and Rab27b control different steps of the exosome secretion pathway

(2009) Matias Ostrowski et al.   NATURE CELL BIOLOGY

Ceramide Triggers Budding of Exosome Vesicles into Multivesicular Endosomes

(2008) K. Trajkovic et al.   SCIENCE